CN1360920A - Nanometer antiphlogistic Lonicerae and Forsythiae medicine and its prepn - Google Patents
Nanometer antiphlogistic Lonicerae and Forsythiae medicine and its prepn Download PDFInfo
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- 239000000463 material Substances 0.000 claims abstract description 20
- XOJVHLIYNSOZOO-SWOBOCGESA-N Arctiin Chemical compound C1=C(OC)C(OC)=CC=C1C[C@@H]1[C@@H](CC=2C=C(OC)C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O3)O)=CC=2)C(=O)OC1 XOJVHLIYNSOZOO-SWOBOCGESA-N 0.000 claims abstract description 10
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 241000555682 Forsythia x intermedia Species 0.000 claims abstract 2
- 238000002360 preparation method Methods 0.000 claims description 19
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- 239000002994 raw material Substances 0.000 claims description 6
- 241000202807 Glycyrrhiza Species 0.000 claims description 5
- 235000014435 Mentha Nutrition 0.000 claims description 5
- 241001072983 Mentha Species 0.000 claims description 5
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- 239000008187 granular material Substances 0.000 claims description 5
- 238000002347 injection Methods 0.000 claims description 5
- 239000007924 injection Substances 0.000 claims description 5
- 239000006187 pill Substances 0.000 claims description 5
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- 239000012141 concentrate Substances 0.000 claims description 4
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- 235000019634 flavors Nutrition 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 239000012528 membrane Substances 0.000 claims description 4
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000443 aerosol Substances 0.000 claims description 2
- 239000006196 drop Substances 0.000 claims description 2
- 239000003094 microcapsule Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000000829 suppository Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 239000003390 Chinese drug Substances 0.000 claims 2
- 230000000694 effects Effects 0.000 abstract description 9
- 241000205585 Aquilegia canadensis Species 0.000 abstract description 4
- 235000013399 edible fruits Nutrition 0.000 abstract 2
- 241000208843 Arctium Species 0.000 abstract 1
- 244000246386 Mentha pulegium Species 0.000 abstract 1
- 235000016257 Mentha pulegium Nutrition 0.000 abstract 1
- 235000004357 Mentha x piperita Nutrition 0.000 abstract 1
- 235000006753 Platycodon grandiflorum Nutrition 0.000 abstract 1
- 240000003582 Platycodon grandiflorus Species 0.000 abstract 1
- 235000001050 hortel pimenta Nutrition 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000000704 physical effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 description 8
- 241000555712 Forsythia Species 0.000 description 7
- 238000001784 detoxification Methods 0.000 description 5
- 239000002671 adjuvant Substances 0.000 description 3
- 230000001147 anti-toxic effect Effects 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 206010022000 influenza Diseases 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
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- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
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- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000004035 construction material Substances 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The nano antiphlogistic Lonicerae and Forsythiae medicine is prepared with nano honeysuckle, nano forsythia fruit, nano balloonflower, nano arctium fruit, nano peppermint and other five konds of nano Chinese medicinal materials in certain proportion as material. It has a grain fineness of 1200-1500 mesh, grain size of 0.1-200 nm and mostly below 100 nm, and new physical property. It is prepared through microwave extraction, decompressing concentration, spray drying in supersonic jet and other steps. It has high biological utilization and high treating effect.
Description
The present invention relates to a kind of relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, heat-clearing and toxic substances removing, cure mainly the nanometer YINQIAO detoxicating preparation medicine of flu, the invention still further relates to the preparation method of this medicine.
Antitoxic bolus of honeysuckle flower and forsythia is a kind of classical Chinese patent medicine, mainly contains effects such as diaphoresis, analgesic, resisting pathogenic microbes, antiinflammatory, analgesia, antiallergic, be used for anemopyretic cold or epidemic febrile disease from the beginning of, but generate heat not aversion to cold, thirsty headache, cough, laryngopharynx swelling and pain etc.But traditional Yinqiao detoxification pill disintegrate is slower, absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nanometer YINQIAO detoxicating preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nanometer YINQIAO detoxicating preparation.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer gold Flos Lonicerae 10-25 part nanometer Fructus Forsythiae 10-25 part nanometer Radix Platycodonis 5-15 part
Nanometer Fructus Arctii 5-15 part nanometer Jing Jie fringe 5-15 part nanometer Herba Menthae 5-15 part
Nanometer Semen Sojae Preparatum 5-10 part nanometer Herba Lophatheri 5-15 part nanometer Radix Glycyrrhizae 5-15 part
Nanometer reed root 3-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer gold Flos Lonicerae 20-25 part nanometer Fructus Forsythiae 20-25 part nanometer Radix Platycodonis 8-12 part
Nanometer Fructus Arctii 6-10 part nanometer Jing Jie fringe 6-10 part nanometer Herba Menthae 5-15 part
Nanometer Semen Sojae Preparatum 5-15 part nanometer Herba Lophatheri 5-15 part nanometer Radix Glycyrrhizae 5-15 part
Nanometer reed root 3-10 part
The best important proportioning of medicine of the present invention is:
8 parts of 23 parts of nanometer Radix Platycodoniss of 23 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
8 parts of 6 parts of nanometer Herba Menthaes of 8 parts of nanometer Jing Jie of nanometer Fructus Arctii fringe
8 parts in 6 parts of nanometer Radix Glycyrrhizaes of 7 parts of nanometer Herba Lophatheris of nanometer Semen Sojae Preparatum
3 parts of nanometer Rhizoma Phragmitiss
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the ultra-micro powder of the particle size＜100nm of the special construction----material of nano material, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Yinqiao detoxification preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia two editions standard preparations in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made nanometer YINQIAO detoxicating preparation medicine is identical.
A kind of important feature of the present invention is, the made drug material of the present invention has reached nanoscale, common antitoxic bolus of honeysuckle flower and forsythia preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, and the overwhelming majority＜100nm can cross the 1200-1500 mesh sieve.
Another important feature of the present invention is, solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the injectable sterile powder of Yinqiao detoxification preparation medicine, the new drug formulation that intravenous drip is had no precedent in the past with injection, cutaneous permeable agent, liniment, oral solution etc.
Pharmaceutical preparation of the present invention can be used for treatments such as flu, influenza, pneumonia, hepatitis B, parotitis, herpangina, measles, rubella, ophthalmic, and clinical efficacy significantly is better than traditional antitoxic bolus of honeysuckle flower and forsythia.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
8 parts of 23 parts of nanometer Radix Platycodoniss of 23 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
8 parts of 6 parts of nanometer Herba Menthaes of 8 parts of nanometer Jing Jie of nanometer Fructus Arctii fringe
8 parts in 6 parts of nanometer Radix Glycyrrhizaes of 7 parts of nanometer Herba Lophatheris of nanometer Semen Sojae Preparatum
3 parts of nanometer Rhizoma Phragmitiss
Production method is as follows:
In the GMP cleaning shop, the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio after, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulatedly with the fully-automatic capsule racking machine, make capsule.Every capsules content of dispersion is the 0.1-0.6 gram, and the patient takes the 1-5 grain at every turn, and take 1-4 every day.
Embodiment 2:
Prepare nano raw material by preceding method:
8 parts of 23 parts of nanometer Radix Platycodoniss of 23 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
8 parts of 6 parts of nanometer Herba Menthaes of 8 parts of nanometer Jing Jie of nanometer Fructus Arctii fringe
8 parts in 6 parts of nanometer Radix Glycyrrhizaes of 7 parts of nanometer Herba Lophatheris of nanometer Semen Sojae Preparatum
3 parts of nanometer Rhizoma Phragmitiss
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, make nanometer Yinqiao detoxification powder needle injection, every injection content 5-20 milligram, each consumption is that 1-2 props up, use 1-3 every day.
Embodiment 3:
8 parts of 23 parts of nanometer Radix Platycodoniss of 23 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
8 parts of 6 parts of nanometer Herba Menthaes of 8 parts of nanometer Jing Jie of nanometer Fructus Arctii fringe
8 parts in 6 parts of nanometer Radix Glycyrrhizaes of 7 parts of nanometer Herba Lophatheris of nanometer Semen Sojae Preparatum
3 parts of nanometer Rhizoma Phragmitiss
Prepare nano raw material by preceding method
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, filmogen adopts polyvinyl alcohol, make nanometer Yinqiao detoxification membrane, every membrane area size 2-100 square centimeter, content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, and paste the medicine position: abdominal part, back, chest etc. are located.
Claims (6)
1. nanometer YINQIAO detoxicating preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made,
Nanometer gold Flos Lonicerae 10-25 part nanometer Fructus Forsythiae 10-25 part nanometer Radix Platycodonis 5-15 part
Nanometer Fructus Arctii 5-15 part nanometer Jing Jie fringe 5-15 part nanometer Herba Menthae 5-15 part
Nanometer Semen Sojae Preparatum 5-10 part nanometer Herba Lophatheri 5-15 part nanometer Radix Glycyrrhizae 5-15 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2. nanometer YINQIAO detoxicating preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer gold Flos Lonicerae 20-25 part nanometer Fructus Forsythiae 20-25 part nanometer Radix Platycodonis 8-12 part
Nanometer Fructus Arctii 6-10 part nanometer Jing Jie fringe 5-10 part nanometer Herba Menthae 5-15 part
Nanometer Semen Sojae Preparatum 5-15 part nanometer Herba Lophatheri 5-15 part nanometer Radix Glycyrrhizae 5-15 part
Nanometer Rhizoma Phragmitis 3-10 part
3. nanometer YINQIAO detoxicating preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
8 parts of 23 parts of nanometer Radix Platycodoniss of 23 parts of nanometer Fructus Forsythiaes of nanometer gold Flos Lonicerae
8 parts of 6 parts of nanometer Herba Menthaes of 8 parts of nanometer Jing Jie of nanometer Fructus Arctii fringe
8 parts in 6 parts of nanometer Radix Glycyrrhizaes of 7 parts of nanometer Herba Lophatheris of nanometer Semen Sojae Preparatum
3 parts of nanometer Rhizoma Phragmitiss
4. according to claim 1 or 2 or 3 described nanometer YINQIAO detoxicating preparation medicines, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
5. according to the pharmaceutical methods of claim 1 or 2 or 3 described nanometer YINQIAO detoxicating preparation medicines, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20-30, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6. wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or after the prepared slices of Chinese crude drugs are processed in this process of preparing Chinese medicine of Chinese medicine mixing, or in making nanometer, mixing behind the medicine decoction pieces.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136789 CN1360920A (en) | 2000-12-28 | 2000-12-28 | Nanometer antiphlogistic Lonicerae and Forsythiae medicine and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00136789 CN1360920A (en) | 2000-12-28 | 2000-12-28 | Nanometer antiphlogistic Lonicerae and Forsythiae medicine and its prepn |
Publications (1)
| Publication Number | Publication Date |
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| CN1360920A true CN1360920A (en) | 2002-07-31 |
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| CN 00136789 Pending CN1360920A (en) | 2000-12-28 | 2000-12-28 | Nanometer antiphlogistic Lonicerae and Forsythiae medicine and its prepn |
Country Status (1)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596231B (en) * | 2009-06-25 | 2012-05-02 | 王战云 | Medicinal composition for treating parotitis |
| CN103393745A (en) * | 2013-08-22 | 2013-11-20 | 河北医科大学 | Preparation method of medicine or health-care product for treating xerophthalmia and use of medicine or health-care product |
| CN104208180A (en) * | 2014-08-19 | 2014-12-17 | 李新民 | Formula treating rubella |
-
2000
- 2000-12-28 CN CN 00136789 patent/CN1360920A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101596231B (en) * | 2009-06-25 | 2012-05-02 | 王战云 | Medicinal composition for treating parotitis |
| CN103393745A (en) * | 2013-08-22 | 2013-11-20 | 河北医科大学 | Preparation method of medicine or health-care product for treating xerophthalmia and use of medicine or health-care product |
| CN104208180A (en) * | 2014-08-19 | 2014-12-17 | 李新民 | Formula treating rubella |
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