JP2008105985A - Hyaluronic acid production promoter, skin care preparation for external use, bathing agent, and food and drink - Google Patents
Hyaluronic acid production promoter, skin care preparation for external use, bathing agent, and food and drink Download PDFInfo
- Publication number
- JP2008105985A JP2008105985A JP2006289311A JP2006289311A JP2008105985A JP 2008105985 A JP2008105985 A JP 2008105985A JP 2006289311 A JP2006289311 A JP 2006289311A JP 2006289311 A JP2006289311 A JP 2006289311A JP 2008105985 A JP2008105985 A JP 2008105985A
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- JP
- Japan
- Prior art keywords
- hyaluronic acid
- extract
- acid production
- production promoter
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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Abstract
Description
本発明は、皮膚の弾力、張り、潤いに重要な役割を担うヒアルロン酸の産生促進剤に関する。更には、ヒアルロン酸産生促進剤を含有する皮膚外用剤、浴用剤及び飲食物に関する。 The present invention relates to a hyaluronic acid production promoter that plays an important role in skin elasticity, tension and moisture. Furthermore, it is related with the skin external preparation, the bath preparation, and food and drink containing a hyaluronic acid production promoter.
近年、高齢化社会や女性の社会進出に伴い、美容に対する意識が向上している。しかし、皮膚の機能は年齢とともに低下し、加齢により弾力や張りを失いシワが生じてくる。この原因として、皮膚中に存在する線維芽細胞が産生するコラーゲンとヒアルロン酸の量の低下が挙げられる。 In recent years, the awareness of beauty has improved with the aging of society and the advancement of women into society. However, the function of the skin decreases with age, and with age, it loses its elasticity and tension, causing wrinkles. This may be due to a decrease in the amount of collagen and hyaluronic acid produced by fibroblasts present in the skin.
皮膚は皮下組織、真皮、表皮の三層から成っていて、皮膚の弾力など皮膚機能に最も影響を与えるのが真皮であり、この真皮にはコラーゲンとヒアルロン酸が多く含まれている。これらコラーゲンやヒアルロン酸は、真皮中に存在する線維芽細胞が産生することが知られており、皮膚の弾力性の保持に重要な役割を担っている。 The skin consists of three layers of the subcutaneous tissue, the dermis, and the epidermis. The dermis has the most influence on the skin function such as the elasticity of the skin, and the dermis is rich in collagen and hyaluronic acid. These collagen and hyaluronic acid are known to be produced by fibroblasts present in the dermis, and play an important role in maintaining the elasticity of the skin.
人間の体は、いくつかの細胞が結合して組織や器官を形成している。これらの器官を一定の形状に保持するための組織を結合組織というが、これは、細胞と細胞の間がヒアルロン酸などのムコ多糖類やコラーゲンなどで構成される物質で埋め尽くされているため各器官が一定の形状を保持することが可能となっている。同時に、生体の運動を円滑にしたり、関節の衝撃吸収に役立つなどの重要な働きを持っている。 In the human body, several cells are connected to form tissues and organs. The tissue that holds these organs in a certain shape is called connective tissue, because the cells are filled with a substance composed of mucopolysaccharides such as hyaluronic acid and collagen. Each organ can maintain a certain shape. At the same time, it has important functions such as smooth movement of the body and absorption of joint shocks.
また、細胞と細胞を結び付けている組織を細胞外マトリックス（Ｅｘｔｒａ Ｃｅｌｌｕｌａｒ Ｍａｔｒｉｘ：ＥＣＭ）といい、これらは単に細胞と細胞を結合させるだけでなく、細胞に必要な成分・栄養分を補給したり、細胞からの不要物質（二酸化炭素や老廃物など）を運搬したり、更には細胞間における重要な調節機能を営んでいる。この細胞外マトリックスの中でも、ムコ多糖と呼ばれる多糖類が大切な役割をしている。このムコ多糖の代表がヒアルロン酸であり、ヒアルロン酸は、皮膚、関節液、大動脈、腎臓、大脳、心臓など、体の重要な臓器や器官の全てに存在していることが判っている。 In addition, cells that connect cells to each other are called extracellular matrix (ECM), which not only binds cells to each other, but also supplies components and nutrients necessary for cells, It transports unnecessary substances (such as carbon dioxide and waste products) from the plant, and also performs important regulatory functions between cells. Among these extracellular matrices, polysaccharides called mucopolysaccharides play an important role. The representative of this mucopolysaccharide is hyaluronic acid, and hyaluronic acid is known to exist in all important organs and organs of the body such as skin, joint fluid, aorta, kidney, cerebrum and heart.
しかし、加齢による皮膚機能の低下に起因して、ヒアルロン酸産生量は減少する。ヒアルロン酸量の減少により水分の保持能力が低下し、それによって皮膚の潤いが失われて肌の乾燥やくすみが生じ、あるいは弾力や張りが失われることによって生じるシワやタルミなどは老化現象の表面化である。 However, hyaluronic acid production is reduced due to a decrease in skin function due to aging. Decrease in hyaluronic acid reduces the ability to retain moisture, resulting in loss of skin moisture and skin dryness and dullness, or wrinkles and tarmi caused by loss of elasticity and tension. It is.
さらに上記のとおりヒアルロン酸は、関節の衝撃吸収などに重要な役割を果たすことが知られていることから、線維芽細胞などの細胞におけるヒアルロン酸産生量を調節することによる、関節炎（リウマチ）などの治療、予防、血漿蛋白の組織漏出の制御、細菌侵入に対する生体防御作用への応用が期待されている。 Furthermore, as described above, since hyaluronic acid is known to play an important role in shock absorption of joints, etc., arthritis (rheumatic) by regulating the amount of hyaluronic acid production in cells such as fibroblasts, etc. It is expected to be applied to the treatment, prevention, control of tissue leakage of plasma proteins, and biological defense against bacterial invasion.
従来、これらヒアルロン酸量の減少を防ぎ肌に潤いを与える薬剤、方法が知られており、例えば、特許文献１には、ヒアルロニダーゼ活性阻害剤を含有する保湿化粧料が開示されている。特許文献１に記載の化粧料は、ヒアルロニダーゼによるヒアルロン酸分解抑制作用を有するものであり、ヒアルロン酸の産生促進作用を有するものでないことから、現状を維持すること以上の効果は期待できない。
本発明は、ヒアルロン酸の産生を促進することによって皮膚中のヒアルロン酸量の低下を防止し、ヒアルロン酸量の低下に伴っておこるシワやタルミを予防、緩和、改善することのできるヒアルロン酸の産生促進剤及び該ヒアルロン酸産生促進剤を含有する皮膚外用剤、浴用剤及び飲食物を提供することを目的としてなされたものである。 The present invention prevents hyaluronic acid production by promoting the production of hyaluronic acid, prevents wrinkles and tarmi caused by the decrease in hyaluronic acid content, can prevent, alleviate and improve hyaluronic acid The object of the present invention is to provide a production promoter and an external preparation for skin, a bath preparation, and food and drink containing the hyaluronic acid production promoter.
本発明者等は、上記課題を解決するために鋭意研究を重ねた結果、特定の植物エキス、有機酸、糖類がヒアルロン酸の産生を促進する作用を有することを見出し、この知見に基づき本発明を完成させた。 As a result of intensive studies to solve the above problems, the present inventors have found that specific plant extracts, organic acids, and saccharides have an action of promoting hyaluronic acid production. Was completed.
すなわち、本発明は、イトヒメハギエキス、クララエキス、ケイヒエキス、シャクヤクエキス、カキエキス、タンジンエキス、ツボクサエキス、プーアルエキス、アルブチン、アスコルビン酸又はアルギン酸オリゴ糖類から選ばれる１種又は２種以上を含有するヒアルロン酸産生促進剤を提供する。
また本発明は、前記ヒアルロン酸産生促進剤を含有することを特徴とする皮膚外用剤、浴用剤又は飲食物を提供する。
That is, the present invention contains one or more kinds selected from Itohime extract, Clara extract, cinnamon extract, peony extract, oyster extract, tandin extract, camellia extract, puer extract, arbutin, ascorbic acid or alginic acid oligosaccharide. A hyaluronic acid production promoter is provided.
Moreover, this invention provides the skin external preparation, the bath preparation, or food-drinks characterized by including the said hyaluronic acid production promoter.
イトヒメハギエキス、クララエキス、ケイヒエキス、シャクヤクエキス、カキエキス、タンジンエキス、ツボクサエキス、プーアルエキス、アルブチン、アスコルビン酸又はアルギン酸オリゴ糖類は、線維芽細胞からヒアルロン酸の産生を促進する効果があり、皮膚の老化防止など様々な用途に利用できるヒアルロン酸産生促進剤として有用である。またこれらのヒアルロン酸産生促進剤は、化粧品をはじめとする各種皮膚外用剤や浴用剤さらには飲食物に配合することができ、ヒアルロン酸量の低下に起因する皮膚表面の変化、例えば、シワ、タルミの予防、緩和、改善をすることができる。 Itohime extract, Clara extract, Keihi extract, Peonies extract, Oyster extract, Tanjin extract, Clover extract, Pual extract, Arbutin, Ascorbic acid or Alginate oligosaccharide has the effect of promoting the production of hyaluronic acid from fibroblasts, skin It is useful as a hyaluronic acid production promoter that can be used for various purposes such as prevention of aging. These hyaluronic acid production promoters can be incorporated into various skin external preparations such as cosmetics, bath preparations, and foods and drinks. Changes in the skin surface caused by a decrease in the amount of hyaluronic acid, such as wrinkles, Can prevent, alleviate and improve tarmi.
本発明のヒアルロン酸産生促進剤は、イトヒメハギエキス、クララエキス、ケイヒエキス、シャクヤクエキス、カキエキス、タンジンエキス、ツボクサエキス、プーアルエキス、アルブチン、アスコルビン酸又はアルギン酸オリゴ糖類から選ばれる１種又は２種以上を含有することを特徴とするものである。 The hyaluronic acid production promoter according to the present invention is one or two kinds selected from citrus extract, clara extract, cinnamon extract, peony extract, oyster extract, tanjin extract, cinnamon extract, puer extract, arbutin, ascorbic acid or alginate oligosaccharide. It contains the above, It is characterized by the above-mentioned.
また、前記植物エキス、アルブチン、アスコルビン酸、アルギン酸オリゴ糖類から選ばれる２種以上含有する本発明のヒアルロン酸産生促進剤としては、
アルギン酸オリゴ糖類とイトヒメハギエキス、クララエキス、シャクヤクエキス、又はツボクサエキスとの組み合わせ；
イトヒメハギエキスとクララエキス、タンジンエキス、又はプーアルエキスとの組み合わせ；
アルギン酸オリゴ糖類とクララエキスとイトヒメハギエキスとの組み合わせ；
アルギン酸オリゴ糖類とクララエキスとカキエキスとの組み合わせ；
から選ばれる組み合わせを含有するものが、皮膚のシワ、タルミの予防、緩和、改善作用に特に優れることから好ましい。
Moreover, as the hyaluronic acid production promoter of the present invention containing two or more selected from the plant extract, arbutin, ascorbic acid, alginic acid oligosaccharides,
A combination of an alginic acid oligosaccharide and a jujube extract, a clara extract, a peony extract or a camellia extract;
A combination of Itohimehagi extract and Clara extract, Tanjin extract or Puer extract;
A combination of an alginate oligosaccharide, Clara extract and Itohime extract;
Combination of alginate oligosaccharide, Clara extract and oyster extract;
Those containing a combination selected from the above are preferred because they are particularly excellent in the prevention, mitigation and improvement of skin wrinkles and talmi.
本発明で使用するイトヒメハギエキスとは、ヒトハギ科植物のイトヒメハギの根を用いて抽出するが、地上部さらに同属植物を用いて抽出することができる。 The extract of Itohimehae used in the present invention is extracted using the root of Itohimehagi, which is a plant belonging to the human family, but can also be extracted using the above-mentioned genus plant.
本発明で使用するクララエキスとは、マメ科植物のクララの根を用いて抽出するが、地上部さらに同属植物を用いて抽出することができる。 The Clara extract used in the present invention is extracted by using the roots of the leguminous plant Clara, but can be extracted by using the above-mentioned part and a plant belonging to the same genera.
本発明で使用するケイヒエキスとは、クスノキ科植物のシナニッケイの樹皮を用いて抽出するが、地上部さらに同属植物を用いて抽出することができる。 The cinnamon extract used in the present invention is extracted using the bark of the cinnamon moss of the camphor family, but can also be extracted using the above-mentioned genus plant.
本発明で使用するシャクヤクエキスとは、ボタン科植物のシャクヤクの根の外皮を除去したものを用いて抽出するが、地上部さらに同属植物を用いて抽出することができる。 The peony extract used in the present invention is extracted using a peony root that has been removed from the peony root, but can be extracted from the above-ground part and a plant belonging to the same genus.
本発明で使用するカキエキスとは、カキノキ科植物のカキの葉を用いて抽出するが、地上部さらに同属植物を用いて抽出することができる。 The oyster extract used in the present invention is extracted using oyster leaves of a cynoaceae plant, but can be extracted using the above-mentioned part and a genus plant.
本発明で使用するタンジンエキスとは、シソ科植物のタンジンの根を用いて抽出するが、地上部さらに同属植物を用いて抽出することができる。 The tanjin extract used in the present invention is extracted using roots of tannins of Labiatae plants, but can be extracted using the above-ground parts and the same genus plants.
本発明で使用するツボクサエキスとは、セリ科植物のツボクサの全草を用いて抽出するが、同属植物を用いて抽出することができる。 The centella extract used in the present invention is extracted by using the whole plant of the celery family plant, but it can be extracted by using a plant belonging to the same genus.
本発明で使用するプーアルエキスとは、ツバキ科植物のチャの葉を黒麹菌などで後発酵させたもの、いわゆるプーアルの葉を用いて抽出する。 The puer extract used in the present invention is extracted by using a so-called puer leaf obtained by post-fermenting tea leaves of a camellia plant with black koji mold or the like.
本発明において、イトヒメハギエキス、クララエキス、ケイヒエキス、シャクヤクエキス、カキエキス、タンジンエキス、ツボクサエキス、プーアルエキスなどの植物エキスとしては、上記の各植物の各種部位を未乾燥のまま又は乾燥させた後そのままに、あるいは、破砕又は粉砕後に搾取して使用することができる。さらに、これらを溶媒で抽出して得られるエキスや、該エキスから抽出溶媒を蒸発又は凍結乾燥して得られる不揮発分を使用することができる。 In the present invention, as plant extracts such as Itohime extract, Clara extract, Keihi extract, peony extract, oyster extract, tanjin extract, camellia extract, puer extract and the like, various parts of each of the above plants are left undried or dried. It can be used as it is or after being crushed or crushed. Furthermore, the extract obtained by extracting these with a solvent, and the non-volatile content obtained by evaporating or lyophilizing the extraction solvent from the extract can be used.
ここで用いられる抽出溶媒としては、水、メタノール、エタノール、エチレングリコール、プロピレングリコール、１,３−ブチレングリコールなどの低級アルコール類、アセトンなどのケトン類、酢酸エチルなどのエステル類、ジエチルエーテルなどのエーテル類、トルエンなどの芳香族類等の各種の溶媒が挙げられ、単独又は２種以上の溶媒を任意に組み合わせて使用することができる。 Examples of the extraction solvent used herein include water, lower alcohols such as methanol, ethanol, ethylene glycol, propylene glycol, and 1,3-butylene glycol, ketones such as acetone, esters such as ethyl acetate, and diethyl ether. Various solvents, such as ethers and aromatics, such as toluene, are mentioned, It can use individually or in combination of 2 or more types.
本発明で使用するアルブチンとは、コケモモ、ウワウルシ、ナシなどの植物に含まれる天然型（β−グルコシド型）の配糖体であり、化学名が４−ヒドロキシフェニル−β−Ｄ−グルコシピラノシドのものを用いることができる。 Arbutin used in the present invention is a natural type (β-glucoside type) glycoside contained in plants such as cowberry, walrus, and pear, and has a chemical name of 4-hydroxyphenyl-β-D-glucosipyrano. Sid's can be used.
本発明で使用するアスコルビン酸とは、ミカン、レモンなどの柑橘類、キウイ、イチゴ、メロンなどの果物や野菜類等に含まれる水溶性のビタミンで、ビタミンＣとも呼ばれる。さらに本発明では、パルミチン酸、ステアリン酸とのモノエステル又はジエステル等の誘導体化したものや、リン酸マグネシウム塩、ナトリウム塩又は配糖体等のアスコルビン酸誘導体も用いることができる。 Ascorbic acid used in the present invention is a water-soluble vitamin contained in citrus fruits such as mandarin orange and lemon, fruits and vegetables such as kiwi, strawberry and melon, and is also called vitamin C. Furthermore, in the present invention, derivatized products such as mono- or diesters with palmitic acid and stearic acid, and ascorbic acid derivatives such as magnesium phosphate, sodium salt or glycoside can also be used.
本発明で使用するアルギン酸オリゴ糖類とは、高分子アルギン酸又は高分子アルギン酸塩（ナトリウム塩、マグネシウム塩、カリウム塩など）を低分子化し、分子量を２０００〜２００００に調製したものを用いる。そして、その分解方法については、酸又はアルカリ分解、酵素分解、熱分解などの方法で良く、その手法は問わず、また、高分子アルギン酸を低分子アルギン酸とした後、低分子アルギン酸塩にしたものでも良い。 As the alginate oligosaccharide used in the present invention, a polymer alginate or a polymer alginate (sodium salt, magnesium salt, potassium salt, etc.) having a reduced molecular weight and a molecular weight of 2000 to 20000 is used. The decomposition method may be acid or alkali decomposition, enzymatic decomposition, thermal decomposition, etc., regardless of the method, and after converting high molecular alginic acid to low molecular alginic acid, low molecular alginate is used. But it ’s okay.
本発明で使用される植物エキスは、医薬又は民間薬、食品、化粧品の成分として一般的に用いられるものであり、その安全性が確認されているものである。 The plant extract used in the present invention is generally used as a component of medicines or folk medicines, foods and cosmetics, and its safety has been confirmed.
本発明のヒアルロン酸産生促進剤は、前記植物エキス、アルブチン、アスコルビン酸、アルギン酸オリゴ糖類から選ばれる１種又は２種以上を含有し、ヒアルロン酸産生促進剤への総配合量はその剤型によっても異なるものであり、蒸発残分をそのまま使用しても構わないし、目的用途によって適宜、配合量を調整すればよく、また、本発明のヒアルロン酸産生促進剤の使用量にも特に制限はなく、用途や適用により適宜調整することができる。 The hyaluronic acid production promoter of the present invention contains one or more selected from the plant extract, arbutin, ascorbic acid and alginic acid oligosaccharides, and the total blending amount in the hyaluronic acid production promoter depends on the dosage form. The evaporation residue may be used as it is, the blending amount may be adjusted as appropriate according to the intended use, and the amount of the hyaluronic acid production promoter of the present invention is not particularly limited. , And can be adjusted as appropriate depending on the application and application.
本発明のヒアルロン酸産生促進剤は、外用、内用、素材への処理など様々な形態に適用できる。また、通常の外用、内用素材への処理などで使用されている薬剤などとも組み合
わせて使用することができ、併用薬剤により本発明の効果がより発現しやすくなる。
The hyaluronic acid production promoter of the present invention can be applied to various forms such as external use, internal use, and treatment of raw materials. In addition, it can be used in combination with a drug used in normal treatment for external or internal use, etc., and the combined drug makes it easier to express the effect of the present invention.
本発明のヒアルロン酸産生促進剤は、医薬品、医薬部外品、局所又は全身用の皮膚化粧品、頭皮・頭髪に適用する薬用又は化粧用の製剤類をはじめとする各種の皮膚外用剤、浴用剤、飲食物などに配合することができる。 The hyaluronic acid production promoter of the present invention is a pharmaceutical, quasi-drug, topical or systemic skin cosmetics, various skin external preparations such as medicinal or cosmetic preparations applied to the scalp / hair, and bath preparations. It can be blended in food and drink.
本発明の皮膚外用剤、浴用剤、飲食物は、前記ヒアルロン酸産生促進剤の１種又は２種以上を含有する。そして前記ヒアルロン酸産生促進剤の皮膚外用剤等への総配合量は、剤型により適宜異なるが、前記皮膚外用剤、浴用剤、飲食物全体の質量に対し、一般的には、前記ヒアルロン酸産生促進剤に含有される植物エキス、アルブチン、アスコルビン酸、アルギン酸オリゴ糖類の配合量に換算して、０.０１質量％〜１０質量％、好ましくは０.０２５質量％〜５質量％、さらに特定すると０.０５質量％〜２.５質量％となるように含有することが望ましい。 The skin external preparation, bath preparation, and food and drink of the present invention contain one or more hyaluronic acid production promoters. The total blending amount of the hyaluronic acid production promoter into the external preparation for skin and the like varies depending on the dosage form. Generally, the hyaluronic acid is generally used relative to the mass of the external preparation for skin, bath preparation, and food and drink. In terms of the amount of plant extract, arbutin, ascorbic acid, and alginate oligosaccharide contained in the production promoter, 0.01% by mass to 10% by mass, preferably 0.025% by mass to 5% by mass, and further specified Then, it is desirable to contain it so that it may become 0.05 mass%-2.5 mass%.
また、本発明の浴用剤は、前記ヒアルロン酸産生促進剤の１種又は２種以上を含有し、浴用剤への総配合量は、剤型により適宜異なる。
更に、本発明の飲食物は、前記ヒアルロン酸産生促進剤の１種又は２種以上を含有し、飲食物への総配合量は、剤型により適宜異なる。
Moreover, the bath agent of this invention contains the 1 type (s) or 2 or more types of the said hyaluronic acid production promoter, and the total compounding quantity to a bath agent changes suitably with dosage forms.
Furthermore, the food / beverage products of this invention contain 1 type, or 2 or more types of the said hyaluronic acid production promoter, and the total compounding quantity to food / beverage products changes suitably with dosage forms.
本発明の皮膚外用剤及び浴用剤には、前記ヒアルロン酸産生促進剤の他に、通常の皮膚外用剤又は浴用剤において従来から使用されている公知の機能成分、例えば、保湿剤、エモリエント剤、血行促進剤、細胞賦活化剤、抗酸化剤、抗炎症剤、抗菌剤、過酸化物抑制剤などを配合することができる。 In addition to the hyaluronic acid production promoter, the skin external preparation and bath preparation of the present invention include known functional ingredients conventionally used in normal skin external preparations or bath preparations, such as humectants, emollients, Blood circulation promoters, cell activators, antioxidants, anti-inflammatory agents, antibacterial agents, peroxide inhibitors and the like can be blended.
公知の機能成分としてより具体的には、グリセリン、ブチレングリコール、尿素、アミノ酸類などの保湿剤；スクワラン、マカデミアナッツ油、オリーブ油、ホホバ油、シリコン油などのエモリエント剤；ビタミンＥ類、トウガラシチンキなどの血行促進剤；核酸などの細胞賦活化剤、ジブチルヒドロキシトルエン（ＢＨＴ）、ジブチルヒドロキシアニソール（ＢＨＡ）、酢酸トコフェロールなどの抗酸化剤；グリチルリチン、アラントインなどの抗炎症剤；ヒノキチオール、塩化ベンザルコニウム、クロルヘキシジン塩、パラヒドロキシ安息香酸エステルなどの抗菌剤；スーパーオキシドジスムターゼ（ＳＯＤ）などの過酸化物抑制剤など、種々の機能成分を配合することができる。
また、オウゴンエキス、イチョウエキス、胎盤抽出物、乳酸菌培養抽出物などの植物・動物・微生物由来の各種抽出物なども制限なく添加して使用することができる。
More specifically, known functional ingredients include humectants such as glycerin, butylene glycol, urea, and amino acids; emollients such as squalane, macadamia nut oil, olive oil, jojoba oil, and silicone oil; vitamin Es, pepper tincture, and the like. Blood circulation promoters; cell activators such as nucleic acids, antioxidants such as dibutylhydroxytoluene (BHT), dibutylhydroxyanisole (BHA), tocopherol acetate; anti-inflammatory agents such as glycyrrhizin and allantoin; hinokitiol, benzalkonium chloride, Various functional components such as antibacterial agents such as chlorhexidine salt and parahydroxybenzoate ester; peroxide inhibitors such as superoxide dismutase (SOD) can be blended.
In addition, various extracts derived from plants, animals, and microorganisms such as hornon extract, ginkgo biloba extract, placenta extract, and lactic acid bacteria culture extract can be added and used without limitation.
本発明の皮膚外用剤とは、外用可能な剤であって、その剤型には特に制限はなく、例えば、ペースト剤、クリーム、ジェル、軟膏、ローション、乳液、パック、パウダー、ハップ剤などが例示できる。 The external preparation for skin of the present invention is an agent that can be applied externally, and there is no particular limitation on the dosage form, for example, paste, cream, gel, ointment, lotion, emulsion, pack, powder, haptic agent, etc. It can be illustrated.
本発明の浴用剤の剤型にも特に制限はなく、例えば、粉末、顆粒状などの固形製剤、乳液、ペースト状などの液体製剤などが例示できる。
本発明の飲食物には、前記ヒアルロン酸産生促進剤の他に、通常食品に使用されている様々な材料を特に制限なく併用することができる。
There is no restriction | limiting in particular also in the dosage form of the bath preparation of this invention, For example, liquid preparations, such as solid preparations, such as a powder and a granular form, an emulsion, and a paste form, etc. can be illustrated.
In addition to the hyaluronic acid production promoter, various materials that are usually used in foods can be used in the food and drink of the present invention without any particular limitation.
本発明の飲食物の剤型としては適用可能なあらゆる形態があり、例えば、ビスケット、クッキー、錠剤、カプセル剤、キャンディー、ガム、粉末などの固形製剤、飲料などの液体製剤、ゼリーなどの半固形製剤などが例示できる。 The dosage form of the food and drink of the present invention includes all applicable forms, for example, solid preparations such as biscuits, cookies, tablets, capsules, candy, gum, and powder, liquid preparations such as beverages, and semisolids such as jelly Examples include preparations.
また、本発明の皮膚外用剤、浴用剤及び飲食物には、その剤型化のために界面活性剤、油脂類などの基材成分や、必要に応じて増粘剤、防腐剤、等張化剤、酸化防止剤、紫外線吸収剤、キレート剤、香料、着色料などの種々の添加物を併用できる。 In addition, the external preparation for skin, bath preparation and food and drink of the present invention include base ingredients such as surfactants and fats and oils, and thickeners, preservatives, isotonic agents as necessary. Various additives such as an agent, an antioxidant, an ultraviolet absorber, a chelating agent, a fragrance, and a coloring agent can be used in combination.
上記の界面活性剤としては特に限定されるものではないが、一般的な非イオン界面活性剤、陰イオン界面活性剤、陽イオン界面活性剤、両性界面活性剤を用いることができる。例えば、高級アルコールのアルキレンオキサイド付加物、高級アルキルアミンのアルキレンオキサイド付加物、高級脂肪酸のアルキレンオキサイド付加物、高級脂肪酸アミドのアルキレンオキサイド付加物、多価アルコールの脂肪酸エステル、硬化ひまし油のアルキレンオキサイド付加物、ポリエチレングリコールソルビタンアルキルエステル、ステロール等のアルキレンオキサイド付加物などの非イオン界面活性剤；アルキル硫酸ナトリウム、アルキロイルメチルタウリンナトリウム、α−オレフィンスルホン酸ナトリウム、ポリオキシアルキレンアルキルエーテル硫酸ナトリウムなどの陰イオン界面活性剤；塩化アルキルピリジニウム、塩化ジステアリルジメリルアンモニウムなどの陽イオン界面活性剤；アミノプロピオン酸ナトリウム、アルキルポリアミノエチルグリシンなどの両性界面活性剤が挙げられる。そして、これらの界面活性剤は１種又は２種以上を選択して使用することができる。 Although it does not specifically limit as said surfactant, A general nonionic surfactant, anionic surfactant, a cationic surfactant, and an amphoteric surfactant can be used. For example, alkylene oxide adduct of higher alcohol, alkylene oxide adduct of higher alkylamine, alkylene oxide adduct of higher fatty acid, alkylene oxide adduct of higher fatty acid amide, fatty acid ester of polyhydric alcohol, alkylene oxide adduct of hardened castor oil , Nonionic surfactants such as alkylene oxide adducts such as polyethylene glycol sorbitan alkyl esters and sterols; anions such as sodium alkyl sulfate, sodium alkylylmethyl taurate, sodium α-olefin sulfonate, sodium polyoxyalkylene alkyl ether sulfate Surfactants; Cationic surfactants such as alkylpyridinium chloride and distearyl dimerylammonium chloride; Sodium aminopropionate Amphoteric surfactants such as alkylpolyaminoethylglycine the like. And these surfactant can select and use 1 type (s) or 2 or more types.
本発明において使用可能な基材成分として、特に限定されるものではないが、例えば、オリーブ油、ツバキ油、アボカド油、マカデミアナッツ油、杏仁油、ホホバ油、スクワラン、スクワレン、馬油、パラフィン、シリコンなど、一般的に知られている油脂類が挙げられる。 The base component usable in the present invention is not particularly limited, and examples thereof include olive oil, camellia oil, avocado oil, macadamia nut oil, apricot oil, jojoba oil, squalane, squalene, horse oil, paraffin, silicon and the like. And generally known fats and oils.
本発明において使用可能な増粘剤として、特に限定されるものではないが、例えば、ポリビニルアルコール、ポリビニルアクリルアミド、ポリエチレングリコール、及びこれらの各種誘導体；ヒドロキシアルキルセルロースなどのセルロース類及びその誘導体；デキストラン、ゼラチン、アラビアガム、トラガントガムなどのガム類；カルボキシビニルポリマーなどの水溶性高分子などが挙げられる。 Although it does not specifically limit as a thickener which can be used in this invention, For example, polyvinyl alcohol, polyvinyl acrylamide, polyethyleneglycol, and these various derivatives; Celluloses, such as a hydroxyalkyl cellulose, and its derivative; Dextran, Examples include gums such as gelatin, gum arabic, and gum tragacanth; and water-soluble polymers such as carboxyvinyl polymer.
本発明において使用可能な防腐剤として、特に限定されるものではないが、例えば、パラヒドロキシ安息香酸エステル、パラオキシ安息香酸塩とその誘導体、フェノキシエタノール、ヒノキチオール、塩化ベンザルコニウム、クロルヘキシジン塩などが挙げられる。 Examples of the preservative that can be used in the present invention include, but are not limited to, parahydroxybenzoic acid esters, paraoxybenzoic acid salts and derivatives thereof, phenoxyethanol, hinokitiol, benzalkonium chloride, chlorhexidine salts, and the like. .
本発明において使用可能な等張化剤として、特に限定されるものではないが、例えば、塩化ナトリウム、塩化カリウム、塩化カルシウムなどの無機塩類が挙げられる。 The isotonic agent that can be used in the present invention is not particularly limited, and examples thereof include inorganic salts such as sodium chloride, potassium chloride, and calcium chloride.
本発明において使用可能な紫外線吸収剤として、特に限定されるものではないが、例えば、パラアミノ安息香酸、ベンゾフェノン系紫外線吸収剤、ベンゾトリアゾール系紫外線吸収剤などが挙げられる。 Although it does not specifically limit as an ultraviolet absorber which can be used in this invention, For example, a para amino benzoic acid, a benzophenone series ultraviolet absorber, a benzotriazole type ultraviolet absorber, etc. are mentioned.
本発明において使用可能なキレート剤として、特に限定されるものではないが、例えば、エチレンジアミン四酢酸、フィチン酸、クエン酸及びこれらの水溶性塩などが挙げられる。 Although it does not specifically limit as a chelating agent which can be used in this invention, For example, ethylenediaminetetraacetic acid, phytic acid, a citric acid, these water-soluble salts, etc. are mentioned.
以下、本発明を更に詳しく説明するために実施例によって説明するが、本発明はこれらの実施例により何ら限定されるものではない。
（１）植物エキスの製造方法
植物エキスは、以下の表１に示す各植物の各部位を、５０質量％エタノール水溶液の環流下で１時間かけて抽出後ろ過し、得られた抽出液から水、エタノールを減圧留去して各植物エキスを得た。得られた植物エキスを以下に示す実施例に使用した。
Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples.
(1) Production method of plant extract The plant extract is filtered after extracting each part of each plant shown in Table 1 below under reflux of 50% by mass ethanol aqueous solution for 1 hour, and water is extracted from the obtained extract. Ethanol was distilled off under reduced pressure to obtain each plant extract. The obtained plant extract was used for the Example shown below.
（２）アルギン酸オリゴ糖類の製造方法
市販のアルギン酸ナトリウムであるＳＫＡＴ−ＵＬＶ（キミカ社製）１.５ｇ、リン酸アンモニウム０.０５ｇ、酵母エキス０.０１ｇ、塩化ナトリウム２ｇをイオン交換水１００ｇ中に溶解させ、オートクレーブで２.１ａｔｍ、１２１℃、２０分間の滅菌操作を行った。滅菌処理後のアルギン酸溶液に対し、アルギン酸分解菌であるＰｓｅｕｄｏ ａｌｔｅｒｏｍｏｎａｓ ｈａｌｏｐｌａｎｃｔｉｃ（ＩＴＭ ２２２）を一白金耳埴菌し、室温下、８時間前培養を行った。
(2) Production method of alginic acid oligosaccharide 1.5 g of commercially available sodium alginate SKAT-ULV (manufactured by Kimika), 0.05 g of ammonium phosphate, 0.01 g of yeast extract, and 2 g of sodium chloride in 100 g of ion-exchanged water Dissolved and sterilized by autoclave at 2.1 atm, 121 ° C. for 20 minutes. The alginate solution after sterilization was platinized with Pseudoalteromonas halloplastic (ITM 222), which is an alginate-degrading bacterium, and precultured at room temperature for 8 hours.
次に、得られた前培溶液１ｍＬを、アルギン酸ナトリウム分解用培地（リン酸アンモニウム０.１５ｇ、酵母エキス０.０１ｇ、アルギン酸ナトリウム（キミカ社製）９.０ｇ、塩化ナトリウム６.０ｇをイオン交換水３００ｇに溶解させ、オートクレーブで２.１ａｔｍ、１２１℃、２０分間の滅菌操作を行ったものを使用）に添加後、室温条件下で４８時間振とう培養を行った。 Next, 1 mL of the obtained preculture solution was ion-exchanged with sodium alginate decomposition medium (0.15 g of ammonium phosphate, 0.01 g of yeast extract, 9.0 g of sodium alginate (manufactured by Kimika), 6.0 g of sodium chloride) It was dissolved in 300 g of water and added to an autoclave that had been sterilized at 2.1 atm, 121 ° C. for 20 minutes, and then cultured with shaking at room temperature for 48 hours.
振とう培養後のアルギン酸ナトリウム分解液から、菌体除去のための遠心分離操作（１００００ｒｐｍ×１０分間）を行い、上澄み液を得た。得られた上澄み液に液量と同量のメタノールを加え、分解後のアルギン酸ナトリウム溶液から高分子量（数万）のアルギン酸ナトリウムを沈降させて濾別し、低分子量のアルギン酸オリゴ糖ナトリウムを含有している濾液を得た。 From the sodium alginate decomposition solution after shaking culture, a centrifugal separation operation (10000 rpm × 10 minutes) was performed to remove the cells, and a supernatant was obtained. Add the same amount of methanol to the resulting supernatant, precipitate high molecular weight (tens of thousands) sodium alginate from the decomposed sodium alginate solution, and filter and contain low molecular weight sodium alginate oligosaccharides. A filtrate was obtained.
アルギン酸オリゴ糖ナトリウムを含有している濾液の中から塩化ナトリウムなどの不純物を除去し、精製を行うために、ゲル濾過操作（Ｓｅｐｈａｄｅｘ ＬＨ−２０、Ｐｈａｒｍａｃｉａ Ｆｉｎｅ Ｃｈｅｍｉｃａｌｓ）を行った。ゲル濾過操作後、得られた液を濃縮して、凍結乾燥機で乾燥を行い、目的とするアルギン酸オリゴ糖ナトリウム（重量平均分子量約２０００）を５.４ｇ（収率６０％）得た。 To remove impurities such as sodium chloride from the filtrate containing sodium alginate oligosaccharide and perform purification, gel filtration operation (Sephadex LH-20, Pharmacia Fine Chemicals) was performed. After the gel filtration operation, the obtained liquid was concentrated and dried with a freeze dryer to obtain 5.4 g (yield 60%) of the desired sodium alginate oligosaccharide (weight average molecular weight: about 2000).
また、振とう培養時間を４８時間から８時間に換えた以外は上記と同様に操作して、重量平均分子量約２万のアルギン酸オリゴ糖ナトリウムを得た。
更に、得られた重量平均分子量２０００又は２万のアルギン酸オリゴ糖ナトリウムをイオン交換樹脂（アンバーライト１００６Ｆ Ｈ、ローム・アンド・ハース・ジャパン社製）と共に操作して、重量平均分子量約２０００又は２万のアルギン酸オリゴ糖を得た。
In addition, alginate oligosaccharide sodium having a weight average molecular weight of about 20,000 was obtained in the same manner as above except that the shaking culture time was changed from 48 hours to 8 hours.
Further, the obtained sodium alginate oligosaccharide having a weight average molecular weight of 2000 or 20,000 is operated together with an ion exchange resin (Amberlite 1006F H, manufactured by Rohm and Haas Japan Co., Ltd.) to obtain a weight average molecular weight of about 2000 or 20,000. Of alginate oligosaccharide was obtained.
なお、重量平均分子量の測定は水系ゲルパーミッションクロマトグラフィー（以下ＧＰＣ）装置を用いて測定した。測定条件は、ＧＰＣ装置（東ソー社製ＧＰＣ−８０２０）、カラム（東ソー社製Ｇ３０００→Ｇ５０００を直結） 、カラム温度４０℃、カラム流量
１.０ｍｌ／ｍｉｎ、溶出液０.１Ｍ ＮａＣｌ水溶液、ＲＩ検出であり、重量平均分子量はＰＥＧを標品として換算した値である。
The weight average molecular weight was measured using an aqueous gel permeation chromatography (hereinafter GPC) apparatus. Measurement conditions are GPC device (GPC-8020 manufactured by Tosoh Corporation), column (G3000 → G5000 manufactured by Tosoh Corporation), column temperature 40 ° C., column flow rate 1.0 ml / min, eluent 0.1M NaCl aqueous solution, RI detection. The weight average molecular weight is a value obtained by converting PEG as a standard.
得られたアルギン酸オリゴ糖ナトリウム、アルギン酸オリゴ糖を以下に示す実施例に使用した。 The obtained sodium alginate oligosaccharide and alginate oligosaccharide were used in the following examples.
（３）アルブチン
和光純薬工業（株）製のアルブチンを以下に示す実施例に使用した。
（４）アスコルビン酸
和光純薬工業（株）製のＬ(＋)−アスコルビン酸を以下に示す実施例に使用した。
(3) Arbutin Arbutin manufactured by Wako Pure Chemical Industries, Ltd. was used in the examples shown below.
(4) Ascorbic acid L (+)-ascorbic acid manufactured by Wako Pure Chemical Industries, Ltd. was used in the examples shown below.
（Ｉ）ヒアルロン酸産生促進剤
［実施例１］
アスコルビン酸を１０ｍｇ／ｍＬとなるよう調製し、その後、クリーンベンチ内で０.２μｍのシリンジフィルターを用いて滅菌した。そして、滅菌精製水を加えて２ｍｇ／ｍＬとなるよう調整して、培地に添加するアルブチンの希釈液を作製した。
次に、倉敷紡績(株)製の正常ヒト皮膚線維芽細胞を規定の調製法に基づき、分化、培養を行った。培地には、低血清増殖添加剤（ＬＳＧＳ）を添加した正常ヒト皮膚線維芽細胞増殖用低血清培地（Ｍｅｄｉｕｍ１０６Ｓ）を用いた。
培地に正常ヒト成人線維芽細胞（５０００００ｃｅｌｌ／ｍＬ）の溶液を播種し、３７℃、５％−ＣＯ2、加湿のインキュベーターに入れ、１日おきに培地を交換し、６日間培養した。
(I) Hyaluronic acid production promoter [Example 1]
Ascorbic acid was prepared to 10 mg / mL, and then sterilized using a 0.2 μm syringe filter in a clean bench. Then, sterilized purified water was added to adjust to 2 mg / mL to prepare a diluted solution of arbutin to be added to the medium.
Next, normal human dermal fibroblasts manufactured by Kurashiki Boseki Co., Ltd. were differentiated and cultured according to a prescribed preparation method. The medium used was a low serum medium (Medium 106S) for normal human skin fibroblast proliferation supplemented with a low serum growth additive (LSGS).
The medium was seeded with a solution of normal human adult fibroblasts (500000 cells / mL), placed in a humidified incubator at 37 ° C., 5% -CO 2 , the medium was changed every other day, and cultured for 6 days.
６日後、シャーレから細胞をはがし、細胞浮遊液を作成した（１５０００ｃｅｌｌ／ｍＬ）。細胞浮遊液を２４ｗｅｌｌ ｐｌａｔｅに１ｍＬずつ播種し、２日間培養した。培地交換の際、前記アスコルビン酸の希釈液を１０μＬ（最終濃度が２０μｇ／ｍＬとなる）添加し、さらに２日間培養した。２日おきに培地交換等を行い、細胞播種８日目に培地を回収した。回収した培地を生化学工業（株）より販売されているヒアルロン酸測定キットを用いて、その使用法に準じて、培養６日目から８日目までの４８時間培養後の上清中に存在するヒアルロン酸量の測定を行った。この時のヒアルロン酸の量は、ヒアルロン酸産生促進成分（アスコルビン酸）の希釈液の代わりに滅菌精製水を添加して、その他は同様の操作をした比較例１のタンパク質量当たりのヒアルロン酸の量と比較したところ１７６％あり、比較例１に比べて１７６％のヒアルロン酸産生促進能を示したこととなる。
なお、回収した培地のタンパク質量は、Ｌｏｗｒｙ法にて測定した。
Six days later, cells were peeled from the petri dish to prepare a cell suspension (15000 cell / mL). 1 mL of the cell suspension was seeded on a 24-well plate and cultured for 2 days. When exchanging the medium, 10 μL of the diluted ascorbic acid solution (final concentration becomes 20 μg / mL) was added, followed by further culturing for 2 days. The medium was changed every two days, and the medium was collected on the 8th day of cell seeding. Using the hyaluronic acid measurement kit sold by Seikagaku Corporation, the collected medium is present in the supernatant after 48 hours of culture from the 6th day to the 8th day of culture according to its usage. The amount of hyaluronic acid to be measured was measured. The amount of hyaluronic acid at this time was the same as that of Comparative Example 1 in which sterilized purified water was added in place of the diluted solution of hyaluronic acid production promoting component (ascorbic acid), and the other operations were performed in the same manner. When compared with the amount, it was 176%, which means that 176% of hyaluronic acid production promoting ability was shown compared with Comparative Example 1.
Note that the amount of protein in the collected medium was measured by the Lowry method.
［実施例２〜４１］
ヒアルロン酸産生促進成分及び添加した最終濃度を表２のように換えた以外は実施例１と同様の操作をして、得られたヒアルロン酸の量と比較例１のヒアルロン酸の量とを、同様に比較した結果を表２に示す。
[Examples 2 to 41]
Except that the hyaluronic acid production promoting component and the added final concentration were changed as shown in Table 2, the same operation as in Example 1 was carried out, and the amount of hyaluronic acid obtained and the amount of hyaluronic acid in Comparative Example 1 were The results of comparison are shown in Table 2.
表２の実施例１〜４１の結果が示すように、ヒアルロン酸産生促進成分として各種植物
エキス、アルブチン、アスコルビン酸、アルギン酸オリゴ糖類及びその組成物を用いたものは、正常ヒト皮膚線維芽細胞におけるヒアルロン酸産生に対し、有意に産生促進効果を示していることがわかる。
As shown in the results of Examples 1 to 41 in Table 2, those using various plant extracts, arbutin, ascorbic acid, alginic acid oligosaccharides and compositions thereof as hyaluronic acid production promoting components were found in normal human skin fibroblasts. It can be seen that production of hyaluronic acid is significantly enhanced.
（II）皮膚外用剤の処方例
表３〜１４に示す組成でヒアルロン酸産生促進剤を配合した皮膚外用剤（化粧水、乳液、クリーム、ボディクリーム）の処方を調製した。調製方法は下記の通りである。なお、配合量の単位はｇで、表中の精製水の「残量」とは全量を１００ｇとする量である。
(II) Formulation example of skin external preparation The formulation of the skin external preparation (skin lotion, milky lotion, cream, body cream) which mix | blended hyaluronic acid production promoter with the composition shown in Tables 3-14 was prepared. The preparation method is as follows. The unit of the blending amount is g, and the “remaining amount” of purified water in the table is an amount that makes the total amount 100 g.
化粧水（実施例４２〜６２、比較例２）
表３〜５のＡ成分、Ｂ成分のそれぞれを８０℃で加温して溶解し、Ｂ成分をＡ成分に撹拌しながら徐々に加えて乳化した。その後撹拌しながら冷却し、４０℃でＣ成分を加えて、３５℃で調製を終了した。
Lotion (Examples 42 to 62, Comparative Example 2)
Each of A component and B component of Tables 3-5 was heated and melt | dissolved at 80 degreeC, and B component was gradually added and emulsified to A component, stirring. Thereafter, the mixture was cooled with stirring, the C component was added at 40 ° C., and the preparation was completed at 35 ° C.
乳液（実施例６３〜８３、比較例３）
表６〜８のＤ成分、Ｅ成分のそれぞれを８０℃に加温して溶解し、Ｄ成分をＥ成分に攪拌しながら加え均一とした後、ホモミキサーで乳化した。その後、ハンドルミキサーで攪拌しながら冷却し、４０℃以下でＦ成分を加えて、調製を終了した。
Latex (Examples 63 to 83, Comparative Example 3)
Each of D component and E component of Tables 6-8 was heated and melt | dissolved at 80 degreeC, and after adding and stirring D component to E component, it emulsified with the homomixer. Then, it cooled, stirring with a handle mixer, added F component at 40 degrees C or less, and complete | finished preparation.
クリーム（実施例８４〜１０４、比較例４）
表９〜１１のＧ成分、Ｈ成分をそれぞれ７５℃に加温して溶解し、Ｇ成分をパドルミキサーで撹拌しながらＨ成分を少量ずつ加えた。その後、撹拌しながら冷却し、４０℃でＩ成分を加えた後、約３５℃で調製を終了した。
Cream (Examples 84 to 104, Comparative Example 4)
The G component and the H component in Tables 9 to 11 were each dissolved by heating to 75 ° C., and the H component was added little by little while stirring the G component with a paddle mixer. Then, it cooled, stirring, and added I component at 40 degreeC, Then, preparation was complete | finished at about 35 degreeC.
ボディクリーム（実施例１０５〜１２５、比較例５）
表１２〜１４のＪ成分、Ｋ成分をそれぞれ７５℃に加温して、Ｊ成分をパドルミキサーで撹拌しながら、Ｋ成分を少量ずつ加えた。その後、撹拌しながら冷却し、４５℃以下でＬ成分を加えて調製を終了した。
The J component and the K component in Tables 12 to 14 were each heated to 75 ° C., and the K component was added little by little while stirring the J component with a paddle mixer. Then, it cooled, stirring, and added L component at 45 degrees C or less, and complete | finished preparation.
評 価
前記実施例４１〜１２５、比較例２〜５の皮膚外用剤について、加齢による肌のしわやハリ、弾力の低下に悩みを有する女性を対象としたモニター試験を行い、その評価を行った。
皮膚外用剤のそれぞれについて、女性２名ずつの（２２群×４処方）計１７６名に対して毎日、朝と夕の２回、適量を肌に塗布することを１ヶ月間続けるモニター試験を行い、その使用感を調べた。下記の基準にて評価を行った結果を表１５に示す。なお、使用期間中に皮膚の異常を訴えたものはいなかった。
有 効 ：肌のハリ・ツヤ・弾力が増した
やや有効：肌のハリ・ツヤ・弾力がやや増した
効果無し：使用前と変化なし
Evaluation Regarding the external preparations for skin of Examples 41 to 125 and Comparative Examples 2 to 5, a monitor test was conducted for women who suffered from wrinkles and firmness of the skin due to aging and a decrease in elasticity, and the evaluation was performed. It was.
For each topical skin preparation, a total of 176 women (22 groups x 4 prescriptions) for a total of 176 women were given a daily monitor test twice a day in the morning and evening for 1 month. , I investigated its feeling of use. Table 15 shows the results of evaluation based on the following criteria. None of the patients complained of skin abnormalities during the period of use.
Effective: Skin elasticity, gloss, elasticity increased slightly Effective: Skin elasticity, gloss, elasticity increased slightly No effect: No change from before use
本発明のヒアルロン酸産生促進剤を配合した実施例４１〜１２５の皮膚外用剤では、各部位にハリや弾力を感じたといった人が多かった一方で、本発明のヒアルロン酸産生促進剤を配合していない比較例２〜５の皮膚外用剤では変化なしとの評価であったことから、本発明のヒアルロン酸産生促進剤を配合した皮膚外用剤は、肌のハリや弾力の向上に対していずれも有意であった。 In the skin external preparations of Examples 41 to 125 containing the hyaluronic acid production promoter of the present invention, there were many people who felt firmness and elasticity at each site, while the hyaluronic acid production promoter of the present invention was formulated. Since it was evaluated that there was no change in the external preparations for skin of Comparative Examples 2 to 5, the external preparation for skin containing the hyaluronic acid production promoter of the present invention was suitable for improving skin firmness and elasticity. Was also significant.
（III）浴用剤の処方
次に、表１６〜１８に示す組成でヒアルロン酸産生促進剤を配合した抗老化浴用剤（入浴剤）の処方を調製した。調製法は下記の通りである。なお、配合量の単位はｇで、表中の精製水の「残量」とは全量を１００ｇとする量である。
(III) Formulation of bathing agent Next, a formulation of an anti-aging bathing agent (bathing agent) containing hyaluronic acid production promoters having the compositions shown in Tables 16 to 18 was prepared. The preparation method is as follows. The unit of the blending amount is g, and the “remaining amount” of purified water in the table is an amount that makes the total amount 100 g.
入浴剤（実施例１２６〜１４６、比較例６）
表１６〜１８のＭ成分とＮ成分をそれぞれ均一になるまで混合した後、Ｍ成分とＮ成分とを混合し、均一になるまで充分混合して調製を終了した。
Bath agent (Examples 126 to 146, Comparative Example 6)
After mixing the M component and the N component in Tables 16 to 18 until uniform, the M component and the N component were mixed and mixed well until uniform, thereby completing the preparation.
評 価
前記実施例１２６〜１４６、比較例６の入浴剤について、肌のしわやハリ、弾力の低下に悩みを有する女性を対象としたモニター試験を行い、その評価を行った。
入浴剤のそれぞれについて、女性２名ずつの（２２群）計４４名に対して、毎日の入浴時にお湯１８０Ｌに対して入浴剤３０ｍＬを溶かして入浴すること以外は通常の生活をするモニター試験を１ヶ月間続けた。１ヶ月後、その使用感を下記の基準で評価した結果を表１９に示す。なお、使用期間中に皮膚の異常を訴えたものはいなかった。
有 効 ：使用前に比べて肌のハリや弾力を感じる
やや有効：使用前に比べて肌のハリや弾力をやや感じる
効果無し：使用前と変化なし
Evaluation The bath tests of Examples 126 to 146 and Comparative Example 6 were evaluated by performing a monitor test for women who suffer from wrinkles and firmness of the skin and a decrease in elasticity.
For each of the bathing agents, a monitor test for normal life, except for bathing by dissolving 30 mL of bathing agent in 180 liters of hot water at the time of daily bathing for a total of 44 women (group 22) for each of the two bathing agents. Continued for a month. Table 19 shows the results of evaluating the feeling of use according to the following criteria after one month. None of the patients complained of skin abnormalities during the period of use.
Effective: Feels firmness and elasticity of skin compared to before use Slightly effective: Feels firmness and elasticity of skin compared to before use No effect: No change from before use
本発明のヒアルロン酸産生促進剤を配合した実施例１２６〜１４６の入浴剤では、肌にハリや弾力を感じたといった人が多かった一方で、本発明のヒアルロン酸産生促進剤を配合していない比較例６の入浴剤では変化なしとの評価であったことから、本発明のヒアルロン酸産生促進剤を配合した入浴剤は、肌のハリや弾力の向上に対しいずれも有意であった。 In the bathing agents of Examples 126 to 146 in which the hyaluronic acid production promoter of the present invention was blended, there were many people who felt firmness and elasticity on the skin, but the hyaluronic acid production promoter of the present invention was not blended. Since it was evaluated that there was no change in the bathing agent of Comparative Example 6, the bathing agent containing the hyaluronic acid production promoter of the present invention was significant for improving skin firmness and elasticity.
（IV）飲食物の処方
次に、表２０〜２３、表２５〜２６に示す組成でヒアルロン酸産生促進剤を配合した抗老化飲食物（パン、ゼリー、サプリメント(錠剤)）の処方を調製した。調製法は下記の通りである。なお、配合量の単位はｇで、表中の精製水の「残量」とは全量を１００ｇとする量である。
(IV) Food / Beverage Formulation Next, a formulation of anti-aging food / beverage (bread, jelly, supplement (tablet)) containing hyaluronic acid production promoters with the compositions shown in Tables 20-23 and 25-26 was prepared. . The preparation method is as follows. The unit of the blending amount is g, and the “remaining amount” of purified water in the table is an amount that makes the total amount 100 g.
パン（実施例１４７〜１５８、比較例７）
表２０〜２１のＯ成分全部を混ぜ合わせたものに、４０℃に加温したＰ成分とＱ成分を混ぜ合わせたもの加えて、均一になった時点でよくこねた。３５℃で４０分間一次発酵させ、空気を抜くように再度こねた。４０℃で４０分間二次発酵後、１８０℃で２５分間焼いた。
Bread (Examples 147 to 158, Comparative Example 7)
A mixture of all the O components in Tables 20 to 21 was added to the mixture of the P and Q components heated to 40 ° C., and kneaded well when the mixture became uniform. Primary fermentation was performed at 35 ° C. for 40 minutes, and kneaded again so as to remove air. After secondary fermentation at 40 ° C. for 40 minutes, baking was performed at 180 ° C. for 25 minutes.
ゼリー（実施例１５９〜１７０、比較例８）
表２２〜２３のＴ成分にＳ成分を溶解した８０℃のお湯にＲ成分を溶かし、よく混ぜ合わせた。型に１０ｇずつ流し入れた後、冷蔵庫で固めて調製を終了した。
Jelly (Examples 159 to 170, Comparative Example 8)
R component was melt | dissolved in the hot water of 80 degreeC which melt | dissolved S component in T component of Table 22-23, and it mixed well. After pouring 10 g into the mold, it was hardened in a refrigerator to complete the preparation.
評 価
前記実施例１４７〜１７０、比較例７、８の飲食物について、肌のしわやハリ、弾力の低下に悩みを有する女性を対象としたモニター試験を行い、その評価を行った。
飲食物のそれぞれについて、女性２名ずつの（１２群×２処方）計４８名に対して、パンについては、毎日の朝食時に前記実施例又は比較例のパンを主食として９０ｇ食べること、ゼリーについては、毎日の夕食後に前記実施例又は比較例のゼリーを５０ｇ摂取すること以外は通常の生活をするモニター試験を１ヶ月間続けた。１ヶ月後、その使用感を下記の基準で評価した結果を表２４に示す。なお、使用期間中に皮膚の異常を訴えたものはいなかった。
有 効 ：使用前に比べて肌のハリや弾力を感じる
やや有効：使用前に比べて肌のハリや弾力をやや感じる
効果無し：使用前と変化なし
Evaluation Regarding the foods and drinks of Examples 147 to 170 and Comparative Examples 7 and 8, a monitor test was conducted on women who suffered from wrinkles and firmness of the skin and a decrease in elasticity, and the evaluation was performed.
For each food and drink, 2 women (12 groups x 2 prescriptions) for a total of 48 people, about bread, eat 90g of the bread of the example or comparative example as a staple food at the time of daily breakfast, jelly Continued the monitor test for one month of normal life except taking 50 g of the jelly of the above example or comparative example after dinner every day. Table 24 shows the results of evaluating the feeling of use according to the following criteria after one month. None of the patients complained of skin abnormalities during the period of use.
Effective: Feels firmness and elasticity of skin compared to before use Slightly effective: Feels firmness and elasticity of skin compared to before use No effect: No change from before use
本発明のヒアルロン酸産生促進剤を配合した実施例１４７〜１７０の飲食物では、肌にハリや弾力を感じたといった人が多かった一方で、本発明のヒアルロン酸産生促進剤を配合していない比較例７、８の飲食物では変化なしとの評価であったことから、本発明のヒアルロン酸産生促進剤を配合した飲食物は、肌のハリや弾力の向上に対しいずれも有意であった。 In the foods and drinks of Examples 147 to 170 in which the hyaluronic acid production promoter of the present invention was blended, there were many people who felt firmness and elasticity on the skin, but the hyaluronic acid production promoter of the present invention was not blended. Since it was evaluation that there was no change in the foods and drinks of Comparative Examples 7 and 8, the foods and drinks containing the hyaluronic acid production promoter of the present invention were both significant for improving skin firmness and elasticity. .
サプリメント(錠剤)（実施例１７１〜１８２、比較例９）
表２５〜２６のＵ成分とＶ成分を良く混ぜ合わせたものを、打錠機を用いてタブレット状に押し固め、錠剤（０.３ｇ）を形成した。
Supplement (Tablet) (Examples 171 to 182 and Comparative Example 9)
A mixture obtained by thoroughly mixing the U component and the V component in Tables 25 to 26 was pressed into a tablet using a tableting machine to form a tablet (0.3 g).
評 価
前記実施例１７１〜１８２、比較例９のサプリメント(錠剤)について、肌のしわやハリ、弾力の低下に悩みを有する女性を対象としたモニター試験を行い、その評価を行った。
サプリメント(錠剤)のそれぞれについて、女性２名ずつの（１２群）計２４名に対して、毎日の３回の食事後に前記実施例又は比較例のサプリメント(錠剤)を５錠（１.５ｇ）摂取すること以外は通常の生活をするモニター試験を１ヶ月間続けた。１ヶ月後、その使用感を下記の基準で評価した結果を表２７に示す。なお、使用期間中に皮膚の異常を訴えたものはいなかった。
有 効 ：使用前に比べて肌のハリや弾力を感じる
やや有効：使用前に比べて肌のハリや弾力をやや感じる
効果無し：使用前と変化なし
Evaluation The supplements (tablets) of Examples 171 to 182 and Comparative Example 9 were subjected to a monitor test for women having worries about skin wrinkles, firmness and reduced elasticity, and evaluated.
For each of the supplements (tablets), 5 tablets (1.5 g) of the supplements (tablets) of the Examples or Comparative Examples after 3 meals per day for a total of 24 women (2 groups) (24 groups). Except for ingestion, the monitor test for normal life was continued for one month. Table 27 shows the results of evaluating the feeling of use according to the following criteria after one month. None of the patients complained of skin abnormalities during the period of use.
Effective: Feels firmness and elasticity of skin compared to before use Slightly effective: Feels firmness and elasticity of skin compared to before use No effect: No change from before use
本発明のヒアルロン酸産生促進剤を配合した実施例１７１〜１８２のサプリメント（錠剤）では、肌にハリや弾力を感じたといった人が多かった一方で、本発明のヒアルロン酸産生促進剤を配合していない比較例９のサプリメント（錠剤）では変化なしとの評価であったことから、本発明のヒアルロン酸産生促進剤を配合したサプリメント（錠剤）は、肌のハリや弾力の向上に対しいずれも有意であった。 In the supplements (tablets) of Examples 171 to 182 in which the hyaluronic acid production promoter of the present invention was blended, there were many people who felt firmness and elasticity on the skin, while the hyaluronic acid production promoter of the present invention was blended. The supplement (tablet) of Comparative Example 9 that was not evaluated was no change, and therefore the supplement (tablet) containing the hyaluronic acid production promoter of the present invention was improved for both skin firmness and elasticity. It was significant.
クララエキス、イトヒメハギエキス、カキエキス、タンジンエキス、シャクヤクエキス、プーアルエキス、アルブチン又はアルギン酸オリゴ糖類及びこれらの混合物はヒアルロン酸産生を促進させる作用があり、ヒアルロン酸産生促進剤として有用である。本発明のヒアルロン酸産生促進剤は、線維芽細胞において産生されるヒアルロン酸の量を増大させるので、その結果として、シワ、タルミの予防、緩和、改善がなされて、老化現象の防止、改善を目的とした化粧品をはじめとする各種の皮膚外用剤、浴用剤、飲食物などへの利用が可能となる。 Clara extract, citrus extract, oyster extract, tanjin extract, peony extract, pual extract, arbutin or alginic oligosaccharides and mixtures thereof have an action of promoting hyaluronic acid production and are useful as hyaluronic acid production promoters. The hyaluronic acid production promoter of the present invention increases the amount of hyaluronic acid produced in fibroblasts. As a result, wrinkles and tarmi are prevented, alleviated and improved, and the aging phenomenon is prevented and improved. It can be used for various skin external preparations, bath preparations, foods and drinks including the intended cosmetics.
Claims (4)
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