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AR099854A1 - Derivados de quinaxolina con acción sobre tirosinquinasas - Google Patents

Derivados de quinaxolina con acción sobre tirosinquinasas

Info

Publication number
AR099854A1
AR099854A1 ARP150100899A ARP150100899A AR099854A1 AR 099854 A1 AR099854 A1 AR 099854A1 AR P150100899 A ARP150100899 A AR P150100899A AR P150100899 A ARP150100899 A AR P150100899A AR 099854 A1 AR099854 A1 AR 099854A1
Authority
AR
Argentina
Prior art keywords
6alkyl
compounds
represents hydrogen
substituted
tyrosinkines
Prior art date
Application number
ARP150100899A
Other languages
English (en)
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50389854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR099854(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of AR099854A1 publication Critical patent/AR099854A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a compuestos derivados de quinoxalina, a composiciones farmacéuticas que comprenden dichos compuestos, a procesos para la preparación de dichos compuestos y al uso de dichos compuestos en el tratamiento de enfermedades, por ejemplo, cáncer. Reivindicación 1: Un compuesto de la fórmula (1), que incluyen cualquiera de sus formas tautómeras o estereoquímicamente isómeras, donde: n representa un número entero igual a 1 ó 2; R¹ representa hidrógeno, C₁₋₆alquilo, hidroxi-C₁₋₆alquilo, C₁₋₆alquilo sustituido con -C(=O)NHCH₃, o C₁₋₆alquilo sustituido con -S(=O)₂-C₁₋₄alquilo; R²ᵃ representa hidrógeno, flúor o cloro; R²ᵇ o R²ᶜ representan, de manera independiente, metoxi o hidroxilo; R³ representa hidrógeno, C₁₋₆alquilo, C₃₋₆cicloalquilo, o C₁₋₂alquilo sustituido con C₃₋₆cicloalquilo; R⁴ representa hidrógeno, metilo o etilo; o una de sus sales farmacéuticamente aceptables o uno de sus solvatos.
ARP150100899A 2014-03-26 2015-03-26 Derivados de quinaxolina con acción sobre tirosinquinasas AR099854A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14161820 2014-03-26

Publications (1)

Publication Number Publication Date
AR099854A1 true AR099854A1 (es) 2016-08-24

Family

ID=50389854

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP150100899A AR099854A1 (es) 2014-03-26 2015-03-26 Derivados de quinaxolina con acción sobre tirosinquinasas

Country Status (38)

Country Link
US (2) US9902714B2 (es)
EP (1) EP3122742B1 (es)
JP (1) JP6625551B2 (es)
KR (1) KR102469506B1 (es)
CN (1) CN106459010B (es)
AP (1) AP2016009536A0 (es)
AR (1) AR099854A1 (es)
AU (1) AU2015238300C1 (es)
BR (1) BR112016022060B1 (es)
CA (1) CA2943683A1 (es)
CL (1) CL2016002382A1 (es)
CR (1) CR20160501A (es)
CY (1) CY1120969T1 (es)
DK (1) DK3122742T3 (es)
EA (1) EA032145B1 (es)
ES (1) ES2702450T3 (es)
HR (1) HRP20182073T1 (es)
HU (1) HUE041738T2 (es)
IL (1) IL247658B (es)
JO (1) JO3512B1 (es)
LT (1) LT3122742T (es)
MA (1) MA39783B1 (es)
MX (1) MX380829B (es)
MY (1) MY194074A (es)
NI (1) NI201600144A (es)
NZ (1) NZ724907A (es)
PH (1) PH12016501898B1 (es)
PL (1) PL3122742T3 (es)
PT (1) PT3122742T (es)
RS (1) RS58088B1 (es)
SG (1) SG11201607961QA (es)
SI (1) SI3122742T1 (es)
SM (1) SMT201800670T1 (es)
TR (1) TR201819138T4 (es)
TW (1) TWI686391B (es)
UA (1) UA117958C2 (es)
WO (1) WO2015144803A1 (es)
ZA (1) ZA201606942B (es)

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