CN1115964C - Composition for agricultural chemicals and preparation thereof - Google Patents

Abstract

The invention relates to a pesticide composition and a preparation method thereof. The pesticide composition of the present invention contains avermectin, imidacloprid, pesticide carrier and auxiliary agent. To prepare, simply mix the ingredients thoroughly and evenly. The pesticide composition of the present invention has quite high biological activity, which is highlighted in that the toxicity to agricultural pests is significantly improved, the dosage is relatively low, it is very safe to use, it has no harmful effect on natural enemies, humans and livestock, and it can also protect the ecology Environment, the two main components have extensive complementarity, which can improve the combined treatment effect of abamectin, expand the control objects of imidacloprid, prolong the residual period of abamectin, delay the emergence of resistance, reduce production costs, and improve economic benefits. The pesticide composition of the invention can be widely applied to crops such as fruit trees, vegetables, cotton, rice, corn, tobacco leaves, etc., and can prevent and control various resistant pests and harmful mites.

Description

A kind of pesticide composition and preparation method

technical field

The present invention relates to a pesticide composition, especially a pesticide with abamectin and imidacloprid as main active ingredients.

Pharmaceutical compositions and methods for their preparation.

Background technique

 In the current prior art, abamectin is an antibiotic insecticide fermented by microorganisms, and imidacloprid is a chemical

Synthetic insecticides, they have similar insecticidal spectrum, but also have differences in key objects of control. Abamectin is used to prevent

It mainly controls Lepidoptera pests, pest mites and psyllids, and also controls Homoptera pests such as aphids. Imidacloprid is mainly used to control rice planthoppers, planthoppers,

Pests such as aphids and leafhoppers are ineffective against lepidopteran pests and pest mites. Abamectin mainly plays a protective role and has no systemic activity

Sex, short residual effect, and imidacloprid has a strong systemic effect, long residual effect. There is a huge difference in the chemical structure of the two,

Their respective targets are also different. Abamectin mainly acts on the insect neurotransmitter GABA, inhibiting neurotransmission,

Imidacloprid binds to the Ach receptor after insect association.

Contents of the invention

The purpose of the present invention is to provide a kind of pesticide composition with abamectin and imidacloprid as main active ingredients.

Another object of the present invention is to provide a preparation method of the above pesticide composition.

 The pesticide composition of the present invention contains pharmaceutical components, pesticide carriers and adjuvants, and the weight parts of each component

The number ratio is:

        Drug Components 0.1-35 parts

                                                           

Auxiliary 1-25 parts

 Wherein, the drug component contains avermectin and imidacloprid, and the ratio of parts by weight of the two is 1:4-99

share.

 The raw material of avermectin can be powdery technical material, syrupy concentrate or mother liquor.

The raw material of imidacloprid can be a powdery original drug.

 The pesticide carrier can be inert powder or organic solvent; inert powder such as clay, diatomaceous earth, talcum powder, white

Carbon black, kaolin, can be used alone or mixed in any proportion; organic solvents such as toluene, xylene, dimethylformaldehyde

Amides, light diesel aromatics, and petroleum aromatics can be used alone or mixed in any proportion.

The adjuvant is a substance with a wetting function or a substance with an emulsifying function. The moisturizing

Substances can be vegetable oil, saponin, alkylbenzene sulfonate, pull-off powder, various non-ionic surfactants, which can be used alone

or mixed in any proportion; the emulsifying substance is aryl polyoxyethyl ether, aryl sulfonate,

Can be used alone or mixed in any proportion.

The preparation method of the pesticide composition of the present invention comprises two kinds of active ingredients abamectin and imidacloprid and selected

The pesticide carrier and adjuvant are mixed according to the specified ratio and stirred evenly.

The pesticide composition of the present invention has quite high biological activity, and the conventional co-toxicity coefficient (C.T.C) comparison method

Judgment proves that imidacloprid and abamectin are compounded in a certain ratio to significantly improve the toxicity of agricultural pests, that is,

CTC>>100; LC ₅₀ of the pesticide composition of the present invention =0.17. The dosage of the pesticide composition of the present invention is relatively low.

 The pesticide composition of the present invention is very safe to use, has no harmful effect on natural enemies, humans and livestock, and can also protect biological

Therefore, the combination of the two has extensive complementarity. Take each other's strengths, make up for each other's shortcomings, eager to improve

High abamectin combined treatment effect, expanding the control object of imidacloprid, prolonging the residual period of abamectin, delaying the generation of resistance

Health, reduce production costs, improve economic efficiency.

The pesticide composition of the present invention can be widely used in fruit trees, vegetables, cotton, rice, corn, tobacco leaves and other crops

In addition, it can control all kinds of resistant pests and harmful mites.

Detailed ways

The present invention is further described below in conjunction with embodiment, but the present invention is not limited to these embodiments.

Example 1

  Dissolve 4.5 parts of imidacloprid powder with a purity of 91% in 82 parts of DMF, add abamectin with a purity of 95%

After stirring 0.5 parts of the powder evenly, add 7.5 parts of 2204 (produced by Jinling Petrochemical) and 5.5 parts of vegetable oil, and mix it evenly

Filter and sub-package to obtain the finished product of emulsifiable concentrate.

Comparative Examples 1-4 were operated in the same manner as in Example 1 to obtain the emulsifiable concentrate product of the proportioning shown in Table 1.

Table 1

Components Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4

Imidacloprid (91%) 2.0 1.0 1.0 0.0

Abamectin (95%) 0.5 0.5 0.0 1.0

DMF 85 86 86.5 86.5

2204 7 7 7 7

Vegetable Oil 5.5 5.5 5.5 5.5

Wherein, the DMF is a commercially available organic solvent code; 2204 is a commercially available pesticide wetting composition.

Comparative example 1

Abamectin: the ratio of imidacloprid is increased to 1: 4, and emulsifiable concentrate is obtained in the same way.

Comparative example 2

Abamectin: the ratio of imidacloprid is increased to 1: 2, and emulsifiable concentrate is obtained in the same way.

Comparative example 3

Only add imidacloprid and carrier and auxiliary agent, obtain emulsifiable concentrate similarly.

Comparative example 4

Only add abamectin and carrier and auxiliary agent, obtain emulsifiable concentrate similarly.

The significant synergistic effect of the selected proportioning of the present invention is illustrated by the following test, from which the pesticide composition of Abamectin and imidacloprid of the present invention can significantly improve the toxicity of agricultural pests.

Experiment 1 Determination of half-lethal concentration (LC ₅₀ ). The object of measurement is the alfalfa aphid on the broad bean seedlings (cotyledon stage) raised indoors. The test insects are treated by conventional dipping method and fed at 25°C for 48 hours. Calculate the virulence regression equation (y=a+bx) of each treatment by multiplication, and calculate the LC ₅₀ value of each treatment. The judgment of synergistic effect was judged by conventional co-toxicity coefficient (CTC) comparison method.

Sun.Y.Cet calculation method:

The results are shown in Table 2

Table 2

Sample Toxicity regression equation LC ₅₀ value Co-toxicity coefficient

(Y＝A+BX) (ppm) C.T.C sun.C.Yet

Example 1 Y＝6.25+1.99X 0.17 852

Comparative example 1 Y＝5.96+1.59X 0.25 440

Comparative example 2 Y＝4.49+2.33X 1.07 77

Comparative example 3 Y＝4.24+2.38X 2.10 /

Comparative example 4 Y＝5.53+1.26X 0.38 /

From the results in Table 2, it can be proved that the ratio of the pesticide composition with avermectin and imidacloprid as the main components of the present invention has a more significant synergistic effect than other blending ratios.

Experiment 2 drug efficacy experiment

The test was carried out in a certain place in Shandong Province. The variety was 30-year-old Perfume pear, with 18 plants planted per mu. The cultivation management was good, the tree vigor was strong, and the occurrence of pear psyllids was moderately severe. In the test, the emulsifiable concentrate product of Example 1 was diluted 5000 times, 8000 times, and 10000 times, and the 5000 times dilution of Comparative Example 4 and 10% imidacloprid wettable powder was used as the standard control, and the sprayed water was used as the blank control. 3 days, 7 days, 10 days and 15 days after the application of the drug, the number of live insects was investigated once respectively, and the population reduction rate and corrected control effect were calculated using the following formula, and the significance was determined. PT ₀ ——Before drug treatment in the treatment area PT ₁ ——CK after drug treatment in the treatment area ₀ ——Before drug treatment in the control area CK ₁ ——After drug treatment in the treatment area

  (head)   Number of Live Insects Reduction Rate Control Efficacy Number of Live Insects Decline Rate Control Efficacy

(Head) ( %) ( %) (head) (head) ( %) ( %) Example 1 905 83 90.83 92.70 35 96.13 97.415000 times A A A A A

                                                                                                                                            15 days

          Number of Live Insects Decline Rate Control Efficacy Number of Live Insects Decline Rate Control Efficacy

(Head) (%) (%) (Head) (%) (%)

                                                                                                                              

A A A Test Treatment of Pentomonic Medicine 3 days after medicine 7 days after medicine

(Head) Number of live insects Reduction rate Control effect Number of live insects Decrease rate Control effect

(Head) ( %) ( %) (head) ( %) ( %) ( %) Example 1 879 161 81.68 85.42 135 84.64 89.718000 times B b b b

                                                                                                                    15 days

        The number of live insects Decrease rate Control effect   The number of live insects Decrease rate Control effect

(head) (%) (%) (head) (%) (%)

                                                                                                                            

                                                                                      

  (Head)   Number of Live Insects Decline Rate Control Efficacy Number of Live Insects Decline Rate Control Efficacy

(Head) ( %) ( %) (head) (head) ( %) ( %) Example 799 214 73.22 78.69 179 77.60 84.9910000 times C C C C

                                                                                                                                  15 days

          Number of live insects Reduction rate Control effect   Number of live insects Decrease rate Control effect

(Head) (%) (%) (Head) (%) (%)

                                                                                                                                  

                                                                                                         

  (Head)   Number of Live Insects Decline Rate Control Efficacy Number of Live Insects Decline Rate Control Efficacy

(Head) ( %) ( %) (head) (head) ( %) ( %) comparison example 4 876 112 87.21 89.82 28 96.80 97.865000 times AB AB A A A

                                                                                                                                      15 days

              Number of live insects Decrease rate Control effect   Number of live insects Decrease rate Control effect

(head) (%) (%) (head) (%) (%)

                                                                                                  

                                                                                                      

  (Head)   Number of Live Insects Decline Rate Control Efficacy Number of Live Insects Decline Rate Control Efficacy

(Head) ( %) ( %) (head) ( %) ( %) ( %) 10 % imidacloprid 895 109 87.82 90.31 25 97.21 98.135000 times AB AB A A A A

                                                                                                                                      15 days

              Number of live insects Decrease rate Control effect   Number of live insects Decrease rate Control effect

(Head) (%) (%) (Head) (%) (%)

                                                                                           

                                                                                                                

  (Head)   Number of Live Insects Decline Rate Control Efficacy Number of Live Insects Decline Rate Control Efficacy

(head) (%) (%) (%) (head) (%) (%) water control 822 1033 -25.67 - 1227 -49.27 -

                                                                                                                              15 days

              Number of live insects Decrease rate Control effect   Number of live insects Decrease rate Control effect

(Head) (%) (%) (Head) (%) (%)

                                                                   

From the results of table 3, it can be proved that the pesticide composition represented by Example 1 is a better medicament for controlling pear psyllid, and its initial effect and after effect are better than that of comparative example 4 and 10% imidacloprid of the same concentration. Wet powder.

Example 2

After 9.9 parts of imidacloprid powder with a purity of 91%, 50 parts of white carbon black and 20 parts of diatomaceous earth and 0.1 part of abamectin powder with a purity of 95% are coarsely pulverized, mix 2202 and 2204 (produced by Jinling Petrochemical Co., Ltd. ) each of 10 parts, stirred evenly, ultra-finely pulverized, and subpackaged to obtain the finished powder.

Example 3

Dissolve 9.9 parts of imidacloprid powder with a purity of 91% in 30 parts of DMF and 59 parts of xylene, add 0.1 part of avermectin powder with a purity of 95% and stir evenly, then mix in 2204 (produced by Jinling Petrochemical) 1 After stirring evenly, coarsely filter and pack to obtain the finished emulsifiable concentrate.

Example 4

Dissolving 0.99 part of imidacloprid powder with a purity of 91% in 75 parts of DMF and 14 parts of xylene, adding 0.1 part of avermectin powder with a purity of 95% and stirring evenly, mixed with 2204 (produced by Jinling Petrochemical) 5 5 parts, 5 parts of vegetable oil, stir evenly, coarsely filter, and pack to obtain the emulsifiable concentrate product.

Example 5

Dissolve 1.9 parts of imidacloprid powder with a purity of 91% in 18 parts of DMF and 65 parts of xylene, add 0.1 part of abamectin powder with a purity of 95% and stir evenly, then mix in 2204 (produced by Jinling Petrochemical) 5 10 parts, 10 parts of vegetable oil, stir evenly, coarsely filter, and pack to obtain the finished product of emulsifiable concentrate.

Claims (2)

1. A pesticide composition, characterized in that it is composed of the following parts by weight: Pharmaceutical components 0.1-35 parts Inert powder 50-98 parts Adjuvant 1-25 parts Wherein, the drug component contains abamectin and imidacloprid, and the ratio of parts by weight is 1:4-99 parts; The inert powder is clay, diatomaceous earth, talcum powder, white carbon black, kaolin, used alone or mixed in any proportion. The auxiliaries are substances with a wetting effect or substances with an emulsifying effect. The substance with wetting effect is vegetable oil, saponin, alkylbenzene sulfonate, pull-off powder, and various nonionic surfactants, which are used alone or mixed in any proportion. The substance with emulsifying effect is aryl polyoxyethyl ether and aryl sulfonate, used alone or mixed in any proportion. 2. A preparation method of the pesticide composition as claimed in claim 1, characterized in that 0.1-35 parts of the drug component, 50-98 parts of the inert powder, and 1-25 parts of the auxiliary agent are mixed and stirred evenly. Wherein, the drug component contains abamectin and imidacloprid, and the ratio of parts by weight is 1:4-99 parts; The inert powder is clay, diatomaceous earth, talcum powder, white carbon black, kaolin, used alone or mixed in any proportion. The auxiliaries are substances with a wetting effect or substances with an emulsifying effect. The substance with wetting effect is vegetable oil, saponin, alkylbenzene sulfonate, pull-off powder, and various nonionic surfactants, which are used alone or mixed in any proportion. The substance with emulsifying effect is aryl polyoxyethyl ether and aryl sulfonate, used alone or mixed in any proportion.