CN1364481A - Nano productive cough clearing medicine and its preparing method - Google Patents
Nano productive cough clearing medicine and its preparing method Download PDFInfo
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- CN1364481A CN1364481A CN 01100255 CN01100255A CN1364481A CN 1364481 A CN1364481 A CN 1364481A CN 01100255 CN01100255 CN 01100255 CN 01100255 A CN01100255 A CN 01100255A CN 1364481 A CN1364481 A CN 1364481A
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- 239000003814 drug Substances 0.000 title claims abstract description 47
- 206010036790 Productive cough Diseases 0.000 title claims description 19
- 238000000034 method Methods 0.000 title claims description 13
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 239000000463 material Substances 0.000 claims description 19
- 239000000843 powder Substances 0.000 claims description 10
- BALXUFOVQVENIU-GNAZCLTHSA-N Ephedrine hydrochloride Chemical compound Cl.CN[C@@H](C)[C@H](O)C1=CC=CC=C1 BALXUFOVQVENIU-GNAZCLTHSA-N 0.000 claims description 9
- 229960002534 ephedrine hydrochloride Drugs 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 241000207929 Scutellaria Species 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000002156 mixing Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 8
- 206010011224 Cough Diseases 0.000 abstract description 5
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 abstract 2
- 241000245165 Rhododendron ponticum Species 0.000 abstract 1
- 241001345012 Syringa reticulata subsp. amurensis Species 0.000 abstract 1
- 235000019270 ammonium chloride Nutrition 0.000 abstract 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 abstract 1
- 229960002179 ephedrine Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 5
- 206010062717 Increased upper airway secretion Diseases 0.000 description 4
- 206010044302 Tracheitis Diseases 0.000 description 4
- 208000006673 asthma Diseases 0.000 description 4
- 208000026435 phlegm Diseases 0.000 description 4
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Mold Materials And Core Materials (AREA)
- Molds, Cores, And Manufacturing Methods Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
The nano cough clearing medicine is prepared with nano amur lilac bark, nano dahurian rhododendron leaf, nano Radix Scutellariae, nano ephedrine and nano ammonium chloride in certain proportion as raw material. The new medicine preparation has a grain fineness of 1200-1500 mesh, grains size of 0.1-200 nm, mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and obvious treating effect.
Description
The present invention relates to the nano productive cough clearing medicine of a kind of removing heat from the lung and dissipating phlegm, relieving cough and asthma, the invention still further relates to the method for this medication preparation.
The clear sheet of productive cough is a kind of classical Chinese patent medicine, mainly contains effects such as removing heat from the lung and dissipating phlegm, relieving cough and asthma, is used for diseases such as phlegm-heat cough, acute and chronic tracheitis asthma.But the clear sheet disintegrate of traditional productive cough is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano productive cough clearing medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano productive cough clearing medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer Cortex Syingae Amurensis 1000-2000 part nanometer Folium Rhododendri Daurici 350-700 part nanometer Radix Scutellariae 350-700 part
Nanometer ephedrine hydrochloride 1-5 part nanometer ammonia chloride 35-70 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer Cortex Syingae Amurensis 1200-1800 part nanometer Folium Rhododendri Daurici 400-600 part nanometer Radix Scutellariae 400-600 part
Nanometer ephedrine hydrochloride 2-3 part nanometer ammonia chloride 40-60 part
The optimum weight proportioning of medicine of the present invention is:
506 parts of 506 parts of nanometer Radix Scutellariaes of 1686 parts of nanometer Folium Rhododendri Daurici of nanometer Cortex Syingae Amurensis
50.56 parts of 2.36 parts of nanometer ammonia chlorides of nanometer ephedrine hydrochloride
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get the productive cough clearing nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nano productive cough clearing medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, the clear tablet preparation material of common productive cough is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano productive cough clearing medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as phlegm-heat cough, acute and chronic tracheitis asthma, and clinical efficacy significantly is better than the clear sheet of traditional productive cough.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
506 parts of 506 parts of nanometer Radix Scutellariaes of 1686 parts of nanometer Folium Rhododendri Daurici of nanometer Cortex Syingae Amurensis
50.56 parts of 2.36 parts of nanometer ammonia chlorides of nanometer ephedrine hydrochloride
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is the 0.1--0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
506 parts of 506 parts of nanometer Radix Scutellariaes of 1686 parts of nanometer Folium Rhododendri Daurici of nanometer Cortex Syingae Amurensis
50.56 parts of 2.36 parts of nanometer ammonia chlorides of nanometer ephedrine hydrochloride
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or the described mixed of powder good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia powder needle injection standard, do not add any adjuvant, make the clear powder needle injection of nanometer productive cough, every injection content is the 5-20 milligram, each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
506 parts of 506 parts of nanometer Radix Scutellariaes of 1686 parts of nanometer Folium Rhododendri Daurici of nanometer Cortex Syingae Amurensis
50.56 parts of 2.36 parts of nanometer ammonia chlorides of nanometer ephedrine hydrochloride
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the clear membrane of nanometer productive cough, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: back, chest.
Claims (6)
1, a kind of nano productive cough clearing medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer Cortex Syingae Amurensis 1000-2000 part nanometer Folium Rhododendri Daurici 350-700 part nanometer Radix Scutellariae 350-700 part
Nanometer ephedrine hydrochloride 1-5 part nanometer ammonia chloride 35-70 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano productive cough clearing medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer Cortex Syingae Amurensis 1200-1800 part nanometer Folium Rhododendri Daurici 400-600 part nanometer Radix Scutellariae 400-600 part
Nanometer ephedrine hydrochloride 2-3 part nanometer ammonia chloride 40-60 part
3, nano productive cough clearing medicine according to claim 1, wherein the weight proportion of each nano raw material is:
506 parts of 506 parts of nanometer Radix Scutellariaes of 1686 parts of nanometer Folium Rhododendri Daurici of nanometer Cortex Syingae Amurensis
50.56 parts of 2.36 parts of nanometer ammonia chlorides of nanometer ephedrine hydrochloride
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano productive cough clearing medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano productive cough clearing medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100255 CN1364481A (en) | 2001-01-12 | 2001-01-12 | Nano productive cough clearing medicine and its preparing method |
| CNB2006101155842A CN100374229C (en) | 2001-01-12 | 2001-07-31 | Deoxidation Casting, Aluminum Casting and Foundry Equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100255 CN1364481A (en) | 2001-01-12 | 2001-01-12 | Nano productive cough clearing medicine and its preparing method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1364481A true CN1364481A (en) | 2002-08-21 |
Family
ID=4651428
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100255 Pending CN1364481A (en) | 2001-01-12 | 2001-01-12 | Nano productive cough clearing medicine and its preparing method |
| CNB2006101155842A Expired - Fee Related CN100374229C (en) | 2001-01-12 | 2001-07-31 | Deoxidation Casting, Aluminum Casting and Foundry Equipment |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2006101155842A Expired - Fee Related CN100374229C (en) | 2001-01-12 | 2001-07-31 | Deoxidation Casting, Aluminum Casting and Foundry Equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN1364481A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973658A (en) * | 2012-12-17 | 2013-03-20 | 伊春金北药制药有限公司 | Sugar-free scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture and preparation method thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2294272B (en) * | 1994-07-28 | 1998-02-25 | Honda Motor Co Ltd | Method for producing metal-ceramic composite materials. |
| US5669434A (en) * | 1994-10-26 | 1997-09-23 | Honda Giken Kogyo Kabushiki Kaisha | Method and apparatus for forming an aluminum alloy composite material |
| JP3630383B2 (en) * | 1996-12-24 | 2005-03-16 | 本田技研工業株式会社 | Method for producing metal / ceramic composite material |
| JP2000280063A (en) * | 1999-03-31 | 2000-10-10 | Nissin Kogyo Co Ltd | Aluminum casting method |
-
2001
- 2001-01-12 CN CN 01100255 patent/CN1364481A/en active Pending
- 2001-07-31 CN CNB2006101155842A patent/CN100374229C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102973658A (en) * | 2012-12-17 | 2013-03-20 | 伊春金北药制药有限公司 | Sugar-free scutellaria baicalensis, manchurian lilac bark and dahurian rhododendron leaf cough-arresting mixture and preparation method thereof |
| CN102973658B (en) * | 2012-12-17 | 2016-03-23 | 伊春金北药制药有限公司 | Sugarless type cough-relieving Qinbaohong mixture and method for making thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1903484A (en) | 2007-01-31 |
| CN100374229C (en) | 2008-03-12 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |