CN1348758A - Melatonin containing composite and its application in cosmetics - Google Patents
Melatonin containing composite and its application in cosmetics Download PDFInfo
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- CN1348758A CN1348758A CN 00125700 CN00125700A CN1348758A CN 1348758 A CN1348758 A CN 1348758A CN 00125700 CN00125700 CN 00125700 CN 00125700 A CN00125700 A CN 00125700A CN 1348758 A CN1348758 A CN 1348758A
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- Prior art keywords
- melatonin
- cosmetics
- skin
- wrinkle
- compositions
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- YJPIGAIKUZMOQA-UHFFFAOYSA-N Melatonin Natural products COC1=CC=C2N(C(C)=O)C=C(CCN)C2=C1 YJPIGAIKUZMOQA-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 229960003987 melatonin Drugs 0.000 title claims abstract description 29
- DRLFMBDRBRZALE-UHFFFAOYSA-N melatonin Chemical compound COC1=CC=C2NC=C(CCNC(C)=O)C2=C1 DRLFMBDRBRZALE-UHFFFAOYSA-N 0.000 title claims abstract description 29
- 239000002537 cosmetic Substances 0.000 title claims abstract description 19
- 239000002131 composite material Substances 0.000 title description 4
- 239000000203 mixture Substances 0.000 claims abstract description 27
- 230000037303 wrinkles Effects 0.000 claims abstract description 19
- 230000001153 anti-wrinkle effect Effects 0.000 claims abstract description 10
- 229920002498 Beta-glucan Polymers 0.000 claims description 13
- 239000000654 additive Substances 0.000 claims description 13
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 claims description 12
- 230000000996 additive effect Effects 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 230000001681 protective effect Effects 0.000 claims description 7
- 239000002884 skin cream Substances 0.000 claims description 7
- 230000001815 facial effect Effects 0.000 claims description 2
- 239000008267 milk Substances 0.000 claims description 2
- 210000004080 milk Anatomy 0.000 claims description 2
- 235000013336 milk Nutrition 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 15
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract description 6
- 229930003427 Vitamin E Natural products 0.000 abstract description 3
- 239000000284 extract Substances 0.000 abstract description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract description 3
- 235000019165 vitamin E Nutrition 0.000 abstract description 3
- 229940046009 vitamin E Drugs 0.000 abstract description 3
- 239000011709 vitamin E Substances 0.000 abstract description 3
- 239000000126 substance Substances 0.000 abstract 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 235000019155 vitamin A Nutrition 0.000 abstract 1
- 239000011719 vitamin A Substances 0.000 abstract 1
- 229940045997 vitamin a Drugs 0.000 abstract 1
- 206010040954 Skin wrinkling Diseases 0.000 description 18
- 230000009759 skin aging Effects 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 238000003756 stirring Methods 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 150000003254 radicals Chemical class 0.000 description 6
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000002421 anti-septic effect Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000003921 oil Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000003643 water by type Substances 0.000 description 4
- 102000008186 Collagen Human genes 0.000 description 3
- 108010035532 Collagen Proteins 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 238000007599 discharging Methods 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 102000008299 Nitric Oxide Synthase Human genes 0.000 description 2
- 108010021487 Nitric Oxide Synthase Proteins 0.000 description 2
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 230000003064 anti-oxidating effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 235000020710 ginseng extract Nutrition 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 239000002502 liposome Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- JLHMJWHSBYZWJJ-UHFFFAOYSA-N 1,2-thiazole 1-oxide Chemical compound O=S1C=CC=N1 JLHMJWHSBYZWJJ-UHFFFAOYSA-N 0.000 description 1
- ZEMPKEQAKRGZGQ-AAKVHIHISA-N 2,3-bis[[(z)-12-hydroxyoctadec-9-enoyl]oxy]propyl (z)-12-hydroxyoctadec-9-enoate Chemical class CCCCCCC(O)C\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CC(O)CCCCCC)COC(=O)CCCCCCC\C=C/CC(O)CCCCCC ZEMPKEQAKRGZGQ-AAKVHIHISA-N 0.000 description 1
- 229940097276 5-methoxytryptamine Drugs 0.000 description 1
- 101100381997 Danio rerio tbc1d32 gene Proteins 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 101100381999 Mus musculus Tbc1d32 gene Proteins 0.000 description 1
- 235000005205 Pinus Nutrition 0.000 description 1
- 241000218602 Pinus <genus> Species 0.000 description 1
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 210000000805 cytoplasm Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 239000008367 deionised water Substances 0.000 description 1
- 229910021641 deionized water Inorganic materials 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 238000011496 digital image analysis Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 210000004177 elastic tissue Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000003328 fibroblastic effect Effects 0.000 description 1
- 210000000630 fibrocyte Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000001243 protein synthesis Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 239000012048 reactive intermediate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
The present invention relates to a composition contaiing melatonin. The melatonin is compounded with beta-dextran according to certain proportion to form a skin anti wrinkle composition, the said two substances possess synergistic action mutually to give greater effect than by single substance. The invented composition can be added to cosmetics to product dominant skin antiwrinkle effect. Compared with cosmetics containing vitamin A, vitamin E and ginse extract alone, the wrinkle elimination effect can raise 15-20 %.
Description
The invention belongs to cosmetics and preparing technical field thereof, relate to a kind of skin wrinkle resisting composition, and the application of said composition in Cosmetic Manufacture.
Aging is the necessary process in the biological life process, includes physiological ageing process that is subjected to gene regulation and the pathological seaility that is caused by extrinsic factors such as surroundings.Same skin aging also is a comprehensive complicated process, is the result who is caused by multiple factor.Human body is subjected to the influence of endogenous and extrinsic factor, particularly the attack of free radical can cause the variation of skin supporting tissue-skin corium, make skin funeral water holding capacity, collagen and elastic fibers put in order unusually, mechanical force that has thus and flexibility decrease, the crack tendency of skin increases, thereby forms wrinkle.People are often with the sign of wrinkle as skin aging.
Cosmetics adopt following several method crease-resistant generally at the injury of external environment to skin: 1. reconstituted cell epimatrix, and mainly make skin recover elasticity by replenishing nature moisturizing factor such as mucopolysaccharide, thus the tiny wrinkle of aufhellung.2. strengthen cell proliferation, metabolic capacity.3. owing to be subjected to the influence of environment, skin surface easily forms the free radical of some active oxygens, to the polysaccharide in the skin, and protein, biomembrane has detrimental effect.Usually the scavenger that adds some free radicals is eliminated, and alleviates the infringement to skin, and common have vitamin and some plants, an extract of Chinese herbal medicine.
Skin aging is unremitting always the exploring of human society as a permanent problem.Along with the raising of people's living standard and going from bad to worse of living environment, wrinkle resistant or the crease-resistant theme that more and more becomes people's care, many patent disclosures contain the cosmetics of external skin wrinkling-preventing agent, as: Chinese patent 95195692.2 discloses a kind of novel melatonin antagonistic and its production and use;
The method that Chinese patent 97199439 discloses a kind of beta-glucan products and extracted from corn;
Chinese patent 98115670 discloses a kind of new scleroglycan and the cosmetic composition that comprises noval chemical compound;
The disclosed technology of above-mentioned patent all exists fairly obvious defective:
These patents are separately some active ingredient of utilization in cosmetics, do not consider skin aging actual be a result that composite factor causes.Therefore, its anti-wrinkle effect of skin wrinkle resisting cosmetics of providing of above-mentioned patent is not very good.
The object of the present invention is to provide a kind of new skin wrinkle resisting composition and the application in cosmetics thereof, to overcome the single defective of existing in prior technology effect.
Design of the present invention is such:
According to the mechanism that wrinkle forms, should be from multi-angle, multi-level going up carried out crease-resistant processing to skin.The present invention is composite mutually with several additives with anti-wrinkle effect separately, makes it produce cooperative comprehensive effect, thereby reaches ideal skin wrinkle resisting effect.
The technical scheme of the object of the invention is as described below:
Said skin wrinkle resisting composition, its component and content are:
Melatonin 0.1-50.0%
Beta glucan 0.1-20%
Water surplus
Below all be weight percentage.
Said melatonin is a kind of pressed powder, is provided by Xi Keda centre of development, Shanghai;
Said beta glucan is a kind of transparency liquid, is provided by the De Weilong company of Germany.
Said melatonin (Melatonin, N-acety-5-methoxytryptamine) or melatonin be one of excretory important hormone of pinus, have the important physical function.Melatonin is stronger antioxidant.Discover that it can pass through antioxidation, suppress the nucleus DNA fracture that extraneous factor causes.This effect has higher fat-soluble and easily accumulate in the nucleus owing to melatonin.After melatonin enters cell, can directly remove hydroxy radical (.OH) and induce the GSH-PX increased activity, in cytoplasm and nuclear, carry out antioxidation.
Melatonin also more and more is subject to people's attention in the effect aspect the removing free radical.Melatonin can remove hydroxy radical (.OH), single line oxygen (
1O
2), nitric oxide (NO) and lipid peroxide ion (LOO.) etc., but directly in and superoxide anion (O
2. -) and hydrogen peroxide (H
2O
2).Melatonin also can stimulate SOD.Expression and the protein synthesis of mRNA such as GSH-PX and 6-glucose 1-phosphate1-(promote GSH synthetic) make the content and the increased activity of these enzymes, and inhibition nitric oxide synthetase (NOS) directly or indirectly suppresses the generation of free radical.
There are melatonin and receptor thereof in the skin, also exist enzyme synthetic and the degraded melatonin, in skin, play important effect.Melatonin reduces with age growth, and additional melatonin can reach the effect of slow down aging.
Said beta glucan is present in the corn that contains D-than the type glucose unit of muttering, and molecular weight is generally 2,500, and about 000.The beta glucan that extracts from Herba bromi japonici can promote macrophage to increase, and the reactive intermediate in the propagation process can act on fibrocyte, promotes the formation of external collagen fiber cell.
Both are mixed use, and melatonin can be removed the free radical of some active oxygens of skin surface formation on the one hand, and beta glucan is used for the reconstituted cell epimatrix simultaneously, and promotes the synthetic of fibroblastic collagen protein.So this mixture is at the multiple factor that causes skin aging, gives comprehensive consideration.More more comprehensive than adopting the effect that a kind of additive reached separately, ideal.
The present invention carries out melatonin and beta glucan composite by a certain percentage, form a kind of skin wrinkle resisting composition, make the bigger effectiveness of the mutual potentiation of these two kinds of materials performance, produce cooperative comprehensive effect, make its anti-wrinkle effect reach single effective additive incomparable level.
Preferred ratio is:
Melatonin 0.5-25.0%
Beta glucan 0.5-10%
Water surplus
Below all be weight percentage.
More preferred ratio is:
Melatonin 1.0-20.0%
Beta glucan 1.0-5.0%
Water surplus
Below all be weight percentage.
Preparation of compositions is a kind of physical mixing processes simply in proportion, equipment that need not be specific and technology.
Above-mentioned compositions can be used as a kind of additive of cosmetics, and its percentage by weight consumption is 5～20%.
The interpolation of said compositions does not influence the production technology of cosmetics.
Added the cosmetics of above-mentioned composition, its anti-wrinkle effect is fairly obvious, general comparablely contain independent additive and exceeds 15～20% as the cosmetics wrinkle resisting improving rate of tieing up main plain A, liposome vitamin E and Radix Ginseng extract etc.
Below will relevant details of the present invention be further described by embodiment.
Embodiment 1
The deionized water of 20 kilograms of melatonin, 10 kilograms, 70 kilograms of beta glucans is placed blender, stir, can obtain the said compositions that prevents skin aging.
The preparation of embodiment 2 wrinkle resistant protective skin cream:
With 60.7 kilograms of deionized waters, 5 kilograms of glycerol (pharmaceutical grade), 1 kilogram of sucrose cocos nucifera oil acid esters, 0.5 kilogram of HANSHENGJIAO, 0.3 kilogram calorie POP, be heated to 85 ℃ stand-by; With 10 kilograms of white oils, 10 kilogram of three caprylic/capric glyceride, 1 kilogram of sorbitol fat acid ester, 1 kilogram of dimethicone, be heated to 85 ℃ and slowly add water, 3000 rev/mins of homogenizing add the back and kept 5 minutes.Stop homogenizing, keep stirring, it is about 7.0 that the adding triethanolamine is neutralized to pH.Be cooled to 50 ℃, add 10 kilograms of above-mentioned prevent skin aging compositions additive, 0.5 kilogram of essence and stir.35 ℃ of parking dischargings promptly obtain wrinkle resistant protective skin cream.
Above-mentioned wrinkle resistant protective skin cream has the fairly obvious effect that prevents wrinkle.To compare as the protective skin cream of tieing up main plain A, liposome vitamin E and Radix Ginseng extract etc. with the independent additive of having reported that contains with the protective skin cream that contains said anti-wrinkle composition of dosage, wrinkle resisting improving rate exceeds 15～20% as a result.
With the protective skin cream that the present invention prepared, by clinical trial, two months by a definite date, number was about 30, and the result tests with the computer image analysis system, and effect is remarkable, and its anti-wrinkle effect reaches 72%, is that single additive is incomparable.
The preparation of embodiment 3 crease-resistant facial treatment milk:
With 75.7 kilograms of deionized waters, 5 kilograms of glycerol (pharmaceutical grade), 1 kilogram of sucrose cocos nucifera oil acid esters, 0.5 kilogram of HANSHENGJIAO, 0.3 kilogram calorie POP, be heated to 85 ℃ stand-by; With 5 kilograms of white oils, 5 kilogram of three caprylic/capric glyceride, 1 kilogram of sorbitol fat acid ester, 1 kilogram of dimethicone, be heated to 85 ℃ and slowly add water, 3000 rev/mins of homogenizing add the back and kept 5 minutes.Stop homogenizing, keep stirring, it is about 7.0 that the adding triethanolamine is neutralized to pH.Be cooled to 50 ℃, add 5 kilograms of above-mentioned prevent skin aging compositions additive, 0.5 kilogram of essence, 1 kilogram of extremely U.S. 2 type compounds and stir.35 ℃ of parking dischargings.Annotate: the antiseptic that extremely U.S. 2 type compounds provide for American I SP company.
The preparation of embodiment 4 crease-resistant astringent:
At room temperature, with 2 kilograms of propylene glycol, 1 kilogram of solubilizing agent LRI mixed dissolution.Under agitation add 0.5 kilogram of essence and 0.4 alkaline antiseptic, be stirred to transparent by hand.In dispersion pot, put into 88.5 kilograms of deionized waters, add 7 kilograms of above-mentioned prevent skin aging compositions additive, stirrings and make it mix homogeneously.Solubilising liquid is dropped into dispersion pot, be stirred to homogeneous transparent.Annotate: the antiseptic that alkaline antiseptic provides for American I SP company.
Embodiment 5 anti-wrinkle face masks:
54.75 kilograms of deionized waters, 8 kilograms of polyoxyethylene are added agitated kettle, be heated to 82 ℃, stirring and dissolving adds 15 kilograms of ethanol, 934, the 1 kilogram of polyoxyethylene hydrogenated Oleum Ricini in 0.35 kilogram calorie POP again, and being neutralized to pH with 0.35 kilogram of triethanolamine is 7.0.Be cooled to 50 ℃, add 20 kilograms of above-mentioned skin aging compositions additive, 0.5 kilogram of essence of preventing again, and 0.05 kilogram of isothiazolone stir 35 ℃ of parking dischargings.
Claims (6)
1. compositions that contains melatonin is characterized in that component and content are:
Melatonin 0.1-50.0%
Beta glucan 0.1-20%
Water surplus
Below all be weight percentage.
2. compositions as claimed in claim 1 is characterized in that component and content are:
Melatonin 0.5-25.0%
Beta glucan 0.5-10%
Water surplus
Below all be weight percentage.
3. compositions as claimed in claim 2 is characterized in that component and content are:
Melatonin 1.0-20.0%
Beta glucan 1.0-5.0%
Water surplus
Below all be weight percentage.
4. as the application of claim 1,2 or 3 described compositionss, it is characterized in that, can be used as the crease-resistant additive of cosmetics.
5. the application of compositions as claimed in claim 4 is characterized in that, said cosmetics are a kind of in wrinkle resistant protective skin cream, crease-resistant facial treatment milk, crease-resistant astringent or the anti-wrinkle face mask.
6. the application of compositions as claimed in claim 4 is characterized in that, the percentage by weight addition of crease-resistant additive in cosmetics is 5～20%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00125700 CN1131021C (en) | 2000-10-17 | 2000-10-17 | Melatonin containing composite and its application in cosmetics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 00125700 CN1131021C (en) | 2000-10-17 | 2000-10-17 | Melatonin containing composite and its application in cosmetics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1348758A true CN1348758A (en) | 2002-05-15 |
| CN1131021C CN1131021C (en) | 2003-12-17 |
Family
ID=4591484
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 00125700 Expired - Lifetime CN1131021C (en) | 2000-10-17 | 2000-10-17 | Melatonin containing composite and its application in cosmetics |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1131021C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303967C (en) * | 2002-12-09 | 2007-03-14 | 库塔杜·索里亚诺安东尼奥 | Toothpaste or mouthwash and animal feed containing melatonin as an active ingredient for human use |
| CN106806256A (en) * | 2017-02-11 | 2017-06-09 | 佛山市芊茹化妆品有限公司 | A kind of after-sun restorative mask |
| WO2019038586A1 (en) | 2017-08-19 | 2019-02-28 | Ftf Pharma Private Limited | Pharmaceutical composition of melatonin |
-
2000
- 2000-10-17 CN CN 00125700 patent/CN1131021C/en not_active Expired - Lifetime
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1303967C (en) * | 2002-12-09 | 2007-03-14 | 库塔杜·索里亚诺安东尼奥 | Toothpaste or mouthwash and animal feed containing melatonin as an active ingredient for human use |
| CN106806256A (en) * | 2017-02-11 | 2017-06-09 | 佛山市芊茹化妆品有限公司 | A kind of after-sun restorative mask |
| WO2019038586A1 (en) | 2017-08-19 | 2019-02-28 | Ftf Pharma Private Limited | Pharmaceutical composition of melatonin |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1131021C (en) | 2003-12-17 |
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