CN1362129A - Nano bone-setting medicine and its preparation - Google Patents
Nano bone-setting medicine and its preparation Download PDFInfo
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- CN1362129A CN1362129A CN 01100182 CN01100182A CN1362129A CN 1362129 A CN1362129 A CN 1362129A CN 01100182 CN01100182 CN 01100182 CN 01100182 A CN01100182 A CN 01100182A CN 1362129 A CN1362129 A CN 1362129A
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- 239000003814 drug Substances 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000463 material Substances 0.000 claims abstract description 20
- 238000000034 method Methods 0.000 claims abstract description 11
- 239000002994 raw material Substances 0.000 claims abstract description 5
- 238000001694 spray drying Methods 0.000 claims abstract description 5
- 229940079593 drug Drugs 0.000 claims description 18
- 241001489978 Eupolyphaga Species 0.000 claims description 7
- 241000287828 Gallus gallus Species 0.000 claims description 7
- 241000533849 Gleditsia Species 0.000 claims description 7
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 7
- 239000012528 membrane Substances 0.000 claims description 6
- 239000006187 pill Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims description 4
- 229940025250 camphora Drugs 0.000 claims description 4
- 239000010238 camphora Substances 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 4
- 235000008504 concentrate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims description 4
- 230000008676 import Effects 0.000 claims description 4
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 4
- 239000000443 aerosol Substances 0.000 claims description 3
- 239000002775 capsule Substances 0.000 claims description 3
- 239000006196 drop Substances 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002347 injection Methods 0.000 claims description 3
- 239000007924 injection Substances 0.000 claims description 3
- 239000003094 microcapsule Substances 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 239000002674 ointment Substances 0.000 claims description 3
- 229940100688 oral solution Drugs 0.000 claims description 3
- 239000000829 suppository Substances 0.000 claims description 3
- 239000006188 syrup Substances 0.000 claims description 3
- 235000020357 syrup Nutrition 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 3
- 239000003390 Chinese drug Substances 0.000 claims 2
- 241000133134 Saussurea Species 0.000 abstract 2
- 241001674044 Blattodea Species 0.000 abstract 1
- 238000000874 microwave-assisted extraction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 8
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 206010024453 Ligament sprain Diseases 0.000 description 3
- 208000010040 Sprains and Strains Diseases 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 230000036592 analgesia Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000002086 nanomaterial Substances 0.000 description 2
- 239000011858 nanopowder Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000825 pharmaceutical preparation Substances 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 230000002040 relaxant effect Effects 0.000 description 2
- 239000007962 solid dispersion Substances 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 240000002299 Symphytum officinale Species 0.000 description 1
- 235000005865 Symphytum officinale Nutrition 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The present invention discloss a nano bone-setting preparation medicine. It is made up by using 22 Chinese medicinal materials of nano jiulongchuan, nano saussurea, nano fengteng, nano wingless cockroach, nano white saussurea and others as raw material through the processes of microwave extraction, reduced pressure concentration and supersonic jet spray drying. Its grain fieness is up to 1200-1500 meshes, grain size is 0.1-200 nm, in which most of grain size is less than 100 nm. Said medicine is high in biological utilization rate and obvious in therapeutic effect.
Description
The present invention relates to the analgesia of a kind of relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis, expelling wind and removing dampness, cure mainly osteopatia sprain, the nano bone-setting preparation medicine of miscellaneous fracture the invention still further relates to the method for this medication preparation.
Bone-setting liquor is a kind of classical Chinese patent medicine, mainly contains effects such as relaxing muscles and tendons and activating QI and blood in the collateral, dissipating blood stasis analgesia, expelling wind and removing dampness, is used for osteopatia sprain, miscellaneous fracture.But traditional bone-setting liquor absorbs not exclusively, and bioavailability is not high, slow curative effect.
The object of the present invention is to provide a kind of bioavailability height, solid dispersion is good, absorbs fully the nano bone-setting preparation medicine of increase evident in efficacy.
Another object of the present invention provides the preparation method of this nano bone-setting preparation medicine.
To achieve these goals, the present invention takes following technical scheme:
Medicine of the present invention is to make (consumption is a weight portion) by following component:
Nanometer JIULONGCHUAN 50-500 part nanometer Radix Aucklandiae 50-500 part nanometer Radix seu Caulis fici Martinii 100-500 part
Nanometer Eupolyphaga Seu Steleophaga 30-400 part nanometer Lignum Aquilariae Resinatum 100-500 part nanometer Fructus Gleditsia 50-400 part
Nanometer Cortex Acanthopancis 50-500 part nanometer Rhizoma Curcumae 100-500 part nano double ferrum money 100-500 part
Nanometer Caulis Entadae 100-600 part nanometer Os Gallus domesticus skin 50-400 part nanometer Radix Cynanchi Paniculati 50-500 part
Nanometer Lignum Dalbergiae Odoriferae 100-500 part nanometer Radix Zanthoxyli 100-500 part nanometer Radix Flemingiae Philippinensis 50-400 part
Nanometer Radix Ardisiae Crenatae 50-400 part nanometer Radix calophylli membranacei 100-500 part nanometer Cauliset Folium Piperis Hancei 50-500 part
Nanometer Radix araliae armatae 100-400 part nanometer Radix Aconiti Kusnezoffii 50-400 part nanometer Mentholum 1-10 part
Nanometer Camphora 1-10 part
The formula optimization weight proportion scope of medicine of the present invention is:
Nanometer JIULONGCHUAN 100-300 part nanometer Radix Aucklandiae 100-300 part nanometer Radix seu Caulis fici Martinii 200-400 part
Nanometer Eupolyphaga Seu Steleophaga 50-300 part nanometer Lignum Aquilariae Resinatum 200-400 part nanometer Fructus Gleditsia 100-300 part
Nanometer Cortex Acanthopancis 100-300 part nanometer Rhizoma Curcumae 200-400 part nano double ferrum money 150-400 part
Nanometer Caulis Entadae 200-500 part nanometer Os Gallus domesticus skin 100-300 part nanometer Radix Cynanchi Paniculati 100-300 part
Nanometer Lignum Dalbergiae Odoriferae 200-400 part nanometer Radix Zanthoxyli 200-400 part nanometer Radix Flemingiae Philippinensis 100-300 part
Nanometer Radix Ardisiae Crenatae 100-300 part nanometer Radix calophylli membranacei 200-400 part nanometer Cauliset Folium Piperis Hancei 100-300 part
Nanometer Radix araliae armatae 150-300 part nanometer Radix Aconiti Kusnezoffii 100-300 part nanometer Mentholum 3-8 part
Nanometer Camphora 5-15 part
The optimum weight proportioning of medicine of the present invention is:
250 parts of 200 parts of nanometer Radix seu Caulis fici Martinii of 150 parts of nanometer Radix Aucklandiae of nanometer JIULONGCHUAN
200 parts in 250 parts of nanometer Fructus Gleditsias of 100 parts of nanometer Lignum Aquilariae Resinatum of nanometer Eupolyphaga Seu Steleophaga
250 parts of 300 parts of nano double ferrum of 150 parts of nanometer Rhizoma Curcumae of nanometer Cortex Acanthopancis money
180 parts of 200 parts of nanometer Radix Cynanchi Paniculati of 300 parts of nanometer Os Gallus domesticus of nanometer Caulis Entadae skin
150 parts of 300 parts of nanometer Radix Flemingiae Philippinensiss of 250 parts of nanometer Radix Zanthoxylis of nanometer Lignum Dalbergiae Odoriferae
200 parts of 250 parts of nanometer Cauliset Folium Piperis Hanceis of 200 parts of nanometer Radix calophylli membranacei of nanometer Radix Ardisiae Crenatae
5 parts of 200 parts of nanometer Mentholums of 250 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Radix araliae armatae
10 parts of nanometer Camphoras
Technical scheme of the present invention is based on the modern material technology.One of modern material Developing Trend in Technology is to develop to the more and more littler direction of yardstick.The granule of the past composition material, its size all are at micron or more than the millimeter magnitude, and have occurred the material to the nanoscale development now.Because extremely refinement of granule, the shared percentage by volume of crystal boundary increases, and makes some performance of material that outstanding variation take place.
The property of nano material be since special construction----the material grains size of nano material less than the ultra-micro powder of 100nm, its body surface area is very big, the atom number ratio at crystal boundary place makes it to produce four big effects up to 15--50%: i.e. small-size effect, quantum effect (containing macro quanta tunnel effect), skin effect and interfacial effect.Thereby has the not available physical and chemical performance of traditional material.Nanotechnology will bring a technological revolution of the field of Chinese medicines.
One of method of above-mentioned each component being made medicine of the present invention is:
1. divide and get the Chinese crude drug of respectively distinguishing the flavor of, be processed into the common Chinese decoction pieces according to process of preparing Chinese medicine of Chinese Pharmacopoeia version in 2000.
2. divide and get the common Chinese decoction pieces of respectively distinguishing the flavor of, be processed into the nanometer prepared slices of Chinese crude drugs, its method comprises the following steps:
1. the common Chinese decoction pieces is placed extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃--and 60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure,, promptly make the nanometer prepared slices of Chinese crude drugs with the instantaneous drying of hypersonic velocity.
3. the nanometer prepared slices of Chinese crude drugs (powder) are prepared mixing in described ratio, according to Chinese Pharmacopoeia version two-shift system in 2000 agent standard, make pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution.
Two of medicine method for making of the present invention is:
1. be equipped with whole common Chinese decoction pieces in the proportioning ratio, place extraction pot, solubilizer also imports microwave extracting, makes its speed with 20--30 hundred million times/second do the change in polarity motion, and the temperature of its microwave extracting is 30 ℃-60 ℃, time 1-10 hour;
2. above-mentioned extract is carried out concentrating under reduced pressure, temperature is 30 ℃--60 ℃, the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition;
3. decompressed concentrate and volatile material merging are placed spray drying tower, use the supersonic jet technology, 330 meters of effluxvelocities--990 meter per seconds, at 30 ℃--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with the instantaneous drying of hypersonic velocity jet, the preparation nano powder must boneset;
4. its nano powder is made aforementioned various preparation according to Chinese Pharmacopoeia version standard preparation in 2000.
The pharmacological effect that above-mentioned two kinds of methods are made the nano bone-setting preparation medicine is identical.
A kind of important feature of the present invention is: the made drug material of the present invention has reached nanoscale, common bone-setting liquor preparation material is micron or the above particle diameter of millimeter, can only cross the 80-120 mesh sieve, the drug material that the present invention is made, particle diameter is at 0.1--200nm, the overwhelming majority can be crossed the 1200--1500 mesh sieve less than 100nm.
Another important feature of the present invention is: solid preparation of the present invention disintegrate rapidly, and solid dispersion is good in water, absorb fully, the bioavailability height, the pharmacological action effect that mainly contains effective constituent is significantly higher than conventional formulation.
The pharmaceutical preparation that the present invention is made does not need to add any adjuvant, and is more favourable to human body.
The present invention has also created the new drug formulation that pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution of nano bone-setting preparation medicine etc. had no precedent in the past.
Pharmaceutical preparation of the present invention can be used for osteopatia sprain, treatment of conditions such as miscellaneous fracture, and clinical efficacy significantly is better than traditional bone-setting liquor.
The present invention's added solvent in microwave extracting is water or ethanol.
The present invention carries out in the concentrating under reduced pressure step at extract, and its concentrating under reduced pressure is conventional scheme.
Embodiment 1:
Prepare nano raw material by preceding method:
250 parts of 200 parts of nanometer Radix seu Caulis fici Martinii of 150 parts of nanometer Radix Aucklandiae of nanometer JIULONGCHUAN
200 parts in 250 parts of nanometer Fructus Gleditsias of 100 parts of nanometer Lignum Aquilariae Resinatum of nanometer Eupolyphaga Seu Steleophaga
250 parts of 300 parts of nano double ferrum of 150 parts of nanometer Rhizoma Curcumae of nanometer Cortex Acanthopancis money
180 parts of 200 parts of nanometer Radix Cynanchi Paniculati of 300 parts of nanometer Os Gallus domesticus of nanometer Caulis Entadae skin
150 parts of 300 parts of nanometer Radix Flemingiae Philippinensiss of 250 parts of nanometer Radix Zanthoxylis of nanometer Lignum Dalbergiae Odoriferae
200 parts of 250 parts of nanometer Cauliset Folium Piperis Hanceis of 200 parts of nanometer Radix calophylli membranacei of nanometer Radix Ardisiae Crenatae
5 parts of 200 parts of nanometer Mentholums of 250 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Radix araliae armatae
10 parts of nanometer Camphoras
Production method is as follows:
In the GMP cleaning shop, with the above-mentioned nanometer prepared slices of Chinese crude drugs or powder by described mixed good after, according to 2000 editions two-shift system agent of Chinese Pharmacopoeia membrane standard, filmogen adopts polyvinyl alcohol, make the nano bone-setting membrane, every membrane area size is the 2-100 square centimeter, and content of dispersion is the 1-50 gram, every medicine film pasted 1-7 days, pasted the medicine position: the affected part.
Claims (6)
1, a kind of nano bone-setting preparation medicine is characterized in that it is the medicament that the nano raw material of following weight proportioning is made:
Nanometer JIULONGCHUAN 50-500 part nanometer Radix Aucklandiae 50-500 part nanometer Radix seu Caulis fici Martinii 100-500 part
Nanometer Eupolyphaga Seu Steleophaga 30-400 part nanometer Lignum Aquilariae Resinatum 100-500 part nanometer Fructus Gleditsia 50-400 part
Nanometer Cortex Acanthopancis 50-500 part nanometer Rhizoma Curcumae 100-500 part nano double ferrum money 100-500 part
Nanometer Caulis Entadae 100-600 part nanometer Os Gallus domesticus skin 50-400 part nanometer Radix Cynanchi Paniculati 50-500 part
Nanometer Lignum Dalbergiae Odoriferae 100-500 part nanometer Radix Zanthoxyli 100-500 part nanometer Radix Flemingiae Philippinensis 50-400 part
Nanometer Radix Ardisiae Crenatae 50-400 part nanometer Radix calophylli membranacei 100-500 part nanometer Cauliset Folium Piperis Hancei 50-500 part
Nanometer Radix araliae armatae 100-400 part nanometer Radix Aconiti Kusnezoffii 50-400 part nanometer Mentholum 1-10 part
Nanometer Camphora 1-10 part
And adopt following method to make: to select the formula Chinese drug material to concoct and be processed into the prepared slices of Chinese crude drugs; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
2, nano bone-setting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
Nanometer JIULONGCHUAN 100-300 part nanometer Radix Aucklandiae 100-300 part nanometer Radix seu Caulis fici Martinii 200-400 part
Nanometer Eupolyphaga Seu Steleophaga 50-300 part nanometer Lignum Aquilariae Resinatum 200-400 part nanometer Fructus Gleditsia 100-300 part
Nanometer Cortex Acanthopancis 100-300 part nanometer Rhizoma Curcumae 200-400 part nano double ferrum money 150-400 part
Nanometer Caulis Entadae 200-500 part nanometer Os Gallus domesticus skin 100-300 part nanometer Radix Cynanchi Paniculati 100-300 part
Nanometer Lignum Dalbergiae Odoriferae 200-400 part nanometer Radix Zanthoxyli 200-400 part nanometer Radix Flemingiae Philippinensis 100-300 part
Nanometer Radix Ardisiae Crenatae 100-300 part nanometer Radix calophylli membranacei 200-400 part nanometer Cauliset Folium Piperis Hancei 100-300 part
Nanometer Radix araliae armatae 150-300 part nanometer Radix Aconiti Kusnezoffii 100-300 part nanometer Mentholum 3-8 part
Nanometer Camphora 5-15 part
3, nano bone-setting preparation medicine according to claim 1, wherein the weight proportion of each nano raw material is:
250 parts of 200 parts of nanometer Radix seu Caulis fici Martinii of 150 parts of nanometer Radix Aucklandiae of nanometer JIULONGCHUAN
200 parts in 250 parts of nanometer Fructus Gleditsias of 100 parts of nanometer Lignum Aquilariae Resinatum of nanometer Eupolyphaga Seu Steleophaga
250 parts of 300 parts of nano double ferrum of 150 parts of nanometer Rhizoma Curcumae of nanometer Cortex Acanthopancis money
180 parts of 200 parts of nanometer Radix Cynanchi Paniculati of 300 parts of nanometer Os Gallus domesticus of nanometer Caulis Entadae skin
150 parts of 300 parts of nanometer Radix Flemingiae Philippinensiss of 250 parts of nanometer Radix Zanthoxylis of nanometer Lignum Dalbergiae Odoriferae
200 parts of 250 parts of nanometer Cauliset Folium Piperis Hanceis of 200 parts of nanometer Radix calophylli membranacei of nanometer Radix Ardisiae Crenatae
5 parts of 200 parts of nanometer Mentholums of 250 parts of nanometer Radix Aconiti Kusnezoffii of nanometer Radix araliae armatae
10 parts of nanometer Camphoras
4,, it is characterized in that said medicine is pill, powder, tablet, suppository, granule, membrane, capsule, microcapsule, drop pill, aerosol, injection, unguentum, medicated wine, syrup, oral solution according to claim 1 or 2 or 3 described nano bone-setting preparation medicines.
5,, it is characterized in that this method comprises the steps: to select the formula Chinese drug material to concoct and is processed into the prepared slices of Chinese crude drugs according to the pharmaceutical methods of claim 1 or 2 or 3 described nano bone-setting preparation medicines; Place extraction pot, solubilizer also imports microwave extracting, makes it do the change in polarity motion with hundred million times/second speed of 20--30, and the temperature of its microwave extracting is 30--60 ℃, time 1-10 hour; Above-mentioned extract is carried out concentrating under reduced pressure, and temperature is 30--60 ℃, and the time is 3-72 hour, collects volatile material in the Chinese medicine simultaneously in addition; Decompressed concentrate and volatile material merging are placed spray drying tower, use the Supersonic fluidics, 30--60 ℃ of temperature, under 0 to the 0.05MPa pressure, with hypersonic velocity instantaneous jet drying, wherein supersonic jet speed is 330 meters-990 meter per seconds, promptly makes the nanometer prepared slices of Chinese crude drugs.
6, wherein respectively distinguish the flavor of Chinese medicine in the ratio of prescription or Chinese crude drug concoct be processed into the prepared slices of Chinese crude drugs after mixing, or after making the nanometer prepared slices of Chinese crude drugs mixing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100182 CN1362129A (en) | 2001-01-04 | 2001-01-04 | Nano bone-setting medicine and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 01100182 CN1362129A (en) | 2001-01-04 | 2001-01-04 | Nano bone-setting medicine and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1362129A true CN1362129A (en) | 2002-08-07 |
Family
ID=4651362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 01100182 Pending CN1362129A (en) | 2001-01-04 | 2001-01-04 | Nano bone-setting medicine and its preparation |
Country Status (1)
| Country | Link |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298380C (en) * | 2004-05-19 | 2007-02-07 | 广西玉林制药有限责任公司 | Chinese traditional medicine composition with effects of activating blood circulation, dissipating blood stasis, relaxing, activating the tendons, reducing swelling and easing pain and preparation met |
-
2001
- 2001-01-04 CN CN 01100182 patent/CN1362129A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1298380C (en) * | 2004-05-19 | 2007-02-07 | 广西玉林制药有限责任公司 | Chinese traditional medicine composition with effects of activating blood circulation, dissipating blood stasis, relaxing, activating the tendons, reducing swelling and easing pain and preparation met |
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