CN1094040C - Nimbin mixed pesticide preparation and its preparing method - Google Patents

Abstract

The present invention provides a kind of mixed nimbin pesticide with high efficiency, low toxicity, no pollution, safety to human body and farm animal and less resistance to pests. The mixed pesticide utilizes the synergistic effect and negative cross resistance relationship between nimbin and some pesticide to overcome the resistance of pests, raise the application effect and expand the application range. Because each component in the mixed pesticide can play a role in a synergistic way in the application process, the self-deficiency of the single pesticide is made up. The pesticide is especially suitable for preventing and controlling various pests with serious drug resistance.

Description

Azadirachtin mixed pesticide preparation and preparation method thereof

The invention belongs to a mixed pesticide and a preparation method thereof, and in particular relates to how azadirachtin is mixed with other pesticides.

Because people rely on a single type of insecticide for a long time, pests are prone to develop resistance, resulting in a sharp increase in the amount of chemical pesticides used, which not only increases the economic burden on farmers and pollutes the environment, but also due to the large number of insecticides. Natural enemies, leading to rampant damage of pests. At present, there are a large number of mixed insecticides on the market, but most of them are mixed with chemical pesticides. Most of these mixed agents contain organic phosphorus, which are highly toxic to humans and animals, and can easily cause human and animal poisoning. Pests can also develop resistance over time.

The purpose of the present invention is to develop a class of azadirachtin in the seeds of neem plant as the insecticidal active ingredient, and obtain the azadirachtin that can overcome the resistance of pests after reasonable mixing with other high-efficiency and low-toxicity pesticides of mixed preparations.

The invention utilizes neem seeds to carry out leaching to obtain an extract solution containing a certain concentration of azadirachtin, and the extract solution is concentrated and evaporated to dryness to form a concentrated solution.

The present invention utilizes azadirachtin in neem seeds as an insecticidal active component, and can be combined with biological pesticides, such as Bt, Avermectin or rotenone, and also with pyrethroids, such as cypermethrin, beta-cypermethrin or quick-killing ketone, etc. , and can also be mixed with nereist toxins such as badan and insecticidal ring, and mixed with appropriate amount of additives to prepare various mixed pesticide preparations. In the mixed pesticides, the content of azadirachtin is 0.1-80%. The content is 0.05-50%, and the rest are additives.

Azadirachtin and Avermectin mixed cream preparation has the following ingredients:

Azadirachtin content 0.1-80% (weight)

Avermectin content 0.05-2% (weight)

                                                                                                                                                                            

Co-solvent 0.2-20% (weight)

Sunscreen 1-2.5% by weight

Preservatives 0.1-2% (weight)

Stabilizer 0.1-30% (weight)

Synergist 0.5-10% (weight)

  Organic Solvent                                                                                                       5-40% (by weight)

  Penetrant                   0.1-24% (by weight)

                                        0.01-0.5% (by weight)

The sum of each component is 100%

A better choice for additives is: surfactants can be anionic sodium alkyl sulfate, calcium alkylbenzenesulfonate, lauryl

Sodium sulfate, etc.; but non-ionic is the best, such as polyoxyethylene ether polysorbate

    Esters, Tween sunscreen     Para-aminobenzoic acid, castor oil, angelica oil preservatives   Granular charcoal, activated charcoal, ethyl acetate, ammonia, sodium benzoate, water amine,

Sodium hypochlorite, alkaline earth metal stabilizers Epoxidized vegetable oils such as epoxidized soybean oil, epoxidized linseed oil synergists Butanostatic ethers, synergistic sulfones, alkyl carbonates, chlorinated fats, formaldehyde, soybean oil co-solvents Isoamyl alcohol, Phenol, ethyl acetate, dimethyl sulfoxide organic solvents xylene, toluene, decalin, methyl ethyl ketone, petroleum distillate penetrating agent laurocaprolactone, JFC-2, fatty sodium sulfenate-based butene Secondary diacid

Sodium octyl sulfonate pH regulator Sodium hydroxide, ammonium hydroxide, azadirachtin acetate and Avermectin EC The best ingredients for the mixed preparation are: azadirachtin content 0.3-15% (weight) Avermectin content 0.1-0.5% (weight) surfactant 8-25% (weight) solubilizer 1-5% (weight) sunscreen 1.2-1.5% (weight) preservative 1-1.2% (weight) stabilizer 2-15% (weight) Effect agent 0.5-2% (weight) organic solvent 6-20% (weight) penetrating agent 1-10% (weight) pH regulator 0.1-0.2% (weight)

The sum of each component is 100%

Preparation method of azadirachtin and Avermectin cream mixture:

According to the capacity of the reactor, select an appropriate amount of neem extract concentrate or azadirachtin preparation, Avermectin according to a certain ratio, first put the neem extract concentrate or azadirachtin preparation into the reactor, and then inject Avermectin, the temperature in the kettle 38°C-60°C, first add a certain amount of solvent and stir for 35-50 minutes, then add a certain amount of the above-mentioned components, continue stirring for 40-80 minutes, then put an effective amount of solvent into the kettle, stir evenly The feeding is the emulsified insecticide.

Azadirachtin and Bt wettable powder preparation has the following composition ranges: azadirachtin content 0.1-35% (weight) Bt content 0.5-5% (weight) wetting agent 1-20% (weight) dispersing agent 7-30% (weight) preservative 0.1-2.9% (weight) filler 40-75% (weight)

The sum of each component is 100%

Good choices for additives are: wetting agent lignosulfonate, alkylbenzenesulfonate, pull-off powder, multisorbate dispersant naphthalenesulfonate, alkylsulfonate, polyoxyethyl Ether Sulfonate, Diisopropyl Phosphate

Acid salt preservatives Activated carbon, alkaline earth metal fillers Kaolin, diatomaceous earth, activated carbon

The optimum range of ingredients for the azadirachtin+Bt wettable powder preparation is: azadirachtin content 0.3-20% (weight) Bt content 1-1.5% (weight) wetting agent 5-15% (weight) dispersing agent 10- 25% (weight) preservative 1-1.5% (weight) filler 45-65% (weight)

The sum of each component is 100%

The preparation method of azadirachtin+Bt wettable powder preparation:

Select an appropriate amount of azadirachtin extract concentrate, Bt original drug (or wettable powder) and additives in a certain proportion to mix, the mixing time is 25 to 40 minutes, and pulverize into parent powder through an airflow mill, and the particle size of the parent powder is 4 ~5 microns, then mixed with a certain amount of dispersant and preliminarily crushed filler, and then crushed by a Raymond machine, the crushing time is 30-45 minutes, mixed by a mixer, the mixing time is 30-40 minutes, and the material is discharged The wettable powder.

The composition range of the azadirachtin and rotenone cream mixture preparation is: azadirachtin content 0.1-80% (weight) rotenone content 0.1-20% (weight) surfactant 1-40% (weight) co-solvent 0.2-20% (weight) sunscreen agent 1-2.5% (weight) preservative 0.1-2% (weight) stabilizer 0.1-30% (weight) synergist 0.5-10% (weight) organic solvent ( Penetrating agent 0.1-24% (weight) pH regulator 0.01-0.5% (weight)

The sum of each component is 100%

A better choice for additives is: surfactants can choose anionic alkyl sodium sulfate, sodium lauryl sulfate, etc.;

The ionic type is the best, such as polyoxyethylene ether polysorbate, Tween sunscreen, p-aminobenzoic acid, castor oil, angelica oil preservatives, granular charcoal, activated carbon, ethyl acetate, ammonia, sodium benzoate, water amine ,

Sodium hypochlorite, alkaline earth metal stabilizers Epoxidized vegetable oils such as epoxidized soybean oil, epoxidized linseed oil synergists Epoxylated ethers, synergistic sulfones, alkyl carbonates, chlorinated fats, formaldehyde, soybean oil co-solvents Isoamyl alcohol, Phenol, ethyl acetate, dimethyl sulfoxide organic solvents xylene, toluene, decalin, methyl ethyl ketone, petroleum distillate penetrating agent laurethone, JFC-2, fatty sodium sulfenate-based butene Secondary diacid

Sodium octyl sulfonate pH regulator Sodium hydroxide, ammonium hydroxide, azadirachtin acetate + rotenone emulsifiable oil mixture preparation best ingredients are: azadirachtin content 0.3-15% (weight) rotenone content 0.2-2% (weight) surfactant 8-25% (weight) solubilizer 1-5% (weight) sunscreen 1.2-1.5% (weight) preservative 1-1.2% (weight) stabilizer 2-15% (weight) increase Effect agent 0.5-2% (weight) organic solvent 6-20% (weight) penetrating agent 1-10% (weight) pH regulator 0.1-0.2% (weight)

The sum of each component is 100%

The preparation method of azadirachtin + rotenone emulsifiable oil mixture preparation:

According to the capacity of the reaction kettle, select an appropriate amount of neem extract concentrate or azadirachtin preparation, rotenone according to a certain ratio, first put the neem extract concentrate or azadirachtin preparation into the reaction kettle, and then inject the Roten extract concentrate Or rotenone preparation, the temperature in the kettle is 40°C-65°C, first add a certain amount of solvent and stir for 35-75 minutes, then add a certain amount of the above-mentioned components, continue stirring for 80-120 minutes, and then add an effective amount of solvent In the kettle, the emulsified insecticide is obtained after being evenly stirred.

The composition range of the azadirachtin and pyrethroid emulsifiable concentrate preparation is: azadirachtin content 0.1-80% (weight) pyrethroid content 0.3-15% (weight) surfactant 1-40% (weight) co-solvent 0.2-20% (weight) sunscreen 1-2.5% (weight) preservative 0.1-2% (weight) stabilizer 0.1-30% (weight) synergist 0.5-10% (weight) organic solvent 0.5% (weight) penetrating agent 0.1-24% (weight) pH regulator 0.01-0.5% (weight)

The sum of each component is 100%

A better choice for additives is: surfactants can choose anionic alkyl sodium sulfate, sodium lauryl sulfate, etc.;

Ionic type is the best, such as polyoxyethylene ether polysorbate ester, Tween sunscreen agent, p-aminobenzoic acid, castor oil, angelica oil preservative, granular charcoal, activated carbon, ethyl acetate, ammonia, sodium benzoate, water amine ,

Sodium hypochlorite, alkaline earth metal stabilizers Epoxidized vegetable oils such as epoxidized soybean oil, epoxidized linseed oil synergists Phenol, ethyl acetate, dimethyl sulfoxide organic solvents xylene, toluene, decalin, methyl ethyl ketone, petroleum distillate penetrating agent laurethone, JFC-2, fatty sodium sulfenate-based butene Secondary diacid

  Sodium Octyl Sulfonate pH Regulator Sodium Hydroxide, Ammonium Hydroxide, Acetic Acid

The best ingredients of the emulsifiable concentrate preparation of azadirachtin+pyrethroids are: azadirachtin content 0.3-15% (weight) pyrethroid content 0.8-25% (weight) surfactant 8-25% (weight) Co-solvent 1-5% (weight) sunscreen agent 1.2-1.5% (weight) preservative 1-1.2% (weight) stabilizer 2-15% (weight) synergist 6 - 0.5-2% (weight) organic solvent 20% (weight) penetrating agent 1-10% (weight) pH regulator 0.1-0.2% (weight)

The sum of each component is 100%

The preparation method of the emulsifiable concentrate preparation of azadirachtin+pyrethroids:

According to the capacity of the reactor, select an appropriate amount of neem extract concentrate or azadirachtin preparation and a certain pyrethroid to be prepared according to a certain ratio, first put the neem extract concentrate or azadirachtin preparation into the reactor, Then inject the selected pyrethroid pesticide, the temperature in the kettle is 33°C-62°C, first add a certain amount of solvent and stir for 25-55 minutes, then add a certain amount of the aforementioned components, and continue stirring for 45-90 minutes, Then put an effective amount of solvent into the kettle, stir evenly, and discharge the material to obtain the emulsified insecticide.

The composition range of the wettable powder preparation of azadirachtin and nereistin is: azadirachtin content 0.1-35% (weight) nereistin content 0.1-50% (weight) wetting agent 1-20% (weight ) dispersant 7-30% (weight) preservative 0.1-2.9% (weight) filler 40-75% (weight)

The sum of each component is 100%

Good choices for additives are: wetting agent lignosulfonate, alkylbenzenesulfonate, pull-off powder, multisorbate dispersant naphthalenesulfonate, alkylsulfonate, polyoxyethyl Ether Sulfonate, Diisopropyl Phosphate

Salt preservatives Activated carbon, alkaline earth metal fillers Kaolin, diatomaceous earth, active carbon azadirachtin+nereistin The best ingredient range of the wettable powder preparation is: azadirachtin 0.3-20% (weight) nereistin Content 5-10% (weight) wetting agent 5-15% (weight) dispersant 10-25% (weight) preservative 1-1.5% (weight) filler 45-65% (weight)

The sum of each component is 100%

The preparation method of the wettable powder preparation of azadirachtin+nereistin:

Select an appropriate amount of neem extract concentrate, nereistoxin original drug (or wettable powder) and additives in a certain proportion and mix them. The mixing time is 25 to 40 minutes, and they are pulverized into mother powder by jet mill. The particle size of mother powder is 4 to 6 microns, and then mixed with a certain amount of dispersant and preliminarily crushed filler, the mixing time is 35 to 56 minutes, and then crushed by Raymond machine, the crushing time is 30 to 40 minutes, and the mixer is mixed, and the mixing time is After 22 to 28 minutes, the wettable powder is obtained after discharging.

In order to better understand the essence of the invention, the technical content of the invention is described in detail below with examples, but the content of the present invention is not limited thereto. Embodiment one: produce 0.8% (Azadirachtin+Avermectin) EC: Azadirachtin content 0.3% (weight) Avermectin content 0.5% (weight) surfactant 25% (weight) cosolvent 5% (weight) sunscreen 1 % (weight) preservative 1 % (weight) stabilizer 15 % (weight) an efficient agent 2 % (weight) organic solvent 40 % (weight) penetrating agent 10 % (weight) pH 0.2 % (weight) ) embodiment two: produce 1% (nimbin+Avermectin) emulsifiable oil azadirachtin content 0.8% (weight) Avermectin content 0.2% (weight) surfactant 25% (weight) cosolvent 1% (weight) sunscreen 1.5 % (weight) preservatives 1 % (weight) stabilizer 25 % (weight) an efficient agent 0.3 % (weight) organic solvent 30 % (weight) penetrating agent 10 % (weight) pH 0.2 % (weight) (weight) pH (weight) pH (weight) pH (weight) pH (weight) ) embodiment three: produce 50% (nimbin+Bt) wettable powder azadirachtin content 3% (weight) Bt content 47% (weight) wetting agent 10% (weight) dispersant 20% (weight) Preservative 1.5% (weight) filler 18.5% (weight) embodiment four: produce 45% (azadirachtin+Bt) wettable powder azadirachtin content 1% (weight) Bt content 44% (weight) wetting agent 5% (weight) dispersant 19% (weight) preservative 1% (weight) filler 30% (weight) embodiment five: produce 1.8% (nimbin+rotenone) emulsifiable oil azadirachtin content 0.6% (weight) Rotenone content 1.2% (weight) surfactant 20% (weight) co-solvent 15% (weight) sunscreen 1.5% (weight) preservative 1.2% (weight) stabilizer 15% (weight) synergist 2.3% ( ) organic solvent 33% (weight) penetrating agent 10% (weight) pH value regulator 0.2% (weight) embodiment six: produce 2.5% (azirachtin+rotenone) emulsifiable oil azadirachtin content 0.5% (weight) Rotenone content 2% (weight) surfactant 21% (weight) co-solvent 5% (weight) sunscreen 1% (weight) preservative 1% (weight) stabilizer 2% (weight) synergist 12% (weight ) organic solvent 45.3% (weight) penetrating agent 10% (weight) pH regulator 0.2% (weight) embodiment seven: produce 1% (azadirachtin+beta-cypermethrin) emulsifiable oil azadirachtin content 0.2% (weight ) beta-cypermethrin content 0.8% (weight) surfactant 2% (weight) co-solvent 7% (weight) sunscreen 2.5% (weight) preservative 2% (weight) stabilizer 10.5% (weight) synergist 1% (weight) organic solvent 45% (weight) penetrating agent 19.5% (weight) pH value adjusting agent 0.5% (weight) embodiment eight: produce 3% (azadirachtin + quick-killed) emulsifiable oil azadirachtin content 0.3% (weight) massacid content 2.7% (weight) surfactant 27% (weight) co-solvent 5% (weight) sunscreen 2.5% (weight) preservative . ) synergist 7% (weight) organic solvent 49.5% (weight) penetrating agent 3% (weight) pH regulator 0.5% (weight) Embodiment nine: produce 55% (Nim+Badan) can Wet powder azadirachtin content 1.5% (weight) badan content 53.5% (weight) wetting agent 5% (weight) dispersant 10% (weight) preservative 1% (weight) filler ten (weight) implementation 9% : Produce 40% (Azadirachtin + Insecticidal Cyclo) WP Azadirachtin content 0.5% (weight) Insecticidal Cyclo content 35% (weight) wetting agent 5% (weight) dispersant 10% (weight) Preservatives 1% (weight) filler 48.5% (weight)

In the enumerated 10 non-limiting examples, the cream type mixture can be prepared according to the above-mentioned related preparation method of the similar mixture; the wettable powder type mixture can be completed according to the above-mentioned preparation method of the related wettable powder.

The mixed preparation provided by the present invention has the following advantages: 1. after azadirachtin and Avermectin (or Bt) are mixed, both can overcome the shortcoming that Avermectin, Bt easily produce resistance, can keep the biological pesticide advantage of mixture again, and It can broaden the application scope of the medicament and improve the efficacy, especially the control effect on the vegetable pest Plutella xylostella is particularly remarkable. 2. After azadirachtin and rotenone are mixed according to the aforementioned selected ratio, not only the advantages of botanical insecticides are maintained, but also the dosage of the mixture is reduced, and the drug effect is greatly improved, which makes up for the azadirachtin phytocidal effect. The insecticide has a weak contact effect on pests, and the mixture has far-reaching significance for the development and application of natural insecticides. 3. Pyrethroid insecticides are a type of pesticide with the highest insecticidal activity among chemical pesticides today, and are favored by people. However, the resistance of pests to them develops rapidly, which may eventually lead to the elimination of such pesticides. Use the concentrated extract of azadirachtin (or azadirachtin preparation) to mix with pyrethroid insecticides. Although the mixture has no obvious synergistic effect, it can delay the resistance of pests and has a certain negative interaction. The resistance effect has an application value that cannot be underestimated for the control of pest resistance. 4. Nereistoxins are emerging organic synthetic biomimetic pesticides, which have good contact and stomach poisoning effects on pests, such as corn borers, rice stem borers, and rice stem borers, which have high control effects on pests. After azadirachtin and nereistin are mixed according to the proportion of the above components, it can not only expand the control spectrum of pests and improve the application effect of pesticides, but also prevent pests from developing resistance to nereistin insecticides. An important way to develop "pollution-free" pesticides. 5. Due to the reasonable compatibility and ratio of the substances required for the preparation of this type of insecticide, it can greatly reduce the poisonous effect on the natural enemies of the various pests that are killed, and the damage and pollution to the ecological environment are small, which is conducive to the protection of humans and animals. Safety. It is a kind of azadirachtin mixture that can prevent and control various agricultural and forestry pests, has little toxic effect, and can overcome the resistance of pests.

Claims (14)

1. A mixed cream preparation of azadirachtin and abamectin, which is characterized in that it contains 0.1-80% azadirachtin, 0.05-2% abamectin, and the balance of additives by weight. 2. The emulsifiable concentrate preparation according to claim 1, characterized in that the preparation contains 0.1-80% azadirachtin by weight, 0.05-2% avermectin, 1-40% surfactant, 0.2-20% paraben Solvent, 1-2.5% sunscreen, 0.1-2% preservative, 0.1-30% stabilizer, 0.5-10% synergist, 5-40% organic solvent, 0.1-24% penetrant, 0.01-0.5 % pH regulator, the sum of each component is 100%. 3. The emulsifiable concentrate preparation according to claim 2, characterized in that the surfactant is a nonionic polyoxyethylene ether surfactant or an anionic surfactant. 4. The emulsifiable concentrate preparation according to claim 3, characterized in that the nonionic polyoxyethylene ether surfactant is polysorbate or Tween. 5. An emulsifiable concentrate formulation according to claim 3, characterized in that the anionic surfactant is sodium alkyl sulfate, sodium lauryl sulfate or alkylbenzenesulfonate. 6. The emulsifiable concentrate formulation according to claim 2, characterized in that the cosolvent is isoamyl alcohol, phenol, ethyl acetate or dimethyl sulfoxide. 7. The emulsifiable concentrate formulation according to claim 2, characterized in that the sunscreen agent is p-aminobenzoic acid, castor oil or angelica oil. 8. The emulsifiable concentrate preparation according to claim 2, characterized in that the preservative is granular charcoal, activated carbon, ethyl acetate, sodium hypochlorite or sodium benzoate. 9. The emulsifiable concentrate formulation according to claim 2, characterized in that the stabilizer is an epoxidized vegetable oil. 10. The emulsifiable concentrate formulation according to claim 9, characterized in that the epoxidized vegetable oil is epoxidized soybean oil or epoxidized linseed oil. 11. The emulsifiable concentrate preparation according to claim 2, characterized in that the synergist is butanobuterol, butanosanthene sulfone or soybean oil. 12. The emulsifiable concentrate preparation according to claim 2, characterized in that the organic solvent is xylene, toluene, decalin, butanone or petroleum distillate. 13. The emulsifiable concentrate formulation according to claim 2, characterized in that the penetrant is laurocapram, JFC-2 or sodium di-sec-octyl maleate sulfonate. 14. The emulsifiable concentrate formulation according to claim 2, characterized in that the pH adjusting agent is sodium hydroxide, ammonium hydroxide or acetic acid.