CN1362242A - Nano dark plum medicine and its preparation - Google Patents
Nano dark plum medicine and its preparation Download PDFInfo
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- CN1362242A CN1362242A CN 01100744 CN01100744A CN1362242A CN 1362242 A CN1362242 A CN 1362242A CN 01100744 CN01100744 CN 01100744 CN 01100744 A CN01100744 A CN 01100744A CN 1362242 A CN1362242 A CN 1362242A
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- 239000003814 drug Substances 0.000 claims abstract description 45
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 12
- 241000758794 Asarum Species 0.000 claims abstract description 10
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 10
- 235000008397 ginger Nutrition 0.000 claims abstract description 10
- 239000002994 raw material Substances 0.000 claims abstract description 7
- 238000001035 drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 20
- 229940032171 plum preparation Drugs 0.000 claims description 11
- 241000213006 Angelica dahurica Species 0.000 claims description 9
- 241000208340 Araliaceae Species 0.000 claims description 9
- 244000247747 Coptis groenlandica Species 0.000 claims description 9
- 235000002991 Coptis groenlandica Nutrition 0.000 claims description 9
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 9
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 9
- 241000972673 Phellodendron amurense Species 0.000 claims description 9
- 244000131415 Zanthoxylum piperitum Species 0.000 claims description 9
- 235000008853 Zanthoxylum piperitum Nutrition 0.000 claims description 9
- 235000008434 ginseng Nutrition 0.000 claims description 9
- 239000006187 pill Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000002775 capsule Substances 0.000 claims description 6
- 238000002347 injection Methods 0.000 claims description 6
- 239000007924 injection Substances 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 6
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- 238000001694 spray drying Methods 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 2
- 239000003826 tablet Substances 0.000 claims description 2
- 244000273928 Zingiber officinale Species 0.000 claims 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 abstract description 9
- 241000234314 Zingiber Species 0.000 abstract description 7
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 241000544270 Angelica acutiloba Species 0.000 abstract 1
- 229940023019 aconite Drugs 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 241000244186 Ascaris Species 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- LAOOXBLMIJHMFO-UHFFFAOYSA-N 1-[2-(diethylamino)ethylamino]-4-methylthioxanthen-9-one;hydron;chloride Chemical compound Cl.S1C2=CC=CC=C2C(=O)C2=C1C(C)=CC=C2NCCN(CC)CC LAOOXBLMIJHMFO-UHFFFAOYSA-N 0.000 description 1
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000087 Abdominal pain upper Diseases 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 201000002045 Ancylostomiasis Diseases 0.000 description 1
- 208000033211 Ankylostomiasis Diseases 0.000 description 1
- 206010008616 Cholecystitis and cholelithiasis Diseases 0.000 description 1
- 208000002881 Colic Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 208000004232 Enteritis Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020376 Hookworm infection Diseases 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 230000036592 analgesia Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 201000009361 ascariasis Diseases 0.000 description 1
- 210000000941 bile Anatomy 0.000 description 1
- 210000003445 biliary tract Anatomy 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
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- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 208000002551 irritable bowel syndrome Diseases 0.000 description 1
- 239000002086 nanomaterial Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001843 schistosomicidal effect Effects 0.000 description 1
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- 210000004514 sphincter of oddi Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloses a nano mume preparation medicine. It is made up by using 9 Chinese medicinal materials of nano mume, nano asarum, nano dried ginger, nano tangkuei, nano aconite and othera as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spary drying. Its grain fineness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to a kind of relieving pain by calming ascaris, the dirty nano dark plum preparation medicine of tonify deficiency temperature, the invention still further relates to the method for this medication preparation.
Wumei pills is a kind of classical Chinese patent medicine, mainly contain the anesthesia polypide, strengthen gallbladder and shrink, increase effects such as bile secretion, lax Oddi's sphincter, antibacterial, analgesia, being used for colic caused by ascaris, headache due to JUE YIN disorder, unhappy vomiting, time ends when sending out, must eat and then tell even do when vomiting ascaris, deadly cold hand and foot, stomachache.But traditional wumei pills absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano dark plum preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano dark plum preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nano dark plum 5-50 part nanometric Herbra Asarum 5-50 part nanometric ginger 5-50 part
Nano Chinese angelica 10-60 part nanometric Radix Aconiti Lateralis Preparata 5-50 part nanometric Zanthoxylum piperitum D.C. 5-50 part
Nano phellodendron bark 10-50 part nanometer coptis 10-50 part nano ginseng 5-50 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nano dark plum 15-40 part nanometric Herbra Asarum 10-30 part nanometric ginger 10-30 part
Nano Chinese angelica 20-50 part nanometric Radix Aconiti Lateralis Preparata 10-30 part nanometric Zanthoxylum piperitum D.C. 15-40 part
Nano phellodendron bark 20-40 part nanometer coptis 18-40 part nano ginseng 10-30 part
The optimum weight proportioning of medicine of the present invention is:
18 parts of 20 parts of nanometric gingers of 25 parts of nanometric Herbra Asarums of nano dark plum
22 parts of 20 parts of nanometric Zanthoxylum piperitum D.C.s of 28 parts of nanometric Radix Aconiti Lateralis Preparatas of nano Chinese angelica
18 parts of 26 parts of nano ginsengs of 30 parts of nanometer coptis of nano phellodendron bark
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material is because the special construction of nano material---the particle size of material is less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15%-50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, add to concoct according to Chinese Pharmacopoeia one one of version in 2000 and be processed into the common Chinese decoction pieces
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition:
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20-30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃-60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters-990 meter per seconds of effluxvelocity, 30 ℃ of-60 ℃ of temperature, under 0 to the 0.05MPa pressure,, get Fructus Mume preparation nano powder with the instantaneous drying of hypersonic velocity jet;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano dark plum preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common wumei pills preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1-200nm, the overwhelming majority can be crossed the 1200-1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that suppository, membrane, microcapsule, drop pill, aerosol, injection, medicated wine, syrup, oral solution of nano dark plum preparation medicine etc. is had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for treatment of conditions such as ascariasis of biliary tract, bellyworm, schistosomicide and ancylostomiasis, diarrhoea, enteritis, irritable bowel syndrome, cholecystitis and cholelithiasis, nerve and spirit disease, ill antrum syndrome, leukorrhagia, metrorrhagia, dysmenorrhea, and clinical efficacy significantly is better than traditional wumei pills.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
18 parts of 20 parts of nanometric gingers of 25 parts of nanometric Herbra Asarums of nano dark plum
22 parts of 20 parts of nanometric Zanthoxylum piperitum D.C.s of 28 parts of nanometric Radix Aconiti Lateralis Preparatas of nano Chinese angelica
18 parts of 26 parts of nano ginsengs of 30 parts of nanometer coptis of nano phellodendron bark
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent capsules agent standard, do not add adjuvant, do not granulate, directly divide encapsulated with the fully-automatic capsule racking machine, make capsule, every capsules content of dispersion is a 0.1-0.6 gram, and the patient takes 1-4 time every day, every day the 1-5 grain.
Embodiment 2:
Prepare nano raw material by preceding method:
18 parts of 20 parts of nanometric gingers of 25 parts of nanometric Herbra Asarums of nano dark plum
22 parts of 20 parts of nanometric Zanthoxylum piperitum D.C.s of 28 parts of nanometric Radix Aconiti Lateralis Preparatas of nano Chinese angelica
18 parts of 26 parts of nano ginsengs of 30 parts of nanometer coptis of nano phellodendron bark
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent powder needle injection standard, do not add any adjuvant, make the nano dark plum powder needle injection, every injection content is the 5-20 milligram, and each consumption is that 1-2 props up, and use 1-3 every day.
Embodiment 3:
Prepare nano raw material by preceding method:
18 parts of 20 parts of nanometric gingers of 25 parts of nanometric Herbra Asarums of nano dark plum
22 parts of 20 parts of nanometric Zanthoxylum piperitum D.C.s of 28 parts of nanometric Radix Aconiti Lateralis Preparatas of nano Chinese angelica
18 parts of 26 parts of nano ginsengs of 30 parts of nanometer coptis of nano phellodendron bark
Production method is as follows:
In the GMP cleaning shop, after the above-mentioned nanometer prepared slices of Chinese crude drugs or powder prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent membrane standard, filmogen adopts polyvinyl alcohol, make the nano dark plum membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: abdominal part.
Claims (6)
1, a kind of nano dark plum preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nano dark plum 5-50 part nanometric Herbra Asarum 5-50 part nanometric ginger 5-50 part
Nano Chinese angelica 10-60 part nanometric Radix Aconiti Lateralis Preparata 5-50 part nanometric Zanthoxylum piperitum D.C. 5-50 part
Nano phellodendron bark 10-50 part nanometer coptis 10-50 part nano ginseng 5-50 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
2, nano dark plum preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nano dark plum 15-40 part nanometric Herbra Asarum 10-30 part nanometric ginger 10-30 part
Nano Chinese angelica 20-50 part nanometric Radix Aconiti Lateralis Preparata 10-30 part nanometric Zanthoxylum piperitum D.C. 15-40 part
Nano phellodendron bark 20-40 part nanometer coptis 18-40 part nano ginseng 10-30 part
3, nano dark plum preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
18 parts of 20 parts of nanometric gingers of 25 parts of nanometric Herbra Asarums of nano dark plum
22 parts of 20 parts of nanometric Zanthoxylum piperitum D.C.s of 28 parts of nanometric Radix Aconiti Lateralis Preparatas of nano Chinese angelica
18 parts of 26 parts of nano ginsengs of 30 parts of nanometer coptis of nano phellodendron bark
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano dark plum preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano dark plum preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1--10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3--72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters--990 meter per seconds, promptly make the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100744 CN1362242A (en) | 2001-01-08 | 2001-01-08 | Nano dark plum medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100744 CN1362242A (en) | 2001-01-08 | 2001-01-08 | Nano dark plum medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362242A true CN1362242A (en) | 2002-08-07 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100744 Pending CN1362242A (en) | 2001-01-08 | 2001-01-08 | Nano dark plum medicine and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1362242A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940882A (en) * | 2015-07-08 | 2015-09-30 | 河南中医学院 | Traditional Chinese medicine for treating chronic diarrhea |
| CN106177344A (en) * | 2016-08-31 | 2016-12-07 | 安徽新盛中药饮片有限公司 | A kind of stomach invigorating removing toxic substances Fructus Mume micro-ferment decoction pieces and preparation method thereof |
-
2001
- 2001-01-08 CN CN 01100744 patent/CN1362242A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104940882A (en) * | 2015-07-08 | 2015-09-30 | 河南中医学院 | Traditional Chinese medicine for treating chronic diarrhea |
| CN104940882B (en) * | 2015-07-08 | 2018-05-01 | 河南中医学院 | A kind of Chinese medicine for treating chronic diarrhea |
| CN106177344A (en) * | 2016-08-31 | 2016-12-07 | 安徽新盛中药饮片有限公司 | A kind of stomach invigorating removing toxic substances Fructus Mume micro-ferment decoction pieces and preparation method thereof |
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