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CN104039844A - 利用乙酰乙酰辅酶a合酶产生异戊二烯、类异戊二烯前体和类异戊二烯 - Google Patents

利用乙酰乙酰辅酶a合酶产生异戊二烯、类异戊二烯前体和类异戊二烯 Download PDF

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Publication number
CN104039844A
CN104039844A CN201280048738.4A CN201280048738A CN104039844A CN 104039844 A CN104039844 A CN 104039844A CN 201280048738 A CN201280048738 A CN 201280048738A CN 104039844 A CN104039844 A CN 104039844A
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CN
China
Prior art keywords
cell
polypeptide
coa
isoprene
synthase
Prior art date
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Pending
Application number
CN201280048738.4A
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English (en)
Chinese (zh)
Inventor
I·S·阿尔多
Z·Q·贝克
M·C·米勒
C·M·派瑞斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goodyear Tire and Rubber Co
Danisco US Inc
Original Assignee
Goodyear Tire and Rubber Co
Danisco US Inc
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Application filed by Goodyear Tire and Rubber Co, Danisco US Inc filed Critical Goodyear Tire and Rubber Co
Publication of CN104039844A publication Critical patent/CN104039844A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F36/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds
    • C08F36/02—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds
    • C08F36/04—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, at least one having two or more carbon-to-carbon double bonds the radical having only two carbon-to-carbon double bonds conjugated
    • C08F36/08—Isoprene
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P5/00—Preparation of hydrocarbons or halogenated hydrocarbons
    • C12P5/007—Preparation of hydrocarbons or halogenated hydrocarbons containing one or more isoprene units, i.e. terpenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01194—Acetoacetyl-CoA synthase (2.3.1.194)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/30—Fuel from waste, e.g. synthetic alcohol or diesel
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201280048738.4A 2011-08-04 2012-08-03 利用乙酰乙酰辅酶a合酶产生异戊二烯、类异戊二烯前体和类异戊二烯 Pending CN104039844A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161515300P 2011-08-04 2011-08-04
US61/515,300 2011-08-04
PCT/US2012/049659 WO2013020118A1 (fr) 2011-08-04 2012-08-03 Production d'isoprène, de précurseurs d'isoprénoïdes et d'isoprénoïdes à l'aide de l'acétoacétyl-coa synthase

Publications (1)

Publication Number Publication Date
CN104039844A true CN104039844A (zh) 2014-09-10

Family

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CN201280048738.4A Pending CN104039844A (zh) 2011-08-04 2012-08-03 利用乙酰乙酰辅酶a合酶产生异戊二烯、类异戊二烯前体和类异戊二烯

Country Status (10)

Country Link
US (1) US20130122562A1 (fr)
EP (1) EP2739658A1 (fr)
JP (1) JP2014528705A (fr)
CN (1) CN104039844A (fr)
AU (1) AU2012289886A1 (fr)
BR (1) BR112014002661A2 (fr)
CA (1) CA2844064A1 (fr)
HK (1) HK1199048A1 (fr)
SG (1) SG2014007991A (fr)
WO (1) WO2013020118A1 (fr)

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CN107815424A (zh) * 2016-09-12 2018-03-20 华东理工大学 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用
CN115820527A (zh) * 2022-12-09 2023-03-21 天津大学 一种生产甲羟戊酸的重组盐单胞菌及构建方法与应用
CN116925991A (zh) * 2023-07-28 2023-10-24 天津大学 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用
CN117965414A (zh) * 2024-04-01 2024-05-03 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用
CN118773228A (zh) * 2024-06-25 2024-10-15 广州新鑫生物科技有限公司 一种改造大肠杆菌代谢通路以提高乙酰辅酶a合成效率的方法

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107815424A (zh) * 2016-09-12 2018-03-20 华东理工大学 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用
CN107815424B (zh) * 2016-09-12 2021-03-05 华东理工大学 一种产柠檬烯的解脂耶氏酵母基因工程菌及其应用
CN115820527A (zh) * 2022-12-09 2023-03-21 天津大学 一种生产甲羟戊酸的重组盐单胞菌及构建方法与应用
CN115820527B (zh) * 2022-12-09 2024-03-19 天津大学 一种生产甲羟戊酸的重组盐单胞菌及构建方法与应用
CN116925991A (zh) * 2023-07-28 2023-10-24 天津大学 高产甲羟戊酸的重组盐单胞菌菌株及构建方法与应用
CN117965414A (zh) * 2024-04-01 2024-05-03 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用
CN117965414B (zh) * 2024-04-01 2024-06-14 北京微构工场生物技术有限公司 一种重组盐单胞菌及其在生产异戊二烯中的应用
CN118773228A (zh) * 2024-06-25 2024-10-15 广州新鑫生物科技有限公司 一种改造大肠杆菌代谢通路以提高乙酰辅酶a合成效率的方法

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CA2844064A1 (fr) 2013-02-07
JP2014528705A (ja) 2014-10-30
AU2012289886A1 (en) 2014-02-20
BR112014002661A2 (pt) 2019-09-24
US20130122562A1 (en) 2013-05-16
HK1199048A1 (en) 2015-06-19

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