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CN106977604A - 拮抗cd40之抗体多肽 - Google Patents

拮抗cd40之抗体多肽 Download PDF

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Publication number
CN106977604A
CN106977604A CN201710070840.9A CN201710070840A CN106977604A CN 106977604 A CN106977604 A CN 106977604A CN 201710070840 A CN201710070840 A CN 201710070840A CN 106977604 A CN106977604 A CN 106977604A
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CN
China
Prior art keywords
ser
gly
leu
ala
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201710070840.9A
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English (en)
Inventor
A.苏里
S.舍里夫
S.苏查德
A.亚姆纽克
S.克里斯特克
J.塔姆拉
J.布莱森
S.格兰特
P.德鲁
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Domantis Ltd
Bristol Myers Squibb Co
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Domantis Ltd
Bristol Myers Squibb Co
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46000407&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN106977604(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Domantis Ltd, Bristol Myers Squibb Co filed Critical Domantis Ltd
Publication of CN106977604A publication Critical patent/CN106977604A/zh
Pending legal-status Critical Current

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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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Abstract

本发明提供特异性结合人类CD40之新颖抗原决定基的抗体多肽。该等抗体多肽不展现CD40促效剂活性。该等抗体多肽适用于治疗涉及CD40活化之疾病，诸如自体免疫疾病。该等抗体多肽可为包含单一VL或VH域之域抗体(domain antibody，dAb)。该等抗体多肽之半衰期可藉由将该等抗体多肽修饰成亦可结合人类血清白蛋白(human serum albumin，HSA)之双特异性试剂而增加。

Description

拮抗CD40之抗体多肽
本发明是基于申请日为2012年4月20日，申请号为“201280030683.4”(国际申请号为PCT/US2012/034519)，发明名称为“拮抗CD40之抗体多肽”的专利申请的分案申请。
发明领域
本发明提供靶向CD40且不展现CD40促效剂活性之抗体及其片段、包含前述者之组合物及使用前述者治疗涉及CD40活性之疾病的方法。
相关申请的交叉引用
本发明要求2011年4月21日提交的美国临时申请61/477,904的权益，在此将其全部内容援引并入本申请。
序列表
本申请案含有ASCII格式之序列表且其据此以全文引用的方式并入本文中。2012年4月17日创建之该ASCII复本被命名为200896WO.txt且大小为1,188,530字节。
现有技术
CD40为属于存在于抗原呈现细胞(antigen presenting cell，APC)(包括树突状细胞、B细胞及巨噬细胞)上之肿瘤坏死因子(tumor necrosis factor，TNF)受体超家族之协同刺激分子。APC在CD40结合TH细胞上之其配位体CD154(CD40L)时活化。CD40介导之APC活化涉及多种免疫反应，包括细胞激素产生、协同刺激分子(诸如CD86)之上调及抗原呈现及B细胞增殖增强。CD40亦可由内皮细胞、平滑肌细胞、纤维母细胞及上皮细胞表现。
CD40活化亦涉及多种与例如自体免疫性、移植排斥反应或过敏反应相关之不当T细胞反应。控制不合乎需要之T细胞反应的一个策略为以拮抗性抗体靶向CD40。举例而言，先前称为Chiron 1212之单株抗体HCD122(鲁卡木单抗(Lucatumumab))有关治疗某些CD40介导之发炎性疾病目前处于临床试验阶段。参见因特网之超文本传送协议：clinicaltrialsfeeds.org/clinical-trials/show/NCT01275209(2011年1月11日最后更新)上之“Study of HCD122(Lucatumumab)and Bendamustine Combination Therapy inCD40+Rituximab-Refractory Follicular Lymphoma”，Clinical Trials Feeds。然而，单株抗体可显示促效剂活性。举例而言，抗CD40抗体Chi220之适用性受限于其弱刺激潜能。参见Adams等人，“Development of a chimeric anti-CD40monoclonal antibody thatsynergizes with LEA29Y to prolong islet allograft survival”，J.Immunol.174:542-50(2005)。
发明内容
在临床环境中仍需要不具有部分促效剂活性之抗CD40抗体拮抗剂。本发明提供特异性结合人类CD40之新颖抗原决定基之新颖抗体多肽。如由竞争分析及由自抗体多肽与CD40共结晶得到之结构所示，CD40抗原决定基不与Chi220抗原决定基重迭。该等抗体多肽有利的是不展现CD40促效剂活性。该等抗体多肽适用于治疗涉及CD40活化之疾病，包括自体免疫疾病、移植排斥反应及过敏反应。该等抗体多肽包含可变域。在一个实施例中，抗体多肽呈含有单一可变域之域抗体(dAb)形式。在另一个实施例中，dAb为包含可结合例如人类血清白蛋白(HSA)之第二可变域之双特异性试剂。
本发明提供一种包含第一可变域之抗体多肽，其中该抗体多肽特异性结合人类CD40之抗原决定基，其中该抗原决定基包含SEQ ID NO:1之氨基酸序列，其中该抗体多肽与域抗体(dAb)BMS3h-56-269(SEQ ID NO:417)竞争结合，且其中该抗原决定基包含至少一个选自由Trp109、Leu121、His122、Ser124、Ser156、Ala157、Phe158、Glu159及His162组成之群的CD40氨基酸残基。
进一步提供一种抗体多肽，其中第一可变域包含选自由BMS3h-37、BMS3h-38、BMS3h-56及BMS3h-198组成之谱系群的抗体多肽之一之氨基酸序列，且其中第一可变域之表观结合常数为1pM至100nM。进一步提供一种抗体多肽，其中第一可变域之表观结合常数为1pM至10nM。
亦提供一种抗体多肽，其中第一可变域之氨基酸序列包含(a)与BMS3h-56-269(SEQ ID NO:417)之CDR1区有至多两个氨基酸不同的CDR1区、(b)与BMS3h-56-269(SEQ IDNO:417)之CDR2区有至多两个氨基酸不同的CDR2区、(c)与BMS3h-56-269(SEQ ID NO:417)之CDR3区有至多两个氨基酸不同的CDR3区、(d)与BMS3h-56-269(SEQ ID NO:417)之FR1区有至多两个氨基酸不同的FR1区、(e)与BMS3h-56-269(SEQ ID NO:417)之FR2区有至多两个氨基酸不同的FR2区、(f)与BMS3h-56-269(SEQ ID NO:417)之FR3区有至多两个氨基酸不同的FR3区及(g)与BMS3h-56-269(SEQ ID NO:417)之FR4区有至多两个氨基酸不同的FR4区。
亦提供一种抗体多肽，其中第一可变域之氨基酸序列包含(a)与BMS3h-56-269(SEQ ID NO:417)之CDR1区有至多两个氨基酸不同的CDR1区、(b)与BMS3h-56-269(SEQ IDNO:417)之CDR2区有至多两个氨基酸不同的CDR2区、(c)与BMS3h-56-269(SEQ ID NO:417)之CDR3区有至多两个氨基酸不同的CDR3区。
进一步提供一种抗体多肽，其中第一可变域之氨基酸序列与BMS3h-56-258(SEQID NO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有至多10个氨基酸不同。
进一步提供一种抗体多肽，其中第一可变域之氨基酸序列与BMS3h-56-258(SEQID NO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有至多5个氨基酸不同。
进一步提供一种抗体多肽，其中第一可变域之氨基酸序列与BMS3h-56-258(SEQID NO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有两个氨基酸不同。
进一步提供一种抗体多肽，其中第一可变域之氨基酸序列与BMS3h-56-258(SEQID NO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有一个氨基酸不同。
进一步提供一种抗体多肽，其中该抗体多肽选自BMS3h-56之谱系群，且其中第一可变域之氨基酸序列进一步包含：(a)具有序列X1-Tyr-Glu-Y1-Trp(SEQ ID NO:1274)之CDR1区，其中X1为Asp或Gly，且Y1为Met或Leu；(b)具有序列Ala-Ile-Asn-Pro-X2-Gly-Y2-Z2-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-A2-Gly(SEQ ID NO:1275)之CDR2区，其中X2为Gln、Tyr、Pro、Trp或Ala，Y2为Thr、Ser、Asn、Gly、Met或Gln，Z2为Arg、Leu、Tyr、His或Phe，且A2为Lys或Met；及(c)具有序列X3-Pro-Y3-Z3-Phe-A3-B3(SEQ ID NO:1276)之CDR3区，其中X3为Leu或Pro，Y3为Phe、Gln、Thr或Met，Z3为Tyr、Pro、Leu、Thr、Ile、Phe或Met，A3为Gln、His、Asp、Ser、Lys、Glu或Gly，且B3为Glu、Asp或Tyr。
进一步提供一种抗体多肽，其中第一可变域之氨基酸序列包含：(a)具有序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly--Leu-Val-Gln-Pro-Gly-Gly-Ser-X1-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Y1(SEQ ID NO:1277)之FR1区，其中X1为Leu或Arg，且Y1为Arg或Ala；(b)具有序列Trp-Val-Arg-X2-Ala-Pro-Gly-Y2-Z2-Leu-Glu-Arg-Val-Ser(SEQ ID NO:1278)之FR2区，其中X2为Gln或Arg，Y2为Lys或Arg，且Z2为Gly或Val；(c)具有序列Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-X3-Lys-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Y3-Asp-Thr-Z3-Val-Tyr-A3-Cys-B3-Lys(SEQ ID NO:1279)之FR3区，其中X3为Thr或Met，Y3为Glu或Asp，Z3为Ala或Ser，A3为Tyr或His，且B3为Ala或Thr；及(d)具有序列X4-Gly-Y4-Gly-Thr-Leu-Val-Thr-Val-Ser-Z4(SEQ ID NO:1280)之FR4区，其中X4为Trp或Arg，Y4为Gln或Pro，且Z4为Ser或Asn。
进一步提供一种抗体多肽，其中第一可变域包含BMS3h-56-258(SEQ ID NO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列。
进一步提供一种抗体多肽，其中该抗体多肽选自BMS3h-37之谱系群，其中第一可变域包含序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-X1-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Glu-Trp-Tyr-Glu-Met-Gln-Trp-Val-Arg-Arg-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Ala-Ile-Ser-Gly-Asp-Gly-Tyr-Arg-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cys-Ala-Lys-Y1-Leu-Z1-A1-Phe-Asp-Tyr-B1-Gly-Arg-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser(SEQ ID NO:1281)；且其中X1为Gln或Arg；Y1为Glu或Gly；Z1为Ala、Leu或Glu；A1为Phe
或Tyr；且B1为Trp或Arg。
亦提供一种抗体多肽，其中该抗体多肽选自BMS3h-38之谱系群，其中第一可变域包含序列Glu-Val-Gln-Leu-Leu-Ala-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-X1-Phe-Glu-Glu-Glu-Glu-Met-Ile-Trp-Val-Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Y1-Ile-Ser-Z1-A1-Gly-B1-C1-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-Tyr-Cys-Gly-Lys-Glu-Pro-Phe-D1-Tyr-Asp-Tyr-Trp-Gly-Gln-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser(SEQ ID NO:1282)；且其中X1为Thr或Pro；Y1为Ala或Ser；Z1为Arg或Gly；A1为Arg、Ser、Asn、Gln、Gly、His或Leu；B1为Tyr、Phe、Trp或Gly；
C1为Ser或Gly；且D1为Arg、Met或Pro。
亦提供一种抗体多肽，其中该抗体多肽选自BMS3h-198之谱系群，其中第一可变域包含序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Ala-Gly-Try-Glu-X1-Trp-Trp-Y1-Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Arg-Val-Ser-Ala-Ile-Ser-Gly-Ser-Gly-Gly-Ser-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Z1-A1-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-B1-Cys-Ala-C1-D1-Pro-Tyr-Ser-E1-Asp-Tyr-F1-G1-H1-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser(SEQ ID NO:1283)；且其中X1为Met或Leu；Y1为Val或Phe；Z1为Asp或Asn；A1为Ser或Thr；B1为Tyr或His；C1为Lys或Arg；D1为Asp或Glu；E1为Tyr或Phe；F1为Trp
或Arg；G1为Gly或Arg；且H1为Gln或His。
进一步提供一种抗体多肽，其中该抗体多肽为域抗体(dAb)。
进一步提供一种抗体多肽，其中可变域融合至Fc域。
进一步提供一种抗体多肽，其中该抗体多肽进一步包含特异性结合第二抗原之第二可变域，其中该第二抗原为除人类CD40以外之抗原。
亦提供一种抗体多肽，其中第二抗原为分化簇(cluster of differentiation，CD)分子或主要组织兼容性复合体(Major Histocompatibility Complex，MHC)II类分子。
亦提供一种抗体多肽，其中第二抗原为血清白蛋白(SA)。
本发明提供一种编码本文所揭示之抗体多肽的核酸。
本发明亦提供一种包含本文所揭示之核酸的载体。
本发明亦提供一种包含本文所揭示之载体的宿主细胞。
本发明提供一种包含治疗有效量之本文所揭示之抗体多肽及医药学上可接受之载剂的医药组合物。本发明亦提供一种进一步包含免疫抑制/免疫调节剂及/或消炎剂之医药组合物。
本发明提供一种治疗需要该治疗之患者的免疫疾病之方法，其包含向该患者投与治疗有效量之本文所揭示之医药组合物。本发明亦提供一种方法，其中该医药组合物与免疫抑制/免疫调节剂及/或消炎剂组合投与。
本发明提供一种治疗免疫疾病之方法，其中该免疫疾病为自体免疫疾病或移植相关疾病。本发明进一步提供一种治疗免疫疾病之方法，其中该免疫疾病选自由以下组成之群：艾迪森氏病(Addison's disease)、过敏症、僵直性脊椎炎、哮喘、动脉粥样硬化、自体免疫性耳病、自体免疫性眼病、自体免疫肝炎、自体免疫腮腺炎、结肠炎、冠心病、克罗恩氏病(Crohn's disease)、糖尿病(包括1型及/或2型糖尿病)、附睪炎、丝球体肾炎、葛瑞夫兹氏病(Graves'disease)、格-巴二氏征候群(Guillain-Barre syndrome)、桥本氏病(Hashimoto's disease)、溶血性贫血、特发性血小板减少性紫癜、发炎性肠病、对重组药品之免疫反应、全身性红斑狼疮、男性不育症、多发性硬化症、重症肌无力、天疱疮、牛皮癣、风湿热、类风湿性关节炎、类肉瘤病、硬皮病、休格连氏症候群(Sjogren's syndrome)、脊椎关节病、甲状腺炎、移植排斥反应、血管炎、AIDS、异位性过敏症、支气管哮喘、湿疹、麻风病、精神分裂症、遗传性抑郁症、组织及器官之移植、慢性疲劳症候群、阿兹海默氏病(Alzheimer's disease)、帕金森氏病(Parkinson's disease)、心肌梗塞、中风、自闭症、癫痫症、阿瑟氏现象(Arthus's phenomenon)、全身性过敏反应、酒精成瘾及药物成瘾。
本发明亦提供一种使用特异性结合包含SEQ ID NO:1之氨基酸序列的人类CD40之抗原决定基的第一可变域靶向CD40之方法，其中抗体多肽与域抗体(dAb)BMS3h-56-269(SEQ ID NO:417)竞争结合。
本发明提供抗体多肽或其医药学上可接受之盐的医学用途，该抗体多肽包含特异性结合包含SEQ ID NO:1之氨基酸序列的人类CD40之抗原决定基的第一可变域，其中该抗体多肽与域抗体(dAb)BMS3h-56-201(SEQ ID NO:9)竞争结合。
本发明提供抗体多肽或其医药学上可接受之盐的用途，该抗体多肽包含特异性结合包含SEQ ID NO:1之氨基酸序列的人类CD40之抗原决定基的第一可变域，其中该抗体多肽与域抗体(dAb)BMS3h-56-201(SEQ ID NO:9)竞争结合，该用途系用于制备用以治疗免疫疾病之药剂。在一些实施例中，医药组合物与免疫抑制/免疫调节剂及/或消炎剂组合投与。在其他实施例中，免疫疾病为自体免疫疾病或移植相关疾病。在其他实施例中，该免疫疾病选自由以下组成之群：艾迪森氏病、过敏症、僵直性脊椎炎、哮喘、动脉粥样硬化、自体免疫性耳病、自体免疫性眼病、自体免疫肝炎、自体免疫腮腺炎、结肠炎、冠心病、克罗恩氏病、糖尿病(包括1型及/或2型糖尿病)、附睪炎、丝球体肾炎、葛瑞夫兹氏病、格-巴二氏征候群、桥本氏病、溶血性贫血、特发性血小板减少性紫癜、发炎性肠病、对重组药品之免疫反应、全身性红斑狼疮、男性不育症、多发性硬化症、重症肌无力、天疱疮、牛皮癣、风湿热、类风湿性关节炎、类肉瘤病、硬皮病、休格连氏症候群、脊椎关节病、甲状腺炎、移植排斥反应、血管炎、AIDS、异位性过敏症、支气管哮喘、湿疹、麻风病、精神分裂症、遗传性抑郁症、组织及器官之移植、慢性疲劳症候群、阿兹海默氏病、帕金森氏病、心肌梗塞、中风、自闭症、癫痫症、阿瑟氏现象、全身性过敏反应、酒精成瘾及药物成瘾。
本发明提供一种抗体多肽或其医药学上可接受之盐，该抗体多肽包含特异性结合包含SEQ ID NO:1之氨基酸序列的人类CD40之抗原决定基的第一可变域，其中该抗体多肽与域抗体(dAb)BMS3h-56-201(SEQ ID NO:9)竞争结合，该抗体多肽或其医药学上可接受之盐系用于制备用以治疗免疫疾病之药剂。该药剂可例如与免疫抑制/免疫调节剂及/或消炎剂组合投与。免疫疾病可为例如自体免疫疾病或移植相关疾病。免疫疾病亦可选自由以下组成之群：艾迪森氏病、过敏症、僵直性脊椎炎、哮喘、动脉粥样硬化、自体免疫性耳病、自体免疫性眼病、自体免疫肝炎、自体免疫腮腺炎、结肠炎、冠心病、克罗恩氏病、糖尿病(包括1型及/或2型糖尿病)、附睪炎、丝球体肾炎、葛瑞夫兹氏病、格-巴二氏征候群、桥本氏病、溶血性贫血、特发性血小板减少性紫癜、发炎性肠病、对重组药品之免疫反应、全身性红斑狼疮、男性不育症、多发性硬化症、重症肌无力、天疱疮、牛皮癣、风湿热、类风湿性关节炎、类肉瘤病、硬皮病、休格连氏症候群、脊椎关节病、甲状腺炎、移植排斥反应、血管炎、AIDS、异位性过敏症、支气管哮喘、湿疹、麻风病、精神分裂症、遗传性抑郁症、组织及器官之移植、慢性疲劳症候群、阿兹海默氏病、帕金森氏病、心肌梗塞、中风、自闭症、癫痫症、阿瑟氏现象、全身性过敏反应、酒精成瘾及药物成瘾。
附图简要说明
图1展示人类CD40(SEQ ID NO:1)之两种不同共晶体结构之结合模式，一者具有dAb BMS3h-56-5(SEQ ID NO:321)及一者具有Chi220抗体之Fab'。BMS3h-56-5及Chi220Fab'分子显示为包含β-股(在dAb中以箭头表示)及非重复二级结构(在dAb中以环表示)之草图。亦显示互补决定区(CDR)，CD40亦显示为包含人类CD40之BMS3h-56-5抗原决定基残基之草图。亦显示Chi220抗原决定基残基。亦显示双硫键。标记CD40之N端(N)及C端(C)。
图2展示接触人类CD40(SEQ ID NO:1)之BMS3h-56-5(SEQ ID NO:321)之空间填充模型，其以草图显示。显示接触CD40之dAb BMS3h-56-5之表面残基。标记BMS3h-56-5CDR3区及FR-2残基Leu45、Arg47、Arg56及Phe99。在此图中使用Kabat编号(Kabat等人，Sequencesof Immunological Interest，第5版，美国健康与人类服务部(U.S.Dept.Health&HumanServices),Washington,D.C.(1991))，且与顺序编号之不同之处在于使用插入残基来保持β-股之残基编号相同。因此，对于BMS3h-56-5，顺序残基53变为残基52A，顺序残基84、85及86分别变为82A、82B、82C，且Kabat残基编号100缺失(其将介于顺序残基103与104之间)；CD40亦以包含非重复二级结构及BMS3h-56-5抗原决定基之草图表示。在人类与长尾猕猴(Macaca fascicularis)(食蟹猕猴(cynomolgus monkey))之间不同的CD40残基Ala115、Phe99、Ser126、His162、Leu121及Trp109以棒图标法显示。作为BMS3h-56-5抗原决定基之一部分的在人类与食蟹猕猴之间不同的CD40残基为Trp109、Leu121及His162。CD40残基Trp109及Leu121处于BMS3h-56-5CDR3与FR-2之间的间隙中。Trp109之突变大大降低或消除BMS3h-56-5活性。
图3展示来自人类及灵长类动物物种之血液样品上聚乙二醇化抗人类CD40 dAbBMS3h38-2C-P40Br之结合。图3A显示BMS3h38-2C-P40Br结合至人类及猕猴B细胞；图3B显示BMS3h38-2C-P40Br结合至人类、恒河猴及黑猩猩B细胞。
图4、图5、图6及图7显示分别来自谱系BMS3h-56、BMS3h-37、BMS3h-38及BMS3h-198之代表性域抗体多肽之ClustalW2比对。
实施方式
本发明提供特异性结合至人类CD40之抗体多肽。该等抗体多肽不展现CD40促效剂活性，且该等抗体多肽适用于治疗涉及CD40活化之疾病，诸如自体免疫疾病。该等抗体多肽可使用利用细胞结合分析之初步筛检，随后进行一或多轮易错或简并寡核苷酸定向亲和力成熟来选择。结果，提供一类特异性结合单一CD40抗原决定基之抗体多肽。
“谱系”为如以下实例中所揭示由常见前驱体藉由易错或简并寡核苷酸定向亲和力成熟而制备且预期结合相同CD40抗原决定基之一组相关抗体多肽。使用抗体多肽之命名表示各种谱系。举例而言，命名“BMS3h-56”系指针对人类CD40所产生之谱系56之抗体多肽。“谱系BMS3h-56”抗体多肽包括BMS3h-56-1直至BMS3h-56-33及BMS3h-56-202直至BMS3h-56-288。
因此，在一个实施方式中，抗体多肽包含特异性结合人类CD40之可变域，其中该抗体多肽与表3中所列之任一域抗体(dAb)竞争结合。举例而言，dAb可能属于选自由以下组成之群的谱系：例如BMS3h-37、BMS3h-38、BMS3h-41、BMS3h-43、BMS3h-56、BMS3h-131、BMS3h-198及BMS3h-202，诸如dAb BMS3h-56-5、BMS3h-56-201或BMS3h-56-258。在另一个实施方式中，抗体多肽特异性结合与表3中所列之任一dAb相同之人类CD40抗原决定基。举例而言，抗体多肽可包含特异性结合与例如dAb BMS3h-56-5、BMS3h-56-201或BMS3h-56-258相同之人类CD40抗原决定基的可变域。如下文所揭示，人类CD40抗原决定基可包含例如SEQ ID NO:1之氨基酸残基Trp109。
抗体多肽可为含有单一可变域之域抗体。抗体多肽亦可包含其他结构域，诸如Fc域。举例而言，抗体多肽可包含特异性结合人类血清白蛋白(HSA)之第二可变域。举例而言，该等双特异性抗体多肽可具有增加之半衰期。
在序列表中，SEQ ID NO:1为人类CD40之氨基酸序列；SEQ ID NO:2为长尾猕猴CD40之氨基酸序列。域抗体BMS3h-56-5之氨基酸序列为SEQ ID NO:321。
如本文所用，“特异性结合”系指抗体多肽结合抗原之解离常数(Kd)如例如藉由表面电浆子共振所量测，为约1μM或1μM以下。适当分析系统包括BIAcoreTM表面电浆子共振系统及BIAcoreTM动力学评估软件(例如2.1版)。特异性结合相互作用之亲和力或Kd可为约500nM或500nM以下或约300nM或300nM以下。
术语“约”将为一般熟习此项技术者所了解且在使用其之情形下将有一定程度之变化。一般而言，约涵盖加上/减去提及值之10％的数值范围。
根据此实施方式，以下缩写及定义适用。须注意，除非本文另外明确规定，否则如本文所用，单数形式“一(a)”、“一(an)”及“该”包括复数个指示物。因此，举例而言，提及“抗体”包括复数个该等抗体，且提及“剂量”包括提及一或多个为熟习此项技术者所知之剂量及其等同量等。
1.CD40及CD40活性
提供结合人类CD40之抗体多肽。CD40亦称为B细胞表面抗原CD40、Bp50、CD40L受体、CDw40、CDW40、MGC9013、p50、TNFRSF5及肿瘤坏死因子受体超家族成员5。人类CD40之相关结构信息可例如以UniProt寄存编号P25942、Q9BYU0及Q53GN5找到。“人类CD40”系指包含以下氨基酸序列之CD40：
亦已在小家鼠(Mus musculus)、野猪(Sus scrofa)、欧洲牛(Bos taurus)、鸡(Gallus gallus)、家犬(Canis familiaris)、长尾猕猴(食蟹猕猴)、绵羊(Ovis aries)、家马(Equus caballus)及褐家鼠(Rattus norvegicus)中对CD40测序。
本发明抗体多肽与CD40之结合拮抗CD40活性。“CD40活性”包括(但不限于)T细胞活化(例如诱导T细胞增殖或细胞激素分泌)、巨噬细胞活化(例如诱生巨噬细胞中之活性氧物质及氧化氮)及B细胞活化(例如B细胞增殖、抗体同型转换或分化成浆细胞)。CD40活性可藉由与其他分子相互作用来介导。“CD40活性”包括CD40与以下分子之间的功能相互作用，该等分子以其Uniprot寄存编号于括号内标识：
CALR (P27797)；
ERP44 (Q9BS26)；
FBL(P22087)；
POLR2H(P52434)；
RFC5 (P40937)；
SGK1 (O00141)；
SLC30A7 (Q8NEW0)；
SLC39A7 (Q92504)；
TRAF2 (Q5T1L5)；
TRAF3 (Q13114)；
TRAF6 (Q9Y4K3)；
TXN (Q5T937)；
UGGT1 (Q9NYU2)；及
USP15 (Q9Y4E8)。
举例而言，CD40“活性”包括与TRAF2之相互作用。CD40/TRAF2相互作用活化NF-κB及JNK。参见Davies等人，Mol.Cell Biol.25:9806-19(2005)。因此，此CD40活性可利用CD40依赖性细胞NF-κB及JNK活化相对于参照组来测定。
如本文所用，术语“活化(activate)”、“活化(activates)”及“活化(activated)”系指既定可量测CD40活性相对于参照组增加至少10％，例如至少10％、25％、50％、75％或甚至100％或100％以上。若活性相对于不存在拮抗剂之情况降低至少10％，且在一个例示性实施例中降低至少约20％、30％、40％、50％、60％、70％、80％、90％、95％、97％或甚至100％(亦即无可侦测活性)，则CD40活性被“拮抗”。举例而言，抗体多肽可拮抗一些或所有CD40活性，而不活化CD40。在一个实施例中，抗体多肽不活化B细胞增殖。在另一个实施例中，抗体多肽不活化T细胞之细胞激素分泌，其中细胞激素为至少一种选自由以下组成之群的细胞激素：IL-2、IL-6、IL-10、IL-13、TNF-α、IFN-γ。
2.CD40抗原决定基
使用人类CD40(SEQ ID NO:1)与dAb BMS3h-56-5(SEQ ID NO:321)之间的复合物之X射线结晶学来揭示由本发明之抗体多肽所识别之抗原决定基。针对电子密度数据拟合CD40及BMS3h-56-5之结构模型以产生七种模型或型式之CD40/BMS3h-56-5复合物，其来自三种呈一种晶形之结晶学独立复合物及四种呈第二晶形之结晶学独立复合物。该等型式之主链原子之真实空间相关系数(real space correlation coefficient)为约0.92且侧链原子之真实空间相关系数为0.80。在七种型式中CD40分子具有一定量之可挠性，但所有型式中均保留CD40/BMS3h-56-5相互作用之总体性质。该等型式在CD40残基Trp109与BMS3h-56-5 Trp103(Kabat编号，参见下文)之间的相互作用不同。BMS3h-56-Trp103与一种型式之CD40Trp109形成边对面相互作用，而与其他型式形成置换堆栈(亦即面对面)相互作用。
七种型式之形状互补性统计值Sc在0.70至0.77之范围内，此显示与典型抗体抗原复合物相比形状互补性之程度较高。举例而言，此等值可与四种蛋白酶/蛋白质抑制剂复合物之0.71至0.76之范围、五种寡聚界面之0.70至0.74之范围及六种抗体/抗原复合物之0.64至0.68之范围比较。参见Lawrence等人，“Shape Complementarity at Protein/Protein Interfaces”，J.Mol.Biol.234:946-950(1993)。
图1中显示人类CD40/BMS3H-56-5复合物模型。一个BMS3h-56-5 dAb结合于一个CD40分子。BMS3h-56-5抗原决定基不与Chi220Fab'片段抗原决定基重迭。所有型式之复合物界定一组接触BMS3h-56-5之CD40残基：Trp109、Leu121、His122、Ser124、Ser156、Ala157、Phe158、Glu159及His162(参考SEQ ID NO:1)。一些型式之复合物中接触BMS3h-56-5之CD40残基为Pro85、Asn86、Leu87、Gly88、Glu106、Glu107、Gly108、His110、Thr112、Cys119、Val120、Gln133、Ile134、Ala135、Thr136、Ser155及Lys160。在所有型式中Val154为内埋CD40残基。在一些型式中内埋之其他CD40残基为Ser118、Arg123、Thr141、Phe151、Asp153、Cys161及Pro163。
如本文所用，术语“接触”系指原子间距离，其最大值决定于如Sheriff等人，J.Mol.Biol.197:273-296(1987)及Sheriff,Immunomethods 3:191-196(1993)所定义之原子型距离依赖性。
如本文所用，术语“内埋”系指一残基具有至少一个具有由程序MS(Connolly,J.Appl.Crystallogr.16:548-558(1983))所定义之表面积、之探针球及如Sheriff,Immunomethods 3:191-196(1993)所定义之原子型依赖性凡得瓦尔半径(Van der Waalsradii)的原子。
图2显示包括接触残基及内埋残基之BMS3h-56-5(SEQ ID NO:321)之表面。CD40(SEQ ID NO:1)表示为带状图，橙色表示非重复二级结构且洋红色表示抗原决定基残基。在各种非人类灵长类动物序列中所显示之CD40残基Trp109、Ala115、Leu121、Ser126及His162不同。CD40残基Ala115及Ser126位于BMS3h-56-5结合位点之对侧。Trp109及Leu121在位于BMS3h-56-5之CDR3与FR-2(残基Leu45及Arg47)之间的间隙中结合。His162与BMS3h-56-5之CDR2中之残基，尤其Lys 56相互作用。总之，CD40抗原决定基包含一或多个表1中所列之残基，参考SEQ ID NO:1中所用之编号。
表1
BMS3h-56-5，如表3中所列之其他dAb，系使用人类CD40作为抗原藉由下文更详细描述之筛检及亲和力成熟方法来制备。预期由常见前驱dAb藉由亲和力成熟产生之dAb将结合相同人类CD40抗原决定基。举例而言，下文所述之竞争研究指示由常见前驱dAb藉由亲和力成熟产生之dAb彼此竞争结合于人类CD40。然而，相同竞争研究显示dAb不与至少Chi220或G28-5抗体竞争。
3.抗体多肽
抗体多肽包含可变域。在一个实施例中，抗体多肽呈含有单一可变域之dAb形式。抗体多肽可为包含藉由双硫键互连之两个重(H)链及两个轻(L)链之全长抗CD40免疫球蛋白分子。在此实施例中，各链之胺基末端部分包括主要经由其中所含之互补决定区(CDR)负责抗原识别的约100至110个氨基酸之可变域(VL或VH)。各重链之羧基末端“半部”界定主要负责效应功能之恒定区(Fc)。
抗体多肽亦可为包含含特异性结合CD40之可变域的全长抗CD40免疫球蛋白分子之一部分的“片段”。因此，术语“抗体多肽”包括例如抗原结合重链、轻链、重链-轻链二聚体、Fab片段、F(ab')2片段、Fv片段、单链Fv(scFv)及dAb。因此，术语“抗体多肽”包括藉由重组工程改造及表现而产生之多肽，以及藉由天然重组及融合瘤细胞克隆分泌所产生之单株抗体。
轻链系分类为κ或λ，且如此项技术中所知其特征在于特定恒定区CL。重链系分类为γ、μ、α、δ或ε，且将抗体之同型分别定义为IgG、IgM、IgA、IgD或IgE。对于IgG、IgD及IgA，重链恒定区包含三个结构域(CH1、CH2及CH3)；且对于IgM及IgE，包含四个结构域(CH1、CH2、CH3及CH4)。抗CD40抗体可具有选自任一免疫球蛋白类别(IgA、IgD、IgG、IgM及IgE)之重链恒定区。
各轻链可变域(VL)及重链可变域(VH)由三个CDR及四个构架区(FR)构成，自胺基末端至羧基末端按以下顺序排列：FR1、CDR1、FR2、CDR2、FR3、CDR3、FR4。轻链之三个CDR被称为“LCDR1、LCDR2及LCDR3”，且重链之三个CDR被称为“HCDR1、HCDR2及HCDR3”。
如本文所用，术语“Fc域”系指包含CH2及CH3恒定域之恒定区抗体序列，如Kabat等人，Sequences of Immunological Interest，第5版，美国健康与人类服务部(U.S.Dept.Health&Human Services),Washington,D.C.(1991)所界定。Fc区可源自例如IgG1或IgG4Fc区。可变域可融合至Fc域。在此情况下，可变域(VL或VH域，包括dAb)之羧基末端可连接或融合至Fc CH2域之胺基末端。或者，可变域之羧基末端可连接或融合至CH1域之胺基末端，CH1域之胺基末端本身融合至Fc CH2域。蛋白质可包含CH1与CH2域之间的铰链区整体或部分。
CDR含有大部分与抗原形成特异性相互作用之残基。如图2中所示，例如CDR2及CDR3加上FR4残基Trp103形成CD40与dAb BMS3h-56-5之间的大部分接触。举例而言，抗体多肽之可变域包含具有与表3中所列之dAb之一的CDR1、CDR2及CDR3区相同之氨基酸序列或各与CDR1、CDR2及CDR3区有一或两个氨基酸不同之CDR1、CDR2及CDR3区。举例而言，抗体多肽可包含具有与例如BMS3h-56-5、BMS3h-56-258或BMS3h-56-201之CDR1、CDR2及CDR3区相同之氨基酸序列的CDR1、CDR2及CDR3区。
“域抗体”(dAb)包含能够特异性及单价结合抗原(诸如CD40)之单一可变(VL或VH)域。举例而言，dAb可具有骆驼科动物dAb所特有之VHH结构。如本文所用，“VH域”意谓包括VHH结构。在另一个实施例中，本发明之VH域(包括作为本文之实施例呈现的所有特征及特征之组合)不为VHH域。dAb可在溶液中形成均二聚体或杂二聚体。咸信二价抗CD40抗体由于能够交联结合细胞表面上之CD40分子而展现促效剂活性。尽管不受任何特定理论限制，但咸信单价dAb不活化CD40，因为该等dAb不与CD40交联。
如本文所用，术语“可变域”系指由Kabat等人，Sequences of ImmunologicalInterest，第5版，美国健康与人类服务部，Washington,D.C.(1991)所定义之免疫球蛋白可变域。可变域内CDR氨基酸残基之编号及定位系根据熟知Kabat编号约定确定。举例而言，在表2中比较BMS3h-56-5(SEQ ID NO:321)之Kabat编号与依序编号之相同序列。在Kabat编号中，BMS3h-56-5具有插入残基52A、82A、82B、82C，且残基100。在两种编号系统中，给予作为表现构筑体之一部分的N端之Ser及Thr负编号。
表2
术语“人类”在应用于抗体多肽时意谓抗体多肽具有源自人类免疫球蛋白之序列，例如FR及/或CH域。当序列系：(a)自人类个体或自人类个体之细胞或细胞株分离而得；(b)自经选殖之人类抗体基因序列或人类抗体可变域序列之文库分离而得；或(c)藉由自一或多个以上多肽突变及选择而多样化时，该序列系“源自”人类免疫球蛋白编码序列。如本文所用，“经分离”之化合物意谓该化合物已与在自然界中与该化合物天然缔合之至少一种组分分离。
可将抗体多肽投与人类患者，同时基本上避免通常藉由投与来自其他物种(例如小鼠)之抗体而引起的抗抗体免疫反应。举例而言，鼠类抗体可根据此项技术中熟知之程序藉由将鼠类CDR移植于人类可变域FR上而“人类化”。然而，如本文所揭示之人类抗体可在不需要鼠类抗体序列之基因操控之情况下产生。
可变域可包含一或多个具有与由人类生殖系抗体基因区段编码之相应构架区相同之氨基酸序列的构架区(FR)。举例而言，域抗体可包含VH生殖系基因区段DP47、DP45或DP38、Vκ生殖系基因区段DPK9、JH区段JH4b或Jκ区段Jκ1。
可改变抗体多肽序列，同时保留特异性结合CD40之能力。特定言之，抗体多肽(例如dAb)可包含保留特异性结合与dAb BMS3h-56-5相同之CD40抗原决定基的功能之变异型可变域。参见表1。亦即，变异型可变域可结合包含SEQ ID NO:1之Trp109、Leu121、His122、Ser124、Ser156、Ala157、Phe158、Glu159及His162中之至少一者的人类CD40抗原决定基。在一个实施例中，变异型可变域抗原决定基可包含Trp109、Leu121、His122、Ser124、Ser156、Ala157、Phe158、Glu159及His162。或者，变异型可变域可特异性结合包含CD40残基Trp109之CD40抗原决定基。在又一个实施例中，变异型可变域可与BMS3h-56-5竞争特异性结合于CD40。如以下实例中所揭示，易错亲和力成熟提供一种制造及鉴别具有特异性结合相同CD40抗原决定基之变异型序列的抗体多肽之例示性方法。
举例而言，变异型可变域与表3中所列之可变域之一可有至多10个或其间之任何整数值个氨基酸不同，其中该变异型可变域特异性结合CD40。或者，变异型可变域相对于本发明序列表中所列之序列可具有至少90％序列一致性(例如至少92％、95％或98％序列一致性)。在两个序列之间不同的非一致氨基酸残基或氨基酸可表示氨基酸取代、添加或缺失。当两个序列藉由诸如BLAST之任何适当氨基酸序列比对算法比对时，在两个序列之间不同之残基以非一致位置呈现。
其限制条件为可对个别FR区进行氨基酸取代，以便一或多个FR相对于由人类生殖系抗体基因区段编码之相应FR之氨基酸序列包含至多两个氨基酸差异。其限制条件进一步为变异型可变域在一或多个CDR中可含有一或两个氨基酸取代。特异性结合CD40之代表性可变域列于表3中。
来自谱系BMS3h-56、BMS3h-37、BMS3h-38及BMS3h-198之抗体多肽之代表性可变域之间的ClustalW2比对分别示于图4、图5、图6及图7中。通常，相关蛋白质序列之比对中氨基酸之保守程度与氨基酸位置对蛋白质功能之相对重要性成比例。亦即，所有相关序列中共有之氨基酸可能起重要作用且不能轻易被取代。另一方面，序列之间不同的位置可能经其他氨基酸取代或以其他方式修饰，同时维持蛋白质之活性。示于图4、图5、图6及图7中之比对以及例如由图1及图2确定之结构关系可引导特异性结合包含SEQ ID NO:1之氨基酸序列的人类CD40之抗原决定基的变异型抗体多肽之建构，其中该抗体多肽与dAb BMS3h-56-201(SEQ ID NO:9)竞争结合。该等变异型抗体多肽包括(但不限于)具有对应于关于表3中所列之任一可变域的取代、插入或缺失之氨基酸修饰的变异型抗体多肽。变异型抗体多肽亦包括具有对应于表3中所列序列之间保守之氨基酸修饰的氨基酸修饰之变异型抗体多肽。
关于重链及轻链基因之VL或VH域之边界的信息可用于设计PCR引子以扩增来自编码已知结合CD40之抗体多肽的经选殖之重链或轻链编码序列之可变域。使用此项技术中熟知之技术，可将扩增之可变域插入适当表现载体(例如pHEN-1)(Hoogenboom等人，(1991)Nucleic Acids Res.19:4133-4137)中且使其单独地或以与另一多肽序列之融合物形式表现。基于所揭示之氨基酸及聚核苷酸序列，可产生融合蛋白且仅使用普通技术于任何适当哺乳动物宿主细胞株(诸如CHO、293、COS、NSO及其类似细胞株)中来纯化，随后使用一种方法或方法之组合来纯化，该等方法包括蛋白质A亲和层析法、离子交换法、逆相技术或其类似方法。
在一个实施方式中，抗体多肽为包含特异性结合包含SEQ ID NO:1之氨基酸序列的人类CD40之第一可变域的“双特异性”抗体多肽。双特异性抗体多肽包含特异性结合除人类CD40以外之第二抗原之第二可变域。
在另一个实施例中，第二抗原可为例如免疫效应细胞之细胞表面分子或可溶性分子(诸如细胞激素)。双特异性抗体多肽之结合可用于拮抗CD40且拮抗第二抗原之生物活性。免疫效应细胞之细胞表面分子包括分化簇(CD)分子。代表性CD标记列于因特网之超文本传送协议en.wikipedia.org/wiki/List_of_human_clusters_of_differentiation上(2012年2月22日进行最后修改)。免疫效应细胞之细胞表面分子亦包括主要组织兼容性复合体(MHC)II类分子。针对此等细胞表面分子之抗体在此项技术中为已知的且可作为可变域来源用于构筑双特异性抗体多肽。
在一个实施例中，双特异性配位体之抗体多肽可藉由“氨基酸连接子”或“连接子”连接。举例而言，dAb可融合至氨基酸连接子之N端，且另一dAb可融合至连接子之C端。尽管氨基酸连接子可为任何长度且由氨基酸之任何组合组成，但连接子长度可能相对较短(例如五个或五个以下氨基酸)以降低所连接结构域之间的相互作用。亦可调节连接子之氨基酸组成以减少具有庞大侧链之氨基酸或可能引入二级结构中之氨基酸的数目。适当氨基酸连接子包括(但不限于)长度为至多3、4、5、6、7、10、15、20或25个氨基酸之氨基酸连接子。代表性氨基酸连接子序列包括(GGGGS)n(SEQ ID NO:4)，其中n可为1与5之间的任何整数。其他适当连接子序列可选自由以下组成之群：AST(SEQ ID NO:5)、TVAAPS(SEQ ID NO:6)、TVA(SEQ ID NO:7)及ASTSGPS(SEQ ID NO:8)。
第二抗原之结合可增加抗体多肽之活体内半衰期。举例而言，双特异性抗体多肽之第二可变域可特异性结合血清白蛋白(SA)，例如人类血清白蛋白(HSA)。经形式设计而可结合HSA之抗体多肽相对于相同的未经形式设计之抗体多肽可具有增加之活体内t-α(“α半衰期”)或t-β(“β半衰期”)半衰期。t-α及t-β半衰期量度物质分布于身体内且自身体内消除有多快。举例而言，键联至HSA可藉由抗体多肽与能够特异性结合HSA之第二可变域之融合来实现。抗人类血清白蛋白抗体在此项技术中为熟知的。参见例如在因特网之超文本传送协议www.abcam.com/index.html上可获知之人类血清白蛋白抗体ab10241、ab2406及ab8940，或在因特网之超文本传送协议www.genwaybio.com上可获知之GenWayALB抗体。特异性结合HSA之可变域可获自任一此等抗体，且接着使用此项技术中熟知之重组技术融合至本发明之抗体多肽。
或者，抗体多肽连接至HSA可藉由使用熟练技术者熟知之技术使抗体多肽序列直接稠合至HSA编码序列来实现。HSA编码序列可藉由PCR使用源自例如可以GenBank寄存编号NM000477获得之cDNA序列之引子来获得。
在一个实施例中，经HSA连接之域抗体组合物之tα半衰期增加10％或10％以上。在另一个实施例中，经HSA连接之域抗体组合物之tα半衰期在0.25小时至6小时之范围内。在另一个实施例中，经HSA连接之域抗体组合物之tβ半衰期增加10％或10％以上。在另一个实施例中，经HSA连接之域抗体组合物之tβ半衰期在12小时至48小时之范围内。
在另一个实施例中，可藉由聚乙二醇化对抗体多肽进行形式设计以增加其活体内半衰期。在一个实施例中，将PEG共价连接。在另一个实施例中，将PEG连接至抗体多肽之半胱氨酸或赖氨酸残基。在又一个实施例中，经PEG连接之抗体多肽之流体动力学尺寸为至少24kD。在又一个实施例中，总PEG尺寸为20kD至60kD且包括20kD及60kD。在又一个实施例中，经PEG连接之域抗体之流体动力学尺寸为至少200kD。
聚乙二醇化可使用若干PEG连接部分达成，该等PEG连接部分包括(但不限于)N-羟基丁二酰亚胺活性酯、丙酸丁二酰亚胺酯、顺丁烯二酰亚胺、乙烯砜或硫醇。PEG聚合物可连接至抗体多肽之预定位置，或可任意地连接至域抗体分子。聚乙二醇化亦可经由连接至域抗体之肽连接子介导。亦即，PEG部分可连接至融合至抗体多肽之肽连接子，其中该连接子提供用于PEG连接之位点(例如游离半胱氨酸或赖氨酸)。聚乙二醇化抗体之方法在此项技术中熟知，例如如Chapman等人，“PEGylated antibodies and antibody fragments forimproved therapy:a review”，Adv.Drug Deliv.Rev.54(4):531-45(2002)中所揭示。
抗体多肽亦可经设计以形成二聚体、三聚体、四聚体或其他多聚体。抗体多肽(例如dAb)可藉由此项技术中已知之若干方法(包括(但不限于)以融合蛋白形式表现单体、两个或两个以上单体经由单体之间的肽连接子键联)、或藉由在转译之后彼此直接或藉由双硫键经由连接子以化学方式接合单体、或藉由键联至二价、三价或多价连接部分(例如多臂PEG)来连接以形成多聚体。在一个实施例中，多聚体可结合单一CD40分子。
4.医药组合物及治疗方法
医药组合物包含治疗有效量之一或多种抗体多肽及视情况选用之医药学上可接受之载剂。医药学上可接受之载剂包括例如水、生理食盐水、磷酸盐缓冲盐水、右旋糖、甘油、乙醇及其类似物以及其组合。医药学上可接受之载剂可进一步包含极少量之可增加融合蛋白之储存期限或效用之助剂物质，诸如湿润剂或乳化剂、防腐剂或缓冲剂。组合物可经调配以在投与之后提供活性成分之快速、持续或延迟释放。适当医药组合物及其制备方法在此项技术中为熟知的。参见例如Remington,The Science and Practice of Pharmacy,A.Gennaro等人编，第21版，Mack Publishing Co.(2005)。
医药组合物进一步可包含免疫抑制/免疫调节剂及/或消炎剂。治疗需要该治疗之患者的免疫疾病之方法可包含向患者投与治疗有效量之医药组合物。拮抗CD40介导之T细胞活化可抑制例如自体免疫性、移植排斥反应或过敏反应期间发生之不当T细胞反应。抑制CD40介导之T细胞活化可减缓此等疾病之进展及/或严重程度。
如本文所用，“患者”意谓动物，例如哺乳动物，包括人类。患者可经诊断患有免疫疾病。“治疗(Treatment)”或“治疗(treat)”或“治疗(treating)”系指涉及减轻症状、病症、病状或疾病之进展或严重程度之方法。“免疫疾病”系指与个体中显现免疫反应，包括细胞及/或体液免疫反应相关之任何疾病。免疫疾病之实例包括(但不限于)发炎、过敏症、自体免疫疾病或移植相关疾病。自体免疫疾病可选自由全身性红斑狼疮、多发性硬化症、类风湿性关节炎、糖尿病、牛皮癣、硬皮病、动脉粥样硬化、发炎性肠病及溃疡性结肠炎组成之群。
可藉由投与医药组合物治疗之疾病可选自由以下组成之群：艾迪森氏病、过敏症、僵直性脊椎炎、哮喘、动脉粥样硬化、自体免疫性耳病、自体免疫性眼病、自体免疫肝炎、自体免疫腮腺炎、结肠炎、冠心病、克罗恩氏病、糖尿病(包括1型及/或2型糖尿病)、附睪炎、丝球体肾炎、葛瑞夫兹氏病、格-巴二氏征候群、桥本氏病、溶血性贫血、特发性血小板减少性紫癜、发炎性肠病、对重组药品之免疫反应(例如血友病患者中之因子VII)、全身性红斑狼疮、男性不育症、多发性硬化症、重症肌无力、天疱疮、牛皮癣、风湿热、类风湿性关节炎、类肉瘤病、硬皮病、休格连氏症候群、脊椎关节病、甲状腺炎、移植排斥反应及血管炎。自体免疫介导之病状包括(但不限于)受影响之组织为主要目标，且在一些情况下为次要目标之病状。该等病状包括(但不限于)AIDS、异位性过敏症、支气管哮喘、湿疹、麻风病、精神分裂症、遗传性抑郁症、组织及器官之移植、慢性疲劳症候群、阿兹海默氏病、帕金森氏病、心肌梗塞、中风、自闭症、癫痫症、阿瑟氏现象、全身性过敏反应、酒精成瘾及药物成瘾。
医药组合物可单独或以与免疫抑制/免疫调节剂及/或消炎剂之组合疗法投与(亦即同时或依序)。不同免疫疾病可能需要使用适用于治疗免疫疾病之特定助剂化合物，此可根据患者对患者之基准来确定。举例而言，医药组合物可与一或多种例如细胞激素(例如IL-10及IL-13)或其他免疫刺激剂(例如趋化因子、肿瘤相关抗原及肽)之适当佐剂组合投与。适当佐剂在此项技术中为已知的。
可使用任何适当方法或途径来投与抗体多肽或医药组合物。投药途径包括例如经口、静脉内、腹膜内、皮下或肌肉内投与。投与之抗体多肽之治疗有效剂量视许多因素而定，包括例如所治疗之免疫疾病之类型及严重程度、组合疗法之用途、抗体多肽或医药组合物之投药途径及患者之体重。域抗体之治疗有效量之非限制性范围相对于患者之体重为0.1mg/kg至20mg/kg，且在一个实施方式中，为1mg/kg至10mg/kg。在疾病病况之活体外及/或活体内模型中，抗体多肽之剂量可由为CD40拮抗作用所需之抗体多肽之量进一步引导。代表性模型描述于下文及实例中。
5.活体外及活体内模型
可在若干可获得之活体外或活体内模型系统中之一者中测试本发明之抗体多肽拮抗CD40之能力。适当动物及细胞模型系统描述于下文。其他细胞分析系统描述于实例中。
5.1.发炎性肠病(IBD)模型：
IBD为不明病因之多因性免疫病症。类似IBD之若干黏膜发炎小鼠模型提供了有关控制正常与病理性黏膜免疫功能之机制的理解。IBD模型包括使用De Winter等人，Am.J.Physiol.276:G1317-1321(1999)之黏膜免疫及发炎系统。在一个实施方式中，将CD4(+)T淋巴细胞之子集(亦即CD4(+)CD45RBhigh细胞)注射至免疫缺陷小鼠中会引起肠发炎。发病机理部分系归因于促炎性细胞因子之分泌。结肠炎之诱发可藉由共转移另一CD4(+)亚群(亦即CD4(+)CD45RBlow T细胞)来预防。就获取活化标记及返回宿主肠而言，此群体之行为类似于CD4(+)CD45RBhigh群体。然而，活化时其淋巴介质概况不同，且CD4(+)CD45RBlowT细胞分泌及/或诱导之消炎细胞激素会预防结肠炎。De Winter等人提供有关过继性转移模型及促进及预防结肠炎发病机理之因素的描述。
5.2.自发性关节炎模型：
Kouskoff等人，Cell 87:811-822(1996)提供由全身性自体免疫性引起之器官特异性疾病之模型。类风湿性关节炎(Rheumatoid arthritis，RA)为慢性关节病，其特征为白血球侵袭及滑膜细胞活化，随后为软骨及骨破坏。Kouskoff等人揭示藉由T细胞受体(Tcell receptor，TCR)转殖基因系与NOD系杂交产生之自发性小鼠RA模型。所有子代均显现极易令人想起人类RA之关节病。鼠类病症之触发为由转殖基因TCR机会性识别NOD源性主要组织兼容性复合体(MHC)II类分子；关节炎之进展涉及CD4+T细胞、B细胞及可能存在之骨髓细胞。
5.3.胶原蛋白诱发之关节炎(Collagen Induced Arthritis，CIA)模型：
Brand等人，Methods Mol.Med.102:295-312(2004)提供胶原蛋白诱发之关节炎之小鼠模型。胶原蛋白诱发之关节炎(CIA)为可在啮齿动物(大鼠及小鼠)及非人类灵长类动物之易感染系中藉由用II型胶原蛋白(CII)(亦即关节软骨之主要成分蛋白质)免疫接种而引发的自体免疫疾病。在免疫接种后，动物显现与RA共有若干临床及组织特征之自体免疫多发性关节炎。在啮齿动物中容易感染CIA与主要组织兼容性复合体(MHC)II类分子有关，且对CII之免疫反应之特征在于刺激胶原蛋白特异性T细胞及产生高效价之对免疫原(异源CII)与自身抗原(小鼠CII)具特异性之抗体。在组织学上，鼠类CIA之特征在于与关节炎之临床发作一致之严重滑膜炎。由于CIA与RA之间具有病理相似性，故此实验数据适用于评估CIA。
5.4.抗原诱发之T细胞增殖活体内模型：
使用T细胞受体(TCR)-转殖基因T细胞之过继性转移为抗原诱发之T细胞增殖提供活体内模型。Pape等人，Immunol.Rev.156:67-78(1997)揭示均一地表现具有已知肽/MHC特异性之可识别TCR的TCR-转殖基因T细胞之过继性转移。可使用该模型来监测抗原特异性T细胞之活体内行为。未处理T细胞最初在次级淋巴组织之T细胞区内活化以按B7依赖性方式增殖。若此时期内存在佐剂或发炎性细胞激素，则T细胞积聚数目增多，迁移至富B细胞之小囊中且获得产生IFN-γ之能力且有助于B细胞产生IgG2a。若发炎得以有效拮抗，则大部分最初活化之抗原特异性T细胞会消失而不进入小囊中，且幸存者为IL-2及IFN-γ之不良产生者。
实施例
表3列出适用于本发明抗体多肽之代表性抗人类CD40可变域氨基酸序列。表4揭示编码表3中所列之可变域序列之代表性核酸。如此项技术中所熟知，多个密码子可编码同一氨基酸。因此，编码蛋白质序列之核酸包括具有密码简并性之核酸。表3中所示之抗体多肽特异性结合CD40且使用以下实施例中所述之反复初始/初步筛检及亲和力成熟方法来制造。
表3
抗人类CD40可变域氨基酸序列
表4
编码人类抗CD40可变域之核苷酸序列
实施例1
经由BMS3h-225产生人类抗CD40可变域BMS3h-1
以下实施例描述经由BMS3h-225产生一系列命名为BMS3h-1之抗人类CD40可变域。在噬菌体表面上重组表现单一免疫球蛋白可变域谱系之后，藉由使噬菌体谱系与固定目标抗原接触，洗涤以移除未结合之噬菌体且传播结合之噬菌体来进行选择。此方法通常称为“淘选”。其适用于筛检单一免疫球蛋白可变域以及可在呈现文库上表现之其他抗体片段，例如scFv、Fab及Fab'。或者，可藉由针对仅藉由折迭成员结合之固定通用配位体(例如蛋白质A或蛋白质L)淘选来预先选择表现适当折迭之成员变异体之噬菌体。此有如下优势：降低非功能成员之比例，由此增加可能结合目标抗原之成员的比例。举例而言，WO 99/20749中教示用通用配位体进行预先选择。举例而言，Harrison等人，Meth.Enzymol.267:83-109(1996)大体描述了噬菌体抗体文库之筛检。
筛检通常使用固定于固体支撑物(例如塑料管或孔)或层析基质(例如SepharoseTM(Pharmacia))上之纯化抗原来执行。筛检或选择亦可在诸如细胞表面之复合抗原上执行(Marks等人，BioTechnology 11:1145(1993)；de Kruif等人，Proc.Natl.Acad.Sci.USA92:3938(1995))。另一替代方法涉及藉由结合溶液中之经生物素标记之抗原来选择，随后捕捉于涂布抗生蛋白链菌素之珠粒上。
克隆BMS3h-1至BMS3h-69：
使用递减浓度之抗原(第1轮100nM；第2轮10nM；第3轮1nM)针对经生物素标记之人类CD40单体(由BMS供应，每莫耳CD40 1.5莫耳生物素)与经生物素标记之人类CD40-Ig(由BMS供应，每莫耳CD40-Ig 3.3莫耳生物素)并行进行三轮选择。在起始选择之前，如下组合来自未处理4G及6G Domantis dAb文库之噬菌体：
1)4G+6G VH CDR3长度在7至9个氨基酸之间。
2)4G+6G VH CDR3长度在10至12个氨基酸之间。
3)4G+6G VH CDR3长度在13至15个氨基酸之间。
4)4G VK
5)6G VK
各轮选择涉及将所要浓度之抗原添加至750μl来自未处理文库池之一之噬菌体或后续选择输出之噬菌体与750μl PBS+2％Marvel(含有2％(w/v)Marvel[Premier Foods,UK]之磷酸盐缓冲盐水)之混合物中且在室温下藉由翻滚混合来培育1小时。接着藉由添加100μl再悬浮M-280抗生蛋白链菌素[Invitrogen,UK]来捕捉经生物素标记之抗原噬菌体复合物，且在室温下藉由翻滚混合来培育5分钟。接着使用KingFisher磁力分离器[Thermo Fisher Scientific,UK]回收且用7×1ml PBS+0.1％吐温20(含有0.1％(v/v)聚氧乙烯脱水山梨糖醇单月桂酸酯[Sigma-Aldrich,UK]之PBS，PBST)，随后用1×1ml PBS洗涤。藉由与500μl胰蛋白酶-PBS(50μl溶解于50mM Tris-HCl(pH 7.4)、1mMCaCl2中之10mg/ml胰蛋白酶[Sigma-Aldrich,UK]添加至450μl PBS中)一起培育来溶离保留在经洗涤上之结合噬菌体。回收含有噬菌体之溶液，且在37℃下使用250μl感染1.75ml对数生长期大肠杆菌(E.coli)TG1(OD600为0.4)30分钟。在微量离心机中在11,600g下离心大肠杆菌TG1噬菌体感染之培养物1分钟。使所得细胞集结粒再悬浮于1ml 2xTY(1公升中有16g胰蛋白胨、10g酵母萃取物及5g NaCl，在121℃下用高压釜处理15分钟)中且接种于含有补充有15μg/ml四环素之TY的9cm皮式培养皿(Petri dish)上。在37℃下培育培养盘隔夜。接着将2ml补充有15％甘油之2xTY添加至各培养盘中，并用玻璃散布器分散该等细胞且充分混合。使用50μl刮落细菌接种50ml补充有15μg/ml四环素之2xTY，且在37℃下在250rpm振荡下生长隔夜。在3,300g下离心隔夜培养物15分钟以集结细菌。为了沉淀析出噬菌体，将10ml PEG/NaCl(20％聚乙二醇8000，2.5M NaCl)添加至40ml上清液中。混合噬菌体/PEG溶液且静置于冰上1小时，接着在4℃下在3,300g下离心30分钟，且去除上清液。使集结粒再悬浮于2ml PBS中且在微量离心机中在11,600g下离心10分钟，移除剩余细菌碎片。含有噬菌体之所得上清液接着用于下一轮针对适当经生物素标记之CD40抗原之选择。
在第2轮及第3轮选择之后，进行单株噬菌体ELISA。使用3次250μl PBST之洗涤，随后3次250μl PBS之洗涤执行所有洗涤。在4℃下，用每孔50μl 1μg/ml中性链亲和素(ThermoScientific,UK)于0.2M碳酸盐-碳酸氢盐缓冲液(pH 9.4)中之混合物涂布培养盘隔夜。洗涤培养盘，且接着在室温下用2％MPBS(含2％w/v Marvel脱脂奶粉[Premier Foods]之PBS)阻断1小时。接着洗涤培养盘且与每孔50μl 0.7μg/ml经生物素标记之人类CD40于2％MPBS中之混合物一起培育。洗涤培养盘，且将噬菌体上清液添加至等体积之2％MPBS中。接着在室温下培育培养盘1小时。洗涤培养盘且用用2％MPBS以1:5000稀释之抗M13-HRP结合物(GEHealthcare,UK)侦测结合噬菌体，且在室温下培育1小时。洗涤培养盘，且使用SureBlue单组分TMB MicroWell过氧化酶溶液(KPL Inc,USA)进行ELISA显色。藉由与涂有中性链亲和素但无生物素标记CD40之培养盘相比较来鉴别特异性噬菌体。使用MidiPrep自pDOM4(Domantis)第2轮及第3轮输出分离dAb V-基因，且选殖至pDOM5(Domantis)中。WO 2007/085815中所揭示之pDOM4为Fd噬菌体载体之衍生物，其中基因III信号肽序列经酵母醣脂锚定表面蛋白(yeast glycolipid anchored surface protein，GAS)信号肽置换(WO 2005/093074)。pDOM4亦在前导序列与基因III之间含有c-myc标签，此将基因III放回框架中。
如下鉴别结合dAb。在37℃下，在Costar 96孔细胞培养集群(CorningIncorporated,USA)中在250rpm振荡下自各输出选取96个个别菌落(于pDOM5中)至200μL含有OnEx自体诱导介质(Novagen,UK)之Terrific培养液中隔夜。离心培养物以集结细胞，且藉由CD40结合dAb之抗原结合ELISA分析上清液。在4℃下用每孔50μl 1μg/ml中性链亲和素于0.2M碳酸盐-碳酸氢盐缓冲液(pH 9.4)中之混合物涂布MaxiSorp 96孔免疫培养盘(Nunc,USA)隔夜。所有洗涤系如噬菌体ELISA所述。在室温下用200μl含有1％吐温20之PBS阻断培养盘1小时。接着洗涤培养盘且与每孔50μl 0.7μg/ml经生物素标记之人类CD40于0.1％MPBS中之混合物一起培育。将澄清之含有dAb之培养物上清液添加至具有等体积0.1％PBS之TELISA培养盘中。在室温下培育培养盘1小时且接着洗涤。使用两步方法侦测结合dAb：首先在室温下添加用0.1％PBST以1:2000稀释之9E10(抗myc IgG，Sigma-Aldrich,UK)持续1小时，接着洗涤，随后在室温下添加用0.1％PBST以1:2000稀释之抗小鼠Fc-HRP(Sigma-Aldrich,UK)持续1小时。洗涤培养盘，且使用SureBlue单组分TMB MicroWell过氧化酶溶液(KPL Inc,USA)进行ELISA显色。允许显色，且藉由添加等体积1M HCl中止比色反应。在450nm下读取ELISA培养盘。藉由与涂有中性链亲和素但无生物素标记CD40之培养盘相比较来鉴别特异性噬菌体。
在基于珠粒或基于ELISA之受体结合分析(receptor-binding assay，RBA)中测试对CD40具特异性之克隆以评估CD40配位体结合之抑制。在B细胞增殖分析中，且接着在多种其他活体外细胞分析中测试在RBA中显示抑制作用之域抗体。下文更详细描述此等分析。
BMS3h-106至BMS3h-225：
BMS3h-106至BMS3h-225系自针对如关于BMS3h-1至BMS3h-69所述但具有以下修饰之生物素标记CD40或生物素标记CD40-Fc之选择来分离。在起始选择之前，如下组合来自未处理4G及6G文库之噬菌体：
6)4G VH CDR3长度在7至9个氨基酸之间。
7)4G VH CDR3长度在10至12个氨基酸之间。
8)4G VH CDR3长度在13至15个氨基酸之间。
9)6G VH CDR3长度在7至9个氨基酸之间。
10)6G VH CDR3长度在10至12个氨基酸之间。
11)6G VH CDR3长度在13至15个氨基酸之间。
12)4G VK
13)6G VK
对于CD40-Fc在160nM之抗原浓度下执行第1轮，且对于CD40在100nM下执行。输出效价在2.0×104至9.0×107TU/ml之范围内(功能病毒效价)。
对于第2轮，来自第1轮之富集噬菌体在用于选择之前被成对组合：
1)4G+6G VH CDR3长度在7至9个氨基酸之间(来自第1轮之池1+池4)。
2)4G+6G VH CDR3长度在10至12个氨基酸之间(来自第1轮之池2+池5)。
3)4G+6G VH CDR3长度在13至15个氨基酸之间(来自第1轮之池3+池6)。
4)4G+6G VK(来自第1轮之池7+池8)
在100nM之抗原浓度下进行选择，且使用与中性链亲和素(Thermo FisherScientific,UK)偶合之M-280甲苯磺酰基活化(Invitrogen)捕捉抗原-噬菌体复合物。输出效价在6.5×107TU/ml至7.5×108TU/ml之范围内。
在20nM之抗原浓度下且在CD40-Fc选择之情况下，在6.7μM游离人类Fc尾(BMS)存在下执行第3轮。输出效价在4.3×107TU/ml至1.6×109TU/ml之范围内。
如关于第2轮所述但在2nM之抗原浓度下且在存在及不存在500倍过量未标记CD40-Fc之情况下执行第4轮。在最初使噬菌体与生物素标记抗原一起培育1小时之后添加此竞争剂，且接着如前所述培育混合物隔夜。包括此竞争步骤，目的在于增强对具有较慢解离速率之dAb之选择。在无竞争之情况下输出效价在1.8×107TU/ml至4.4×107TU/ml之范围内，且在有竞争之情况下在1.8×106TU/ml至2.3×107TU/ml之范围内。
为了监测选择之进展，在第2轮及第3轮之后进行单株噬菌体ELISA。如关于BMS3h-1至BMS3h-69所述执行此等操作。如关于BMS3h-1至BMS3h-69所述鉴别结合dAb，其中例外为在VK文库筛检之情况下，包括最终浓度为0.8μg/ml之蛋白质L。添加蛋白质L会藉由使dAb交联而增加信号强度。
BMS3h-70至BMS3h-105：
BMS3h-70至BMS3h-105系自针对已被动吸附至免疫管之抗原的选择来分离。在起始选择之前，如下组合来自未处理4G及6G Domantis dAb文库之噬菌体：
1)4G VH CDR3长度在7至9个氨基酸之间。
2)4G VH CDR3长度在10至12个氨基酸之间。
3)4G VH CDR3长度在13至15个氨基酸之间。
4)6G VH CDR3长度在7至9个氨基酸之间。
5)6G VH CDR3长度在10至12个氨基酸之间。
6)6G VH CDR3长度在13至15个氨基酸之间。
7)4G VK
8)6G VK
对于第一轮选择，将1ml 10μg/ml人类CD40-Fc融合物(BMS)于0.2M碳酸盐-碳酸氢盐缓冲液(pH 9.4)中之混合物添加至Nunc MaxiSorp免疫管中且接着在4℃下，在滚动下培育隔夜。接着排空该管且用磷酸盐缓冲盐水(PBS)洗涤三次。接着藉由用MPBS填充至满且在室温下培育1小时来阻断该管。接着排空该管且用PBS洗涤三次。将含文库噬菌体之4mlMPBS添加至该管中且在室温下，在旋转翻滚下培育1小时。
排空该管且用PBST(具有0.1％(v/v)吐温20之PBS)洗涤10次。在室温下，藉由在旋转翻滚下与500μl胰蛋白酶-PBS(50μl溶解于50mM Tris-HCl(pH7.4)、1mM CaCl2中之10mg/ml胰蛋白酶[Sigma-Aldrich,UK]添加至450μl PBS中)一起培育10min来溶离保留在经洗涤管上之结合噬菌体。回收含有噬菌体之溶液，且在37℃下使用250μl感染1.75ml对数生长期大肠杆菌TG1(OD600为0.4)30分钟。在微量离心机中在11,600g下离心大肠杆菌TG1噬菌体感染之培养物1分钟，且使所得细胞集结粒再悬浮于1ml 2xTY(1公升中有16g胰蛋白胨、10g酵母萃取物及5g NaCl，该悬浮液在121℃下以高压釜处理15分钟)中且接种于含有补充有15μg/ml四环素之LB琼脂之9cm皮式培养皿中。在37℃下培育培养盘隔夜。接着将2ml补充有15％甘油之2xTY添加至各培养盘中，且用玻璃散布器分散该等细胞且充分混合。
使用50μl刮落细菌接种50ml补充有15μg/ml四环素之2xTY，且在37℃下在250rpm振荡下生长隔夜。在3,300g下离心隔夜培养物15分钟以集结细菌。为了沉淀析出噬菌体，将10ml PEG/NaCl(20％聚乙二醇8000，2.5M NaCl)添加至40ml上清液中。混合噬菌体/PEG溶液且静置于冰上1小时。接着在4℃下在3,300g下离心溶液30分钟，且去除上清液。使集结粒再悬浮于2ml PBS中且在微量离心机中在11,600g下离心10分钟，移除剩余细菌碎片。含有噬菌体之所得上清液接着用于下一轮针对CD40-Fc抗原之选择。第1轮之输出效价在7.5×104TU/ml至1.5×107TU/ml之范围内(每毫升之感染单位)。
使用自第一轮选择回收之富集噬菌体执行第二轮选择。如上所述精确执行此操作且输出效价在2.5×107TU/ml至1.2×108TU/ml之范围内。
使用自第二轮选择回收之富集噬菌体执行第三轮选择。如上所述但在1μg/ml之抗原浓度下执行此等操作。输出效价在5.1×107TU/ml至7.5×108TU/ml之范围内。
为了监测选择之进展，在第2轮及第3轮之后进行单株噬菌体ELISA。将个别菌落之样品选取至200μL补充有15μg/ml四环素之2xTY中，且在37℃下，在Costar 96孔细胞培养集群(Corning Incorporated,USA)中在250rpm振荡下培育隔夜。离心培养物以集结细胞，且藉由CD40结合噬菌体dAb之抗原结合ELISA分析上清液。使用3次250μl PBST之洗涤，随后3次250μl PBS之洗涤执行所有洗涤。在4℃下用每孔50μl 0.5μg/ml CD40-Fc(BMS)于0.2M碳酸盐-碳酸氢盐缓冲液(pH 9.4)中之混合物涂布MaxiSorp 96孔免疫培养盘(Nunc,USA)隔夜。洗涤培养盘，且接着在室温下用250μl 2％MPBS阻断1小时。洗涤培养盘，且将噬菌体上清液添加至等体积2％MPBS中且在室温下培育1小时。洗涤培养盘且用用2％MPBS以1:5000稀释之抗M13-HRP结合物(GE Healthcare,UK)侦测结合噬菌体，且在室温下培育1小时。洗涤培养盘，且使用SureBlue单组分TMB MicroWell过氧化酶溶液(KPL Inc,USA)进行ELISA显色。藉由与涂有游离Fc之培养盘相比较来鉴别特异性噬菌体dAb。
将来自以上第2轮及第3轮选择输出中之每一者之dAb基因以池形式次选殖至大肠杆菌菌株HB2151中之可溶性表现载体pDOM5中。此载体允许在大肠杆菌中表现具有c-myc标签之游离dAb(Roche Diagnostics GmbH)且分泌至上清液中。
如下鉴别来自被动选择之CD40结合dAb。在37℃下，在Costar 96孔细胞培养集群(Corning Incorporated,USA)中在250rpm振荡下自各输出选取96个个别菌落(于pDOM5中)至200μL含有OnEx自体诱导介质(Novagen,UK)之Terrific培养液中隔夜。离心培养物以集结细胞，且藉由CD40结合dAb之抗原结合ELISA分析上清液。在4℃下用每孔50μl 0.5μg/mlCD40-Fc(BMS)于0.2M碳酸盐-碳酸氢盐缓冲液(pH 9.4)中之混合物涂布MaxiSorp 96孔免疫培养盘(Nunc,USA)隔夜。所有洗涤系如噬菌体ELISA所述。在室温下用250μl含有1％吐温20之PBS(PBST)阻断培养盘1小时。将澄清之含有dAb之培养物上清液添加至具有等体积0.1％PBST之ELISA培养盘中。在室温下培育培养盘1小时且接着洗涤。使用两步方法侦测结合dAb：首先在室温下添加用0.1％PBST以1:5000稀释之生物素标记9E10(抗myc IgG，Sigma-Aldrich,UK)持续1小时，接着洗涤，随后在室温下添加用0.1％PBST以1:5000稀释之抗生蛋白链菌素-HRP(Bender MedSystems,Austria)持续1小时。洗涤培养盘且使用SureBlue单组分TMB进行ELISA显色。藉由与涂有游离Fc之培养盘相比较来鉴别特异性dAb。
在基于珠粒或基于ELISA之受体结合分析(RBA)中测试对CD40具特异性之克隆以评估CD40配位体结合之抑制。表5中给出自RBA获得之效能量测(初步筛检工作)。在B细胞增殖分析中，且接着在多种其他活体外细胞分析中测试在RBA中显示抑制作用之域抗体。
BMS3h-210至BMS3h-225
BMS3h-210至BMS3h-225系自针对完整细胞之选择来分离。在起始选择之前，如下组合来自未处理4G及6G Domantis dAb文库之噬菌体：
1)4G+6G VH CDR3长度在7至9个氨基酸之间。
2)4G+6G VH CDR3长度在10至12个氨基酸之间。
3)4G+6G VH CDR3长度在13至15个氨基酸之间。
4)4G and 6G VK
在第1轮中，将用细胞表面表现之人类CD40(由BMS供应)稳定转染之DG44CHO细胞株用作抗原。在针对此等细胞作选择之前，使上文所述之文库池与未经转染之CHO细胞一起培育以去除其对除CD40以外之细胞表面抗原具特异性之噬菌体呈现dAb。藉由在评估存活力之前与凡尔生(Versene)(Invitrogen)一起培育来收集两种类型之细胞。使六百万个活的未经转染之CHO细胞再悬浮于4ml具有2％(w/v)BSA之PBS(PBS/BSA)中且在4℃下旋转翻滚1小时以进行阻断。除非另外说明，否则在4℃下执行所有后续步骤。在185g下离心细胞5分钟，且将含有经去除之文库噬菌体之上清液转移至新鲜管中。向此管中添加含6×106个活CHO-CD40细胞之1ml PBS/BSA，且旋转混合物1小时。接着藉由在185g下离心5分钟来洗涤该等细胞5次，且再悬浮于10ml PBS/BSA中。在最终洗涤后，如先前集结细胞且接着再悬浮于0.5ml 1mg/ml牛胰腺之XIII型胰蛋白酶(Sigma Aldrich,UK)于补充有5mM Tris-HCl(pH7.4)、0.1mM CaCl2之PBS中的混合物中，且转移至微量离心管中。在室温下旋转细胞10分钟，随后在16000g下离心5分钟。使用上清液中之溶离之噬菌体感染大肠杆菌，且输出噬菌体效价经测定在5.1×105TU/ml与2.7×106TU/ml(每毫升之感染单位)之间。
使用自第一轮选择回收之富集噬菌体执行第二轮选择。如上所述但无初始去除(去选择)步骤且使用RAMOS人类B细胞(ATCC)替代CHO-CD40来执行此等操作。输出效价在2.3×105TU/ml至7.5×105TU/ml之范围内。
如第二轮般执行第三轮选择。输出效价在1.9×108TU/ml至3.5×108TU/ml之范围内。
将来自以上第2轮及第3轮选择输出中之每一者之dAb基因以池形式次选殖至大肠杆菌菌株HB2151中之可溶性表现载体pDOM5中。此载体允许在大肠杆菌中表现具有c-myc标签之游离dAb且分泌至上清液中。
在CHO细胞受体结合分析(RBA)中测试对CD40具特异性之克隆以评估CD40配位体结合之抑制。在B细胞增殖分析中，且接着在多种其他活体外细胞分析中测试在RBA中显示抑制作用之域抗体。
藉由易错PCR进行亲和力成熟
构筑13个在下文实施例6中所述之B细胞增殖分析中显示中和活性之BMS3h dAb的易错噬菌体文库(参见表17)。此系藉由使用Mutazyme II聚合酶(来自AgilentTechnologies之GeneMorph II套组之一部分)在扩增期间藉由聚合酶链反应(PCR)将错误任意引入dAb基因中来执行。在GAS1前导序列控制下将突变dAb基因以与fd噬菌体基因III蛋白质之基因融合物形式选殖至pDOM4载体中，该载体含有为产生感染性噬菌体粒子所必需之所有fd基因。此等文库之尺寸为约1×108个CFU(菌落形成单位)，每个dAb基因之错误率为2至5个氨基酸。
使由此等文库产生之噬菌体经受三轮针对可溶性生物素标记人类CD40之选择。第一轮噬菌体选择系藉由将噬菌体文库与2％MPBS(补充有2％(w/v)Marvel干脱脂奶粉之磷酸盐缓冲盐水)预混合且添加生物素标记人类CD40(BMS)至最终浓度为于1ml之最终体积中20nM来执行。在室温下，在翻滚混合下培育混合物至少1小时。接着使用50μl M-280抗生蛋白链菌素(Invitrogen)捕捉抗原-噬菌体复合物且用1ml PBST洗涤7次，随后用1ml PBS洗涤一次。藉由与0.5ml 1mg/ml来自牛胰腺之XIII型胰蛋白酶(Sigma Aldrich,UK)于补充有5mM Tris-HCl(pH 7.4)、0.1mM CaCl2之PBS中的混合物一起培育而自抗原/珠粒复合物溶离洗涤之噬菌体。使用溶离之噬菌体感染大肠杆菌，且输出噬菌体效价经测定在2×105TU/ml与9×107TU/ml(每毫升之感染单位)之间。
使用自第一轮选择回收之富集噬菌体用最终浓度之2nM生物素标记CD40执行第二轮选择，随后如上所述使用抗生蛋白链菌素珠粒捕捉。输出效价在3×104TU/ml至5×106TU/ml之范围内。
使用2nM生物素标记CD40进行第三轮选择，随后使用抗生蛋白链菌素珠粒捕捉。溶离之噬菌体效价在8×104TU/ml至4×106TU/ml之范围内。
BIAcoreTM筛检
将来自以上第3轮选择输出各自之dAb基因以池形式次选殖至大肠杆菌HB2151中之可溶性表现载体pDOM13(Domantis)中。pDOM13载体亦称为pDOM33且揭示于WO/2008/149143中。此载体允许在大肠杆菌中表现游离dAb且分泌至上清液中。在37℃下，在Costar96孔细胞培养集群(Corning Incorporated,USA)中在250rpm振荡下自各输出选取47个个别菌落且在200μl含有Novagen隔夜表现自体诱导介质(Merck Chemicals,UK)之Terrific培养液(TB)中表现隔夜。在相同培养盘中，用表现适当亲本(野生型)dAb之大肠杆菌接种单一孔。离心培养物以集结细胞，且用BIAcoreTM 3000仪器(GE Healthcare)筛检上清液与亲本dAb相比“解离速率”(亦即解离速率常数，kd)之改良。
将约1600个反应单位(RU)之生物素标记人类CD40(BMS)固定于抗生蛋白链菌素(SA)BIAcoreTM芯片之一个流槽上。将未固定有任何配位体之第二流槽用作参比流槽进行线内参比。用HBS-EP缓冲液(具有0.15M NaCl、3mM EDTA及0.005％v/v界面活性剂P20之0.01MHEPES(pH 7.4)，GE Healthcare)以1:3稀释各待分析之dAb上清液。使用仪器之KINJECT功能将10微升各dAb上清液注射于串联之固定CD40之流槽及参比流槽上，线内减去来自参比槽之信号。在25℃及10μl/min之HBS-EP流速下执行实验。各注射完成后，允许在缓冲液中自配位体解离dAb 120秒，随后由注射5μl 10mM甘氨酸(pH 2.0)而再生。使用BIAevaluation4.1软件(GE Healthcare)自各分析物迹线减去参比流槽迹线。使用同一软件来近似拟合分析物迹线之解离阶段的1:1(朗缪尔(Langmuir))动力学模型。此模型产生各克隆之近似解离速率常数(“解离速率”或kd)且允许与野生型dAb进行相对比较。
鉴别除BMS3h-129及BMS3h-197外之所有谱系的解离速率改良之克隆。如上所述，在基于珠粒或基于ELISA之受体结合分析(RBA)中测试解离速率改良之克隆以对效能之改良进行评估。在标注为“易错成熟之克隆”的表中给出由RBA获得之效能量测结果。随后在B细胞增殖分析中测试在RBA中更有效之克隆以评估生物效能之提高，且表17中给出所获得之此等量测结果。亦在多种其他活体外细胞分析中测试在B细胞增殖分析中效能改良之域抗体。
藉由三联体扫描多样化进行亲和力成熟
选择自易错成熟分离的5种效能改良之dAb，亦即BMS3h-37-2、BMS3h-38-2、BMS3h-56-2、BMS3h-193-25及BMS3h-217-23，以藉由三重扫描多样化进一步亲和力成熟。基于如上针对易错文库所述之此等亲本构筑噬菌体文库，其中例外为替代使用易错PCR，使用一系列重迭简并三联寡核苷酸来多样化各dAb之互补决定(CDR)区。对于待亲和力成熟之各dAb，使用含有NNS密码子三联体之寡核苷酸(参见Arkin等人(1992)Proc.Nat'l Acad.Sci.USA89:7811-7815)藉由重迭延伸拼接(slicing by overlap extension，SOE)PCR制得各CDR之许多文库。利用寡核苷酸针对两个密码子重迭之既定CDR使三联体多样化，每个CDR产生2至4个文库。BMS3h-37-2文库中多样化之氨基酸残基在位置30、31、32、33、35、50、52、53、55、56、95、96、97及98(Kabat编号)。BMS3h-38-2文库中多样化之残基如同BMS3h-37-2一般，但添加了位置100。BMS3h-56-2文库中多样化之残基如同BMS3h-37-2一般，但添加了位置100及101。BMS3h-193-25及BMS3h-217-23文库中多样化之残基在位置27、28、30、31、32、34、49、50、51、53、89、91、92、93、94及96。
由此等文库产生之噬菌体藉由CDR混合且如上所述执行选择，其中例外为对于BMS3h-37-2、BMS3h-38-2、BMS3h-56-2及BMS3h-193-25，第1轮、第2轮及第3轮所用抗原之浓度分别为10nM、1nM及0.1nM。对于BMS3h-217-23，第1轮、第2轮及第3轮之所用抗原之浓度分别为20nM、2nM及0.2nM。对于对猕猴CD40具交叉反应性之BMS3h-193-25，亦并行地针对猕猴CD40执行选择。另外，分别在存在或不存在100倍或1000倍过量之未标记CD40之情况下执行第2轮及第3轮选择。在最初使噬菌体与生物素标记抗原一起培育1小时之后添加此竞争剂，且接着如前所述再培育混合物1小时。包括此竞争步骤，目的在于增强对具有较慢解离速率之dAb之选择。第1轮效价在1.4×106至1.4×109之范围内。在无竞争之情况下第2轮之效价为1.3×105至4.0×108，且在有竞争之情况下为8.6×104至1.3×108。在无竞争之情况下第3轮中之效价为1.2×105至1.9×108，且在有竞争之情况下为6.0×105至1.2×108。
如关于易错亲和力成熟所述次选殖且筛检此等选择输出。鉴别除BMS3h-193-25外之所有谱系的解离速率改良之克隆。在ELISA受体结合分析(RBA)中测试解离速率改良之克隆以对效能改良进行评估。在标注为“进一步成熟之克隆”的表中给出由RBA获得之效能量测结果。随后在B细胞增殖分析中测试在RBA中更有效之克隆以评估生物效能之提高，且表17中给出所获得之此等量测结果。亦在多种其他活体外细胞分析中测试在B细胞增殖分析中效能改良之域抗体。
实施例2
使用受体结合分析(RBA)进行筛检
使用若干活体外受体结合分析(RBA)测定实施例1中产生之抗人类CD40可变域氨基酸序列之CD40亲和力。使用三种RBA格式：(1)珠粒RBA、(2)ELISA RBA及(3)CHO细胞RBA。
珠粒RBA：
经磷酸盐缓冲盐水(PBS)洗涤之Sphero抗生蛋白链菌素聚苯乙烯粒子(SaxonEurope,UK)用0.5μg/ml生物素标记人类IZ-CD40L(BMS)涂布。涂布之后，用PBS洗涤生物素标记CD40L粒子且用含0.1％(w/v)胎牛血清白蛋白(BSA)(Sigma-Aldrich,UK)之PBS分析缓冲液以1:10稀释。在384孔透明底黑色壁培养盘(Applied Biosystems)中，等量组合稀释范围之纯化dAb、0.25μg/ml人类CD40(BMS,CY24FEB06-01)、1/5000小鼠抗人类IgG(Fc)mAb克隆GG-7(Sigma-Aldrich,UK)、0.25μg/ml山羊抗小鼠ALEXA Fluor 647(Invitrogen,Molecular probes,UK)及生物素标记CD40L聚苯乙烯粒子且在无光存在下在室温下培育6小时。培育之后，使用相对荧光用AB8200细胞侦测机制(Applied Biosystems)评估dAb相对于人类CD40与生物素标记CD40L粒子之竞争性结合。
ELISA RBA：
在4℃下用25μl 1μg/ml中性链亲和素于0.2M碳酸盐碳酸氢盐缓冲液(pH 9.4)中之混合物涂布透明壁高结合384孔培养盘(Corning,UK)隔夜。第二天，用0.1％(v/v)吐温PBS缓冲液洗涤分析培养盘，在室温下用含1％(w/v)BSA之PBS阻断1小时且再次洗涤。在移除过量洗涤缓冲液之后，在室温下使25μl 1μg/ml生物素标记人类IZ-CD40L(BMS)与该等分析培养盘一起培育1小时。同时，稀释范围之纯化dAb与1μg/ml人类CD40(BMS,CY24FEB06-01)以1:1之比率复合。在洗涤分析培养盘之后，在室温下，在轻微搅动下，在分析培养盘中培育dAb:人类CD40复合物2小时。在1/5000小鼠抗人类IgG(Fc)mAb克隆GG-7(Sigma-Aldrich,UK)，随后1/10,000辣根过氧化物酶(horse radish peroxidase，HRP)结合之山羊抗小鼠IgG(Fc)第二侦测抗体(Sigma-Aldrich,UK)相继培育下，侦测dAb相对于人类CD40与生物素标记CD40L之竞争性结合。在用1M HCl溶液中和之后，使用SpectraMax M5e培养盘读取器(Molecular Devices)在450nm下量测吸亮度信号。
细胞分析：CD40 CHO细胞RBA：
使用凡尔生(Invitrogen)自细胞培养烧瓶分离稳定转染之表现人类CD40之CHO-DG44细胞或天然CHO-DG44细胞(皆为BMS)。将每孔4万个细胞于具有稀释范围之dAb、0.25μg/ml生物素标记人类IZ-CD40L(BMS)及0.25μg/ml抗生蛋白链菌素Alexa Fluor 647(Invitrogen,Molecular probes,UK)之0.1％(w/v)BSA PBS分析缓冲液中接种至96孔高结合黑色壁透明底培养盘(Corning,UK)中。在无光存在下培育混合物6小时。培育之后，使用相对荧光用AB8200细胞侦测机制(Applied Biosystems)评估dAb相对于人类CD40 CHO细胞与可溶性生物素标记IZ-CD40L之竞争性结合。
表5至表7分别显示测试之抗人类CD40 dAb之初步筛检工作(“未处理克隆”)及后续各轮亲和力成熟(“易错成熟之克隆”及“进一步成熟之克隆”)的结果。
表5
初步筛检工作：
表5
初步筛检工作：
表6
易错成熟之克隆：
表7
进一步成熟之克隆：
实施例3
CD40结合动力学
测定初步筛检工作(“未处理克隆”)及后续各轮亲和力成熟(“易错成熟之克隆”)中所鉴别之抗人类CD40 dAb的结合动力学。所用之方法直接量测dAb对CD40之亲和力。
使用BIAcoreTM 3000仪器(GE Healthcare)分析CD40特异性dAb与CD40之结合动力学。将约600个反应单位(RU)之生物素标记人类CD40(BMS)固定于抗生蛋白链菌素(SA)BIAcoreTM芯片之一个流槽上。将未固定有任何配位体之第二流槽用作参比流槽进行线内参比。用HBS-EP缓冲液(具有0.15M NaCl、3mM EDTA及0.005％v/v界面活性剂P20之0.01MHEPES(pH 7.4)，GE Healthcare)制备一系列适当二倍稀释之各待分析之dAb。使用仪器之KINJECT功能一式两份注射180μl各dAb。将各dAb注射于串联之固定CD40之流槽及参比流槽上，线内减去来自参比槽之信号。在25℃及30μl/min之HBS-EP流速下执行实验。在各注射完成后，允许在缓冲液中自配位体解离dAb 300秒，随后由注射10μl 10mM甘氨酸(pH 2.0)而再生。亦在相同条件下注射HBS-EP缓冲液空白参比注射剂(不包含分析物)，以用作自各分析物迹线减去之第二参比。使用BIAevaluation 4.1软件(GE Healthcare)自各分析物迹线减去参比流槽迹线与缓冲液空白迹线。使用同一软件同时整体拟合分析物稀释液系列迹线之缔合及解离阶段的1:1(朗缪尔)动力学模型。此模型产生相互作用之缔合及解离速率常数(分别为ka及kd)及平衡解离常数(KD)；此等常数详示于表8及表9中。
表8
未处理克隆：
表9
易错成熟之克隆：
实施例4
生物物理表征
藉由生物物理参数之分析进一步表征初步筛检工作(“未处理克隆”)及后续各轮亲和力成熟(“易错成熟之克隆”及“进一步成熟之克隆”)中所鉴别之抗人类CD40 dAb。为了量测dAb之相对稳定性，藉由差示扫描热量测定法(differential scanning calorimetry，DSC)测定其熔点。具有较高熔融温度之dAb更稳定。为了测定dAb是否在溶液中形成多聚聚集体，藉由尺寸排阻层析法/多角雷射光散射(size exclusion chromatography/multiangle laser light scattering，SEC-MALLS)分析dAb。结果示于表10至表12中。
表10
未处理克隆：
表11
易错成熟之克隆：
表12
进一步成熟之克隆：
实施例5
竞争分析
使用BIAcoreTM 3000仪器(GE Healthcare)分析CD40特异性dAb是否结合相同CD40抗原决定基。将约600个反应单位(RU)之生物素标记人类CD40(BMS)固定于抗生蛋白链菌素(SA)BIAcoreTM芯片之一个流槽上。将未固定有任何配位体之第二流槽用作参比流槽进行线内参比。用HBS-EP缓冲液(具有0.15M NaCl、3mM EDTA及0.005％v/v界面活性剂P20之0.01MHEPES(pH 7.4)，GE Healthcare)制备适当稀释之各待分析之dAb或Fab。所选稀释液为在如下文所述注射时对于特定抑制剂(典型地为1μM至10μM)产生>80％之最大可能结合RU的稀释液。接着，制备与上文(在相同最终浓度下)相同之dAb或Fab与待进行竞争分析之第二dAb或Fab的混合物。使用仪器之COINJECT功能将60μl单一抑制剂稀释液注射于串联之固定CD40之流槽及参比流槽上，随后立即注射60μl两抑制剂混合物。藉由仪器之控制软件线内减去来自参比槽之信号。在25℃及30μl/min之HBS-EP流速下执行实验。各次共注射完成后，允许在缓冲液中自配位体解离抑制剂60秒，随后由注射10μl 10mM甘氨酸(pH 2.0)而再生。记下获得之第二注射剂(两抑制剂之混合物)之最大RU且表示为单独注射时获得之相同抑制剂的RU之百分比。
若第二抑制剂保留在单独注射其时通常结合之RU的至少100％，则此表示两种抑制剂结合至个别抗原决定基。若观测到第二抑制剂之结合小于100％，则此指示两种抑制剂之间结合至CD40的竞争。此竞争存在若干可能原因：两种抑制剂可结合至同一或重迭抗原决定基，可能存在结合之空间抑制，或第一抑制剂之结合可能诱发能阻止或减少第二抑制剂结合之抗原构形变化。
测试来自各谱系之实施例克隆(BMS3h-217除外)与重迭群组中之其他dAb之竞争。如表13及表14中所示，所有所测试之dAb似乎会彼此竞争结合于CD40。此数据表明所有选自由谱系BMS3h-37、BMS3h-38、BMS3h-41、BMS3h-43、BMS3h-56、BMS3h-131、BMS3h-198及BMS3h-202组成之群的抗体多肽应与来自任一此等谱系之dAb与人类CD40的结合竞争。
表13
竞争BIAcoreTM：
表14
类似地，如表15及表16中所示，测试各种dAb与Chi220Fab'之竞争。在此情况下，所有dAb不与Chi220Fab'竞争，其中例外为BMS3h-217，其显示竞争。在结合之Chi220或G28-5Fab'存在下，BMS3h-56-5及BMS3h-193-12 dAb以至少100％之单一dAb RU结合，从而表明Fab'结合与dAb不同之抗原决定基。Chi220 Fab'显示在G28-5存在下结合RU降低。在相反次序之结合中观测到相同之结果。此表明G28-5 Fab'结合与Chi220 Fab'相同之抗原决定基。
表15
表16
实施例6
CD40活性分析
功能上分析抗人类CD40 dAb拮抗CD40活性之能力。所测试之CD40活性为藉由hCD40L驱动之初级人类单核细胞衍生之树突状细胞(dendritic cells，DC)活化进行之B细胞增殖及细胞激素产生。除非另外说明，否则所有分析均在补充有10％胎牛血清(fetalcalf serum，FCS)之RPMI培养基中执行。使用各种分析得到之结果示于表17中。
可溶性IZ-hCD40L驱动之初级人类B细胞增殖：
在96孔圆底培养盘中以每孔200μl之最终体积用0.6μg/ml IZ-hCD40L以及不同滴定量之抗体多肽培育1×105个扁桃体人类B细胞。在37℃下培育培养盘72小时，接着添加胸腺嘧啶核苷(3H；0.5μci/孔)6小时。基于胸腺嘧啶核苷并入法定量B细胞增殖。
CHO-hCD40L驱动之初级人类B细胞增殖：
用人类CD40L转染CHO细胞以产生以较高CD40L表现程度表现于细胞表面上之稳定细胞株。以10,000拉德(Rad)照射CHO-CD40L细胞，随后用人类B细胞培育。在96孔圆底培养盘中以每孔200μl之最终体积用1×103个CHO-CD40L细胞(CHO-CD40L:人类B细胞之比率为1:100)以及不同滴定量之抗体多肽培育1×105个扁桃体人类B细胞。在37℃下培育培养盘72小时，随后添加3H-胸腺嘧啶核苷(0.5μci/孔)6小时。基于胸腺嘧啶核苷并入法定量B细胞增殖。
可溶性IZ-hCD40L驱动之猕猴脾人类B细胞增殖：
在96孔圆底培养盘中以每孔200μl之最终体积用0.5μg/ml IZ-hCD40L以及不同滴定量之抗体多肽培育1×105个猕猴脾B细胞。在37℃下培育培养盘72小时，随后添加3H-胸腺嘧啶核苷(0.5μci/孔)6小时。基于胸腺嘧啶核苷并入法定量B细胞增殖。
初级T细胞驱动之人类B细胞增殖：
自人类周边血液单核细胞(peripheral blood mononuclear cells，PBMC)分离T细胞且使用绵羊红血球(sheep red blood cell，SRBC)花结法富集。藉由将扁桃体组织均质化于单细胞悬浮液中分离人类扁桃体B细胞。藉由菲科尔分离(ficoll separation)获得白血球，接着使用SRBC花结法被动选择B细胞且藉由去除花结细胞来富集。
在37℃下用PM-LCL(EBV转化B细胞株；以10,000拉德照射)以5:1之比率(T:LCL)培养富集人类T细胞6天以产生同种异体T细胞群。在第6天，分离扩增之T细胞且以3000拉德照射，且接着在涂有抗CD3 mAb(OKT3)之96孔平底培养盘中，用初级人类扁桃体B细胞(每孔1×105个B细胞)以1:2之比率培养(每孔5×104个T细胞)。将不同滴定量之抗体多肽添加至各孔中；各孔之最终体积为200μl。在37℃下培育测试培养盘3天。在最后18小时内经由添加3H-胸腺嘧啶核苷(0.5μci/孔)至培养物中测定人类B细胞增殖。
CHO-hCD40L驱动之初级人类单核细胞衍生之树突状细胞(DC)活化：
藉由经由SRBC花结法去除T细胞来使人类PBMC富集单核细胞。在37℃，下在6孔培养盘中用10ng/ml GM-CSF及5ng/ml IL-4培养富集单核细胞之PBMC 6天。在第2天及第5天用新鲜培养基(具有GM-CSF及IL-4)补充所培养之培养盘。在细胞分析中在第6天使用未成熟树突状细胞(DC)。在96孔平底培养盘中，用4×103个CHO-hCD40L细胞(以10,000拉德照射)以及不同滴定量之抗体多肽培养8×104个未成熟DC。24小时后，收集上清液且测试各种细胞激素(IL-12、TNF、IL-23)之存在。DC活化藉由细胞激素之产生量来测定。
表17
实施例7
结合CD40及血清白蛋白之双特异性dAb
构筑特异性结合CD40及人类血清白蛋白(HSA)或猕猴血清白蛋白(CSA)之双特异性dAb且在基于细胞之分析中测试其活性。白蛋白特异性dAb称为“AlbudAb”。在此实施例中，AlbudAb融合物包含结合CD40之BMS3h dAb及识别HSA之另一域抗体DOM7h。将两种dAb在框架中融合至氨基酸连接子之胺基及羧基末端以形成串联融合(inline fusion，ILF)多肽。ILF多肽以重组方式表现为单一融合蛋白。表明AlbudAb ILF之活性的RBA描述于下文，且结果示于表18中。表19概述所测试AlbudAb ILF中所用之连接子序列。藉由BIAcoreTM分析测定之动力学结合数据示于表20中。
在上清液中侦测dAb之人类CD40 CHO细胞ELISA：
使用0.25％胰蛋白酶EDTA自细胞培养烧瓶分离稳定转染之表现人类CD40之CHO-DG44细胞或天然CHO-DG44细胞(皆为BMS)，且将每孔100,000个细胞于生长培养基中接种至96孔组织培养物处理之培养盘(NUNC)中。在37℃、5％CO2下，在湿润氛围中使细胞黏附隔夜。分析当天，用PBS洗涤细胞片，随后用2％三聚甲醛(Sigma-Aldrich)固定20分钟。固定之后，再用PBS洗涤细胞片，随后用含15％胎牛血清(FBS，PAA)之PBS阻断1小时。再洗涤培养盘一次，随后添加每孔100μl dAb上清液且在室温下培育2小时。用细胞培育dAb上清液之后，洗涤培养盘且视dAb为VH或VL域而定由培育辣根过氧化物酶(HRP)结合物抗蛋白质A或L来侦测dAb结合。在用1M HCl中和之后，使用SpectraMax M5e培养盘读取器(MolecularDevices)在450nm下量测吸亮度信号。
ICAM-1上调细胞分析：
使用凡尔生(Invitrogen)自细胞培养烧瓶分离稳定转染之表现人类CD40L之COS细胞。将每孔20,000个细胞于分析缓冲液(无酚红(Sigma-Aldrich,UK)+1％青霉素/链霉素+10％FBS Gold(皆来自PAA Laboratories,UK)之RPMI 1640)中接种至96孔高结合黑壁透明底培养盘(Corning,UK)中。在37℃及5％CO2下，在湿润氛围中使细胞黏附隔夜。第二天，用100μl新鲜分析缓冲液补充含有非附着细胞之废分析缓冲液。为此，除稀释范围之dAb之外，在分析缓冲液中添加每孔20,000个RAMOS细胞。将分析培养盘再放回37℃及5％CO2下之湿润氛围中24小时。对于阴性对照孔，不添加RAMOS细胞。dAb抑制RAMOS细胞之细胞表面上的ICAM-1响应暴露于COS细胞之细胞表面上的CD40L而上调之能力藉由添加0.5μg/ml小鼠抗人类ICAM-1抗体(R&D systems)及0.2μg/ml山羊抗小鼠ALEXA flour 647(Invitrogen,Molecular probes,UK)来评估。在无灯存在下3小时培育期之后，如由AB8200细胞侦测平台(Applied Biosystems)所量测来侦测相对荧光。
结合至血清白蛋白之串联融合(ILF)动力学分析
使用BIAcoreTM 3000仪器(GE Healthcare)分析抗CD40-AlbudAb ILF对人类及猕猴血清白蛋白之结合动力学。使用胺偶合套组(GE Healthcare)将约400反应单位(RU)之人类血清白蛋白(HSA)或猕猴血清白蛋白(CSA)固定于CM5 BIAcoreTM芯片之流槽上。将未固定有任何配位体之第二流槽用作参比流槽进行线内参比。用HBS-EP缓冲液(具有0.15M NaCl、3mM EDTA及0.005％v/v界面活性剂P20之0.01M HEPES(pH 7.4)，GE Healthcare)制备一系列适当二倍稀释之各待分析之dAb。使用仪器之KINJECT功能一式两份注射两种100微升各ILF。在串联之固定血清白蛋白之流槽及参比流槽上进行注射，线内减去来自参比槽之信号。在25℃及40μl/min之HBS-EP流速下执行实验。各注射完成后，允许在缓冲液中自配位体解离dAb 120秒，随后由注射10μl 10mM甘氨酸(pH 2.0)而再生。亦在相同条件下注射HBS-EP缓冲液空白参比注射剂(不包含分析物)，以用作自各分析物迹线减去之第二参比。使用BIAevaluation 4.1软件(GE Healthcare)自各分析物迹线减去参比流槽迹线与缓冲液空白迹线。使用同一软件同时整体拟合分析物稀释液系列迹线之缔合及解离阶段的1:1(朗缪尔)动力学模型。此模型产生相互作用之缔合及解离速率常数(分别为ka及kd)及平衡解离常数(KD)。参数值示于表20中。
表21列出可特异性结合CD40及HSA或CSA之代表性AlbudAb ILF之氨基酸序列。各ILF之名称鉴别特定连接符序列：“GxS”意谓连接符具有“x”个甘氨酸残基之后为丝氨酸，且“(GxS)y”意谓连接符具有y个GxS之重复单元。表22揭示编码表21中所列之ILF序列之代表性核酸。如此项技术中所熟知，多个密码子可编码同一氨基酸。因此，编码蛋白质序列之核酸包括具有密码简并性之核酸。
表21
双特异性dAb氨基酸序列
(表21揭示分别如SEQ ID NO 5至7、1207至1209及8所示之“AST”、“TVAAPS”、“TVA”、“G4S”、“(G4S)3”、“(G4S)5”及“ASTSGPS”)
表22
编码双特异性dAb之聚核苷酸
(表22揭示分别如SEQ ID NO 5至7、1207至1209及8所示之“AST”、“TVAAPS”、“TVA”、“G4S”、“(G4S)3”、“(G4S)5”及“ASTSGPS”)
实施例8
抗猕猴CD40 dAb
本文所揭示之产生特异性结合人类CD40之抗体多肽之方法可用以产生特异性结合其他物种之CD40之抗体多肽。举例而言，可使用目前揭示之方法产生抗猕猴CD40(anti-cynomolgus/anti-cyno)抗体多肽。举例而言，可使用相同之初始/初步筛检及亲和力成熟流程产生抗猕猴CD40抗体多肽，作为抗人类CD40 dAb。且以下表23中揭示获得抗猕猴CD40dAb之方法且提供抗猕猴CD40 dAb之代表性实施例。
ELISA RBA：
在4℃下，透明壁高结合384孔培养盘(Corning,UK)用25μl 1μg/ml中性链亲和素于碳酸盐缓冲液中之溶液涂布隔夜。第二天，用0.1％吐温PBS缓冲液洗涤分析培养盘，在室温下用含1％BSA之PBS阻断1小时，且再次洗涤。移除过量洗涤缓冲液之后，在室温下用分析培养盘培育25μl 1μg/ml生物素标记人类IZ-CD40L(BMS,1.2mg/ml储备液浓度)1小时。同时，稀释范围之纯化dAb与1μg/ml猕猴CD40(BMS)以1:1之比率复合。洗涤分析培养盘之后，在室温下，在轻微搅动下，在分析培养盘中培育dAb:猕猴CD40复合物2小时。用辣根过氧化物酶(HRP)结合之抗人类(Fc)二次抗体(Sigma-Aldrich,UK)侦测dAb相对于猕猴CD40与生物素标记CD40L之竞争性结合。在用1M HCl中和之后，在450nm下，使用Spectromax M5e培养盘读取器(Molecular Devices)量测吸亮度信号。
使用AB8200 FMAT之猕猴CD40 CHO细胞RBA：
使用凡尔生(Invitrogen)自细胞培养烧瓶分离稳定转染之表现猕猴CD40之CHO-DG44细胞或天然CHO-DG44细胞(BMS)。将每孔40,000个细胞于具有稀释范围之dAb、0.25μg/ml生物素标记人类IZ-CD40,000L(BMS，1.2mg/ml储备液浓度)及0.25μg/ml抗生蛋白链菌素Alexa Fluor 647(Invitrogen,Molecular probes,UK)之0.1％BSA PBS分析缓冲液中接种至96孔高结合黑色壁透明底培养盘(Corning,UK)中。在无光存在下培育混合物6小时。培育之后，如用AB8200细胞侦测平台(Applied Biosystems)所量测，使用相对荧光评估dAb相对于猕猴CD40 CHO细胞与可溶性生物素标记IZ-CD40L之竞争性结合。
CHO-hCD40L驱动之初级人类B细胞增殖：
用人类CD40L转染CHO细胞(ATCC)以产生以较高CD40L表现程度表现于细胞表面上之稳定细胞株。以10,000拉德照射CHO-CD40L细胞，随后用人类B细胞培育。在96孔圆底培养盘中以每孔200μl之最终体积用1×103个CHO-CD40L细胞(CHO-CD40L:人类B细胞之比率为1:100)以及不同滴定量之dAb或单株抗体培育1×105个扁桃体人类B细胞。在37℃下培育培养盘72小时，随后添加胸腺嘧啶核苷(3H；0.5μci/孔)6小时。基于胸腺嘧啶核苷并入法定量B细胞增殖。除非另外说明，否则所有分析均在补充有10％胎牛血清(FCS)之RPMI培养基中执行。
可溶性IZ-hCD40L驱动之猕猴脾B细胞增殖：
在96孔圆底培养盘中以每孔200μl之最终体积用0.5μg/ml IZ-hCD40L以及不同滴定量之dAb或mAb培育1×105个自食蟹猕猴脾脏分离之B细胞。在37℃下培育培养盘72小时，在此之后添加3H-胸腺嘧啶核苷(μci/孔)6小时。基于胸腺嘧啶核苷并入法定量B细胞增殖。除非另外说明，否则所有分析均在补充有10％胎牛血清(FCS)之RPMI培养基中执行。
表23
实施例9
抗人类CD40 dAb不结合猕猴CD40
如同人类CD40中，但猕猴CD40具有Leu109残基替代Trp109。以下复制长尾猕猴CD40之氨基酸序列：
使用流式细胞测量方法测试抗人类CD40 dAb与食蟹猕猴、恒河猴及黑猩猩血液中B细胞及来自狨猿血液之淋巴细胞之交叉反应性。以下详述之程序概述用于多个实验中侦测CD40 dAb之方法。表24中所示之结果表明抗人类CD40 dAb不结合猕猴CD40。此情况与上文所揭示之迹象(参见图1及图2)一致，人类CD40中之Trp109(猕猴CD40中不存在)对于dAb与人类CD40之间的复合物形成十分重要。
方法：
在37℃下用旋转器使聚乙二醇化抗人类CD40 dAb(BMS3h-56-5C-40L及BMS3h38-2C-P40Br)或生物素结合dAb(BMS3h38-2-生物素)与人类及灵长类动物血液样品一起培育1小时。将100μl各血液样品等分至12×75mm管中且用FACS缓冲液(0.5％FBS/PBS/0.1％迭氮化钠)洗涤3次。在1500rpm下将管离心5分钟，且在洗涤之间倾析上清液。洗涤之后，将管置于冰上且与人类IgG一起培育5分钟以经由Fc受体阻断非特异性结合。
对于聚乙二醇化dAb侦测，将抗PEG抗体(克隆CH-2074，Silver Lake Research，或克隆2-2，Open Biosystems)添加至管中且培育30分钟。用FACS缓冲液洗涤样品一次，接着在冰上用APC标记CD20抗体(克隆2H7，BD Biosciences)及PE标记抗小鼠IgG(具Fcγ1特异性；Calbiochem)再培育30分钟。
对于生物素结合dAb侦测，将PE标记抗生蛋白链菌素(Invitrogen)及APC标记CD20抗体(克隆2H7，BD Biosciences)添加至管中且在室温下培育30分钟。
另外，为量测人类及灵长类动物血液之CD40含量，在室温下用与灵长类动物物种(克隆5C3，BD Biosciences)交叉反应之APC标记CD20抗体(克隆2H7，BD Biosciences)及PE标记抗人类CD40抗体培育各血液样品之等分试样30分钟。
为在侦测抗体培育之后溶解红血球且固定白血球，将FACS溶解溶液(BDBiosciences)添加至所有管中，且在室温下培育样品15分钟。离心样品且再悬浮于FACS溶解溶液中，且经BD FACSCantoTM藉由流式细胞测量术分析，对CD20+B细胞设门进行分析。对于狨猿样品，CD20抗体不具有交叉反应性；因此对如前向及侧向散射特性(尺寸)所鉴别之所有淋巴细胞执行分析。
结果：
根据上文方法，在人类及灵长类动物血液样品中测试聚乙二醇化及生物素标记抗人类CD40 dAb之结合。侦测到抗人类CD40 dAb结合至人类血液样品中之CD20+B细胞。相反，在猕猴、恒河猴或黑猩猩血液样品中之CD20+B细胞上或在狨猿血液样品中之淋巴细胞上未侦测到聚乙二醇化及生物素标记dAb之结合。BMS3h-38-2C-P40Br dAb之结果示于图3画面A及画面B中。其他dAb获得类似结果。使用与灵长类动物CD40交叉反应之抗人类CD40抗体确定人类及灵长类动物物种之B细胞上CD40之可比含量。此等资料指示来自BMS3h-56及BMS3h-38谱系之人类CD40 dAb不能结合灵长类动物物种中之CD40。该等数据与CD40与抗CD40 dAb之间形成复合物中Trp109残基之重要性一致，如图1及图2中所示。
实施例10
CD40与dAb BMS3h-56-5之间的复合物之X射线结晶学
数据收集及处理：
在人类CD40(SEQ ID NO:1)/BMS3h-56-5(SEQ ID NO:321)复合物之结构测定期间分析两种不同晶体形式。自CD40/BMS3h56-5复合物之晶体收集数据，骤冷且维持于100K，且安装于Rigaku AFC-9测角器上。X射线源为使用具有MicroMaxTM共焦光学器件及Saturn 92侦测器之铜目标的Rigaku FR-E。在极高冗余度下收集数据以增加硫反常绕射信号，希望使用彼信号以使数据分阶段。用HKL2000处理数据(HKL Research；Otwinowski等人，InMethods Enzymol.Macromolecular Crystallography第A部分，Carter等人编，第276卷，第307-326页，Academic Press,Inc.,New York,NY(1997))。此晶体之数据收集统计概述于下文及表24中：
空间群：I222；
单位晶胞：
镶嵌度为0.59至0.84；排斥观测：1028；0.06％。
表24
由骤冷至100K且安装于Rayonix MX-225侦测器上之晶体在加拿大光源束线CMCF1(Canadian Light Source beamline CMCF1)(08-ID-1)下收集第二晶形，且波长为此等数据藉由夏姆洛克结构(Shamrock Structures)(R.Walter及G.Ranieri)收集且用HKL2000处理。此晶体之数据收集统计概述于下文及表25中：
空间群：C2；
单位晶胞：β＝118.2°；
镶嵌度为0.62至0.71；排斥观测：70；0.08％。
表25
分子置换模型：
dAb之模型BMS3h-56-5系源自PDB ID 2VYR链E残基1至124，其中与CDR 31至35、50至57及99至111对应之连续残基藉由SPLIT_PDB(其与kabat编号31至35、50至56及95至100G)对应移除，且接着穿过MUTATE且最终藉由RENUMBER重新编号。MUTATE使非一致残基变为最小一致，亦即通常Ala或Gly，但例如Tyr→Phe及Phe→Tyr将产生Phe。其不会建立任何原子，但对于Thr→Val、Val→Thr、Cys→Ser及Ser→Cys，其将取代适当原子名称，而不会改变位置。RENUMBER将编号变为Kabat编号(Kabat等人，Sequences of ImmunologicalInterest，第5版，美国健康与人类服务部,Washington,D.C.(1991))，其为直接描述CDR及构架残基之抗体之标准编号系统。
使用phenix.ensembler(University of Cambridge,UK)，自PDB IDs 1JMA(链B)、1NCF(链A)、1TNR(链R)、2HEV(链R)、2HEY(链R，T)及2UWI(链A、B)构筑CD40模型，产生结构集合。此等分子之N端(残基24至78)加6个残基区段(残基95至100)可与Cα原子之可接受之均方根距离重迭，且用作CD40之N端区之模型。
分子置换方法：
使用程序PHASER(McCoy等人，J.Appl.Crystallogr.40:658-674(2007))进行分子置换。监测转译功能Z分数(translation function Z-score，TFZ)及对数似然增益增加，判定是否存在实际溶液。8及8以上之TFZ分数一般表示溶液。较小之TFZ分数伴随对数似然增益之实质增加(>50)亦为可接受之指示。
模型建立、密度改良及结晶改进方法：
用于分子图形之模型建立手段包括COOT程序(Emsley等人，Acta CrystallogrSect.D 60:2126-2132(2004)；Emsley等人，“Features and Development of Coot”，ActaCrystallogr Sect.D 66:486-501(2010))。使用已知密度改良程序及计算分子之间的欧拉角(Eulerian angle)及平移的其他程序执行使用非结晶对称图平均法之密度改良。使用自动BUSTER进行改进(GlobalPhasing,Ltd.:Bricogne等人，Acta Crystallogr.Sect.D 60:2210-2221(2004)；Tronrud等人，Acta Crystallogr.Sect.A 43:489-501(1987))。
域抗体编号系统：
用于域抗体之残基编号系统遵循Kabat。以下比较BMS3h-56-5之Kabat编号与直顺序编号：
在Kabat编号中，BMS3h-56-5具有插入残基52A、82A、82B、82C，且遗漏残基100。在两种编号系统中，给予作为表现构筑体之一部分的N端之Ser及Thr负编号。
测定CD40/BMS3h-56-5复合物之结构：
PHASER能够将4个BMS3h-56-5 dAb分子定位于I222晶形中且将3个BMS3h-56-5dAb分子定位于C2晶形中。在I222晶形中，TFZ分数在7.6至41.0之范围内，且对数似然增益之增加在77至446之范围内。用于BMS3h-56-5 dAb分子之此等溶液经由I222晶体形成螺旋状dAb分子行，其藉由大信道与其他行分离。在C2晶形中，TFZ分数在7.7至16.5之范围内，且对数似然增益之增加在110至150之范围内。将dAb包装于此晶形中并不重复或对称。
使用CD40N端结构域之集合模型，可将CD40之N端结构域之4个分子置于I222晶形中，其中TFZ分数在5.7至8.5之范围内，且对数似然增益之增加在83至389之范围内。I222晶形中CD40之4个N端结构域在4行dAb分子之间的正中心形成凝块。然而，其不会触碰BMS3h-56-5 dAb分子。在C2晶形中置放CD40之N端结构域之3个分子，其中TFZ分数在5.8至12.1之范围内，且对数似然增益之增加在100至198之范围内。在此晶形中，N端结构域亦不接触BMS3h-56-5 dAb分子。
在I222晶形中，可将来自CD40/Chi220 Fab复合物之CD40之N端结构域及来自2UWI之N端结构域重迭于CD40 N端结构域上。将N端与特定BMS3h-56-5 dAb关联之能力允许使用非结晶对称(NCS)图平均法。NCS平均法之起始相关系数得到非对角值为0.71至0.81。最终非对角值为0.88至0.92。接近于N端区之电子密度是清楚的，且可追踪BMS3h-56-5 dAb之CDR3之路径。将来自CD40/Chi220 Fab'复合物之残基82至94及101至121重迭于2UWI上之相应残基上，且接着使用COOT手动改良拟合。接着将CD40之第二结构域(残基82至94及101至121)之此位置变换至其他三个N端结构域上。
进行一个改进周期，其中自由剩余值(R-free)由0.437降至0.380且加工剩余值(R-work)由0.447降至0.381，与理想之均方根键及角偏差有所改良。所得电子密度图显示残基109具有与Trp一致之侧链，且显示CD40之C端70个残基中之至少一些残基所存在之密度。
因为CD40具有小二级结构，从而证明使C端约70个残基与电子拟合困难，所以搜索结构生物学合作研究协蛋白质数据库(Research Collaboratory for StructuralBioinformatics Protein Data Base)之适当模型以有助于引导链追踪。44个中有16个一致及44个中有24个匹配之前两个采样数为2AW2及1JMA，其具有相同序列：
一致残基以适当单一字母码记录于共同序列在线，且类似残基以星号记录于共同序列在线。此情况与CD40之N端结构域之残基41至84具有相同残基段：
一致残基以适当单一字母码记录于共同序列在线，且类似残基以星号记录于共同序列在线。
匹配双硫键：
比较CD40之残基41至84及125至168中之双硫键
残基41至84残基125至168
C41-C59C125-C143
[C38]-C51
C62-C77C146-C161
C83[-C103]C167[-C186]
括号中之残基不属于序列重复中之残基范围。
以1JMA/2AW2模型作为指导，使用COOT程序拟合一个CD40链。接着将此拟合模型重迭于其他3个CD40链中之一者上。然而，似乎在其他两个CD40链中此新颖残基段之位置定向不用，且此时其不能拟合。进行一个改进周期，其中自由剩余值由0.393降至0.366且加工剩余值由0.400降至0.349，与理想之均方根键及角偏差有相当大改良。
将来自I222晶形中之一个分子的BMS3h-56-5 dAb重迭于C2晶形中之3个dAb中之每一者上。使用彼变换矩阵定向I222晶形之第二及C端结构域。使用COOT程序重建该模型。进行一个改进周期，其中自由剩余值由0.361降至0.334且加工剩余值由0.375降至0.306，与理想之均方根键及角偏差有所改良。所得电子密度图对置放更多CD40残基提供指导。进行另一改进周期，其中自由剩余值由0.302降至0.287且加工剩余值由0.299降至0.270，与理想之均方根键及角偏差有所改良。
接着使用习知模型建立及改进完成结构测定。若干轮优化产生具有以下统计量之最终改进：自由剩余值0.260，加工剩余值0.228，均方根键均方根角1.4°。主链原子之真实空间相关系数为约0.92且侧链原子之真实空间相关系数为0.80。最终模型具有13个水分子。
使用来自C2晶形之C端结构域之模型作为指导，使I222晶形中之CD40模型进一步改进。若干周期使用COOT程序建立模型及用自动BUSTER程序改进产生以下统计量：自由剩余值0.323，加工剩余值0.292，均方根键均方根角1.5°。主链原子之真实空间相关系数为0.91且侧链原子之真实空间相关系数为0.80。该模型不包含水分子。
CD40/BMS3h-56-5复合物之整体结构：
一个BMS3h-56-5 dAb结合至一个CD40分子。如图1中所示，BMS3h-56-5结合至不同于抗体Chi220之抗原决定基，其在N末区中结合。CD40残基(SEQ ID NO:1)显示为绿色，抗原决定基残基除外。Chi220之CD40抗原决定基残基显示为蓝色；BMS3h-56-5 dAb抗原决定基残基显示为青色。Chi220 Fab及BMS3h-56-5β-股显示为红色，CDR残基显示为洋红色，且其他环显示为橙色。具有硫原子之CD40、Chi220及BMS3h-56-5分子之双硫键显示为黄色。
I222晶形含有4个结晶学独立CD40/BMS3h-56-5复合物，且C2晶体含有3个结晶学独立CD40/BMS3h-56-5复合物。CD40分子具有一定量之可挠性，且结构域以7种唯一复合物型式不同地排列，但在所有情况下均保留相互作用之总体性质。
BMS3h-56-5 dAb抗原决定基残基：
BMS3h-56-5之最小CD40抗原决定基定义为含有至少一个与BMS3h-56-5原子之凡得瓦尔或氢键接触之原子的CD40残基。所有复合物中之最小抗原决定基含有以下关于SEQID NO:1之CD40残基：Trp109、Leu121、His122、Ser124、Ser156、Ala157、Phe158、Glu159及His162。在一些复合物中以下其他残基以凡得瓦尔或氢键接触：Pro85、Asn86、Leu87、Gly88、Glu106、Glu107、Gly108、His110、Thr112、Cys119、Val120、Gln133、Ile134、Ala135、Thr136、Ser155、Lys160。
最大CD40抗原决定基定义为含有藉由探针球内埋之原子的残基。此等残基包括以上所有残基加所有复合物中之Val 154。在一些复合物中，其他内埋残基为：Ser118、Arg123、Thr141、Phe151、Asp153、Cys161及Pro163。
具有接触残基之BMS3h-56-5之表面的描述示于图2中。显示接触BMS3h-56-5残基。亦显示内埋残基。CD40表示为用橙色表示非重复二级结构且用洋红色表示抗原决定基残基之草图。亦显示为棒(呈青色之碳原子)的是CD40残基Trp109、Ala115、Leu121、Ser126及His162，其为人类与食蟹猕猴(长尾猕猴)之间不同之七种残基中之五者。Ala115及Ser126位于CD40之BMS3h-56-5结合位点之相对侧。Trp109及Leu121在位于CDR-3与FR-2(BMS-3h-56-5残基Leu45及Arg47)之间的BMS-h-56-5之间隙中结合。CD40之His162与BMS3h-56-5dAb之CDR-2之Arg56相互作用。Trp109之突变会显著降低或消除BMS3h-56-5活性。
视结晶学独立复合物而定，660至之CD40表面积由16至21个接触残基(更精确地表示为46至67个接触原子)内埋。对于BMS3h-56-5，660至 之表面积由14至17个接触残基(更精确地表示为48至62个接触原子)内埋。视结晶学独立复合物而定，此等接触产生3至7个氢键及111至142凡得瓦尔作用力。
实施例11
鉴别CD40上之dAb结合抗原决定基
为了鉴别CD40上之dAb结合抗原决定基，针对七种在残基76、109或121处含有特定氨基酸残基取代之CD40-Fc融合蛋白测试dAb结合。此等CD40-Fc融合蛋白包括野生型人类CD40(wt-hCD40)、野生型食蟹猕猴CD40(wt-cCD40)及特定氨基酸残基突变为来自食蟹猕猴CD40(M1、M2、M4、M5)或黑猩猩CD40(M3)之序列之相应残基的五种突变型人类CD40蛋白(M1至M5)。氨基酸取代列于表26中。
野生型人类CD40细胞外域(1至193)之序列系来自REFSEQ:寄存编号NM_001250.3。在表26所示之位置使用野生型序列之定点突变诱发产生猕猴及突变型构筑体。细胞外域与凝血酶可裂解连接符DPGGGGGRLVPRGFGTGDP(SEQ ID NO:1273)融合，该凝血酶可裂解连接符与人类IgG1 Fc融合。该等蛋白质表现于用TIG-pYD7-GATE Durocher表现载体转染之HEK-293-6E细胞中。五天之后收集上清液。使用蛋白质A速流层析自条件培养基纯化各CD40蛋白质。管柱用PBS(20mM磷酸钠、0.15M NaCl，pH 7.2)洗涤，且接着使用80mM乙酸钠(pH 3)溶离至五分之一体积之1M Tris-HCl(pH 8)中。溶离液于PBS中流过Superdex-200管柱。
表26
分析来自3h217、3h37、3h38及3h56谱系之代表性dAb与表26中所列之CD40-Fc融合蛋白的结合。用BioRad ProteOn XPR36SPR仪器执行分析。SPR表面系藉由在乙醇胺阻断下使用标准乙基(二甲基胺基丙基)碳化二亚胺(EDC)/N-羟基丁二酰亚胺(NHS)化学反应，将8μg/ml抗人类IgG(Fc)抗体(Biacore/GE Healthcare)于10mM乙酸钠(pH 4.5)中之混合物固定于BioRad GLC传感器芯片上来制备。用于固定及动力学结合分析之操作缓冲液为10mM磷酸钠、130mM氯化钠、0.05％吐温20，pH 7.1。在此等表面上经由Fc尾在垂直方向上捕捉浓度为20μg/ml之CD40-Fc融合蛋白，且将缺乏CD40-Fc蛋白之参比表面用于参比减去。藉由在25℃下，使用240秒缔合时间及420秒解离时间，以30μl/min之流速使405、135、45、15及5nMdAb分析物水平方向流经捕捉之CD40-Fc表面来执行动力学实验。该等表面用30秒脉冲之3MMgCl2，随后用操作缓冲液以60μl/min流过在水平与垂直方向再生。双重参比传感器图谱数据，且接着使用BioRad ProteOn Manager V.2.1.0.38软件拟合成1:1朗缪尔模型，以测定缔合速率常数(ka)、解离速率常数(kd)及平衡解离常数(KD)。
发现3h-37、3h-38及3h-56谱系之所有dAb以高亲和力(KD<10-8M)结合至含有人类CD40残基W109及L121之CD40-Fc融合蛋白，但与具有来自食蟹猕猴CD40(L109、P121)或黑猩猩CD40(R109)之相应残基之CD40-Fc融合蛋白的结合显著降低或不可侦测到。此情况指示来自3h37、3h38及3h56-谱系各者之dAb特异性结合至包括人类CD40之残基109及121之抗原决定基。相反，3h-217谱系之所有测试成员以类似亲和力结合至所有所测试CD40-Fc融合蛋白，指示3h-217谱系之成员结合至不包括残基76、109或121之CD40上之位点。因此，3h-217谱系结合至与3h-37、3h-38及3h-56谱系不同之抗原决定基。表27概示使用SPR用ProteOnXPR36仪器针对dAb结合至CD40-Fc融合蛋白所测定之KD值。表27中之“X”意谓没有任何证据表明在此等条件下存在结合。
表27
表28显示使用SPR用ProteOn XPR36仪器针对dAb结合至CD40-Fc融合蛋白所测定之缔合速率常数(ka)、解离速率常数(kd)及平衡解离常数(KD)。表28中之“X”意谓没有任何证据表明在此等条件下存在结合。
表28
实施例12
构筑Fc融合多肽
如本文所揭示，可构筑各种组态之包含dAb之抗体多肽。在此实施例中，各种dAb与Fc域融合产生抗人类CD40可变域构筑体之Fc融合多肽，诸如3h37-202、3h37-235、3h37-258及3h37-202。
在一个代表性实施例中，dAb BMS3h-56-269(SEQ ID NO:417)与经修饰之IgG1(IgG1*)Fc域(SEQ ID NO:1284)融合。在dAb-IgG1*Fc域融合多肽中，dAb BMS3h-56-269之C端融合至具有序列Ala-Ser-Thr之连接符三肽，其又与IgG1*Fc域(SEQ ID NO:1284)融合。IgG1*Fc域含有修饰C5S，系指SEQ ID NO:1284中之位置编号。IgG1 Fc域之C5通常与IgG分子之轻链中之Cys残基形成双硫键。IgG1*Fc域亦含有C11S及C14S突变以消除IgG1铰链区中之链间双硫键。最终，IgG1*Fc域含有P23S突变以降低Fc域效应功能。dAb-IgG1*Fc融合多肽具有以下序列，其中Ala-Ser-Thr连接符呈粗体且Fc域之修饰呈粗斜体：
SEQ ID NO:1286中所示之dAb-IgG1*Fc融合多肽为计算分子量为39,127Da之单体。其可形成计算分子量为78,254Da之二聚体。
或者，dAb BMS3h-56-269(SEQ ID NO:417)与人类IgG4Fc域(SEQ ID NO:1285)融合。dAb BMS3h-56-269之C端又融合至Ala-Ser-Thr连接符，该Ala-Ser-Thr连接符与IgG4Fc域(SEQ ID NO:1285)融合。IgG4Fc域含有修饰S10P，系指SEQ ID NO:1285中之位置编号。BMS3h-56-269-IgG4Fc融合多肽具有以下序列，其中Ala-Ser-Thr连接符呈粗体且S10P修饰呈粗斜体：
SEQ ID NO:1287中所示之BMS3h-56-269-IgG4Fc融合多肽为计算分子量为38,867Da之单体。其可形成计算分子量为77,734Da之二聚体。
下文比对BMS3h-56-269(SEQ ID NO:417)、BMS3h-56-269-IgG1*Fc融合多肽(SEQID NO:1286)及BMS3h-56-269-IgG4Fc融合多肽(SEQ ID NO:1287)之序列，其中Fc域之起始用箭头标出：
使用实施例11中所揭示之细胞培养方法表现Fc融合多肽。管柱用PBS(20mM磷酸钠、0.15M NaCl，pH 7.2)洗涤，且接着使用80mM乙酸钠(pH 3)溶离至五分之一体积之1MTris-HCl(pH 8)中。溶离液于PBS中流过Superdex-200管柱。
实施例13
CD40 Fc融合多肽活性分析
功能上分析抗人类CD40 Fc融合多肽拮抗CD40活性之能力。所测试之CD40活性为藉由hCD40L驱动之初级人类单核细胞源性树突状细胞(DC)活化发生之B细胞增殖及细胞激素产生。使用实施例6中所揭示之分析量测B细胞增殖及细胞激素产生。除非另外说明，否则所有分析均在补充有10％胎牛血清(FCS)之RPMI培养基中执行。dAb-Fc域融合多肽展示CD40依赖性活化之有效抑制作用(亦即拮抗作用)。注意到在任何人类CD40特异性dAb-Fc域融合多肽中无促效特性。使用各种分析得到之结果示于表29中。使用实施例11中所揭示之分析来分析3h56-269-IgG4与固定之人类CD40之结合。对于3h56-269-IgG4，在30pM、25℃下及在40pM、37℃下量测结合固定之人类-CD40的表观亲合力影响之Kd值。
表29
尽管已根据上文实施例详细描述了本发明实施例，但应了解在不背离此等实施例之精神的情况下可作出各种修改，且将易于为习此相关技艺之人士所知。
序列表
<110> 百时美施贵宝公司
<110> 多曼蒂斯有限公司
<120> 拮抗CD40之抗体多肽
<130> 200896-0004-00-WO (481834)
<140>
<141>
<150> 61/477,904
<151> 2011-05-18
<160> 1287
<170> PatentIn version 3.5
<210> 1
<211> 277
<212> PRT
<213> 人
<400> 1
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<212> PRT
<213>食蟹猕猴（Macaca fascicularis）
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<220>
<221> misc_feature
<222> (1)..(25)
<223> This sequence may encompass 1 to 5 "Gly Gly Gly Gly Ser"
repeating units
<400> 4
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
1 5 10 15
Gly Gly Gly Ser Gly Gly Gly Gly Ser
20 25
<210> 5
<211> 3
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 5
Ala Ser Thr
1
<210> 6
<211> 6
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 6
Thr Val Ala Ala Pro Ser
1 5
<210> 7
<211> 3
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 7
Thr Val Ala
1
<210> 8
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 8
Ala Ser Thr Ser Gly Pro Ser
1 5
<210> 9
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 9
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 10
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 10
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 11
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 11
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 12
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 12
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 13
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 13
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 14
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 14
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Ala Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 15
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 15
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 16
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 16
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Asp Ala Asp Gly Leu Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Gly Pro Gln Phe Gly Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 17
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 17
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Asp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ala Ser Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Pro Asn Arg Phe Ala Leu Asn Asn Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 18
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 18
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Gly Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 19
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 19
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 20
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 20
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 21
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 21
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 22
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 22
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 23
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 23
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Lys Asn
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Glu Ser Asp Gly Gln Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Arg Ile Pro Asp Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 24
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 24
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ala Gly
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Lys Glu Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Gly Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 25
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 25
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Ala
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gln Pro Met Gly Asp Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 26
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 26
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Ser
20 25 30
Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Thr Ser Asn Gly Tyr Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 27
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 27
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu His
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Gly Pro Asp Gly Phe His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 28
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 28
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr
20 25 30
His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Pro Leu Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 29
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 29
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Asn
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Pro Gly Gly Asp Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Val Pro Asp Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 30
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 30
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ser Glu
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Ala Asp Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Val Pro Asp Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 31
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 31
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Asp
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ala Val Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Lys Val Pro Ser Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 32
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 32
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Met
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Gly Asp Gly Met Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 33
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 33
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Asp
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Ala Gly Gly Val His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 34
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 34
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Asp
20 25 30
Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Ser Asp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 35
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 35
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Glu
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Ser Val Gly Glu Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 36
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 36
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Ser
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Asn Pro Gly Gln His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 37
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 37
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gln His
20 25 30
Ser Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Gly Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Glu Val Pro Arg Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 38
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 38
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gln Glu
20 25 30
Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ala Tyr Asn Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Thr Pro Asn Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 39
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 39
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asn Tyr
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Ala Thr Gly Ser Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Ile Pro His Leu Met Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 40
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 40
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Gly Thr Gly Asn Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Gly Val Val Pro Tyr Leu Ala Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 41
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 41
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ala Asp
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Val Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 42
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 42
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Arg Ala
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Gly Glu Gly Lys Cys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Met Val Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 43
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 43
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Trp Glu
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Ser Ser Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Met Val Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 44
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 44
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Glu
20 25 30
Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Pro Pro Glu Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Thr Pro Asn Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 45
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 45
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Asn His
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Arg Gly Gly Leu Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Val Pro Asp Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 46
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 46
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Gly Asp Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Ile Pro Ala Met Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 47
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 47
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Val
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Pro Tyr Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Met Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 48
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 48
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Ala Leu Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gln Leu Pro Ala Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 49
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 49
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Arg Tyr
20 25 30
Tyr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val
35 40 45
Ser Gly Ile Val Pro Ser Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Asp Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 50
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 50
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Pro Thr Gly Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Ile Pro Tyr Leu Ser Phe Ser Pro Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 51
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 51
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Lys Tyr
20 25 30
Trp Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Ser His Gly Ala Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Val Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ala Pro Lys Phe Met Thr Thr Tyr Thr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 52
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 52
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Leu Ser Tyr
20 25 30
Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Ser Arg Gly Ser Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly His Ser Trp Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 53
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 53
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ser
20 25 30
Asn Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Pro Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Arg Ile Pro Thr Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 54
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 54
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Pro Arg
20 25 30
Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Asp Ile Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Ala Gln Gly Val Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 55
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 55
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr
20 25 30
Arg Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Thr Ser Gly Glu Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Thr Ala Gly Gln Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 56
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 56
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Tyr
20 25 30
Glu Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Glu Gly Arg Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Asn Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 57
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 57
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Gly Asn Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 58
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 58
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Thr Glu
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Asn Gly Ala Phe Thr Phe Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 59
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 59
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly His Tyr
20 25 30
Asp Met Val Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asn Gly Ala Gly Leu Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Ser Ala Ser Arg Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 60
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 60
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Ser Tyr
20 25 30
Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Thr Leu Gly Thr Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Ser Ser Thr His Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 61
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 61
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ile Arg Tyr
20 25 30
Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ser Gly Trp Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Asp Ala His Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 62
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 62
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ala Tyr
20 25 30
Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Asp Asp Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Leu Gly Gln Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 63
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 63
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp His
20 25 30
Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Gly Pro Ser Gly Glu Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 64
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 64
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser Gln
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ser Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 65
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 65
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Asp Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Arg His Pro Gly Gly Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Val Pro Lys Gly Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 66
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 66
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Val Tyr
20 25 30
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Pro Gln Gly Gly Met Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Arg Ile Pro Asn Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 67
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 67
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Glu
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Pro Thr Gly Ser Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Lys Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 68
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 68
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Ser
20 25 30
Glu Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ala His Asn Gly Gly His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly His Pro Gln Gln Thr Glu Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 69
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 69
Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Thr Tyr
20 25 30
Asp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Lys Ile Ser Pro Asn Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Gln Thr His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 70
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 70
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr
20 25 30
Asp Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ser Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Pro Lys Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 71
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 71
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Glu
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Thr Arg Ser Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 72
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 72
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Lys Tyr
20 25 30
Ile Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asp Tyr Trp Gly Gln His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Ser His Leu Ile Pro Leu Gln Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 73
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 73
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
20 25 30
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Tyr Val Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Lys Ala Leu Arg Gly Glu Ala Phe Thr Glu Arg Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 74
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 74
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Pro Tyr
20 25 30
Met Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Glu Val Asn Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Trp Val Gly Ser Lys Thr Ser Ser Asp Lys Ser Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 75
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 75
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Thr Thr
20 25 30
Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gly Ser Ala Gly Ala Trp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ile Gly Gly His Pro Gln Gly Gln Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 76
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 76
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Arg Glu
20 25 30
Trp Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gln Pro Met Gly Gln Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Ser Arg Asn Lys Gly Phe Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 77
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 77
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Ser Glu
20 25 30
Tyr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gln Arg Tyr Gly Ser Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys His Glu Ser Asn Trp Glu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 78
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 78
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Val Tyr
20 25 30
Ser Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Thr Pro Asn Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Thr Leu Gly Arg Gly Ser Tyr Pro Gly Val Asp Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 79
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 79
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Ser Tyr
20 25 30
Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Ala Asp Gly Thr Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ser Ile Pro Met Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 80
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 80
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Asn Gly Thr Gly Ile Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Gln Ser Val His His Ala Val Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 81
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 81
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asn Tyr
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ala Pro His Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gln Ile Pro Met Leu Asp Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 82
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 82
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr
20 25 30
Met Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser His Phe Gly Asp Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Asp Met Val Met Lys Asn Gly Gly Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 83
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 83
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Ser Arg Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Val Pro His Leu Arg Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 84
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 84
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ala
20 25 30
Gln Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Ala Met Gly Asp Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Lys Val Pro Ser Ile Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 85
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 85
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Ala
20 25 30
Gln Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Ala Met Gly Asp Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Ile Pro Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 86
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 86
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asn Asp
20 25 30
Arg Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Thr Gly Thr Asn Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 87
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 87
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gln Pro
20 25 30
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Ala Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 88
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 88
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Glu
20 25 30
Asn Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Gly Gly Gly Tyr Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gln Val Pro Glu Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 89
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 89
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Ser Ser
20 25 30
Asn Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 90
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 90
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Ser Ser
20 25 30
Asn Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 91
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 91
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Asp Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Ile Pro Leu Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 92
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 92
Glu Met Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Ser Asp
20 25 30
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ile Pro Asp Leu Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 93
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 93
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Glu
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ile Gly Gly Gly His Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Ile Pro Leu Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 94
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 94
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Glu
20 25 30
Asn Met Thr Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Glu Arg Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 95
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 95
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Glu
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ile Gly Gly Gly His Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 96
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 96
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Glu Thr
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Arg Leu Gly Gln Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Gly Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 97
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 97
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Asp Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Thr Val Pro Thr Leu Glu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 98
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 98
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asn Glu
20 25 30
Asn Met Thr Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Glu Arg Gly Asp Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 99
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 99
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Asp
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asn Asp Ala Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Thr Pro Asn Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 100
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 100
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Glu
20 25 30
Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Pro Pro Glu Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ile Pro Asp Leu Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 101
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 101
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asp Ser
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ala Ala Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Arg Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 102
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 102
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Ser Asp
20 25 30
Thr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Gly Thr Gly Gly Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gln Val Pro Glu Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 103
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 103
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asp Ser
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ala Ala Pro Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 104
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 104
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp Leu Ala
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Glu Asp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Val Ile Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 105
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 105
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asp Lys
20 25 30
His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Pro Asp Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Val Ile Pro Ser Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 106
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 106
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Asp
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ala Val Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Thr Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Lys Thr Pro His Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 107
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 107
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ala Gly Phe Thr Phe Asp Leu Ala
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Glu Asp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gln Val Pro Ala Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 108
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 108
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Ser
20 25 30
Met Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Pro Gly Gly Ala Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 109
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 109
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu His Ala
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Ser Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Asn Ser Gly Gln Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 110
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 110
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Ala
20 25 30
Glu Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Thr Thr Asp Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 111
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 111
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Ser
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Val
35 40 45
Ser Tyr Ile Arg Gly Asp Asp Asp Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Arg Ile Pro Asp Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 112
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 112
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Val Ala
20 25 30
Asp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys His Ala Ser Thr Glu Gly Pro Thr Ala Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 113
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 113
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Pro Tyr
20 25 30
Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Trp Ile Ser Ala His Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Trp Pro Tyr Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 114
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 114
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Gly
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Gly Ser Asn Gly Ala Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Met Val Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 115
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 115
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Arg Phe
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 116
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 116
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Ser
20 25 30
Asp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Pro Ser Ser Arg Leu Lys Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 117
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 117
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Ser
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Glu Asn Gln Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Arg Ile Pro Asn Leu Val Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 118
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 118
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Leu Asp Ala Tyr
20 25 30
Pro Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Trp Ile Ala Ser Gly Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Thr Lys Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 119
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 119
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Ser Tyr
20 25 30
Ser Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Thr Ser Asn Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Thr Gly Ala Asn Ser Arg Asn Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 120
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 120
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gly Tyr
20 25 30
Leu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ala Ala Asn Gly Met Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Lys Pro Arg Gly Ile Trp Asp Gly Asp Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 121
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 121
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe His Glu Ser
20 25 30
Thr Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Arg His Pro Gly Glu Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Gly Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Ile Pro Asp Leu Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 122
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 122
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Met Tyr
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ala Pro Pro Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Ser Leu Thr Gly Tyr Ser Arg Ser Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 123
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 123
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gln Asn
20 25 30
Pro Met Ser Trp Val Arg His Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Pro Ala Asn Gly Arg Pro Thr Ser Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Ser Gln Gln Pro Gly Arg Arg Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 124
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 124
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asn Tyr
20 25 30
His Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Pro Asp Ser Gly Lys Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Ser Leu Leu Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 125
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 125
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gln Tyr
20 25 30
His Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asn Asp Ile Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Gly Gly Arg Gly Ser Phe Ser Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 126
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 126
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
20 25 30
Asp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ala Ser Gly Val Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Glu His Ala Gly Gln Pro Pro Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 127
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 127
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Gly Tyr
20 25 30
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asn Ala Asn Gly Lys Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Lys Leu Thr Leu Ala Ser Asn Tyr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 128
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 128
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Met Asp Tyr
20 25 30
Asp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Thr Ala Leu Gly Lys Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Ser Val Lys Tyr Pro Leu Asn Leu Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 129
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 129
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro His Tyr
20 25 30
Thr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gln Ser Pro Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Gly Asp Gly Leu Pro Leu Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 130
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 130
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Thr
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Gly Asp Glu Gly Gln Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Val Thr Pro Asp Leu Thr Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 131
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 131
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser
20 25 30
Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Ser Asp Gly Pro Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 132
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 132
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Pro Gly
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Gly Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Ile Pro Thr Leu His Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 133
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 133
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Ser
20 25 30
Met Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gly Tyr Pro Gly Ala Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Ser Arg Asp Asp Asn Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 134
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 134
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gln His
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Val Pro Gly Pro Lys Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Leu Arg Asp Leu Arg Pro Gly Asp Ser Lys Ser Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 135
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 135
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ser Ala
20 25 30
Ala Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asn Asp Met Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Gly Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 136
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 136
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Tyr Asp
20 25 30
Arg Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Gly Pro Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Arg Arg Val Pro Asp Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 137
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 137
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Glu Tyr
20 25 30
Glu Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Pro Phe Gly Ser Glu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Val Val Pro Asp Leu Asn Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 138
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 138
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Lys Tyr
20 25 30
Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Gly Ser Tyr Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Leu Thr Leu Ser Ala Thr Lys Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 139
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 139
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Tyr
20 25 30
Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ala His Arg Gly Asp Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Arg Arg Leu Ser Asp Tyr Arg Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 140
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 140
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gln Phe
20 25 30
Asp Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Ala Gly Thr Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly Asp Arg Ser Ser Leu Phe Asp Tyr Arg Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 141
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 141
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Asp Thr
20 25 30
Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Tyr Gly Arg Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Asn Ala Ala Leu Gly Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 142
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 142
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Pro Tyr
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asn Ala Pro Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Gln Met Ser Ser Gly Val Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 143
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 143
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Gln
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Ser Ser Gly Gln Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Lys Ser Leu Ala Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 144
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 144
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Glu Ser
20 25 30
Asp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Ala Gln Val Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 145
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 145
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Gln Tyr
20 25 30
Val Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Gly Thr Ser Gly Lys Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Arg Arg Ser Leu Thr Arg Val His Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 146
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 146
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Val Glu
20 25 30
His Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Thr Gly Asp Gly Asp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Thr Val Ser Trp Asn Gly Arg Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 147
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 147
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Trp Tyr
20 25 30
Asn Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ala Pro Ser Gly Ile Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Arg Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 148
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 148
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr
20 25 30
Glu Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Ala Gly Thr Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Ser Leu Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 149
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 149
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Asp Glu Glu
20 25 30
Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ile Ile Asp Pro Gly Gly Gly Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Asn Ser Met Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 150
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 150
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr
20 25 30
Pro Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ala Ser Ser Gly Ile Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Phe Thr Arg Leu His Phe Pro Ala Gln Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 151
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 151
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Tyr
20 25 30
Ala Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Ser Pro Glu Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Arg Pro Tyr Ala Ser Lys Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 152
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 152
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Pro Tyr
20 25 30
Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser His Gln Gly Asn Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Ser His His Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 153
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 153
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Tyr
20 25 30
Asn Met Trp Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Trp Ile Asn Ser Thr Gly Ser Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Trp His Arg Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 154
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 154
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Arg Tyr
20 25 30
Arg Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asn Arg Leu Gly Gln Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Lys Lys His Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 155
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 155
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala His Tyr
20 25 30
Asn Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Thr Lys Thr Gly Phe Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly Gln Phe Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 156
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 156
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Pro Tyr
20 25 30
Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asp Gly Ser Gly Met Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Asp Ser Leu Lys Ala Ser Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 157
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 157
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Leu Tyr
20 25 30
Gly Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Gly Pro Tyr Gly His Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Lys Arg Lys Lys Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 158
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 158
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Arg Tyr
20 25 30
Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Thr Pro Tyr Gly Ala His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Gly Lys Trp Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 159
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 159
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr
20 25 30
Ala Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asp Arg Leu Gly Leu His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Gly Pro Phe Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 160
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 160
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Arg Tyr
20 25 30
Asn Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asp Arg Leu Gly Leu Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 161
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 161
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ile Tyr
20 25 30
Asp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ser Ser Gly Thr His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Pro Gln Pro Tyr Pro Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 162
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 162
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Trp Val Tyr
20 25 30
Asp Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ala Thr Gly Val His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Pro Pro Ala Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 163
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 163
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
Asp Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Asn Gly Thr Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Pro Gln Val Asn Thr Glu Phe Asp Tyr Arg Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 164
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 164
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Lys Glu
20 25 30
Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser His Ile Ser Pro Asn Gly Tyr Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Trp Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 165
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 165
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ala Thr
20 25 30
Pro Met Glu Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Glu Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Trp Asn Ser Thr Thr Gly Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 166
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 166
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Val
20 25 30
Asp Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Ala Pro His Arg Ala Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 167
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 167
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Asp Lys
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Ala Leu Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Gly Met Val Pro Arg Leu Lys Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 168
<211> 114
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 168
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His
20 25 30
Ser Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Asp Ile Glu Pro His Gly Val His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Asn Pro Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val
100 105 110
Ser Ser
<210> 169
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 169
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Pro His
20 25 30
Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Gly Pro Asp Gly Thr Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Ser Tyr Ser Trp Asp Arg Gly Trp Thr Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 170
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 170
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Tyr Ala Ser
20 25 30
Asp Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Pro Asn Gly Trp Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Asp Tyr Thr Tyr His Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 171
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 171
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala His Tyr
20 25 30
Asn Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Thr Lys Thr Gly Phe Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Gly Gln Phe Asp Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 172
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 172
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser His Tyr
20 25 30
His Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Gly Pro Arg Gly Ile Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Pro Ser Arg His Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 173
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 173
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Glu Tyr
20 25 30
Ala Met Arg Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Asp Arg Leu Gly Leu His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Gly Pro Phe Thr Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 174
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 174
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr
20 25 30
Ser Met Lys Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Thr Pro Asp Gly Trp Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Val Gly Asp Ala Val Trp Gly Trp Ile Gly Gly Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 175
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 175
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asp Tyr
20 25 30
Gly Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Thr Ser Asn Gly Asp Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Leu Tyr Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 176
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 176
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Pro Thr Tyr
20 25 30
Lys Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Phe Ile Asp Tyr Trp Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Pro Tyr Ser Trp Thr His Asp Ser Pro His Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 177
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 177
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Pro Tyr
20 25 30
Thr Met Cys Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Cys Ile Ser Asp Ala Gly Ser Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Met Ser Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 178
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 178
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gln Asn Tyr
20 25 30
Gln Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Gly Thr Gly Lys Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Thr Pro Gln Asn Tyr Phe Ser Val Arg Arg Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 179
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 179
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Tyr
20 25 30
Thr Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Lys Ile Ser Thr Ser Gly Gly Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Leu Asn Trp Trp Ala Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 180
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 180
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Ala Tyr
20 25 30
Pro Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Arg Ile Asp Gly Tyr Gly Arg His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Ile Pro Asn Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 181
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 181
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Val
20 25 30
Asp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Ser Gly Ser Ala Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Arg Val Pro Asp Leu Gly Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 182
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 182
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Tyr
20 25 30
Ala Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Ala Lys Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Ala Arg Gly Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 183
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 183
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Arg Tyr
20 25 30
Gln Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Val Ile Asn Val Trp Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Met Ser Gly Lys Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 184
<211> 117
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 184
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Tyr
20 25 30
Ser Met Met Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ile Pro Ala Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Ser Ile Arg Leu Phe Asp Tyr Trp Gly Gln Gly Thr Leu
100 105 110
Val Thr Val Ser Ser
115
<210> 185
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 185
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Tyr
20 25 30
Asp Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Trp Ile Ser Pro Asn Gly Tyr Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Val Lys Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 186
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 186
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Val Trp Tyr
20 25 30
Glu Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Gln Ala Asp Gly Glu Gln Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Ser Tyr Ala Leu Val Tyr Pro Pro Glu Glu Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 187
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 187
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Asn Tyr
20 25 30
Arg Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asp Asp Leu Gly Val Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Trp Arg Leu Lys Asn Ser Gln Pro Thr Asp Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 188
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 188
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gln Ala
20 25 30
His Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Phe Ile Asn Pro Ser Gly Tyr Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Ser Leu Ser Pro Ser Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 189
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 189
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Thr Gly
20 25 30
Gln Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Asn Ile Asp Gly Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ser Thr Gln Asn Tyr Arg Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 190
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 190
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Ala Tyr
20 25 30
Pro Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile His Lys Asp Gly Arg Ile Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Gly Thr Pro Val Asp Gly Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 191
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 191
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asp Glu
20 25 30
Gly Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Glu Thr Gly Gly Thr Val Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Met Asp Gly Ser Gly Thr Trp Gln Thr Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 192
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 192
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Ser Leu
20 25 30
Gly Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Tyr Ile Arg Ala Glu Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Leu Ala Asp Ser Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 193
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 193
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Glu Ser
20 25 30
Tyr Met Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asp His Ile Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Asp Gly Arg Gly Gly Ser Met Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 194
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 194
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Gly
20 25 30
Tyr Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Gly Ala Ser Gly Ala Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Thr Gly Gly Arg Leu Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 195
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 195
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Gly
20 25 30
His Met Gly Trp Val Arg Gln Ala Pro Gly Lys Asp Leu Glu Trp Val
35 40 45
Ser Tyr Ile Gly Ser Leu Gly Leu His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Arg Glu Phe Ser Asn Gly Gly Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 196
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 196
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Lys Thr Ser
20 25 30
Pro Met Tyr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Asp Arg Thr Gly Gly His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gln Ala Leu Leu Thr Asp Ala Lys Arg Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 197
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 197
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Gly Arg
20 25 30
Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro Ser Gly Leu Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Glu Arg Pro Gln Met Leu Val Thr Asn Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 198
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 198
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Asn Asp
20 25 30
Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Gly Arg Glu Gly Asp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Ser Met Arg His Gln Pro Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 199
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 199
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Glu Thr
20 25 30
Tyr Met Lys Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Gly Ala Ser Gly Ala Asp Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Phe Thr His Leu Asn Gly Arg Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 200
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 200
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gly Trp
20 25 30
Pro Met Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Asp Ile Asp Gly Ala Pro Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Glu Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 201
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 201
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Gln
20 25 30
Ala Met Trp Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Phe Ile Gln Gly Asp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Pro Ser Lys Pro Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 202
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 202
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Thr Gly
20 25 30
Gln Met Gly Trp Ala Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Asn Ile Asp Gly Ser Gly Thr Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Ala Val Arg Asn Phe Ala Phe Asp Tyr Trp Gly Gln Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 203
<211> 124
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 203
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly His
20 25 30
Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Pro His Gly Thr His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Ile Arg Gly Trp Ile Gly His Asp Thr Gln Pro Phe Asp
100 105 110
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 204
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 204
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Ser Lys
20 25 30
Asp Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ser Asp Gly Thr His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Gln Glu Leu Gly Gly Ser Trp Gln Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 205
<211> 122
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 205
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Asp Arg
20 25 30
Asp Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Gly Ala Ser Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Gly Thr Gly Pro Thr Asp Leu Trp Asp Phe Asp Tyr Trp
100 105 110
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 206
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 206
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp Asp Glu
20 25 30
Lys Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Val Ser Gly Leu His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Glu Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 207
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 207
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Gln Glu
20 25 30
Arg Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Asp Ile Ser Ala Ser Gly Gly Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Glu Ala Gly Ser Trp Ser Phe Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 208
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 208
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Met Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 209
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 209
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 210
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 210
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Val Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 211
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 211
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 212
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 212
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Val Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 213
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 213
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 214
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 214
Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Thr Ser
115
<210> 215
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 215
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe His Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 216
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 216
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Val Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Gln Ala Pro Gly Asn Gly Leu Glu Trp Ile
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 217
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 217
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 218
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 218
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 219
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 219
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Met Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 220
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 220
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 221
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 221
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Trp Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 222
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 222
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Leu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 223
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 223
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gly Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 224
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 224
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Glu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 225
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 225
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Gly Leu Glu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 226
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 226
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Ala Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 227
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 227
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Leu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 228
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 228
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Glu Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 229
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 229
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gln Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 230
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 230
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Leu Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 231
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 231
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Glu Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 232
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 232
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Leu Phe Phe Asp Tyr Arg Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 233
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 233
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ile Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asn Leu Glu Tyr Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 234
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 234
Glu Val Arg Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Leu Gln Phe Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 235
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 235
Glu Val Gln Leu Leu Gly Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ser Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 236
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 236
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 237
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 237
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 238
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 238
Glu Val Gln Leu Leu Asp Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Lys Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 239
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 239
Glu Val Gln Leu Leu Gly Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 240
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 240
Glu Val Gln Leu Leu Glu Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Leu Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ser Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 241
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 241
Glu Val Gln Leu Leu Asp Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Lys Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 242
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 242
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile His Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ser Lys Glu Pro Phe Arg Phe Asp Tyr Arg Gly Leu Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 243
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 243
Glu Val Gln Leu Leu Asp Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Gly Lys Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 244
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 244
Glu Val Gln Leu Leu Asp Ser Gly Gly Gly Phe Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 245
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 245
Glu Val Gln Leu Leu Asp Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Asn Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Arg Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 246
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 246
Glu Val Arg Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 247
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 247
Glu Val Gln Gln Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 248
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 248
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 249
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 249
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 250
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 250
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Lys
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Phe Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 251
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 251
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Gln Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 252
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 252
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Phe Ala Ala
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 253
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 253
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Pro Gly Thr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 254
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 254
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Met Gly Phe Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 255
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 255
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Trp Gly His Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 256
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 256
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Leu Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 257
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 257
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Trp Gly Ala Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 258
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 258
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Gln Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 259
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 259
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Val Ser Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 260
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 260
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Trp Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 261
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 261
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Leu Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 262
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 262
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Leu Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 263
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 263
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Ala Leu Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 264
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 264
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Arg Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 265
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 265
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg His Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 266
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 266
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Arg Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 267
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 267
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Ile Gly Asn Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 268
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 268
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly His Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 269
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 269
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Trp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 270
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 270
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Met Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 271
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 271
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Pro Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 272
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 272
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 273
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 273
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Leu Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 274
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 274
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Met Tyr Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 275
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 275
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Phe Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 276
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 276
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Thr Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 277
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 277
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Glu Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 278
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 278
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Pro Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Gln Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 279
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 279
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 280
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 280
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Thr Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 281
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 281
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 282
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 282
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 283
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 283
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Lys Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 284
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 284
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Gly Gly Trp Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 285
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 285
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Ser Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 286
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 286
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Met Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 287
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 287
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 288
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 288
Glu Val Gln Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu His
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 289
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 289
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 290
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 290
Glu Val Gln Leu Leu Glu Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Lys Ala Pro Gly Lys Gly Met Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Gly Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 291
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 291
Glu Val Gln Leu Leu Asp Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 292
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 292
Glu Val Gln Leu Leu Gly Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Ser Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Tyr Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 293
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 293
Glu Val Gln Pro Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Asn Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 294
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 294
Glu Val Gln Leu Leu Glu Ser Gly Glu Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 295
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 295
Glu Val Gln Leu Leu Asp Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Ser
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 296
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 296
Glu Val Gln Leu Leu Glu Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Lys Ala Pro Gly Lys Gly Met Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 297
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 297
Glu Val Gln Leu Leu Glu Ser Gly Val Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 298
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 298
Glu Val Gln Leu Leu Glu Ser Arg Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu His
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 299
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 299
Glu Val Gln Pro Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 300
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 300
Glu Val Gln Leu Leu Glu Ser Ala Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Tyr Trp Gly Gln Gly Ala Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 301
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 301
Glu Val Gln Leu Leu Glu Pro Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Glu Tyr
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Gly Asn Gly Ala Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Leu Arg Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 302
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 302
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Leu Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 303
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 303
Glu Glu Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Ala Thr Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 304
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 304
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Phe Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Gly Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 305
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 305
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Asn
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Asn
115 120
<210> 306
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 306
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Thr Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Gly Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Leu Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 307
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 307
Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Tyr Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 308
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 308
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ala Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg His Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Val Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Ser Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 309
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 309
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Ser Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 310
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 310
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Ser Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Ser Gly Leu Gly Thr Met Val Thr Val Ser Ser
115 120
<210> 311
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 311
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Ser Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 312
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 312
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg His Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 313
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 313
Glu Val Gln Leu Phe Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 314
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 314
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 315
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 315
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Ser Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Gly
115 120
<210> 316
<211> 123
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 316
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Thr Ala Ser Gly Phe Thr Phe Asn Met Tyr
20 25 30
Glu Met Ser Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Gly Ile Ser Arg Arg Gly Phe Thr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Ile Thr Tyr Asp Met Arg Tyr Ala Arg Phe Asp Tyr
100 105 110
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 317
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 317
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 318
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 318
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 319
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 319
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Lys Leu Pro Phe Ile Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 320
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 320
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 321
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 321
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 322
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 322
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Ile Phe Asp Asn Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 323
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 323
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ser Val Tyr His Cys
85 90 95
Ala Lys Pro Pro Phe Ile Phe Gly Asp Trp Gly Pro Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 324
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 324
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 325
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 325
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 326
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 326
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Val Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 327
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 327
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 328
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 328
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Leu Lys Leu Pro Phe Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 329
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 329
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr His Cys
85 90 95
Thr Lys Leu Pro Phe Ile Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 330
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 330
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Met Val Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe Asp Ser Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 331
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 331
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 332
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 332
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 333
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 333
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 334
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 334
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Val Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 335
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 335
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 336
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 336
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 337
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 337
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Leu Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 338
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 338
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Asp Asp Thr Ala Val Tyr His Cys
85 90 95
Thr Lys Leu Pro Phe Ile Phe Glu Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 339
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 339
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Ser Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 340
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 340
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 341
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 341
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 342
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 342
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 343
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 343
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 344
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 344
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Leu Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 345
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 345
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Leu Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 346
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 346
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 347
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 347
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 348
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 348
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 349
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 349
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Met Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 350
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 350
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Thr Tyr Phe Ser Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 351
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 351
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe Glu Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 352
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 352
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Thr Tyr Phe Lys Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 353
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 353
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Ser Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 354
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 354
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Asn
115
<210> 355
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 355
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Pro Phe Ser Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 356
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 356
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Ser Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 357
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 357
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Asn Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 358
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 358
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Pro Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 359
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 359
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 360
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 360
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Met Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 361
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 361
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 362
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 362
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 363
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 363
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro His Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 364
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 364
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ala Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 365
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 365
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 366
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 366
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 367
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 367
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Asp Ser Gly Phe Thr Phe Pro Pro Val
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 368
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 368
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 369
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 369
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Asn His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 370
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 370
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro His Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 371
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 371
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Pro Gly Met Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 372
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 372
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gln Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 373
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 373
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 374
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 374
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 375
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 375
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ser Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 376
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 376
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ser Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 377
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 377
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 378
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 378
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 379
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 379
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 380
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 380
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser His Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 381
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 381
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 382
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 382
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Asn Gly Arg Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Ala Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 383
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 383
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gln Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 384
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 384
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro His Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 385
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 385
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ala Gly Met Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 386
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 386
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro His Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 387
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 387
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 388
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 388
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 389
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 389
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ala Gly Phe Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 390
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 390
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Arg Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 391
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 391
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 392
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 392
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 393
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 393
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asp Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 394
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 394
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Thr Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 395
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 395
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 396
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 396
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Tyr Gly Asn Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 397
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 397
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro His Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 398
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 398
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ala Gly Phe Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 399
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 399
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ala Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Asp Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 400
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 400
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ala Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro His Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 401
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 401
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Ala Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Phe Thr Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 402
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 402
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Trp Phe Thr Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 403
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 403
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Met Phe Ser Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 404
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 404
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Leu Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 405
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 405
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Thr Arg Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 406
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 406
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 407
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 407
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 408
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 408
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Thr Phe Phe Lys Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 409
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 409
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 410
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 410
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Gln Leu Phe His Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 411
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 411
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Gln Leu Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 412
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 412
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Phe Gly Phe Ser Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 413
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 413
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Gln Leu Phe Gln Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 414
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 414
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 415
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 415
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro His Tyr Phe Lys Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 416
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 416
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Ser Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Glu Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 417
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 417
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Arg Phe Ser Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 418
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 418
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Thr Leu Phe Gln Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 419
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 419
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Ser Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Asn
115
<210> 420
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 420
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Trp Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 421
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 421
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 422
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 422
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Asn
115
<210> 423
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 423
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 424
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 424
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 425
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 425
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Ser Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 426
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 426
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 427
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 427
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Asn
115
<210> 428
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 428
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 429
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 429
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 430
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 430
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Phe Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 431
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 431
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 432
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 432
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Asn
115
<210> 433
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 433
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 434
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 434
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 435
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 435
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Trp Gly Gly Leu Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Phe Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 436
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 436
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Leu Pro Met Phe Phe Glu Asp Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 437
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 437
Glu Val Gln Leu Leu Glu Thr Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
His Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Asp Ala Asp Gly Leu Gly Thr Tyr Tyr Ala Asp Pro Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Lys Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Pro Gly Pro Gln Phe Gly Gln Phe Asp Tyr Leu Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 438
<211> 119
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 438
Glu Val Gln Leu Phe Glu Ser Gly Gly Gly Leu Val Gln Thr Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr
20 25 30
His Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Met Ile Asp Ala Asp Gly Leu Gly Lys Tyr Tyr Ala Asp Pro Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Lys Pro Gly Pro Gln Phe Gly Gln Tyr Asp Tyr Trp Gly Gln Gly
100 105 110
Thr Leu Val Thr Val Ser Ser
115
<210> 439
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 439
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Asp Met Gln Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ala Ser Gly Val Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Tyr Pro Asn Arg Phe Ala Leu Asn Ser Phe Asp Tyr Arg Gly
100 105 110
Arg Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 440
<211> 121
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 440
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Gly Tyr
20 25 30
Asp Met Gln Trp Val Arg Gln Ala Pro Gly Arg Gly Leu Glu Trp Val
35 40 45
Ser Thr Ile Ser Ala Ser Gly Val Tyr Thr Tyr Tyr Thr Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Thr Lys Tyr Pro Asn Arg Phe Ala Arg Asn Asn Phe Asp Tyr Trp Gly
100 105 110
Gln Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 441
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 441
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Ser Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 442
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 442
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asp Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 443
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 443
Asp Ile Gln Met Thr Val Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asp Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 444
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 444
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Asp Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 445
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 445
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Thr Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 446
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 446
Asp Ile Gln Met Thr Val Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 447
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 447
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asp Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Asp Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 448
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 448
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Glu Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 449
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 449
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Asn Lys Arg
100 105
<210> 450
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 450
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 451
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 451
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 452
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 452
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 453
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 453
Asp Ile Leu Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 454
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 454
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Thr Gly Thr Asp Phe Thr Leu Thr Ile Ser Gly Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Asp Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 455
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 455
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Pro Cys Arg Ala Asn Ser Ser Ile Leu Trp Ala
20 25 30
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Glu Ser Ser Ser Gly Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Ala Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Val Gln Asn Ala Val Trp Pro Gly
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 456
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 456
Asp Ile Gln Met Ala Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 457
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 457
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Asn Val Glu Ile Lys Arg
100 105
<210> 458
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 458
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Ala Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 459
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 459
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 460
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 460
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Glu Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 461
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 461
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 462
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 462
Asp Ile Gln Ile Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Asp Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 463
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 463
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Trp
100 105
<210> 464
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 464
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 465
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 465
Asp Ile Gln Met Ser Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Met Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 466
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 466
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Asp Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 467
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 467
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 468
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 468
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Phe Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 469
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 469
Asp Ile Gln Met Thr Gln Tyr Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 470
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 470
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Pro Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 471
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 471
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Leu Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 472
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 472
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ala Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 473
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 473
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 474
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 474
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 475
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 475
Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Lys Ile Lys Arg
100 105
<210> 476
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 476
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Ser Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 477
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 477
His Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 478
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 478
Asp Val Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Glu Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Thr Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Ala Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 479
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 479
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Val Ile Lys Arg
100 105
<210> 480
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 480
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 481
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 481
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 482
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 482
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 483
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 483
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Ile Arg
100 105
<210> 484
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 484
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 485
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 485
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Tyr Leu Ala Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 486
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 486
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Phe Glu His Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 487
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 487
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Phe Pro Ile Asp Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 488
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 488
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Thr Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 489
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 489
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Ser Gln Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 490
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 490
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Arg Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 491
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 491
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gln Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 492
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 492
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Pro Ile Ala Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 493
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 493
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gly Asn Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 494
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 494
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Asn Ile Asp Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 495
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 495
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 496
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 496
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asn Ile Gly Thr Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 497
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 497
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Val Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 498
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 498
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ala Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 499
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 499
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Thr Ser Ile Ala Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 500
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 500
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Leu Asn Ile Gly Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ala Thr Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 501
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 501
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Thr Ile Glu Arg Arg
20 25 30
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Arg Leu Leu Ile
35 40 45
Tyr Leu Ser Ser Lys Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys His Gln Tyr Glu Ser Pro Pro Leu
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 502
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 502
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 503
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 503
Glu Val Gln Pro Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Ile
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 504
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 504
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Thr Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Ser Val Ser Ser
115
<210> 505
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 505
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 506
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 506
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 507
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 507
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Val Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 508
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 508
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Pro Val
100 105 110
Thr Val Ser Ser
115
<210> 509
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 509
Glu Val Gln Leu Met Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Tyr Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Arg Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 510
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 510
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 511
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 511
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Ile Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 512
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 512
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Ser Val Ser Ser
115
<210> 513
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 513
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 514
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 514
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Thr Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 515
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 515
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Thr Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Arg Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 516
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 516
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Val Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 517
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 517
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Ile
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Lys Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 518
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 518
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 519
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 519
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ala Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 520
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 520
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Leu Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 521
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 521
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Pro Gly Phe Thr Leu Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 522
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 522
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Thr Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 523
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 523
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly His Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 524
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 524
Glu Val Gln Pro Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Asn Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Gly Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 525
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 525
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp Ser Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 526
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 526
Glu Ala Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 527
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 527
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp His Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 528
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 528
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Ser Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 529
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 529
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 530
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 530
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Glu Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp His Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 531
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 531
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Phe Asp His Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 532
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 532
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 533
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 533
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 534
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 534
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 535
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 535
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 536
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 536
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr His Cys
85 90 95
Ala Lys Glu Pro Tyr Ser Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 537
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 537
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Met Trp Trp Phe Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Asn Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 538
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 538
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Leu Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Asp Pro Tyr Ser Phe Asp Tyr Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 539
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 539
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Tyr
20 25 30
Glu Leu Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Arg Asp Pro Tyr Ser Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 540
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 540
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 541
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 541
Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Pro Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 542
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 542
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Val Trp Val Arg Lys Ala Pro Gly Met Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Tyr Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Met Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Ala Leu Val Thr Val Thr Ser
115 120
<210> 543
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 543
Glu Val Gln Leu Leu Val Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Ser Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly His
100 105 110
Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 544
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 544
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 545
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 545
Glu Ala Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Arg
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 546
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 546
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Ser Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Pro
100 105 110
Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 547
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 547
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 548
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 548
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Pro
100 105 110
Gly Ala Leu Val Thr Val Ser Ser
115 120
<210> 549
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 549
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Tyr Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 550
<211> 120
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 550
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Pro Thr Ala
20 25 30
Glu Met Leu Trp Val Arg Lys Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ser Ile Ser Ala Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Ala Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Glu Pro Val Ser Tyr Val Ala Thr Phe Asp Tyr Trp Gly Gln
100 105 110
Gly Thr Leu Val Thr Val Ser Ser
115 120
<210> 551
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 551
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Thr Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 552
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 552
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Arg Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu His Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 553
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 553
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Thr Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Asn Ile Arg
100 105
<210> 554
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 554
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 555
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 555
Asp Ile Gln Met Thr Gln Ser Pro Ser Phe Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 556
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 556
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Thr Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 557
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 557
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 558
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 558
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 559
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 559
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 560
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 560
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 561
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 561
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Thr Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 562
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 562
Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 563
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 563
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Asn Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln His Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 564
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 564
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Thr Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 565
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 565
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Tyr Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Val Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Gln
100 105
<210> 566
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 566
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Arg Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 567
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 567
Asp Ile Gln Ile Ile Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 568
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 568
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 569
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 569
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Asn Lys Arg
100 105
<210> 570
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 570
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 571
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 571
Asp Ile Gln Met Thr Gln Ala Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Asn Lys Arg
100 105
<210> 572
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 572
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Ala Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 573
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 573
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 574
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 574
Asp Ile Leu Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 575
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 575
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Tyr Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 576
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 576
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Asn Lys Arg
100 105
<210> 577
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 577
Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Met Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 578
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 578
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 579
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 579
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 580
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 580
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Leu Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 581
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 581
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Glu Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 582
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 582
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Ser Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Leu Ala Thr Tyr Tyr Cys Gly Gln Glu Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 583
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 583
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Gln Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Phe Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Glu Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 584
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 584
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Phe Gly Thr Glu Phe Thr Leu Thr Ile Gly Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 585
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 585
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Thr Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Pro
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
100 105
<210> 586
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 586
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 587
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 587
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Gln Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 588
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 588
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Ala Gln Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Arg Arg
100 105
<210> 589
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 589
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Tyr Ile Ala Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Ala Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 590
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 590
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Ala Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 591
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 591
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Thr Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 592
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 592
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Ser Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 593
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 593
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 594
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 594
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Ala Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 595
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 595
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Ser Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 596
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 596
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Trp Ile Ala Gln Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 597
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 597
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Arg Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 598
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 598
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Arg Ile Ala Gln Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 599
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 599
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Tyr Ile Ala Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 600
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 600
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Arg Phe Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 601
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 601
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Lys Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 602
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 602
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Trp Gly Ser Tyr Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 603
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 603
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Trp Gly Pro
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Ser Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 604
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 604
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Trp Ile Ala Thr Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 605
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 605
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Trp Gly Pro
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 606
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 606
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Asn Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Leu Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 607
<211> 108
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 607
Gly Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser His Phe Ile Gly Ser Leu
20 25 30
Leu Ser Trp Tyr Gln Val Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Thr Tyr Gly Ser Trp Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Gly Val Leu Trp Pro Ala
85 90 95
Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys Arg
100 105
<210> 608
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 608
gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 609
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 609
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 610
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 610
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 611
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 611
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 612
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 612
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 613
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 613
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg ctatgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 614
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 614
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttatttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 615
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 615
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg acttatcata tgcagtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaatg attgatgcgg atggtcttgg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgggt 300
ccgcagtttg gtcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 616
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 616
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cttccggatt caccttttcg gggtatgata tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attagtgcgt cgggtgtttt tacatactac 180
gcagactccg tgaagggccg gttcaccacc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcct 300
aatcgttttg cgcttaataa ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 617
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 617
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcgggtt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 618
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 618
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 619
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 619
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 620
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 620
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tggtgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 621
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 621
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 622
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 622
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg aagaatgaga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgagtcgg atggtcaggc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgctgaggac accgcggtat attactgtgc gaaaaatcgg 300
attcctgatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 623
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 623
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gctggggcta tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attgataagg agggtctgtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtagg 300
attcctgggc tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 624
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 624
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt gatgcggcga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attcagccta tgggtgatgg tacatactac 180
gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
attcctactc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 625
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 625
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gattcgccta tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attacttcga atggttatga gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 626
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 626
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gagcatgata tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attggtccgg atggttttca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 627
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 627
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt gagtatcata tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attactcctc ttggtacgct tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
attccttcgc ttacgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 628
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 628
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt acgaatgcga tgagttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaagg atttcgccgg gtggtgatta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtgt attactgtgc gaaagggcgt 300
gttccggatc tgctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 629
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 629
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg tctgaggaga tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg atttcggctg atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaagggcgt 300
gttccggatc tgctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 630
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 630
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gaggatgata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgcggttg atggtgatcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtaag 300
gttccgtctc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 631
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 631
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggggatc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagg acgatggata tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attacgggtg atggtatgaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccggggac accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 632
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 632
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag cgtgatgata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatgctg ggggtgtgca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 633
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 633
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gatgattcta tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg atttcgagtg atggtgcgag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 634
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 634
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gaggaggata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatagtg ttggtgaggg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 635
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 635
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gattcggcga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg attgataatc ctggtcagca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtact 300
gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 636
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 636
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg cagcatagta tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatggtg ggggttataa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggag 300
gttcctcgtc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 637
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 637
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt caggagccta tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg attgcgtata atggtggtga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
actcctaatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 638
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 638
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag aattatccga tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatgcta cgggttctat tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtt 300
attcctcatt tgatgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 639
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 639
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgt gattatgata tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attactggta ctggtaatag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaggggtg 300
gtgccgtatc ttgcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 640
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 640
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gctgatgcga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attaatgtgg atggtgatcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300
gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 641
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 641
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat cgggcggata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg atttcggggg agggtaagtg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatg 300
gttcctaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 642
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 642
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcat tgggagccga tgtcttgggt ccgccaggct 120
ccggggaagg gtctagagtg ggtctcacgt attaattctt ctggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatg 300
gttcctaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 643
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 643
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gatgagccga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attcctcctg agggtgctcc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
actcctaatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 644
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 644
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcat aatcatgata tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attagtcggg gtggtcttca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
gtgccggatc tgcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 645
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 645
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat gagtatccta tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatgggg atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
attccggcta tgcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 646
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 646
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gatgtgccta tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attgatcctt atggttctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtatt 300
atgcctagtc ttacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 647
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 647
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg gattatgata tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt atttcggcgc ttggtgctac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcag 300
cttccggcgt tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 648
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 648
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaag cgttattata tgacttgggt ccgccaggct 120
ccagggaagg atctagagtg ggtctcaggt attgttcctt ctggtaatag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtagg 300
attccggatc tgcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 649
<211> 366
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 649
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gattatgata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg atttctccga cgggtgggca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtgtt 300
attccgtatt tgtctttttc tccgtttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc 366
<210> 650
<211> 366
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 650
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct aagtattgga tgggttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgattcgc atggtgctgg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgtcgaggac accgcggtat attactgtgc gaaaggtgct 300
cctaagttta tgactacgta tacgtttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc 366
<210> 651
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 651
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttttg tcttatccga tgcattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgattcga ggggttcggt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcat 300
agttggacgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 652
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 652
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg aatagtaata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatccgg atggtgggtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggcgt 300
attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 653
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 653
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg ccgaggagga tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgatgata ttggtcgtag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaggggcg 300
cagggtgtgt tgttgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 654
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 654
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gattatagga tggtttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg atttctactt ctggtgagct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaacggcg 300
ggtcagtttt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 655
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 655
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg gagtatgaga tggtttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcagcg atttcgcgtg agggtcgggc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acaacctgcg tgccgaggat accgcggtat attactgtgc gaaagagcct 300
gttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 656
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 656
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg acttatgaga tgctttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcttctt ctggtaatta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
ctgatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 657
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 657
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat actgaggaga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attagtccta atggtgcttt tacattctac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagcct 300
attctgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 658
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 658
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt cattatgata tggtttgggt ccgccaggct 120
ccagggaggg gtctagagtg ggtctcaact attaatggtg ctggtctgaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaaagtgct 300
agtcgtattt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 659
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 659
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagg agttatgaga tggcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attagtactc tgggtacgaa gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaatcttct 300
actcatattt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 660
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 660
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttatt aggtatgaga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt atttcgtcgt ctggttggac gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaagtgat 300
gctcatattt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 661
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 661
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttat gcttatgaga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggatg atggtacgcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatctg 300
gggcaggggt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 662
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 662
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gatcatggga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggg attggtccgt ctggtgaggc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 663
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 663
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tctcaggata tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatagg 300
tctgattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 664
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 664
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gattatgata tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attcgtcatc cgggtggtgt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctgtt 300
cctaagggtt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 665
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 665
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gtttattgga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attgatccgc agggtgggat gacatactac 180
gcagactccg tgaagggccg gttcaccatc tctcgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagcgcgt 300
attcctaatt tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 666
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 666
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggagtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gcttatgata tgacgtgggt ccgccaggct 120
ccagggaagg gtcttgagtg ggtctcacgt attaatccga cgggttctta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagctaag 300
attccgaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 667
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 667
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg gatagtgaga tgatgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attgcgcata atggtgggca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctggt 300
catcctcagc agactgaggc ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 668
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 668
gagatgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct acttatgata tgtattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaaag atttctccga atggttggag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcag 300
acgcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 669
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 669
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gtttatgata tgaggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg atttcttctt cgggtacgta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcct 300
aagaattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 670
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 670
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct catgaggata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtact 300
aggagtaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 671
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 671
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag aagtatatta tgggttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attgattatt ggggtcagca tacatactac 180
gcagactccg tgaagggccg gttcactatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtagt 300
catcttattc ctctgcagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 672
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 672
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gattatgcga tggggtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaacg atttcgtatg tgggttatta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaaggct 300
ctgcgggggg aggcgtttac ggagcgtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 673
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 673
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt ccgtatatga tgcattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attgaggtta atggtaatag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatgggtt 300
ggttcgaaga cgtcgtcgga taagagtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 674
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 674
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt acgacggaga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attggtagtg ctggtgcttg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaattggt 300
gggcatcctc agggtcagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 675
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 675
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60
tcctgtgcag cctccggatt cacctttcct agggagtgga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attcagccta tgggtcagac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatattct 300
cggaataagg ggttttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 676
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 676
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttacg agtgagtata tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attcagaggt atggtagtac gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacatgag 300
tctaattggg agacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 677
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 677
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg gtgtatagta tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attactccta atggtactcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactctt 300
ggtcggggtt cttatcctgg tgttgatttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 678
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 678
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg agttatgcta tgacgtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcacgt attacggcgg atggtactgt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggttct 300
attccgatgc ttacgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 679
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 679
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg acttatgata tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct atttctccta atggtactgg tatatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaatcag 300
agtgttcatc atgctgtttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 680
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 680
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag aattatgaga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgcgccgc atggtcggct tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtcag 300
attccgatgc ttgattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 681
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 681
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg cattatatga tgatgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg atttctcatt ttggtgatat tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaatgat 300
atggtgatga agaatggggg gtttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 682
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 682
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag aggtatgata tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgattcgc ggggttggtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggttg 300
gtgccgcatc tgaggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 683
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 683
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg aatgcgcaga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attgatgcta tgggtgatgc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtaag 300
gttccgagta ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 684
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 684
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg aatgcgcaga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attgatgcta tgggtgatgc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtgtt 300
attccggcgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 685
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 685
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcag aatgatcgga tgcattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg atttctgcta ctggtggtga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagacg 300
ggtacgaatc gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 686
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 686
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat cagccttata tgtcgtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct attgatgctt cgggtggtac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 687
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 687
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat aatgagaata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatggtg ggggttataa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcag 300
gttcctgagc tgctgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 688
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 688
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgtt tcgtcgaata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactat 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcgg 300
attcctacgt tggtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 689
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 689
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgtt tcgtcgaata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactat 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 690
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 690
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gatgattcga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatgatg ctggtagttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300
attcctcttc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 691
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 691
gagatgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgtt tcggatacta tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatggga ctggtggtga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccggggac accgcggtat attactgtgc gaaagggctt 300
attcctgatc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 692
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 692
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gaggaggaga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attattggtg gtggtcatga gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300
attcctcttc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 693
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 693
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat aatgagaata tgacttgggt ccgccaggct 120
ccagggaagg atctagagtg ggtctcacgg attactgaga ggggtgatgt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300
gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 694
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 694
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gaggaggaga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attattggtg gtggtcatga gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300
gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 695
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 695
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcat gagacggaga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attaatcggc tgggtcagga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtagg 300
attcctgggc tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 696
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 696
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gatgattcga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatgatg ctggtagttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtact 300
gttcctacgc tggagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 697
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 697
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat aatgagaata tgacttgggt ccgccaggct 120
ccagggaagg atctagagtg ggtctcacgg attactgaga ggggtgatgt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcgg 300
attcctacgt tggtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 698
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 698
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gatgattcga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attaatgatg ctggtagttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
actcctaatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 699
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 699
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gatgagccga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attcctcctg agggtgctcc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggctt 300
attcctgatc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 700
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 700
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcag gatagtgata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attgctgcgc ctggtggtag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttaggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 701
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 701
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgtt tcggatacta tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatggga ctggtggtga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcag 300
gttcctgagc tgctgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 702
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 702
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcag gatagtgata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attgctgcgc ctggtggtag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 703
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 703
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag ccgccggatt cacctttgat ctggcggaga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatgagg atggtgcttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc ggaaggtgtt 300
attccgtctc tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 704
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 704
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gataagcata tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg atttcgcctg atggtacgta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc ggaaggtgtt 300
attccgtctc tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 705
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 705
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gaggatgata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgcggttg atggtgatcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg taccgaggac accgcggtat attactgtgc gaaagggaag 300
acgccgcatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 706
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 706
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag ccgccggatt cacctttgat ctggcggaga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attgatgagg atggtgcttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtcag 300
gttcctgctt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 707
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 707
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gattcgatga tgtcgtgggt ccgccaggcg 120
ccagggaagg gtctagagtg ggtctcacgg attgatcctg ggggtgctca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 708
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 708
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag catgcggata tgagttgggt ccgccaggct 120
tcagggaagg gtctagagtg ggtctcacgt attgataata gtggtcagtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 709
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 709
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gaggcggaga tgaattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attacgacgg atggtgattc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 710
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 710
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctcaggatt cacctttgat gatagtgata tgacttgggt ccgccaggct 120
ccagggaaga gtctagagtg ggtctcatat attcggggtg atgatgatga gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaatcgg 300
attcctgatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 711
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 711
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat gtggcggata tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacatgct 300
tctacggagg ggccgactgc ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 712
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 712
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg ccgtatgata tggggtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatgg atttctgctc atggttcgtt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatggcct 300
tataagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 713
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 713
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg agtgggtcta tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg attggtagta atggtgcgga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatg 300
gttcctaatt tggtttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 714
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 714
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat cgttttgata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 715
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 715
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gagagtgata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctcct 300
tcttctcgtc ttaagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 716
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 716
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat agtagtgaga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgagaatc agggtggtgc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcgt 300
attcctaatc ttgtgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 717
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 717
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacccttgat gcgtatccta tgtattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatgg attgcttcgg gtggtggtgc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtacg 300
aagaattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 718
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 718
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttatg agttattcta tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggg attacttcta atggtaatcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatcgact 300
ggggctaata gtaggaattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 719
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 719
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gggtatctga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attgcggcta atggtatgca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaagccg 300
aggggtattt gggatgggga ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 720
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 720
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcat gagtctacga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact attcggcatc cgggtgagtt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccggggac accgcggtat attactgtgc gaaagggctt 300
attcctgatc ttcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 721
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 721
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg atgtatagta tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgcgccgc cgggtggtag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacagtcg 300
ctgacggggt atagtaggtc ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 722
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 722
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg cagaatccga tgtcgtgggt ccgccacgct 120
ccagggaagg gtctagagtg ggtctcaacg attcctgcga atggtcgtcc tacatcctac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatagt 300
cagcagccgg gtcgtcggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 723
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 723
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct aattatcata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attcctgata gtggtaagca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctacaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggtagg 300
attccgtctc ttctttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 724
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 724
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg cagtatcata tgcgttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attaatgata ttggtagtaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttggg 300
gggcggggga gtttttcttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 725
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 725
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct tcgtatgata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attagtgcgt ctggtgtgtt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgggag 300
catgcgggtc agccgccttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 726
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 726
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat ggttatgcta tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact attaatgcta atggtaagta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaagttg 300
actcttgctt ctaattattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 727
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 727
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttatg gattatgata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attactgcgc ttggtaagaa gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatagt 300
gttaagtatc ctcttaatct ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 728
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 728
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg cattatacga tggcgtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct attcagtcgc ctggttggcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatggg 300
gatggtcttc ctttgacttt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 729
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 729
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt ggtacgccga tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgt attggggatg agggtcagga gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaggggtg 300
actccggatt tgacttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 730
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 730
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt agtagttcga tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attgggtctg atggtccgag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 731
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 731
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat cctggtgaga tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attgatgggt ctggttcttc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgatgac accgcggtat attactgtgc gaaagggcgt 300
attcctactc ttcattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 732
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 732
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcct gagtctatga tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgggtatc ctggtgctac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaggtggt 300
agtcgggatg ataattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 733
<211> 372
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 733
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgcctc 60
tcctgtgcag cctccggatt cacctttggt cagcatagta tgcattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtgttc cgggtccgaa gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtctt 300
agggatttgc gtccgggtga tagtaagagt tttgactact ggggtcaggg aaccctggtc 360
accgtctcga gc 372
<210> 734
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 734
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt tctgctgcta tggattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attaatgata tgggttctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagggt 300
ggtcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 735
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 735
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt tatgatagga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgatggtc ctggtggggc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggagg 300
agggttcctg attttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 736
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 736
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt gagtatgaga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg attgatccgt ttggttctga gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaaggtgtg 300
gttcctgatt tgaattttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 737
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 737
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat aagtatgtta tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact attggtagtt atggtggggc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaaggctt 300
actcttagtg cgactaagtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 738
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 738
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gattatgtga tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact attgcgcatc ggggtgatat tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgtagg 300
cgtcttagtg attatcggtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 739
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 739
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg cagtttgata tgtattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attagtccgg ctggtactgg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300
gatcggtcta gtctttttga ctacaggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 740
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 740
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaag gatacgggta tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt atttctagtt atggtcgtga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaattgaat 300
gcggcgctgg gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 741
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 741
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt ccgtatccga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attaatgcgc cgggtacgag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaacagatg 300
tctagtgggg tttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 742
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 742
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg aatcaggata tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attgatagtt ctggtcagct tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagttaag 300
tctcttgcgc ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 743
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 743
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttcct gagtctgata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaccggct 300
caggttctgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 744
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 744
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag cagtatgtga tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attggtacgt cgggtaagta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaacgtagg 300
tctctgactc gggttcattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 745
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 745
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt gtggagcata tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attacgggtg atggtgatcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacggtt 300
tcgtggaatg gtcgttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 746
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 746
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg tggtataata tgggttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaagg attgctccgt ctggtattat tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggttg 300
cgtggtaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 747
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 747
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg aattatgaga tgaggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcttcgg ctggtactga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagtcg 300
cttaattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 748
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 748
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgtag cctccggatt cacctttgat gaggagccga tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaatt attgatccgg gtggtggggc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctaat 300
agtatgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 749
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 749
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gcgtatccta tgcattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attgcttctt cgggtattac gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttact 300
cggctgcatt ttcctgcgca gtttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 750
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 750
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gattatgcga tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagg atttctcctg agggttctag gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaattgcgg 300
ccgtatgcgt cgaagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 751
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 751
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagg ccgtatgata tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg atttctcatc agggtaatcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgtct 300
catcattttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 752
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 752
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct gcgtataata tgtggtgggc ccgccaggct 120
ccagggaagg gtttagagtg ggtctcatgg attaattcga ctggttctcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaattgg 300
catcggggga ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 753
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 753
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat aggtatcgga tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attaatcggc tgggtcagag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgaag 300
aagcataagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 754
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 754
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg cattataata tgcggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attacgaaga ctggttttcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300
cagtttgatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 755
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 755
gaggtgcagc tgttggagtc tgggggaggc ttagtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttat ccttatagta tgcattgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaact attgatggta gtggtatgtt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagattct 300
ctgaaggctt cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 756
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 756
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg ctttatggga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatat attgggcctt atggtcatac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaagcgg 300
aagaagaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 757
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 757
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcct aggtatcgga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attactccgt atggtgctca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatggt 300
aagtggtatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 758
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 758
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat gagtatgcga tgaggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attgatcgtc tgggtcttca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtggg 300
ccttttacgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 759
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 759
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag cggtataata tgcgttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attgatcggc tgggtcttgc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggt 300
tcgtggtctt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 760
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 760
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt atttatgata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg atttcgtcgt cgggtactca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcct 300
cagccttatc cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 761
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 761
gaggtgcagc tattggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttgg gtgtatgata tgcgttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg atttctgcga ctggtgtgca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatccg 300
cctgctggtc ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 762
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 762
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg acttatgata tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct atttctccta atggtactgg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctccg 300
caggtgaata ctgagtttga ctaccggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 763
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 763
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag aaggaggata tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacat atttcgccga atggttatgc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagttgg 300
tctagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 764
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 764
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gctactccga tggagtgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact atttctgaga gtggttatag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggaat 300
tcgactactg gttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 765
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 765
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat acggtggata tggagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagctccg 300
catcgggcgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 766
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 766
gaggtgcagc tgttggagtc tggggggggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gataaggaga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg attgatgctt tgggtgattc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaagggatg 300
gttcctcgtc tgaagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 767
<211> 342
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 767
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gatcattcga tgatgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagat attgagccgc atggtgttca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaatcctact 300
tttgactact ggggtcaggg aaccctggtc accgtctcga gc 342
<210> 768
<211> 366
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 768
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg ccgcatacta tgcattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attggtccgg atggtactac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgttcg 300
tatagttggg atcgtgggtg gacgtttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc 366
<210> 769
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 769
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttat gcttcggata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtccga atggttggga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagctgat 300
tatacttatc attcttttga ctactggggt caggggaccc tggtcaccgt ctcgagc 357
<210> 770
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 770
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg cattataata tgcggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attacgaaga ctggttttcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcgggg 300
cagtttgatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 771
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 771
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg cattatcata tgggttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagtt attgggccga ggggtatttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatcgcct 300
tcgcgtcata ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 772
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 772
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat gagtatgcga tgaggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attgatcgtc tgggtcttca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtggg 300
ccttttacgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 773
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 773
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt aattatagta tgaagtgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact attactcctg atggttggta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagtgggg 300
gatgctgttt gggggtggat tggtgggttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 774
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 774
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gattatggta tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attacgtcta atggtgattt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatctttg 300
tataagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 775
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 775
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag gctccggatt cacctttcct acttataaga tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcattt attgattatt ggggttggcg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtccg 300
tattcttgga ctcatgatag tcctcatttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 776
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 776
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagg ccttatacga tgtgttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatgt attagtgatg ctggttcttt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaggatg 300
tcttcttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 777
<211> 366
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 777
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcag aattatcaga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaact attagtggga ctggtaagaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaactcct 300
cagaattatt ttagtgtgcg tcggtttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc 366
<210> 778
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 778
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gcgtatacta tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaaag atttcgacgt ctggtgggca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctttg 300
aattggtggg cgtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 779
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 779
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaat gcgtatccta tgacttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcacgg attgatggtt atggtcggca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
attcctaatt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 780
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 780
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gcggttgata tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg atttcgccta gtggttctgc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggcgt 300
gtgccggatc ttggttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 781
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 781
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat agttatgcga tggggtgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attggggcta agggtttgtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcggct 300
aggggtaagt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 782
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 782
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact cggtatcaga tgggttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagtt attaatgttt ggggttcgag tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaatgtct 300
gggaagtttg cctactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 783
<211> 351
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 783
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctt 60
tcctgtgcag cctccggatt cacctttggg aattatagta tgatgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attattcctg ctggtacgtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccgtcg 300
attaggttgt ttgactactg gggtcaggga accctggtca ccgtctcgag c 351
<210> 784
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 784
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt gcgtatgata tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatgg atttctccga atggttatga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggggt 300
gtgaagtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 785
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 785
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgtt tggtatgaga tggcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attcaggctg atggtgagca gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagcttcg 300
tatgctcttg tgtatcctcc tgaggagttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 786
<211> 366
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 786
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttacg aattatagga tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attgatgatc tgggtgtgtc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatggagg 300
cttaagaata gtcagccgac ggattttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc 366
<210> 787
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 787
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat caggctcata tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcattt attaatcctt cgggttatta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaccttcg 300
cttagtccgt cttcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 788
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 788
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag actggtcaga tgggttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaaat attgatgggt ctggtacgta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaagtacg 300
cagaattatc ggtttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 789
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 789
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt gcttatccga tgtattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attcataagg atggtaggat tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacagggt 300
acgccggttg atgggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 790
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 790
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcct gatgagggta tgacgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attgagactg gtggtacggt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaatggat 300
gggtctggta catggcagac gtttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 791
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 791
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat agtctgggta tgggttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatat attcgggctg agggtgctta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaatatctt 300
gcggattctg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 792
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 792
gaggtgcagc tgttggaatc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gagtcgtata tggagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attgatcata ttggtggtgg gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagatgat 300
ggtcgtggtg ggtctatgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 793
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 793
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttct ggtgggtata tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attggggcta gtggtgcgta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaaacgggg 300
ggtaggttag actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 794
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 794
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gaggggcata tggggtgggt ccgccaggct 120
ccagggaagg atctagagtg ggtctcatat attgggagtc tgggtttgca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacgggag 300
tttagtaatg gggggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 795
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 795
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttaag actagtccta tgtattgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatcg attgatcgga ctggtgggca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacaggct 300
ctgcttactg atgcgaagcg ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 796
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 796
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat ggtcgggata tggtttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtccga gtggtctgga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc ggaacgtcct 300
cagatgctgg ttactaattt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 797
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 797
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggt aatgatccga tgagttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggg attggtcggg agggtgattc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagattct 300
atgcggcatc agccgtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 798
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 798
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gagacttata tgaagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg attggggcgt cgggtgctga tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatttacg 300
catctgaatg gtcggtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 799
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 799
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg gggtggccta tggggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attgatattg atggtgctcc gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaggag 300
gcgggttctt ggtcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 800
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 800
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gatcaggcga tgtggtgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcattt attcagggtg atggtggttt tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacctagt 300
aagccgtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 801
<211> 354
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 801
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag actggtcaga tgggttgggc ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaaat attgatgggt ctggtacgta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagcggtg 300
cggaattttg cttttgacta ctggggtcag ggaaccctgg tcaccgtctc gagc 354
<210> 802
<211> 372
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 802
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttagt gggcatgata tgtcttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcctc atggtacgca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagggatt 300
aggggttgga ttggtcatga tacgcagcct tttgactact ggggtcaggg aaccctggtc 360
accgtctcga gc 372
<210> 803
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 803
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag agtaaggata tgctttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcgtcgg atggtactca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gcaagagctg 300
ggtgggtctt ggcagtttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 804
<211> 366
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 804
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgcg gatcgtgata tggtttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attggggcgt cgggtacgtc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaaggtggg 300
acgggtccta ctgatttgtg ggattttgac tactggggtc agggaaccct ggtcaccgtc 360
tcgagc 366
<210> 805
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 805
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgat gatgagaaga tgctttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagt attagtgtga gtggtctgca tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaggag 300
gcgggttctt ggtcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 806
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 806
gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg caggagagga tgatttgggt ccgccaggct 120
cctgggaagg gtctagagtg ggtctcagat atttcggctt cgggtgggac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaggag 300
gcgggttctt ggtcttttga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 807
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 807
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc tctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccatgaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actacagggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 808
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 808
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 809
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 809
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actaccgggt tcagggaacc ctggtcaccg tctcgagc 348
<210> 810
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 810
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 811
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 811
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg gatctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actacagggt tcagggaacc ctggtcaccg tctcgagc 348
<210> 812
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 812
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccgagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 813
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 813
gaggtgcagc tgttggagac tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatgg acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tcacgagc 348
<210> 814
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 814
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcacgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttc actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 815
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 815
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgtag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccaggct 120
ccagggaatg gtctagagtg gatctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 816
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 816
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctctggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gtctagagtg ggtctcagcg atatctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgctaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtatttcg actactgggg tcggggaacc ctcgtcaccg tctcgagc 348
<210> 817
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 817
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actacagggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 818
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 818
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc catgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gtctagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actacagggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 819
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 819
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gattagagtg ggtctcaatg atttccgggg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 820
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 820
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg acggttggcg cacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctt 300
gggtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 821
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 821
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300
ctctactttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 822
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 822
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300
gggttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 823
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 823
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg 300
gagtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 824
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 824
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagggttg 300
gagtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 825
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 825
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300
gccttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 826
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 826
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctc 300
ttgtactttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 827
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 827
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg 300
gagttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 828
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 828
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagctg 300
cagttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 829
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 829
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagctg 300
ctcttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 830
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 830
gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagttg 300
gagttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 831
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 831
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg 300
ctcttctttg actaccgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 832
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 832
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt catctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaaaacttg 300
gagtattttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 833
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 833
gaggtgcggc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag tggtatgaga tgcagtgggt ccgccgggct 120
ccagggaagg gactagagtg ggtctcagcg atttctggtg atggttatcg tacatactac 180
gcagactccg tgaaaggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagttg 300
cagttctttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 834
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 834
gaggtgcagc tgttggggtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttc gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 835
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 835
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 836
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 836
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg gatctcagct attagtggaa gtggtggtag cacatactac 180
gcagactccg tgaagggccg gtttaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 837
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 837
gaggtgcagc tgttggatcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg aaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 838
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 838
gaggtgcagc tgttggggtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 839
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 839
gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctgggggctc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgctaatga acagcctgcg tgccgaggat accgcggtat attactgttc gaaagagccg 300
tttcgttttg actactgggg tcagggagcc ctggtcaccg tctcgagc 348
<210> 840
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 840
gaggtgcagc tgttggatcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg aaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attagtggta gtggtggtag cacatactac 180
gcagactccg ttaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
ttacgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 841
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 841
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatctgggt ccgccaggct 120
cctgggaagg gtctagagtg gatctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc caccgcgaca attctaagaa cactctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttc gaaagagccg 300
tttcgttttg actacagggg tctgggaacc ttggtcaccg tctcgagc 348
<210> 842
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 842
gaggtgcagc tgttggatcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttggg aaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
ttacgttttg actactgggg tcaggggacc ctggtcaccg tctcgagc 348
<210> 843
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 843
gaggtgcagc tgttggattc tgggggaggc tttgtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg gatctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtgt attactgtgc gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 844
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 844
gaggtgcagc tgttggatcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg gatctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaataa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gagagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 845
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 845
gaggtgcggc tgttggagtc tggggaaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcacgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 846
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 846
gaggtgcagc agttggagtc tgggggaggc ctggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 847
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 847
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
ttctactacg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 848
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 848
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
ttctacttcg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 849
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 849
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gagaaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
ttcttctacg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 850
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 850
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttccc caggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 851
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 851
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttttc gccgccgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 852
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 852
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtaggc ccggtacgag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 853
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 853
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgga tgggtttcag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 854
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 854
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcggt ggggtcacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 855
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 855
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgcc tcggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 856
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 856
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgct ggggtgccag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 857
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 857
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtaggc agggtgggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 858
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 858
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtgtgt ccggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 859
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 859
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcggt ggggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 860
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 860
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgga acggtctgag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 861
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 861
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtgggc tgggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 862
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 862
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtgcgt tgggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 863
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 863
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgca ggggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 864
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 864
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtaggc acggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 865
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 865
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaagc attagcagga gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 866
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 866
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgga tcggtaacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 867
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 867
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtgggc acggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 868
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 868
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct atttcgaggt ggggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 869
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 869
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
ttcatgtatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 870
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 870
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
ttcccgtacg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 871
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 871
gaggtgcagc tgttggcgtc tgggggaggc ttggtgcagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtgg cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 872
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 872
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
ttgtactatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 873
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 873
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgtcaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccc 300
atgtactatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 874
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 874
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggtttcag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 875
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 875
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgca cgggtgggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 876
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 876
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcggg agggtgggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 877
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 877
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccgggtt cccctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcggc agggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 878
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 878
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtaggg gcggtgggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 879
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 879
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgca cgggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 880
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 880
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggtaggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 881
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 881
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 882
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 882
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga agggtagcag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 883
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 883
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcggg gcggttggag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 884
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 884
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtcgct cgggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 885
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 885
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggtatgag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 886
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 886
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 887
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 887
gaggtgcagc tgttggagtc tggggaaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagcatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tcccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg ccagggaacc ctggtcaccg tctcgagc 348
<210> 888
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 888
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc cacctttact gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg gatctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat atttctgtgc gaaagagccg 300
cttaggtttg actacagggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 889
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 889
gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgcaaggct 120
ccagggaagg gtatggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg gctactgggg tcagggtacc ctggtcaccg tctcgagc 348
<210> 890
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 890
gaggtgcagc tgttggattc tgggggaggc ttggtacagc ctggggggtc actgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctacaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 891
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 891
gaggtgcagc tgttggggtc agggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120
ccagggaaga gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtatg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 892
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 892
gaggtgcagc cgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgttcag cctccggatt cacctttaat gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 893
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 893
gaggtgcagc tgttggagtc tggggaaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gagtatgaga tgatttgggt ccgccaggct 120
ccagggaaag gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 894
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 894
gaggtgcagc tgttggaccc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtctgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggaa atggtgctaa tacatactac 180
gcggactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 895
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 895
gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgcaaggct 120
ccagggaagg gtatggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tcccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 896
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 896
gaggtgcagc tgttggagtc tggggtaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgcaaggcc 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaaccg 300
cttaggtttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 897
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 897
gaggtgcagt tgttggagtc tcggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagcatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttctccgtc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 898
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 898
gaggtgcagc cgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgctg cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 899
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 899
gaggtgcagc tgttggagtc tgcgggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatca atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg actactgggg tcagggagcc ctggtcaccg tctcgagc 348
<210> 900
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 900
gaggtgcagc tgttggagcc tgggggaggc ttggtacagc ctggggggtc gctgcgtctc 60
tcctgtgcag cctccggatt cacctttact gagtatgaga tgatttgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcatct atttcgggta atggtgctaa tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
cttaggtttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 901
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 901
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc tctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtagac gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atttgaggta tgcgcgtttt gactactcgg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 902
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 902
gaggagcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtagac gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg ctacgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 903
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 903
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca atttcaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactacgggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 904
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 904
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gacaactggg gtcagggaac cctggtcacc 360
gtctcgaac 369
<210> 905
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 905
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat acgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attggtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atttgaggta tgcgcgtttt gactactcgg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 906
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 906
gaggtgcagc tgatggagtc agggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt ctcctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaaag gtctagagtg ggtctcaggt attagtaggc gtggttatac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactactggg gtcggggaac cctggtcacc 360
gtctcgagc 369
<210> 907
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 907
gaggtgcagc tgttggagtc tgggggaggc ttggtgcagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cgcctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gactagagtg ggtctcaggt attagtaggc atggttttac tacgtactac 180
gcagactccg tgaagggccg gttcaccgtc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgcggta tgcgcgttct gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 908
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 908
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atttctgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgttct gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 909
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 909
gaggtgcagc tgttggagtc tggggggggc ttggttcagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccgggtt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatt ctatgaggta tgcgcgtttt gactactcgg gtctgggaac catggtcacc 360
gtctcgagc 369
<210> 910
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 910
gaggtgcagc tgctggagtc tgggggaggc ttggtacagc ctggggggtc ccttcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactacagtg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 911
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 911
gaggtgcagc tgttggagtc tggaggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc atggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 912
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 912
gaggtgcagc tgttcgagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaggagccg 300
attacgtatg atatgaggta tgcgcgtttt gactactggg gtcggggaac cctggtcacc 360
gtctcgagc 369
<210> 913
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 913
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctgggggatc cctgcgtctc 60
tcctgtacag cctccggttt cacctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactactggg gtcggggaac cctggtcacc 360
gtctcgagc 369
<210> 914
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 914
gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt ctcctttaat atgtatgaga tgtcgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgggc 369
<210> 915
<211> 369
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 915
gaggtgcagc tgttggagtc tgggggaggc ttggtacaac ctggggggtc cctgcgtctc 60
tcctgtacag cctccggatt cacctttaat atgtatgaga tgtcgtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcaggt attagtaggc gtggttttac tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgtgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagccg 300
attacgtatg atatgaggta tgcgcgtttt gactactggg gtcagggaac cctggtcacc 360
gtctcgagc 369
<210> 916
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 916
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 917
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 917
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 918
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 918
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgcagaggat accgcggtat attactgtac gaaacttccg 300
tttatttttg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 919
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 919
gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 920
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 920
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 921
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 921
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt ctcctttcgg gattatgaga tgtggtggta ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatattac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttatttttg acaaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 922
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 922
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat acctcggtat atcactgtgc gaaacctccg 300
tttatttttg gcgactgggg tccgggaacc ctggtcaccg tctcgagc 348
<210> 923
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 923
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc ccggcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccggggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcacgatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 924
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 924
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 925
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 925
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg ttctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 926
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 926
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg agccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 927
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 927
gaggtgcagc tgttggagtc tgggggaggc ttgatacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttt gaaacttccg 300
tttattttcg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 928
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 928
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaacccgc agggtacgcg tacatactat 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgatgat accgcggtat atcactgtac gaaacttccg 300
tttatttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 929
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 929
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggatgg ttctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctatat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttttttttg actccagggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 930
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 930
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccgggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 931
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 931
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 932
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 932
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt ctcctttcgg gattatgaga tgtggtggta ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatattac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 933
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 933
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg ttctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 934
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 934
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 935
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 935
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtac gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 936
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 936
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgttt gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 937
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 937
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaacccgc agggtacgcg tacatactat 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgatgat accgcggtat atcactgtac gaaacttccg 300
tttatttttg aatactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 938
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 938
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagaacct 300
tatagttttg actcctgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 939
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 939
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300
tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 940
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 940
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccgggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 941
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 941
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccgggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 942
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 942
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 943
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 943
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 944
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 944
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 945
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 945
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 946
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 946
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 947
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 947
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 948
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 948
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtcta 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgatgggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat actgcggtat attactgtgc gaaacttccg 300
tttatgtttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 949
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 949
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
acctactttt ccgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 950
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 950
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttttctttg aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 951
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 951
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
acgtacttta aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 952
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 952
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttt ccgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 953
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 953
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat atcactgtgc gaaacttccg 300
atgttctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac 348
<210> 954
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 954
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttccgtttt cggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 955
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 955
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatgg acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttt ccgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 956
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 956
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtaacct cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 957
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 957
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc ccggtacctt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 958
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 958
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtggctt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 959
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 959
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccga tgggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 960
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 960
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgca cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 961
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 961
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ccggtgggct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 962
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 962
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc acggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 963
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 963
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgg ccggtcggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 964
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 964
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtagctt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 965
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 965
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccc gactacgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 966
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 966
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag actccggatt cacctttccg cccgtggaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 967
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 967
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtgggct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 968
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 968
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtaacca cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 969
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 969
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc acggtggcta cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 970
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 970
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaggg gtctagagcg ggtctcagct attaatccgc ccggtatgct cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 971
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 971
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtcagtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 972
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 972
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtggcta cacatactac 180
gcagactccg tgaagggccg attcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 973
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 973
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt cgggtgggct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 974
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 974
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt cgggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 975
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 975
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt cgggtacgct cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 976
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 976
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt acggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 977
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 977
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtggcta cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 978
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 978
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtgggct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 979
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 979
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttccca cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 980
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 980
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtacctt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaggaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 981
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 981
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccga acggtcggct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg cggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 982
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 982
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtcagct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 983
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 983
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc acggtggcct cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 984
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 984
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctggagcg ggtctcagct attaatccgg cgggtatgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 985
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 985
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc acggtacctt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 986
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 986
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 987
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 987
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtggcct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 988
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 988
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattacgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgg ccggtttctt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 989
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 989
gaggtgcagc tgttggagtc tgggggaggc ttggtacggc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctggagcg ggtctcagct attaatccgt acggtggcct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 990
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 990
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 991
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 991
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 992
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 992
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtgggct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatgg acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 993
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 993
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtacgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 994
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 994
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtggcta cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 995
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 995
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt acggtaacct gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 996
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 996
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc acggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 997
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 997
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgg ccggtttcta cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 998
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 998
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgg cgggtggcct cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg acgactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 999
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 999
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cgcctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc acggttccct cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1000
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1000
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgt gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgg ccggtgggta cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
tttacttttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1001
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1001
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttggttta cggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1002
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1002
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
ttcatgtttt ccgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1003
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1003
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttttgtttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1004
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1004
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
acgcggtttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1005
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1005
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1006
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1006
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1007
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1007
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
acgttcttta aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1008
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1008
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacacg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1009
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1009
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
cagttgtttc acgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1010
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1010
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
cagctctttg aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1011
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1011
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
tttgggtttt ccgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1012
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1012
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
cagttgtttc aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1013
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1013
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1014
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1014
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
cactacttta aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1015
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1015
gaggtgcagc tgttggagtc tgggggaggc ttggtacagt ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
ttttactttg aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1016
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1016
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttaggtttt ccgaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1017
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1017
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
acgctgtttc aggactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1018
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1018
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttt ccgagtgggg tcagggaacc ctggtcaccg tctcgaac 348
<210> 1019
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1019
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttggtttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1020
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1020
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1021
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1021
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
atgttctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac 348
<210> 1022
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1022
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1023
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1023
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1024
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1024
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggttcgtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1025
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1025
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1026
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1026
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
atgttctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac 348
<210> 1027
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1027
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1028
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1028
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1029
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1029
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1030
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1030
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1031
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1031
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaacttccg 300
atgttctttg aggactgggg tcagggaacc ctggtcaccg tctcgaac 348
<210> 1032
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1032
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1033
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1033
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttttctttc aggagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1034
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1034
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgt ggggtgggtt gacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaacttccg 300
tttttctttc acgagtgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1035
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1035
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat atcactgtgc gaaacttccg 300
atgttctttg aggactgggg tcagggaacc ctggtcaccg tctccagc 348
<210> 1036
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1036
gaggtgcagc tgttggagac tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg acttatcata tgcagtgggt ccgccgggct 120
ccagggaagg gcctggagtg ggtctcaatg attgatgcgg atggtcttgg gacatactac 180
gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccaaggac accgcggtat attactgtgc gagaccgggt 300
ccgcagtttg gtcagtttga ctacttgggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 1037
<211> 357
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1037
gaggtgcagc tgtttgagtc tgggggaggc ttggtacaga ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccttttcg acttatcata tgcagtgggt ccgccaggct 120
ccagggaagg gtctggagtg ggtctcaatg attgatgcgg atggtcttgg gaaatactac 180
gcagaccccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgt gaaaccgggt 300
ccgcagtttg gtcagtatga ctactggggt cagggaaccc tggtcaccgt ctcgagc 357
<210> 1038
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1038
gaggtgcagc tgttggagtc agggggaggc ttggtacagc ctggggggtc cctgcggctc 60
tcctgttcag cttccggatt caccttttcg gggtatgata tgcagtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcaacg attagtgcgt cgggtgttta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaatatcct 300
aatcgttttg cgcttaatag ttttgactac aggggtcggg gaaccctggt caccgtctcg 360
agc 363
<210> 1039
<211> 363
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1039
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cttccggatt caccttttcg gggtatgata tgcagtgggt ccgccaggct 120
ccagggaggg gtctagagtg ggtctcaacg attagtgcgt cgggtgttta tacatactac 180
acagactccg tgaagggccg gttcaccacc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtac gaaatatcca 300
aatcgttttg cgcgtaataa ttttgactac tggggtcagg gaaccctggt caccgtctcg 360
agc 363
<210> 1040
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1040
gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
ggggaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcagccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1041
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1041
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcagacag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcatccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1042
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1042
gacatccaga tgaccgtgtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcagatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggat tgcaaagcgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1043
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1043
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcgaccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1044
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1044
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tctaccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1045
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1045
gacatccaga tgaccgtgtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggat tgcaaagcgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1046
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1046
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcagatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcgaccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1047
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1047
gacatccaga tgacccagtc tccatcctca ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctgagctcct gatcgagagt tcttccggtc tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1048
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1048
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcgaatag ttctatattg tgggcgttgg cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaaacaa acgg 324
<210> 1049
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1049
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattctg tgggcgttag cttggtacca gcagaaacct 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaaccc 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1050
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1050
gacatccaga tgacccagtc tccatcctcc ctgtctgctt ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg gatcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1051
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1051
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggat tgcaaagcgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1052
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1052
gacatcctgt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1053
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1053
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gaagtggaac tgggacagat ttcactctca ccatcagcgg tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcgaccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1054
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1054
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcccttgcc gggcaaatag ttctattttg tgggcgttag cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcgagagt tcttccggtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtgcatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgttcag aatgcggttt ggcctggtac gttcggccaa 300
gggaccaagg tggagatcaa acgg 324
<210> 1055
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1055
gacatccaga tggcccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gttaggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1056
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1056
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
ggggaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgccatcag tatgcgagtc cacctttgac gttcggccaa 300
gggaccaatg tggaaatcaa acgg 324
<210> 1057
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1057
gacatccaga tgacccagtc tccatcctcc ctatctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctgcgtacta ctgtcatcag tacgagagtc cacctttgac gtttggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1058
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1058
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcgcgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1059
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1059
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga acgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattctg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gttaggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1060
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1060
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagcca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaggccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gttaggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1061
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1061
gacatccaga taacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagacc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc ctcctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1062
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1062
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
ggggaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa atgg 324
<210> 1063
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1063
gacatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1064
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1064
gacatccaga tgtcccagtc tccatccacc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgct tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgat gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1065
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1065
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
attacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagacc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacca 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1066
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1066
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ccgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa actggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1067
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1067
gacatccaga tgacccagtc tccatcctcc ctgtttgcat ctgtagggga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1068
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1068
gacatccaga tgacccagta tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gtcgattgag cgtcgtttaa attggtatca gcagaaacca 120
ggggaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggactaaag tggaaatcaa acgg 324
<210> 1069
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1069
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcgcgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatccg tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1070
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1070
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ggcgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatct 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcagcca 240
gaagattttg ctacgtacta ctgtcatcag tatgcgagtc cacctttgac gctcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1071
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1071
aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ggcgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttctcgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1072
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1072
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattggg cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggtcagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1073
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1073
gacatccaga tgacccagtc tccatcctcc ctttctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gagcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagaa tttactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1074
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1074
gacatccaga tgacccagac tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
ggggaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ccacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tgaaaatcaa acgg 324
<210> 1075
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1075
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaaccc 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1076
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1076
cacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgccatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1077
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1077
gacgtccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
ggggaagccc ctaagctcct gatctatctt acttcccgtt tgcaaagcgg ggtcccatca 180
cgtttcagtg gtagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgccatcag tatgcgagtc cacctttgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1078
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1078
gacatccaga tgacccagtc gccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcaccag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggtaatcaa acgg 324
<210> 1079
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1079
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1080
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1080
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gccgattgag cgtcgtttaa attggtatca gcagaagcca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacatacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1081
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1081
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gacgattggg cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1082
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1082
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gtcgattgag cgccgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc ctcctttgac gttcggccaa 300
gggaccaaag tggaaatcat acgg 324
<210> 1083
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1083
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaagctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1084
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1084
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gtcgattgag cgccgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaagctcct gatctatctt gcttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc ctcctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1085
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1085
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag ttcgagcacc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1086
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1086
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagttt ccccattgac cgtcgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1087
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1087
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagttc caccattggc cgtcgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1088
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1088
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagttacc 60
atcacttgcc gggcaagttc ccagattggg cgtcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1089
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1089
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtga gcggattggg cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1090
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1090
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gcagattggc cgccgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1091
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1091
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gccgattgcc cggcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1092
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1092
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtgg gaacattggc cgtcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa gcgg 324
<210> 1093
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1093
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtcg gaacattgac cgtcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1094
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1094
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gagcattggg cgtcgtttaa attggtacca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1095
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1095
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gaacattggg acgcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1096
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1096
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtga ggtcattggg cgtcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1097
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1097
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtga ggcgattggc cgtcgtttaa attggtatca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1098
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1098
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtac cagcattgcg cgtcgtttaa attggtatca gcagaaacct 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1099
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1099
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagttt gaacattggg cgtcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt gctacccgtt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1100
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1100
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca gacgattgag cgtcgtttaa attggtacca gcagaaacca 120
gggaaagccc ctaggctcct gatctatctt tcgtcgaagt tgcaaagtgg ggtcccatca 180
cgcttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtcatcag tatgagagtc cacctttgac gttcggccaa 300
gggaccaaag tggaaatcaa acgg 324
<210> 1101
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1101
gaggtgcagc tgttggagtc tgggggaggc ttggttcagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc caccattgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg tgtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgagacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1102
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1102
gaggtgcagc cgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg gatctcagct attagcggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1103
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1103
gaggtgcagc tgttggagtc tgggggaggc tcggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag ccaccggatc cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tacagttatg actactgggg tcagggaacc ctggtctccg tctcgagc 348
<210> 1104
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1104
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggact cacctttgct gggtatgaga tgtggtgggt ccgccaggca 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcagtat atcactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1105
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1105
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactctg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300
tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1106
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1106
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tcccgaggat accgcggtat attactgtgt gaaagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1107
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1107
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc caccattgcc gggtatgaga tgtggtgggt ccgccaggct 120
ccggggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ccggtcaccg tctcgagc 348
<210> 1108
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1108
gaggtgcagc tgatggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc cacctttgct gggtatgaga tgtggtggta ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtagaag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1109
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1109
gaggtgcagc tgctggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacgtactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcagtat attactgtgc gaaagaacct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1110
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1110
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc caccattgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcca 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1111
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1111
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagaccct 300
tatagttttg actactgggg tcagggaacc ctggtctccg tctcgagc 348
<210> 1112
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1112
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt caccattgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctccgct attagtggta gtggtggtag cacatactac 180
gcggactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tttcgagc 348
<210> 1113
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1113
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg tgtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc acccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagagcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1114
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1114
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg ataccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg actactggcg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1115
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1115
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc cacctttgct gggtatgagg tgtggtgggt ccgccaggct 120
ccagggaagg gtctggagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1116
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1116
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg gatctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgaaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1117
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1117
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1118
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1118
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggact cacctttgct gggtatgaga tgtggtgggt ccgccgggct 120
ccagggaagg gtctagagcg ggtcgcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1119
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1119
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggcc 120
ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1120
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1120
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cccccggatt caccttagct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1121
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1121
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggact cacctttgct gggtatgaga tgtggtgggt ccgtcgggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccacc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcggggaacc ctggtcaccg tctcgagc 348
<210> 1122
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1122
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ccggggggtc cctgcgtctc 60
tcctgtgccg cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gcggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttatg actactgggg tcatggaacc ctggttactg tctcgagc 348
<210> 1123
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1123
gaggtgcagc cgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtaa cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accggggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggtacc ctggtcaccg tctcgagc 348
<210> 1124
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1124
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttttg actcctgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1125
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1125
gaggcgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt aaccttcgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg cgtctcagct attagtggta gtggcggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1126
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1126
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatc cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttctccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttttg accactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1127
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1127
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctcgggatc cacctttgct gggtatgaga tgtggtgggt ccgcagggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1128
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1128
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1129
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1129
gaggtgcagc tgttggagtc tgggggaggc ttggtagagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttttg accaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1130
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1130
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggata cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttttg accaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1131
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1131
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactctg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300
tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1132
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1132
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1133
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1133
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactctg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagaacct 300
tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1134
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1134
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
cccgggaagg gtctagagcg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1135
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1135
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactctg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat atcactgtgc gaaagaacct 300
tatagttatg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1136
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1136
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgaga tgtggtggtt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtggta gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg acaactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1137
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1137
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggcc 120
ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gaaagatcct 300
tatagttttg actaccgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1138
<211> 348
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1138
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttgct gggtatgagt tgtggtgggt ccgccaggcc 120
ccagggaagg gtctagagcg ggtctcagct attagtggaa gtggtggtag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgc gagagatcct 300
tatagttttg actactgggg tcagggaacc ctggtcaccg tctcgagc 348
<210> 1139
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1139
gaggtgcagc tgttggagtc tggggggggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 1140
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1140
gaggtgcagc tgttggtgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tgttgtgggt ccgccaggct 120
ccagggaagg gtccagagtg ggtctcatca atttcggcta gtggtggttc tacatactat 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 1141
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1141
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcgtgtgcag cctccggatt cacctttccg actgccgaga tggtgtgggt ccgcaaggct 120
ccagggatgg gtctagagtg ggtctcatct atttcggcta gtggtggtta tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa catgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcagggag ccctggtcac cgtcacgagc 360
<210> 1142
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1142
gaggtgcagc tgttggtgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tggtgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttctccatc tcccgcgacg attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcatggag ccctggtcac cgtctcgagc 360
<210> 1143
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1143
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacatttccg actgctgaga tgttgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg agccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcaacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 1144
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1144
gaggcgcagc tgttggagtc tgggggtggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tggtgtgggt ccgccaggct 120
ccagggaagg gtctagagtg gatctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaattga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcggggaa ccctggtcac cgtctcgagc 360
<210> 1145
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1145
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacatttccg actgctgaga tgttgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagag cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtccaggag ccctggtcac cgtctcgagc 360
<210> 1146
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1146
gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgttt 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc caaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 1147
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1147
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacatttccg actgctgaga tgttgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtccaggag ccctggtcac cgtctcgagc 360
<210> 1148
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1148
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ttgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaagagccg 300
gtgtattatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 1149
<211> 360
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1149
gaggtgcagc tgttggagtc cgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttccg actgctgaga tgctgtgggt ccgcaaggct 120
ccagggaagg gtctagagtg ggtctcatct atttcggcta gtggtggttc tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac gccgcggtat attactgtgc gaaagagccg 300
gtgagttatg tggcgacgtt tgactactgg ggtcagggaa ccctggtcac cgtctcgagc 360
<210> 1150
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1150
aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttaa cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1151
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1151
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
cggaaagccc ctaaactcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcatcct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggtcaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1152
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1152
gacatccaga tgacccagtc tccgtcctcc ctgactgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct ggtcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctcctac gttcggccaa 300
gggaccaagg tggaaaacat acgg 324
<210> 1153
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1153
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattgct actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1154
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1154
gacatccaga tgacccagtc tccatccttc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattgct actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1155
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1155
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagcca ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagactttg ctacgtacta ctgtggtcag ggggtgctgt ggcccccgac gttcggccag 300
gggaccaagg tggaaatcaa acgt 324
<210> 1156
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1156
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt tctctgttat cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1157
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1157
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1158
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1158
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccatgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg caacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1159
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1159
gacatccaga tgactcagtc tccatcctcc ctgtctgcat ctgtaggaga ccgagtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cctggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacctat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggagtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1160
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1160
gacatccaga tgacccagtc tccatcctcc ctgactgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagaa ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1161
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1161
aacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1162
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1162
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcaattgcc gggcaagtca ttttattggt actctgttat cttggtacca gcataaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1163
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1163
gacatccagt tgacccagtc accatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagcca ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1164
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1164
gacatccaga tgacacagtc tccatcctcc ctgtatgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggtaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca gcatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcccccgac gttcggacaa 300
gggaccaagg tggaaatcaa acag 324
<210> 1165
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1165
gacattcaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
aggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1166
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1166
gacatccaga ttatccagtc tccatcctcc ctttctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1167
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1167
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1168
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1168
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120
gggaaagccc caaagctcct gatcacttat ggttcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tagaaaacaa acgg 324
<210> 1169
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1169
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcttaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaacgtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1170
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1170
gacatccaga tgacccaggc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcagagtgg ggtcccatca 180
cgtttcagtg gtagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg ttgaaaacaa acgg 324
<210> 1171
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1171
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt tctctgttat cttggtacca gcagaaacca 120
gggaaagccc caaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcgctctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1172
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1172
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1173
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1173
gacatcctga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1174
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1174
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctggtat cttggtacca gcagaaaccg 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gtacggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1175
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1175
gacatccaga tgacccagtc tccatcctct ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctggtat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac tttcggccaa 300
gggaccaagg tggaaaacaa acgg 324
<210> 1176
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1176
gacatcaaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcgagtca ttttattggt actctggtat cttggtacca gcagaaacca 120
gggaaagccc caaagctcct gatcacttat ggttccatgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1177
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1177
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc aggcaagtca ttttattggt actctggtat cctggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcccgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1178
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1178
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1179
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1179
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgttggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gctgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1180
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1180
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaaccg 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatt tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag gaggtgctgt ggcctgcgac gttcggccaa 300
gggactaagg tggaaatcaa acgg 324
<210> 1181
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1181
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtctcc 60
atcacttgcc gagcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatt tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagatcttg ctacgtacta ctgtggtcag gaggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1182
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1182
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc aggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatt tgggacagat ttcactctca ccatcagcag tctgcaaccc 240
gaagattttg ctacgtacta ctgtggtcag gaggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1183
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1183
gacatccaga tgacccagtc tccatcctcc ctgtctgcat cagtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacct 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatt tgggacagaa ttcactctca ccatcggcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1184
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1184
gacatccaga tgacccagtc accatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt actctgttat cttggtacca gcagaaacca 120
gggaaagcca ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctccgac gttcggccaa 300
gggaccaagg tggaaatcaa acgg 324
<210> 1185
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1185
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca cttcattgcc agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1186
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1186
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca tttcattgcc cagctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1187
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1187
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca tttcattgcc cagctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcag acgg 324
<210> 1188
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1188
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttacattgcc tccctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcagagtgg ggccccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1189
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1189
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg gcctcctact tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1190
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1190
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg acgtcctact tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1191
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1191
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg tcgtcctact tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1192
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1192
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg gggtcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1193
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1193
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg gcgtcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1194
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1194
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg agctcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1195
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1195
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttggattgcc cagctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1196
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1196
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt tcgctcttac gctggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1197
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1197
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca tcggattgcc cagctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1198
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1198
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttacattgcc tccctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1199
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1199
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatccggttc ggctccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1200
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1200
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttac aagtcctact tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1201
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1201
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttgg ggctcctact tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1202
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1202
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttatttgg gggcccttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattctg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1203
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1203
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttggattgcc accctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1204
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1204
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttatttgg gggcccttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1205
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1205
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agcctcttaa actggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttat ggttccttgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1206
<211> 324
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1206
ggcatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca ttttattggt agtctgttat cttggtacca ggtgaaacca 120
gggaaagccc ctaagctcct gatcacttac gggtcctggt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtggtcag ggggtgctgt ggcctgcgac gttcggccaa 300
gggacaacgg tggaaatcaa acgg 324
<210> 1207
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 1207
Gly Gly Gly Gly Ser
1 5
<210> 1208
<211> 15
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 1208
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
1 5 10 15
<210> 1209
<211> 25
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 1209
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly
1 5 10 15
Gly Gly Gly Ser Gly Gly Gly Gly Ser
20 25
<210> 1210
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1210
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Thr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Trp Asn Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1211
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1211
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Met Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His His Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1212
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1212
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Thr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Trp Asn Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1213
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1213
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Met Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His His Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1214
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1214
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Thr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Trp Asn Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1215
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1215
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His His Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1216
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1216
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Thr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Trp Asn Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1217
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1217
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His His Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1218
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1218
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1219
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1219
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Val Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1220
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1220
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Val His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe Gln Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1221
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1221
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Thr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Trp Asn Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu
130 135 140
Glu Glu Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Trp Val Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1222
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1222
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Thr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Trp Asn Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1223
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1223
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Trp Ile Gly Ser Gln
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Met Trp Arg Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Gly Leu Arg His Pro Lys
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu
130 135 140
Glu Glu Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Trp Val Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1224
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1224
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Gln Trp Ile Gly Ser Gln Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Met Trp Arg Ser Ser Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Gly Leu Arg His Pro Lys Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1225
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1225
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Thr Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Trp Asn Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1226
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1226
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Met Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Asn Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1227
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1227
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Thr
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Trp Asn Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu
130 135 140
Glu Glu Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Trp Val Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1228
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1228
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu
130 135 140
Glu Glu Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Trp Val Ser Ala Ile Ser Arg Asn Gly Tyr Ser Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Gly Lys Glu Pro Phe Arg Tyr Asp Tyr Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1229
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1229
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Glu
100 105 110
Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser
115 120 125
Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr Glu
130 135 140
Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val Ser
145 150 155 160
Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys
165 170 175
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
180 185 190
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
195 200 205
Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val Thr
210 215 220
Val Ser Ser
225
<210> 1230
<211> 231
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1230
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Ala Ser Thr Ser
100 105 110
Gly Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln
115 120 125
Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe
130 135 140
Arg Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
145 150 155 160
Glu Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala
165 170 175
Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn
180 185 190
Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val
195 200 205
Tyr Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly
210 215 220
Thr Leu Val Thr Val Ser Ser
225 230
<210> 1231
<211> 229
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1231
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly
100 105 110
Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
115 120 125
Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp
130 135 140
Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg
145 150 155 160
Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser
165 170 175
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
180 185 190
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
195 200 205
Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu
210 215 220
Val Thr Val Ser Ser
225
<210> 1232
<211> 239
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1232
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly
100 105 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Glu Val Gln Leu Leu
115 120 125
Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser
130 135 140
Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr Glu Met Trp Trp Val
145 150 155 160
Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val Ser Ala Ile Asn Pro
165 170 175
Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr
180 185 190
Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser
195 200 205
Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Lys Leu Pro Phe
210 215 220
Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
225 230 235
<210> 1233
<211> 249
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1233
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Gly Gly Gly Gly
100 105 110
Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
115 120 125
Gly Gly Gly Gly Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu
130 135 140
Val Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe
145 150 155 160
Thr Phe Arg Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys
165 170 175
Gly Leu Glu Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr
180 185 190
Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
195 200 205
Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr
210 215 220
Ala Val Tyr Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly
225 230 235 240
Gln Gly Thr Leu Val Thr Val Ser Ser
245
<210> 1234
<211> 227
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1234
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Thr Val Ala Asp Ile Gln Met Thr Gln Ser Pro Ser
115 120 125
Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala
130 135 140
Ser Arg Pro Ile Gly Thr Met Leu Ser Trp Tyr Gln Gln Lys Pro Gly
145 150 155 160
Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe Ser Arg Leu Gln Ser Gly
165 170 175
Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu
180 185 190
Thr Ile Ser Asn Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala
195 200 205
Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu
210 215 220
Ile Lys Arg
225
<210> 1235
<211> 231
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1235
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Ser Gly Pro Ser Asp Ile Gln Met Thr
115 120 125
Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile
130 135 140
Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met Leu Ser Trp Tyr Gln
145 150 155 160
Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe Ser Arg
165 170 175
Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr
180 185 190
Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Phe Ala Thr
195 200 205
Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly
210 215 220
Thr Lys Val Glu Ile Lys Arg
225 230
<210> 1236
<211> 229
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1236
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Gly Gly Gly Gly Ser Asp Ile Gln Met Thr Gln Ser
115 120 125
Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys
130 135 140
Arg Ala Ser Arg Pro Ile Gly Thr Met Leu Ser Trp Tyr Gln Gln Lys
145 150 155 160
Pro Gly Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe Ser Arg Leu Gln
165 170 175
Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
180 185 190
Thr Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr
195 200 205
Cys Ala Gln Ala Gly Thr His Pro Thr Thr Phe Gly Gln Gly Thr Lys
210 215 220
Val Glu Ile Lys Arg
225
<210> 1237
<211> 239
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1237
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala
130 135 140
Ser Val Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile
145 150 155 160
Gly Thr Met Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
165 170 175
Leu Leu Ile Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg
180 185 190
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn
195 200 205
Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr
210 215 220
His Pro Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
225 230 235
<210> 1238
<211> 249
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1238
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly
115 120 125
Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Asp Ile Gln
130 135 140
Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val
145 150 155 160
Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met Leu Ser Trp
165 170 175
Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Leu Ala Phe
180 185 190
Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser
195 200 205
Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro Glu Asp Phe
210 215 220
Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr Thr Phe Gly
225 230 235 240
Gln Gly Thr Lys Val Glu Ile Lys Arg
245
<210> 1239
<211> 230
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1239
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
1 5 10 15
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Arg Pro Ile Gly Thr Met
20 25 30
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
35 40 45
Leu Ala Phe Ser Arg Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
50 55 60
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Asn Leu Gln Pro
65 70 75 80
Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gln Ala Gly Thr His Pro Thr
85 90 95
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
100 105 110
Pro Ser Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro
115 120 125
Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg
130 135 140
Asp Tyr Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu
145 150 155 160
Arg Val Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp
165 170 175
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr
180 185 190
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
195 200 205
Tyr Cys Ala Lys Leu Pro Phe Tyr Phe His Glu Trp Gly Gln Gly Thr
210 215 220
Leu Val Thr Val Ser Ser
225 230
<210> 1240
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1240
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg acgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat cctttggaat tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1241
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1241
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc aggagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg atgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc atacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1242
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1242
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg acgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat cctttggaat tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1243
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1243
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg atgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc atacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1244
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1244
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcctttgg aattcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1245
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1245
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcatacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1246
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1246
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcctttgg aattcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcacgagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1247
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1247
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcatacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcacgagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1248
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1248
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tccgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1249
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1249
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagatgttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1250
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1250
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctggggtgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcaggagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1251
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1251
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcctttgg aattcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420
ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag 480
tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg ataccgcggt atattactgt gggaaagagc cgtttcgtta tgactactgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1252
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1252
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg acgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat cctttggaat tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1253
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1253
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtca gtggattggg tctcagttat cttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcatgtgg cgttcctcgt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgctcag ggtttgaggc atcctaagac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gctgcaccat ctgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420
ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag 480
tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg ataccgcggt atattactgt gggaaagagc cgtttcgtta tgactactgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1254
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1254
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc tagcaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcagtg gattgggtct cagttatctt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat catgtggcgt tcctcgttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgctcagggt ttgaggcatc ctaagacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1255
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1255
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggct 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc ttcaaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg acgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat cctttggaat tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcagtct gcaacctgaa 600
gattttgcta cgtactactg tgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1256
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1256
gaggtgcagc tgttggcgtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgcgcag cctccggatt cacctttgag gaggaggaga tgatttgggt ccgccaggcc 120
ccagggaagg gtctagagtg ggtctcagct attagtagga acggttacag cacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggat accgcggtat attactgtgg gaaagagccg 300
tttcgttatg actactgggg tcagggaacc ctggtcaccg tctcgagcgc ttcaaccgac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg atgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcaatct gcaacctgaa 600
gattttgcta cgtactactg cgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1257
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1257
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgacgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatcctttgg aattcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcag tctgcaacct 240
gaagattttg ctacgtacta ctgtgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acggaccgtg gcggcgccga gtgaggtgca gctgttggcg 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420
ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag 480
tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg ataccgcggt atattactgt gggaaagagc cgtttcgtta tgactactgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1258
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1258
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acggaccgtg gcggcgccga gtgaggtgca actgttggcg 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgcgc agcctccgga 420
ttcacctttg aggaggagga gatgatttgg gtccgccagg ctccagggaa gggtctagag 480
tgggtctcag ctattagtag gaacggttac agcacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg ataccgcggt atattactgt gggaaagagc cgtttcgtta tgactactgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1259
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1259
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgtacggtg gcggaggtgc agctgttgga gtctggggga 360
ggcttggtac agcctggggg gtccctgcgt ctctcctgtg cagcctccgg attcaccttt 420
cgggattatg agatgtggtg ggtccgccag gctccaggga agggtctaga gcgggtctca 480
gctattaatc cgcagggtac gcgtacatac tacgcagact ccgtgaaggg ccggttcacc 540
atctcccgcg acaattccaa gaacacgctg tatctgcaaa tgaacagcct gcgtgccgag 600
gacaccgcgg tatattactg tgcgaaactt ccgttttact ttcacgagtg gggtcaggga 660
accctggtca ccgtctccag c 681
<210> 1260
<211> 693
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1260
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acgggctagc acctcaggtc catcggaggt gcagctgttg 360
gagtctgggg gaggcttggt acagcctggg gggtccctgc gtctctcctg tgcagcctcc 420
ggattcacct ttcgggatta tgagatgtgg tgggtccgcc aggctccagg gaagggtcta 480
gagcgggtct cagctattaa tccgcagggt acgcgtacat actacgcaga ctccgtgaag 540
ggccggttca ccatctcccg cgacaattcc aagaacacgc tgtatctgca aatgaacagc 600
ctgcgtgccg aggacaccgc ggtatattac tgtgcgaaac ttccgtttta ctttcacgag 660
tggggtcagg gaaccctggt caccgtctcc agc 693
<210> 1261
<211> 687
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1261
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acggggtgga ggtggctctg aggtgcagct gttggagtct 360
gggggaggct tggtacagcc tggggggtcc ctgcgtctct cctgtgcagc ctccggattc 420
acctttcggg attatgagat gtggtgggtc cgccaggctc cagggaaggg tctagagcgg 480
gtctcagcta ttaatccgca gggtacgcgt acatactacg cagactccgt gaagggccgg 540
ttcaccatct cccgcgacaa ttccaagaac acgctgtatc tgcaaatgaa cagcctgcgt 600
gccgaggaca ccgcggtata ttactgtgcg aaacttccgt tttactttca cgagtggggt 660
cagggaaccc tggtcaccgt ctccagc 687
<210> 1262
<211> 717
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1262
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acggggtgga ggtggctctg gaggtggcgg tagcggcgga 360
ggcggttcag aggtgcagct gttggagtct gggggaggct tggtacagcc tggggggtcc 420
ctgcgtctct cctgtgcagc ctccggattc acctttcggg attatgagat gtggtgggtc 480
cgccaggctc cagggaaggg tctagagcgg gtctcagcta ttaatccgca gggtacgcgt 540
acatactacg cagactccgt gaagggccgg ttcaccatct cccgcgacaa ttccaagaac 600
acgctgtatc tgcaaatgaa cagcctgcgt gccgaggaca ccgcggtata ttactgtgcg 660
aaacttccgt tttactttca cgagtggggt cagggaaccc tggtcaccgt ctccagc 717
<210> 1263
<211> 747
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1263
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acggggtgga ggtggctctg gaggtggcgg tagcggcggt 360
ggcggttcag gtggcggagg ttctggaggc ggtggatctg aggtgcagct gttggagtct 420
gggggaggct tggtacagcc tggggggtcc ctgcgtctct cctgtgcagc ctccggattc 480
acctttcggg attatgagat gtggtgggtc cgccaggctc cagggaaggg tctagagcgg 540
gtctcagcta ttaatccgca gggtacgcgt acatactacg cagactccgt gaagggccgg 600
ttcaccatct cccgcgacaa ttccaagaac acgctgtatc tgcaaatgaa cagcctgcgt 660
gccgaggaca ccgcggtata ttactgtgcg aaacttccgt tttactttca cgagtggggt 720
cagggaaccc tggtcaccgt ctccagc 747
<210> 1264
<211> 681
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1264
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tttcgagcac ggtggcggac 360
atccagatga cccagtctcc atcctccctg tctgcatctg taggagaccg tgtcaccatc 420
acttgccggg caagtcgtcc gattgggacg atgttaagtt ggtaccagca gaaaccaggg 480
aaagccccta agctcctgat ccttgctttt tcccgtttgc aaagtggggt cccatcacgt 540
ttcagtggca gtggatctgg gacagatttc actctcacca tcagcaatct gcaacctgaa 600
gattttgcta cgtactactg cgcgcaggct gggacgcatc ctacgacgtt cggccaaggg 660
accaaggtgg aaatcaaacg g 681
<210> 1265
<211> 693
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1265
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgc tagcacctca 360
ggtccatcgg acatccagat gacccagtct ccatcctccc tgtctgcatc tgtaggagac 420
cgtgtcacca tcacttgccg ggcaagtcgt ccgattggga cgatgttaag ttggtaccag 480
cagaaaccag ggaaagcccc taagctcctg atccttgctt tttcccgttt gcaaagtggg 540
gtcccatcac gtttcagtgg cagtggatct gggacagatt tcactctcac catcagcaat 600
ctgcaacctg aagattttgc tacgtactac tgcgcgcagg ctgggacgca tcctacgacg 660
ttcggccaag ggaccaaggt ggaaatcaaa cgg 693
<210> 1266
<211> 687
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1266
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgg tggaggcggc 360
tctgacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agaccgtgtc 420
accatcactt gccgggcaag tcgtccgatt gggacgatgt taagttggta ccagcagaaa 480
ccagggaaag cccctaagct cctgatcctt gctttttccc gtttgcaaag tggggtccca 540
tcacgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag caatctgcaa 600
cctgaagatt ttgctacgta ctactgcgcg caggctggga cgcatcctac gacgttcggc 660
caagggacca aggtggaaat caaacgg 687
<210> 1267
<211> 717
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1267
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgg tggaggtggc 360
tctggaggtg gcggtagcgg cggtggcggt tcagacatcc agatgaccca gtctccatcc 420
tccctgtctg catctgtagg agaccgtgtc accatcactt gccgggcaag tcgtccgatt 480
gggacgatgt taagttggta ccagcagaaa ccagggaaag cccctaagct cctgatcctt 540
gctttttccc gtttgcaaag tggggtccca tcacgtttca gtggcagtgg atctgggaca 600
gatttcactc tcaccatcag caatctgcaa cctgaagatt ttgctacgta ctactgcgcg 660
caggctggga cgcatcctac gacgttcggc caagggacca aggtggaaat caaacgg 717
<210> 1268
<211> 747
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1268
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgcgtctc 60
tcctgtgcag cctccggatt cacctttcgg gattatgaga tgtggtgggt ccgccaggct 120
ccagggaagg gtctagagcg ggtctcagct attaatccgc agggtacgcg tacatactac 180
gcagactccg tgaagggccg gttcaccatc tcccgcgaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgcg tgccgaggac accgcggtat attactgtgc gaaacttccg 300
ttttactttc acgagtgggg tcagggaacc ctggtcaccg tctcgagcgg tggaggtggc 360
tctggaggtg gcggtagcgg cggtggcggt tcaggtggcg gaggttctgg aggcggtgga 420
tctgacatcc agatgaccca gtctccatcc tccctgtctg catctgtagg agaccgtgtc 480
accatcactt gccgggcaag tcgtccgatt gggacgatgt taagttggta ccagcagaaa 540
ccagggaaag cccctaagct cctgatcctt gctttttccc gtttgcaaag tggggtccca 600
tcacgtttca gtggcagtgg atctgggaca gatttcactc tcaccatcag caatctgcaa 660
cctgaagatt ttgctacgta ctactgcgcg caggctggga cgcatcctac gacgttcggc 720
caagggacca aggtggaaat caaacgg 747
<210> 1269
<211> 690
<212> DNA
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多核苷酸
<400> 1269
gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga ccgtgtcacc 60
atcacttgcc gggcaagtcg tccgattggg acgatgttaa gttggtacca gcagaaacca 120
gggaaagccc ctaagctcct gatccttgct ttttcccgtt tgcaaagtgg ggtcccatca 180
cgtttcagtg gcagtggatc tgggacagat ttcactctca ccatcagcaa tctgcaacct 240
gaagattttg ctacgtacta ctgcgcgcag gctgggacgc atcctacgac gttcggccaa 300
gggaccaagg tggaaatcaa acggaccgta gcggcgccga gtgaggtgca gctgttggag 360
tctgggggag gcttggtaca gcctgggggg tccctgcgtc tctcctgtgc agcctccgga 420
ttcacctttc gggattatga gatgtggtgg gtccgccagg ctccagggaa gggtctagag 480
cgggtctcag ctattaatcc gcagggtacg cgtacatact acgcagactc cgtgaagggc 540
cggttcacca tctcccgcga caattccaag aacacgctgt atctgcaaat gaacagcctg 600
cgtgccgagg acaccgcggt atattactgt gcgaaacttc cgttttactt tcacgagtgg 660
ggtcagggaa ccctggtcac cgtctccagc 690
<210> 1270
<211> 44
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1270
Cys Ser Pro Gly Phe Gly Val Lys Gln Ile Ala Thr Gly Val Ser Asp
1 5 10 15
Thr Ile Cys Glu Pro Cys Pro Val Gly Phe Phe Ser Asn Val Ser Ser
20 25 30
Ala Phe Glu Lys Cys His Pro Trp Thr Ser Cys Glu
35 40
<210> 1271
<211> 44
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1271
Cys Ser Pro Gly Tyr Arg Val Lys Glu Ala Cys Gly Glu Leu Thr Gly
1 5 10 15
Thr Val Cys Glu Pro Cys Pro Pro Gly Thr Tyr Ile Ala His Leu Asn
20 25 30
Gly Leu Ser Lys Cys Leu Gln Cys Gln Met Cys Asp
35 40
<210> 1272
<211> 44
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1272
Cys Gln Pro Gly Gln Lys Leu Val Ser Asp Cys Thr Glu Phe Thr Glu
1 5 10 15
Thr Glu Cys Leu Pro Cys Gly Glu Ser Glu Phe Leu Asp Thr Trp Asn
20 25 30
Arg Glu Thr His Cys His Gln His Lys Tyr Cys Asp
35 40
<210> 1273
<211> 19
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<400> 1273
Asp Pro Gly Gly Gly Gly Gly Arg Leu Val Pro Arg Gly Phe Gly Thr
1 5 10 15
Gly Asp Pro
<210> 1274
<211> 5
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Asp or Gly
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Met or Leu
<400> 1274
Xaa Tyr Glu Xaa Trp
1 5
<210> 1275
<211> 17
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<220>
<221> MOD_RES
<222> (5)..(5)
<223> Gln, Tyr, Pro, Trp or Ala
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Thr, Ser, Asn, Gly, Met or Gln
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Arg, Leu, Tyr, His or Phe
<220>
<221> MOD_RES
<222> (16)..(16)
<223> Lys or Met
<400> 1275
Ala Ile Asn Pro Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val Xaa
1 5 10 15
Gly
<210> 1276
<211> 7
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Leu or Pro
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Phe, Gln, Thr or Met
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Tyr, Pro, Leu, Thr, Ile, Phe or Met
<220>
<221> MOD_RES
<222> (6)..(6)
<223> Gln, His, Asp, Ser, Lys, Glu or Gly
<220>
<221> MOD_RES
<222> (7)..(7)
<223> Glu, Asp or Tyr
<400> 1276
Xaa Pro Xaa Xaa Phe Xaa Xaa
1 5
<210> 1277
<211> 30
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<220>
<221> MOD_RES
<222> (18)..(18)
<223> Leu or Arg
<220>
<221> MOD_RES
<222> (30)..(30)
<223> Arg or Ala
<400> 1277
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Xaa Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Xaa
20 25 30
<210> 1278
<211> 14
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<220>
<221> MOD_RES
<222> (4)..(4)
<223> Gln or Arg
<220>
<221> MOD_RES
<222> (8)..(8)
<223> Lys or Arg
<220>
<221> MOD_RES
<222> (9)..(9)
<223> Gly or Val
<400> 1278
Trp Val Arg Xaa Ala Pro Gly Xaa Xaa Leu Glu Arg Val Ser
1 5 10
<210> 1279
<211> 32
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<220>
<221> MOD_RES
<222> (12)..(12)
<223> Thr or Met
<220>
<221> MOD_RES
<222> (23)..(23)
<223> Glu or Asp
<220>
<221> MOD_RES
<222> (26)..(26)
<223> Ala or Ser
<220>
<221> MOD_RES
<222> (29)..(29)
<223> Tyr or His
<220>
<221> MOD_RES
<222> (31)..(31)
<223> Ala or Thr
<400> 1279
Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Xaa Lys Tyr Leu Gln
1 5 10 15
Met Asn Ser Leu Arg Ala Xaa Asp Thr Xaa Val Tyr Xaa Cys Xaa Lys
20 25 30
<210> 1280
<211> 11
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
肽
<220>
<221> MOD_RES
<222> (1)..(1)
<223> Trp or Arg
<220>
<221> MOD_RES
<222> (3)..(3)
<223> Gln or Pro
<220>
<221> MOD_RES
<222> (11)..(11)
<223> Ser or Asn
<400> 1280
Xaa Gly Xaa Gly Thr Leu Val Thr Val Ser Xaa
1 5 10
<210> 1281
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<220>
<221> MOD_RES
<222> (13)..(13)
<223> Gln or Arg
<220>
<221> MOD_RES
<222> (99)..(99)
<223> Glu or Gly
<220>
<221> MOD_RES
<222> (101)..(101)
<223> Ala, Leu or Glu
<220>
<221> MOD_RES
<222> (102)..(102)
<223> Phe or Tyr
<220>
<221> MOD_RES
<222> (106)..(106)
<223> Trp or Arg
<400> 1281
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Xaa Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Glu Trp Tyr
20 25 30
Glu Met Gln Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Ala Ile Ser Gly Asp Gly Tyr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Xaa Leu Xaa Xaa Phe Asp Tyr Xaa Gly Arg Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 1282
<211> 116
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<220>
<221> MOD_RES
<222> (28)..(28)
<223> Thr or Pro
<220>
<221> MOD_RES
<222> (50)..(50)
<223> Ala or Ser
<220>
<221> MOD_RES
<222> (53)..(53)
<223> Arg or Gly
<220>
<221> MOD_RES
<222> (54)..(54)
<223> Arg, Ser, Asn, Gln, Gly, His or Leu
<220>
<221> MOD_RES
<222> (56)..(56)
<223> Tyr, Phe, Trp or Gly
<220>
<221> MOD_RES
<222> (57)..(57)
<223> Ser or Gly
<220>
<221> MOD_RES
<222> (102)..(102)
<223> Arg, Met or Pro
<400> 1282
Glu Val Gln Leu Leu Ala Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Xaa Phe Glu Glu Glu
20 25 30
Glu Met Ile Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
35 40 45
Ser Xaa Ile Ser Xaa Xaa Gly Xaa Xaa Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Gly Lys Glu Pro Phe Xaa Tyr Asp Tyr Trp Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser
115
<210> 1283
<211> 118
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<220>
<221> MOD_RES
<222> (36)..(36)
<223> Met or Leu
<220>
<221> MOD_RES
<222> (39)..(39)
<223> Val or Phe
<220>
<221> MOD_RES
<222> (76)..(76)
<223> Asp or Asn
<220>
<221> MOD_RES
<222> (77)..(77)
<223> Ser or Thr
<220>
<221> MOD_RES
<222> (97)..(97)
<223> Tyr or His
<220>
<221> MOD_RES
<222> (100)..(100)
<223> Lys or Arg
<220>
<221> MOD_RES
<222> (101)..(101)
<223> Asp or Glu
<220>
<221> MOD_RES
<222> (105)..(105)
<223> Tyr or Phe
<220>
<221> MOD_RES
<222> (108)..(108)
<223> Trp or Arg
<220>
<221> MOD_RES
<222> (109)..(109)
<223> Gly or Arg
<220>
<221> MOD_RES
<222> (110)..(110)
<223> Gln or His
<400> 1283
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ala Gly Thr
20 25 30
Arg Tyr Glu Xaa Trp Trp Xaa Arg Gln Ala Pro Gly Lys Gly Leu Glu
35 40 45
Arg Val Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp
50 55 60
Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Xaa Xaa Lys Asn Thr
65 70 75 80
Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr
85 90 95
Xaa Cys Ala Xaa Xaa Pro Tyr Ser Xaa Asp Tyr Xaa Xaa Xaa Gly Thr
100 105 110
Leu Val Thr Val Ser Ser
115
<210> 1284
<211> 232
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1284
Glu Pro Lys Ser Ser Asp Lys Thr His Thr Ser Pro Pro Ser Pro Ala
1 5 10 15
Pro Glu Leu Leu Gly Gly Ser Ser Val Phe Leu Phe Pro Pro Lys Pro
20 25 30
Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val
35 40 45
Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val
50 55 60
Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln
65 70 75 80
Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln
85 90 95
Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala
100 105 110
Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro
115 120 125
Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr
130 135 140
Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
145 150 155 160
Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr
165 170 175
Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr
180 185 190
Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe
195 200 205
Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
210 215 220
Ser Leu Ser Leu Ser Pro Gly Lys
225 230
<210> 1285
<211> 229
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1285
Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe
1 5 10 15
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
20 25 30
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
35 40 45
Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val
50 55 60
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser
65 70 75 80
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
85 90 95
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser
100 105 110
Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
115 120 125
Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln
130 135 140
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
145 150 155 160
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
165 170 175
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu
180 185 190
Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser
195 200 205
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
210 215 220
Leu Ser Leu Gly Lys
225
<210> 1286
<211> 351
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1286
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Arg Phe Ser Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Glu Pro Lys Ser Ser Asp Lys Thr His
115 120 125
Thr Ser Pro Pro Ser Pro Ala Pro Glu Leu Leu Gly Gly Ser Ser Val
130 135 140
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr
145 150 155 160
Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu
165 170 175
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys
180 185 190
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
195 200 205
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
210 215 220
Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile
225 230 235 240
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro
245 250 255
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu
260 265 270
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn
275 280 285
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser
290 295 300
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg
305 310 315 320
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu
325 330 335
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
340 345 350
<210> 1287
<211> 348
<212> PRT
<213> 人工序列
<220>
<223> 描述人工序列: 合成的
多肽
<400> 1287
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
1 5 10 15
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
20 25 30
Glu Met Trp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Arg Val
35 40 45
Ser Ala Ile Asn Pro Gln Gly Thr Arg Thr Tyr Tyr Ala Asp Ser Val
50 55 60
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65 70 75 80
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
85 90 95
Ala Lys Leu Pro Phe Arg Phe Ser Asp Arg Gly Gln Gly Thr Leu Val
100 105 110
Thr Val Ser Ser Ala Ser Thr Glu Ser Lys Tyr Gly Pro Pro Cys Pro
115 120 125
Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe
130 135 140
Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
145 150 155 160
Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe
165 170 175
Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro
180 185 190
Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr
195 200 205
Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val
210 215 220
Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala
225 230 235 240
Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln
245 250 255
Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly
260 265 270
Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro
275 280 285
Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser
290 295 300
Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu
305 310 315 320
Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
325 330 335
Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys
340 345

Claims (32)

1.一种包含第一可变域之抗体多肽，其中该抗体多肽特异性结合人类CD40之抗原决定基，其中该抗体多肽与域抗体(domain antibody，dAb)BMS3h-56-269(SEQ ID NO:417)竞争结合于CD40，其中CD40包含SEQ ID NO:1之氨基酸序列，且其中该抗原决定基包含至少一个选自由Trp109、Leu121、His122、Ser124、Ser156、Ala157、Phe158、Glu159及His162组成之群的CD40氨基酸残基。
2.如权利要求1之抗体多肽，其中该第一可变域包含选自由BMS3h-37、BMS3h-38、BMS3h-56及BMS3h-198组成之谱系群的抗体多肽之一之氨基酸序列，且其中该第一可变域之表观结合常数为1pM至100nM。
3.如权利要求1至2中任一项之抗体多肽，其中该第一可变域包含选自由BMS3h-37、BMS3h-38及BMS3h-56组成之谱系群的抗体多肽之一之氨基酸序列，且其中该第一可变域之hIZCD40L驱动之人类B细胞增殖EC50为0.01nM至100.0nM。
4.如权利要求1之抗体多肽，其中该第一可变域之氨基酸序列包含：
(a)与BMS3h-56-269(SEQ ID NO:417)之CDR1区有至多两个氨基酸不同的CDR1区，
(b)与BMS3h-56-269(SEQ ID NO:417)之CDR2区有至多两个氨基酸不同的CDR2区，
(c)与BMS3h-56-269(SEQ ID NO:417)之CDR3区有至多两个氨基酸不同的CDR3区，
(d)与BMS3h-56-269(SEQ ID NO:417)之FR1区有至多两个氨基酸不同的FR1区，
(e)与BMS3h-56-269(SEQ ID NO:417)之FR2区有至多两个氨基酸不同的FR2区，
(f)与BMS3h-56-269(SEQ ID NO:417)之FR3区有至多两个氨基酸不同的FR3区，及
(g)与BMS3h-56-269(SEQ ID NO:417)之FR4区有至多两个氨基酸不同的FR4区。
5.如权利要求1之抗体多肽，其中该第一可变域之氨基酸序列包含：
(a)与BMS3h-56-269(SEQ ID NO:417)之CDR1区有至多两个氨基酸不同的CDR1区，
(b)与BMS3h-56-269(SEQ ID NO:417)之CDR2区有至多两个氨基酸不同的CDR2区，
(c)与BMS3h-56-269(SEQ ID NO:417)之CDR3区有至多两个氨基酸不同的CDR3区。
6.如权利要求1之抗体多肽，其中该第一可变域之氨基酸序列与BMS3h-56-258(SEQ IDNO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有至多10个氨基酸不同。
7.如权利要求6之抗体多肽，其中该第一可变域之氨基酸序列与BMS3h-56-258(SEQ IDNO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有至多5个氨基酸不同。
8.如权利要求7之抗体多肽，其中该第一可变域之氨基酸序列与BMS3h-56-258(SEQ IDNO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有两个氨基酸不同。
9.如权利要求8之抗体多肽，其中该第一可变域之氨基酸序列与BMS3h-56-258(SEQ IDNO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列有一个氨基酸不同。
10.如权利要求2至3中任一项之抗体多肽，其中该抗体多肽选自BMS3h-56之谱系群，且其中该第一可变域之氨基酸序列进一步包含：
(a)具有序列X1-Tyr-Glu-Y1-Trp(SEQ ID NO:1274)之CDR1区，其中X1为Asp或Gly，且Y1为Met或Leu；
(b)具有序列
Ala-Ile-Asn-Pro-X2-Gly-Y2-Z2-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-A2-Gly(SEQ ID NO:1275)之CDR2区，其中X2为Gln、Tyr、Pro、Trp或Ala，Y2为Thr、Ser、Asn、Gly、Met或Gln，Z2为Arg、Leu、Tyr、His或Phe，且A2为Lys或Met；及
(c)具有序列X3-Pro-Y3-Z3-Phe-A3-B3(SEQ ID NO:1276)之CDR3区，其中X3为Leu或Pro，Y3为Phe、Gln、Thr或Met，Z3为Tyr、Pro、Leu、Thr、Ile、Phe或Met，A3为Gln、His、Asp、Ser、Lys、Glu或Gly，且B3为Glu、Asp或Tyr。
11.如权利要求10之抗体多肽，其中该第一可变域之氨基酸序列包含：
(a)具有序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-X1-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Ph e-Y1(SEQ ID NO:1277)之FR1区，其中X1为Leu或Arg，且Y1为Arg或Ala；(b)具有序列Trp-Val-Arg-X2-Ala-Pro-Gly-Y2-Z2-Leu-Glu-Arg-Val-Ser(SEQ ID NO:1278)之FR2区，其中X2为Gln或Arg，Y2为Lys或Arg，且Z2为Gly或Val；(c)具有序列
Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-X3-Lys-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Y3-Asp-Thr-Z3-Val-Tyr-A3-Cys-B3-Lys(SEQ ID NO:1279)之FR3区，其中X3为Thr或Met，Y3为Glu或Asp，Z3为Ala或Ser，A3为Tyr或His，且B3为Ala或Thr；及
(d)具有序列X4-Gly-Y4-Gly-Thr-Leu-Val-Thr-Val-Ser-Z4(SEQ ID NO:1280)之FR4区，其中X4为Trp或Arg，Y4为Gln或Pro，且Z4为Ser或Asn。
12.如权利要求2至3中任一项之抗体多肽，其中该第一可变域包含BMS3h-56-258(SEQID NO:10)或BMS3h-56-269(SEQ ID NO:417)之氨基酸序列。
13.如权利要求2至3中任一项之抗体多肽，其中该抗体多肽选自BMS3h-37之谱系群，其中该第一可变域包含序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-X1-Pro-Gly-Gly-Ser-Leu-A rg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Glu-Trp-Tyr-Glu-Met-Gln-Trp-Va l-Arg-Arg-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Ala-Ile-Ser-Gly-Asp-Gly-Tyr-Arg-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-As n-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-A la-Val-Tyr-Tyr-Cys-Ala-Lys-Y1-Leu-Z1-A1-Phe-Asp-Tyr-B1-Gly-Arg-Gly-Thr-Le u-Val-Thr-Val-Ser-Ser(SEQ ID NO:
1281)；且
其中X1为Gln或Arg；Y1为Glu或Gly；Z1为Ala、Leu或Glu；A1为Phe或Tyr；且B1为Trp或Arg。
14.如权利要求2至3中任一项之抗体多肽，其中该抗体多肽选自BMS3h-38之谱系群，其中该第一可变域包含序列Glu-Val-Gln-Leu-Leu-Ala-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-X1-Phe-Glu-Glu-Glu-Glu-Met-Ile-Trp-V al-Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Trp-Val-Ser-Y1-Ile-Ser-Z1-A1-Gly-B1-C1-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Asn-Ser-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Va l-Tyr-Tyr-Cys-Gly-Lys-Glu-Pro-Phe-D1-Tyr-Asp-Tyr-Trp-Gly-Gln-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser(SEQ ID NO:
1282)；且
其中X1为Thr或Pro；Y1为Ala或Ser；Z1为Arg或Gly；A1为Arg、Ser、Asn、Gln、Gly、His或Leu；B1为Tyr、Phe、Trp或Gly；C1为Ser或Gly；且D1为Arg、Met或Pro。
15.如权利要求2至3中任一项之抗体多肽，其中该抗体多肽选自BMS3h-198之谱系群，其中该第一可变域包含序列Glu-Val-Gln-Leu-Leu-Glu-Ser-Gly-Gly-Gly-Leu-Val-Gln-Pro-Gly-Gly-Ser-Leu-Arg-Leu-Ser-Cys-Ala-Ala-Ser-Gly-Phe-Thr-Phe-Ala-Gly-Try-Glu-X1-Trp-Trp-Y1-Arg-Gln-Ala-Pro-Gly-Lys-Gly-Leu-Glu-Arg-Val-Ser-Ala-Ile-Ser-Gly-Ser-Gly-Gly-Ser-Thr-Tyr-Tyr-Ala-Asp-Ser-Val-Lys-Gly-Arg-Phe-Thr-Ile-Ser-Arg-Asp-Z1-A1-Lys-Asn-Thr-Leu-Tyr-Leu-Gln-Met-Asn-Ser-Leu-Arg-Ala-Glu-Asp-Thr-Ala-Val-Tyr-B1-Cys-Ala-C1-D1-Pro-Tyr-Ser-E1-Asp-Tyr-F1-G1-H1-Gly-Thr-Leu-Val-Thr-Val-Ser-Ser(SEQ ID NO:
1283)；且
其中X1为Met或Leu；Y1为Val或Phe；Z1为Asp或Asn；A1为Ser或Thr；B1为Tyr或His；C1为Lys或Arg；D1为Asp或Glu；E1为Tyr或Phe；F1为Trp或Arg；G1为Gly或Arg；且H1为Gln或His。
16.如权利要求1至15中任一项之抗体多肽，其中该抗体多肽为域抗体(dAb)。
17.如权利要求1至16中任一项之抗体多肽，其中该抗体多肽为包含该第一可变域及Fc域之融合多肽。
18.如权利要求17之融合多肽，其中该融合多肽包含IgG4Fc域。
19.如权利要求18之融合多肽，其中该融合多肽包含IgG1Fc域。
20.如权利要求17至19中任一项之融合多肽，其中该融合多肽包含选自由BMS3h-37、BMS3h-38及BMS3h-56组成之谱系群的抗体多肽之一之氨基酸序列，且其中该融合多肽之hIZCD40L驱动之人类B细胞增殖EC50为0.001nM至100.0nM。
21.如权利要求1至20中任一项之抗体多肽，其中该抗体多肽进一步包含特异性结合第二抗原之第二可变域，其中该第二抗原为除人类CD40以外之抗原。
22.如权利要求21之抗体多肽，其中该第二抗原为分化簇(cluster ofdifferentiation，CD)分子或主要组织兼容性复合体(Major HistocompatibilityComplex，MHC)II类分子。
23.如权利要求21之抗体多肽，其中该第二抗原为血清白蛋白(SA)。
24.一种核酸，其编码如权利要求1至23中任一项之抗体多肽。
25.一种载体，其包含如权利要求24之核酸。
26.一种经分离之宿主细胞，其包含如权利要求25之载体。
27.一种医药组合物，其包含治疗有效量之如权利要求1之抗体多肽及医药学上可接受之载剂。
28.如权利要求27之医药组合物，其进一步包含免疫抑制/免疫调节剂及/或消炎剂。
29.一种治疗需要该治疗之患者的免疫疾病之方法，其包含向该患者投与治疗有效量之如权利要求27之医药组合物。
30.如权利要求29之方法，其中该医药组合物系与免疫抑制/免疫调节剂及/或消炎剂组合投与。
31.如权利要求29之方法，其中该免疫疾病为自体免疫疾病或移植相关疾病。
32.如权利要求29之方法，其中该免疫疾病选自由以下组成之群：艾迪森氏病(Addison's disease)、过敏症、僵直性脊椎炎、哮喘、动脉粥样硬化、自体免疫性耳病、自体免疫性眼病、自体免疫肝炎、自体免疫腮腺炎、结肠炎、冠心病、克罗恩氏病(Crohn'sdisease)、糖尿病(包括1型及/或2型糖尿病)、附睪炎、丝球体肾炎、葛瑞夫兹氏病(Graves'disease)、格-巴二氏征候群(Guillain-Barre syndrome)、桥本氏病(Hashimoto'sdisease)、溶血性贫血、特发性血小板减少性紫癜、发炎性肠病、对重组药品之免疫反应、全身性红斑狼疮、男性不育症、多发性硬化症、重症肌无力、天疱疮、牛皮癣、风湿热、类风湿性关节炎、类肉瘤病、硬皮病、休格连氏症候群(Sjogren's syndrome)、脊椎关节病、甲状腺炎、移植排斥反应、血管炎、AIDS、异位性过敏症、支气管哮喘、湿疹、麻风病、精神分裂症、遗传性抑郁症、组织及器官之移植、慢性疲劳症候群、阿兹海默氏病(Alzheimer's disease)、帕金森氏病(Parkinson's disease)、心肌梗塞、中风、自闭症、癫痫症、阿瑟氏现象(Arthus's phenomenon)、全身性过敏反应、酒精成瘾及药物成瘾。
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Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI3556774T3 (fi) 2011-03-11 2024-03-15 Beth Israel Deaconess Medical Ct Inc Anti-cd40-vasta-aineita ja niiden käyttötapoja
ES2664619T3 (es) 2011-04-21 2018-04-20 Bristol-Myers Squibb Company Polipéptidos de anticuerpos que antagonizan CD40
US8778345B2 (en) 2011-04-29 2014-07-15 Apexigen, Inc. Anti-CD40 antibodies
SMT202000091T1 (it) 2011-10-13 2020-05-08 Bristol Myers Squibb Co Polipeptidi anticorpali che antagonizzano cd40l
WO2014070934A1 (en) 2012-10-30 2014-05-08 Apexigen, Inc. Anti-cd40 antibodies and methods of use
WO2015134988A1 (en) * 2014-03-07 2015-09-11 Bristol-Myers Squibb Company Method of using antibody polypeptides that antagonize cd40 to treat ibd
JP6830437B2 (ja) 2014-12-10 2021-02-17 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 疾患を処置するための遺伝子改変された細胞、組織および臓器
ES2806500T3 (es) 2015-01-20 2021-02-17 Igm Biosciences Inc Moléculas de unión al receptor de la superfamilia de TNF (factor de necrosis tumoral) y usos de las mismas
MA41459A (fr) 2015-02-03 2017-12-12 Als Therapy Development Inst Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
US20190016818A1 (en) * 2015-05-27 2019-01-17 La Jolla Biologics, Inc. Antibodies against glypican-3 and their uses in cancer diagnosis and treatment
PE20180193A1 (es) 2015-05-29 2018-01-26 Abbvie Inc Anticuerpos anti-cd40 y sus usos
HUE056769T2 (hu) 2015-09-04 2022-03-28 Primatope Therapeutics Inc Humanizált anti-CD40 antitestek és felhasználásuk
US20190086405A1 (en) 2016-03-16 2019-03-21 Bristol-Myers Squibb Company Methods of diagnosing and treating lupus
SG11201810509PA (en) 2016-06-20 2018-12-28 Kymab Ltd Anti-pd-l1 antibodies
US11905331B2 (en) 2016-11-11 2024-02-20 Kumho Ht, Inc. Antibody binding specifically to CD40 and use thereof
JP2020504105A (ja) 2016-12-19 2020-02-06 グレンマーク・ファーマシューティカルズ・エスエー 新規なｔｎｆｒアゴニストおよびその使用
MX2019011252A (es) 2017-03-23 2020-01-23 Univ Pennsylvania Anticuerpos anti-c5a y usos de los mismos.
RU2770209C2 (ru) 2017-05-24 2022-04-14 ЭйЭлЭс ТЕРАПИ ДЕВЕЛОПМЕНТ ИНСТИТЬЮТ Терапевтические антитела против лиганда cd40
KR20200012907A (ko) * 2017-05-25 2020-02-05 브리스톨-마이어스 스큅 컴퍼니 변형된 IgG1 Fc 도메인 및 그와의 항-CD40 도메인 항체 융합체
JP7257335B2 (ja) 2017-05-25 2023-04-13 ブリストル－マイヤーズ スクイブ カンパニー アンタゴニスト性ｃｄ４０モノクローナル抗体およびその使用
MX2019012038A (es) 2017-05-30 2019-11-18 Bristol Myers Squibb Co Composiciones que comprenden una combinacion de un anticuerpo anti gen 3 de activacion del linfocito (lag-3), un inhibidor de la trayectoria del receptor de muerte programada 1 (pd-1), y un agente inmunoterapeutico.
BR112019025048A2 (pt) * 2017-06-01 2020-06-30 Jiangsu Hengrui Medicine Co., Ltd. anticorpo anti-cd40, fragmento de ligação ao antígeno do mesmo, e uso médico dos mesmos
US20210251994A1 (en) 2018-06-15 2021-08-19 Flagship Pioneering Innovations V, Inc. Increasing immune activity through modulation of postcellular signaling factors
AR117091A1 (es) 2018-11-19 2021-07-07 Bristol Myers Squibb Co Anticuerpos monoclonales antagonistas contra cd40 y sus usos
TW202039558A (zh) 2018-11-30 2020-11-01 大陸商江蘇恆瑞醫藥股份有限公司 抗ｃｄ４０抗體、其抗原結合片段及其醫藥用途
CA3121291A1 (en) 2018-11-30 2020-06-04 Jiangsu Hengrui Medicine Co., Ltd. Cd40 antibody pharmaceutical composition and use thereof
JP2022519082A (ja) * 2019-02-01 2022-03-18 ラヴァ・セラピューティクス・ベー・フェー 新規ｃｄ４０結合抗体
MA55805A (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V Inc Métodes de modulation de l'activité immunitaire
US20210032356A1 (en) * 2019-08-02 2021-02-04 Eastern Virginia Medical School Method for treating seizures
EP4076434A1 (en) 2019-12-17 2022-10-26 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
UY38995A (es) 2019-12-20 2021-06-30 Amgen Inc Constructos de anticuerpo multiespecíficos agonistas de cd40 dirigidos a mesotelina para el tratamiento de tumores sólidos
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
US11862306B1 (en) 2020-02-07 2024-01-02 Cvs Pharmacy, Inc. Customer health activity based system for secure communication and presentation of health information
CA3172092A1 (en) * 2020-04-23 2021-10-28 David Cheresh Compositions and methods for treating cancer
WO2021236546A1 (en) 2020-05-18 2021-11-25 Bristol-Myers Squibb Company Antibody variants with improved pharmacokinetic properties
CN116096906A (zh) 2020-06-29 2023-05-09 旗舰创业创新五公司 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途
JP2024512669A (ja) 2021-03-31 2024-03-19 フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド タノトランスミッションポリペプチド及び癌の処置におけるそれらの使用
CA3224374A1 (en) 2021-06-29 2023-01-05 Flagship Pioneering Innovations V, Inc. Immune cells engineered to promote thanotransmission and uses thereof
US12234294B2 (en) 2021-11-05 2025-02-25 Kiniksa Pharmaceuticals, Gmbh Pharmaceutical composition of a humanized anti-CD40 antibody
CN114149508B (zh) * 2021-11-25 2023-04-28 苏州普乐康医药科技有限公司 一种结合cd40l的融合蛋白及其应用
JP2025508076A (ja) 2022-03-08 2025-03-21 アレンティス・セラピューティクス・アクチェンゲゼルシャフト Ｔ細胞の利用能を向上させるための抗クローディン－１抗体の使用
CN116023495B (zh) * 2022-09-05 2023-10-03 上海百英生物科技股份有限公司 一种抗cd40纳米抗体及其制备方法与应用
WO2024077191A1 (en) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer
WO2024151687A1 (en) 2023-01-09 2024-07-18 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer
KR20250057233A (ko) 2023-10-20 2025-04-29 한상진 이동식 무선 자동 제습기
WO2025129007A1 (en) * 2023-12-15 2025-06-19 Werewool Inc. Soy alginate fibers
US20250277048A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. The use of cd40 inhibitors for inhibiting an immune response and enabling immunogen administration and re-administration
WO2025184567A1 (en) 2024-03-01 2025-09-04 Regeneron Pharmaceuticals, Inc. Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101061140A (zh) * 2004-09-17 2007-10-24 多曼蒂斯有限公司 单价结合cd40l的组合物和应用方法
CN101282993A (zh) * 2005-06-02 2008-10-08 阿斯利康公司 针对cd20的抗体和其用途
CN101374865A (zh) * 2005-12-16 2009-02-25 健泰科生物技术公司 抗ox40l抗体及其使用方法
WO2009134976A1 (en) * 2008-04-30 2009-11-05 Immunogen, Inc Potent conjugates and hydrophilic linkers
US20100172862A1 (en) * 2008-11-28 2010-07-08 Abbott Laboratories Stable antibody compositions and methods of stabilizing same

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182368A (en) 1986-06-13 1993-01-26 Ledbetter Jeffrey A Ligands and methods for augmenting B-cell proliferation
US5247069A (en) 1986-06-13 1993-09-21 Oncogen Ligands and methods for augmenting B-cell proliferation
US5506126A (en) 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
IL104684A0 (en) 1992-02-14 1993-06-10 Bristol Myers Squibb Co The cd40cr receptor and ligands therefor
US5397703A (en) 1992-07-09 1995-03-14 Cetus Oncology Corporation Method for generation of antibodies to cell surface molecules
DK0751781T3 (da) 1993-12-23 2004-08-09 Immunex Corp Anvendelse af monoklonale antistoffer eller oplöselige oligomere ligander til fremstillingen af et medikament til forebyggelse eller behandling af neoplastiske sygdomme
WO1997034633A1 (en) 1996-03-20 1997-09-25 Bristol-Myers Squibb Company Methods for inhibiting an immune response by blocking the gp39/cd40 and ctla4/cd28/b7 pathways and compositions for use therewith
GB9722131D0 (en) 1997-10-20 1997-12-17 Medical Res Council Method
US6051228A (en) 1998-02-19 2000-04-18 Bristol-Myers Squibb Co. Antibodies against human CD40
CA2424296A1 (en) 2000-10-02 2002-04-11 Chiron Corporation Human anti-cd40 antibodies
AR039067A1 (es) 2001-11-09 2005-02-09 Pfizer Prod Inc Anticuerpos para cd40
US8277810B2 (en) 2003-11-04 2012-10-02 Novartis Vaccines & Diagnostics, Inc. Antagonist anti-CD40 antibodies
EP1694360B1 (en) * 2003-11-04 2010-08-04 Novartis Vaccines and Diagnostics, Inc. Use of antagonist anti-cd40 antibodies for treatment of autoimmune and inflammatory diseases and organ transplant rejection
PL1707627T3 (pl) 2003-12-25 2013-04-30 Kyowa Hakko Kirin Co Ltd Mutant antagonistycznego przeciwciała anty-CD40
EP2172553A1 (en) 2004-03-24 2010-04-07 Domantis Limited Gas1 universal leader
KR20070026522A (ko) 2004-04-27 2007-03-08 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 길항제 항-ｃｄ40 모노클론 항체 및 이들의 사용 방법
US7563443B2 (en) * 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
AR053579A1 (es) 2005-04-15 2007-05-09 Genentech Inc Tratamiento de la enfermedad inflamatoria intestinal (eii)
JP2009523460A (ja) 2006-01-24 2009-06-25 ドマンティス リミテッド Ｉｌ−４および／またはｉｌ−１３に結合するリガンド
NZ571757A (en) 2006-04-21 2012-01-12 Novartis Ag Antagonist anti-CD40 antibody pharmaceutical compositions comprising arginine-HCl and a citrate or citric acid buffer
EP1854810A1 (en) 2006-05-09 2007-11-14 PanGenetics B.V. Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody
GB0724331D0 (en) 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
EP2552965A2 (en) 2010-03-31 2013-02-06 Boehringer Ingelheim International GmbH Anti-cd40 antibodies
AR083847A1 (es) 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
ES2664619T3 (es) 2011-04-21 2018-04-20 Bristol-Myers Squibb Company Polipéptidos de anticuerpos que antagonizan CD40

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101061140A (zh) * 2004-09-17 2007-10-24 多曼蒂斯有限公司 单价结合cd40l的组合物和应用方法
CN101282993A (zh) * 2005-06-02 2008-10-08 阿斯利康公司 针对cd20的抗体和其用途
CN101374865A (zh) * 2005-12-16 2009-02-25 健泰科生物技术公司 抗ox40l抗体及其使用方法
WO2009134976A1 (en) * 2008-04-30 2009-11-05 Immunogen, Inc Potent conjugates and hydrophilic linkers
US20100172862A1 (en) * 2008-11-28 2010-07-08 Abbott Laboratories Stable antibody compositions and methods of stabilizing same

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