CN1095263A - 含有抗齿斑、抗齿垢剂的口用组合物 - Google Patents

含有抗齿斑、抗齿垢剂的口用组合物 Download PDF

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Publication number: CN1095263A
Authority: CN; China
Prior art keywords: compositions; mol ratio; agent; zinc; zinc ion
Prior art date: 1992-12-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

CN 93119922

Other languages

English (en)

Chinese (zh)

Inventor

R·E·蒙哥马利

J·W·派兹

M·M·科伊尔-里斯

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Procter and Gamble Co

Original Assignee

Procter and Gamble Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-18

Filing date

1993-12-18

Publication date

1994-11-23

1993-12-18 Application filed by Procter and Gamble Co filed Critical Procter and Gamble Co

1994-11-23 Publication of CN1095263A publication Critical patent/CN1095263A/zh

Status Pending legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 135
230000002882 anti-plaque Effects 0.000 title description 7
239000011701 zinc Substances 0.000 claims abstract description 44
229910052725 zinc Inorganic materials 0.000 claims abstract description 41
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims abstract description 36
239000003795 chemical substances by application Substances 0.000 claims abstract description 27
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 claims abstract description 25
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 24
206010006326 Breath odour Diseases 0.000 claims abstract description 15
238000011282 treatment Methods 0.000 claims abstract description 15
208000032139 Halitosis Diseases 0.000 claims abstract description 13
235000011180 diphosphates Nutrition 0.000 claims abstract description 13
238000000034 method Methods 0.000 claims abstract description 13
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229920000388 Polyphosphate Polymers 0.000 claims abstract description 10
239000001205 polyphosphate Substances 0.000 claims abstract description 10
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230000002265 prevention Effects 0.000 claims abstract description 9
208000007565 gingivitis Diseases 0.000 claims abstract description 8
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LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 15
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239000004094 surface-active agent Substances 0.000 claims description 12
XPPKVPWEQAFLFU-UHFFFAOYSA-N diphosphoric acid Chemical compound OP(O)(=O)OP(O)(O)=O XPPKVPWEQAFLFU-UHFFFAOYSA-N 0.000 claims description 9
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239000000551 dentifrice Substances 0.000 claims description 6
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229940050390 benzoate Drugs 0.000 description 1
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
230000001680 brushing effect Effects 0.000 description 1
239000000872 buffer Substances 0.000 description 1
229960005069 calcium Drugs 0.000 description 1
229910000019 calcium carbonate Inorganic materials 0.000 description 1
JUNWLZAGQLJVLR-UHFFFAOYSA-J calcium diphosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])(=O)OP([O-])([O-])=O JUNWLZAGQLJVLR-UHFFFAOYSA-J 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229940043256 calcium pyrophosphate Drugs 0.000 description 1
239000004202 carbamide Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000004075 cariostatic agent Substances 0.000 description 1
235000010418 carrageenan Nutrition 0.000 description 1
239000000679 carrageenan Substances 0.000 description 1
229920001525 carrageenan Polymers 0.000 description 1
229940113118 carrageenan Drugs 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
230000008859 change Effects 0.000 description 1
229940112822 chewing gum Drugs 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
238000004040 coloring Methods 0.000 description 1
239000007859 condensation product Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
125000004122 cyclic group Chemical group 0.000 description 1
210000004268 dentin Anatomy 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
235000019821 dicalcium diphosphate Nutrition 0.000 description 1
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 1
DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
229960001259 diclofenac Drugs 0.000 description 1
230000029087 digestion Effects 0.000 description 1
PXLWOFBAEVGBOA-UHFFFAOYSA-N dihydrochalcone Natural products OC1C(O)C(O)C(CO)OC1C1=C(O)C=CC(C(=O)CC(O)C=2C=CC(O)=CC=2)=C1O PXLWOFBAEVGBOA-UHFFFAOYSA-N 0.000 description 1
QGGZBXOADPVUPN-UHFFFAOYSA-N dihydrochalcone Chemical compound C=1C=CC=CC=1C(=O)CCC1=CC=CC=C1 QGGZBXOADPVUPN-UHFFFAOYSA-N 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
235000019820 disodium diphosphate Nutrition 0.000 description 1
GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
229940038485 disodium pyrophosphate Drugs 0.000 description 1
231100000673 dose–response relationship Toxicity 0.000 description 1
229960003722 doxycycline Drugs 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
239000003937 drug carrier Substances 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
239000000975 dye Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
239000000835 fiber Substances 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012530 fluid Substances 0.000 description 1
229910052731 fluorine Inorganic materials 0.000 description 1
239000011737 fluorine Substances 0.000 description 1
150000002222 fluorine compounds Chemical class 0.000 description 1
235000019152 folic acid Nutrition 0.000 description 1
150000002224 folic acids Chemical class 0.000 description 1
229960002737 fructose Drugs 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
239000007789 gas Substances 0.000 description 1
239000008103 glucose Substances 0.000 description 1
235000001050 hortel pimenta Nutrition 0.000 description 1
150000004677 hydrates Chemical class 0.000 description 1
239000012535 impurity Substances 0.000 description 1
230000007794 irritation Effects 0.000 description 1
USSBDBZGEDUBHE-UHFFFAOYSA-L magnesium;2-oxidooxycarbonylbenzoate Chemical compound [Mg+2].[O-]OC(=O)C1=CC=CC=C1C([O-])=O USSBDBZGEDUBHE-UHFFFAOYSA-L 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 1
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 1
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
229960000282 metronidazole Drugs 0.000 description 1
VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
230000000897 modulatory effect Effects 0.000 description 1
210000002200 mouth mucosa Anatomy 0.000 description 1
229920001206 natural gum Polymers 0.000 description 1
230000035764 nutrition Effects 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
150000001451 organic peroxides Chemical class 0.000 description 1
239000007800 oxidant agent Substances 0.000 description 1
LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 description 1
235000019629 palatability Nutrition 0.000 description 1
210000003254 palate Anatomy 0.000 description 1
XCRBXWCUXJNEFX-UHFFFAOYSA-N peroxybenzoic acid Chemical class OOC(=O)C1=CC=CC=C1 XCRBXWCUXJNEFX-UHFFFAOYSA-N 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
229920001983 poloxamer Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
239000002491 polymer binding agent Substances 0.000 description 1
229940045916 polymetaphosphate Drugs 0.000 description 1
229920000136 polysorbate Polymers 0.000 description 1
229940068965 polysorbates Drugs 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
239000011591 potassium Substances 0.000 description 1
229960003975 potassium Drugs 0.000 description 1
239000001508 potassium citrate Substances 0.000 description 1
229960002635 potassium citrate Drugs 0.000 description 1
QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
235000011082 potassium citrates Nutrition 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 1
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
229940005657 pyrophosphoric acid Drugs 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
229950000975 salicylanilide Drugs 0.000 description 1
239000011833 salt mixture Substances 0.000 description 1
229940084560 sanguinarine Drugs 0.000 description 1
YZRQUTZNTDAYPJ-UHFFFAOYSA-N sanguinarine pseudobase Natural products C1=C2OCOC2=CC2=C3N(C)C(O)C4=C(OCO5)C5=CC=C4C3=CC=C21 YZRQUTZNTDAYPJ-UHFFFAOYSA-N 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002028 silica xerogel Inorganic materials 0.000 description 1
239000000344 soap Substances 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
239000011775 sodium fluoride Substances 0.000 description 1
235000013024 sodium fluoride Nutrition 0.000 description 1
229960004711 sodium monofluorophosphate Drugs 0.000 description 1
229940045919 sodium polymetaphosphate Drugs 0.000 description 1
YKOLYTVUIVUUDY-UHFFFAOYSA-K sodium;zinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Na+].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YKOLYTVUIVUUDY-UHFFFAOYSA-K 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
241000894007 species Species 0.000 description 1
150000005846 sugar alcohols Polymers 0.000 description 1
239000000516 sunscreening agent Substances 0.000 description 1
239000000271 synthetic detergent Substances 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
RYCLIXPGLDDLTM-UHFFFAOYSA-J tetrapotassium;phosphonato phosphate Chemical compound [K+].[K+].[K+].[K+].[O-]P([O-])(=O)OP([O-])([O-])=O RYCLIXPGLDDLTM-UHFFFAOYSA-J 0.000 description 1
235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
239000004408 titanium dioxide Substances 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229910052723 transition metal Inorganic materials 0.000 description 1
150000003624 transition metals Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
VSJRDSLPNMGNFG-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate;trihydrate Chemical compound O.O.O.[Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O VSJRDSLPNMGNFG-UHFFFAOYSA-H 0.000 description 1
241001148471 unidentified anaerobic bacterium Species 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
235000021419 vinegar Nutrition 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
229940085658 zinc citrate trihydrate Drugs 0.000 description 1
239000011576 zinc lactate Substances 0.000 description 1
235000000193 zinc lactate Nutrition 0.000 description 1
229940050168 zinc lactate Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1
235000014692 zinc oxide Nutrition 0.000 description 1
229940077935 zinc phosphate Drugs 0.000 description 1
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
RNWHGQJWIACOKP-UHFFFAOYSA-N zinc;oxygen(2-) Chemical class [O-2].[Zn+2] RNWHGQJWIACOKP-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/27—Zinc; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Birds (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Oral & Maxillofacial Surgery (AREA)
Cosmetics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

CN 93119922 1992-12-18 1993-12-18 含有抗齿斑、抗齿垢剂的口用组合物 Pending CN1095263A (zh)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US148,776		1980-05-12
US99333692A	1992-12-18	1992-12-18
US993,336		1992-12-18
US14877693A	1993-11-16	1993-11-16

Publications (1)

Publication Number	Publication Date
CN1095263A true CN1095263A (zh)	1994-11-23

Family

ID=26846152

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CN 93119922 Pending CN1095263A (zh)	1992-12-18	1993-12-18	含有抗齿斑、抗齿垢剂的口用组合物

Country Status (10)

Country	Link
EP (1)	EP0675706A1 (pt)
JP (1)	JPH08505843A (pt)
CN (1)	CN1095263A (pt)
AU (1)	AU5740094A (pt)
BR (1)	BR9307688A (pt)
CA (1)	CA2151913A1 (pt)
CZ (1)	CZ156795A3 (pt)
HU (1)	HUT72041A (pt)
MX (1)	MX9400053A (pt)
WO (1)	WO1994014407A1 (pt)

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US6190644B1 (en) *	1996-11-21	2001-02-20	The Procter & Gamble Company	Dentifrice compositions containing polyphosphate and monofluorophosphate
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DK176196B1 (da)	1997-10-07	2007-01-08	Ejvind Jersie Pedersen	Mundhygejnepræparat til behandling af halitosis samt anvendelse af et chelat omfattende en metaliondel og en aminosyredel som en komponent i præparatet
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US6350438B1 (en) *	1998-02-27	2002-02-26	The Procter & Gamble Company	Oral care compositions comprising chlorite and methods
JPH11246376A (ja) *	1998-02-27	1999-09-14	Sunstar Inc	口腔用組成物
ES2225260T3 (es)	1999-11-12	2005-03-16	THE PROCTER & GAMBLE COMPANY	Composiciones bucales estannosas de doble fase mejoradas.
US10470985B2 (en)	1999-11-12	2019-11-12	The Procter & Gamble Company	Method of protecting teeth against erosion
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MY151134A (en) *	2005-12-21	2014-04-30	Colgate Palmolive Co	Improved oral compositions comprising zinc citrate and / or tocopherol agents
EP1837009B1 (en)	2006-03-22	2009-05-13	The Procter and Gamble Company	Oral zinc compositions
WO2009060385A2 (en)	2007-11-09	2009-05-14	The Procter & Gamble Company	Oral stannous compositions
RU2523900C2 (ru)	2009-10-29	2014-07-27	Колгейт-Палмолив Компани	Средство для чистки зубов, содержащее фторид двухвалентного олова и цитрат цинка и небольшие количества воды
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US4869898A (en) *	1988-01-25	1989-09-26	Colgate-Palmolive Co.	Anticalculus oral composition
GB8804817D0 (en) *	1988-03-01	1988-03-30	Unilever Plc	Anticalculas oral compositions
GB8922434D0 (en) *	1989-10-05	1989-11-22	Unilever Plc	Oral compositions
AU9160791A (en) *	1990-12-18	1992-07-22	Procter & Gamble Company, The	Oral compositions effective against plaque and gingivitis
US5240697A (en) *	1991-10-17	1993-08-31	Colgate-Palmolive Company	Desensitizing anti-tartar dentifrice

1993
- 1993-12-06 BR BR9307688-6A patent/BR9307688A/pt not_active Application Discontinuation
- 1993-12-06 JP JP6515185A patent/JPH08505843A/ja active Pending
- 1993-12-06 AU AU57400/94A patent/AU5740094A/en not_active Abandoned
- 1993-12-06 EP EP94903459A patent/EP0675706A1/en not_active Withdrawn
- 1993-12-06 HU HU9501784A patent/HUT72041A/hu unknown
- 1993-12-06 CA CA 2151913 patent/CA2151913A1/en not_active Abandoned
- 1993-12-06 WO PCT/US1993/011787 patent/WO1994014407A1/en not_active Ceased
- 1993-12-06 CZ CZ951567A patent/CZ156795A3/cs unknown
- 1993-12-18 CN CN 93119922 patent/CN1095263A/zh active Pending
1994
- 1994-01-03 MX MX9400053A patent/MX9400053A/es unknown

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN100360109C (zh) *	2001-05-15	2008-01-09	宝洁公司	口腔护理组合物

Also Published As

Publication number	Publication date
CA2151913A1 (en)	1994-07-07
HUT72041A (en)	1996-03-28
WO1994014407A1 (en)	1994-07-07
MX9400053A (es)	1994-07-29
CZ156795A3 (en)	1996-01-17
HU9501784D0 (en)	1995-08-28
EP0675706A1 (en)	1995-10-11
JPH08505843A (ja)	1996-06-25
AU5740094A (en)	1994-07-19
BR9307688A (pt)	1999-09-08

Publication	Publication Date	Title
CN1095263A (zh)	1994-11-23	含有抗齿斑、抗齿垢剂的口用组合物
CN1095262A (zh)	1994-11-23	含有抗齿斑和齿垢的口用组合物
US5358705A (en)	1994-10-25	Use of N-acetylated amino acid complexes in oral care compositions
US5004597A (en)	1991-04-02	Oral compositions comprising stannous flouride and stannous gluconate
US4666708A (en)	1987-05-19	Dental rinse
DE69903710T2 (de)	2003-07-10	Zahnpflegemittel enthaltend chlorit
EP0609215B1 (en)	1995-08-30	Anticalculus dentifrices
CN1153470A (zh)	1997-07-02	抗菌性牙膏
CN1147762A (zh)	1997-04-16	口腔用组合物
US5578295A (en)	1996-11-26	Oral care compositions comprising certain substituted diphenyl ethers
US5500208A (en)	1996-03-19	Oral compositions comprising a novel tripeptide
CA2140874C (en)	1999-01-19	Oral compositions
JP2010538074A (ja)	2010-12-09	口腔乾燥症を治療するための歯磨剤組成物
WO1995033764A1 (en)	1995-12-14	Oral compositions comprising a novel tripeptide
JPH08510239A (ja)	1996-10-29	口内組成物
EP0311260B1 (en)	1994-12-28	Oral compositions
JPH01207227A (ja)	1989-08-21	歯石予防組成物
US5500206A (en)	1996-03-19	Oral compositions comprising actinomyces viscosus fimbriae
US11723847B2 (en)	2023-08-15	Dual component oral composition for enhancing remineralization of teeth
EP0311259A2 (en)	1989-04-12	Oral compositions
US20240148619A1 (en)	2024-05-09	Dual component oral composition for enhancing remineralization of teeth
CN1083358A (zh)	1994-03-09	含有某些取代苯醚的口腔保护组合物
GB2319726A (en)	1998-06-03	Polymyxin A, B, C, D or E containing compositions for the treatment of periodontal disease, plaque and breath malodor

Legal Events

Date	Code	Title
1994-11-23	C06	Publication
1994-11-23	PB01	Publication
1999-05-05	C01	Deemed withdrawal of patent application (patent law 1993)
1999-05-05	WD01	Invention patent application deemed withdrawn after publication

CN1095263A - 含有抗齿斑、抗齿垢剂的口用组合物 - Google Patents

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