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CL2016002382A1 - Derivados de quinoxalina útiles como moduladores de fgfr quinasa - Google Patents

Derivados de quinoxalina útiles como moduladores de fgfr quinasa

Info

Publication number
CL2016002382A1
CL2016002382A1 CL2016002382A CL2016002382A CL2016002382A1 CL 2016002382 A1 CL2016002382 A1 CL 2016002382A1 CL 2016002382 A CL2016002382 A CL 2016002382A CL 2016002382 A CL2016002382 A CL 2016002382A CL 2016002382 A1 CL2016002382 A1 CL 2016002382A1
Authority
CL
Chile
Prior art keywords
modulators
derivatives useful
quinoxaline derivatives
fgfr kinase
fgfr
Prior art date
Application number
CL2016002382A
Other languages
English (en)
Inventor
Wim Vermeulen
Steven Anna Hostyn
Filip Albert Celine Cuyckens
Russell Mark Jones
Diego Fernando Domenico Broggini
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50389854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2016002382(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of CL2016002382A1 publication Critical patent/CL2016002382A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/55131,4-Benzodiazepines, e.g. diazepam or clozapine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

<p>COMPUESTOS DERIVADOS DE 1-[3-(1h-PIRAZOL-4-IL)QUINOXALIN-6-IL]-2,3,4,5-TETRAHIDRO-1H-1,4-(BENZODIAZEPINA/BENZODIAZOCINA), MODULADORES DE FGFR; PROCESO DE PREPARACION; COMPOSICION FARAMCEUTICA; Y SU USO PARA EL TRATAMIENTO O LA PROFILAXIS DEL CANCER.</p>
CL2016002382A 2014-03-26 2016-09-22 Derivados de quinoxalina útiles como moduladores de fgfr quinasa CL2016002382A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14161820 2014-03-26

Publications (1)

Publication Number Publication Date
CL2016002382A1 true CL2016002382A1 (es) 2017-01-20

Family

ID=50389854

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002382A CL2016002382A1 (es) 2014-03-26 2016-09-22 Derivados de quinoxalina útiles como moduladores de fgfr quinasa

Country Status (38)

Country Link
US (2) US9902714B2 (es)
EP (1) EP3122742B1 (es)
JP (1) JP6625551B2 (es)
KR (1) KR102469506B1 (es)
CN (1) CN106459010B (es)
AP (1) AP2016009536A0 (es)
AR (1) AR099854A1 (es)
AU (1) AU2015238300C1 (es)
BR (1) BR112016022060B1 (es)
CA (1) CA2943683A1 (es)
CL (1) CL2016002382A1 (es)
CR (1) CR20160501A (es)
CY (1) CY1120969T1 (es)
DK (1) DK3122742T3 (es)
EA (1) EA032145B1 (es)
ES (1) ES2702450T3 (es)
HR (1) HRP20182073T1 (es)
HU (1) HUE041738T2 (es)
IL (1) IL247658B (es)
JO (1) JO3512B1 (es)
LT (1) LT3122742T (es)
MA (1) MA39783B1 (es)
MX (1) MX380829B (es)
MY (1) MY194074A (es)
NI (1) NI201600144A (es)
NZ (1) NZ724907A (es)
PH (1) PH12016501898B1 (es)
PL (1) PL3122742T3 (es)
PT (1) PT3122742T (es)
RS (1) RS58088B1 (es)
SG (1) SG11201607961QA (es)
SI (1) SI3122742T1 (es)
SM (1) SMT201800670T1 (es)
TR (1) TR201819138T4 (es)
TW (1) TWI686391B (es)
UA (1) UA117958C2 (es)
WO (1) WO2015144803A1 (es)
ZA (1) ZA201606942B (es)

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