CL2013002029A1 - Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos. - Google Patents
Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos.Info
- Publication number
- CL2013002029A1 CL2013002029A1 CL2013002029A CL2013002029A CL2013002029A1 CL 2013002029 A1 CL2013002029 A1 CL 2013002029A1 CL 2013002029 A CL2013002029 A CL 2013002029A CL 2013002029 A CL2013002029 A CL 2013002029A CL 2013002029 A1 CL2013002029 A1 CL 2013002029A1
- Authority
- CL
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- Prior art keywords
- vitro culture
- oligodendrocytes
- myelin
- treat
- loss
- Prior art date
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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- A61P9/00—Drugs for disorders of the cardiovascular system
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
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- C12N5/0623—Stem cells
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- C12N2500/00—Specific components of cell culture medium
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/13—Nerve growth factor [NGF]; Brain-derived neurotrophic factor [BDNF]; Cilliary neurotrophic factor [CNTF]; Glial-derived neurotrophic factor [GDNF]; Neurotrophins [NT]; Neuregulins
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
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- C12N2533/00—Supports or coatings for cell culture, characterised by material
- C12N2533/30—Synthetic polymers
- C12N2533/32—Polylysine, polyornithine
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- Biotechnology (AREA)
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- Wood Science & Technology (AREA)
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- Neurosurgery (AREA)
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- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161431944P | 2011-01-12 | 2011-01-12 | |
| US201161558527P | 2011-11-11 | 2011-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2013002029A1 true CL2013002029A1 (es) | 2014-05-09 |
Family
ID=45529155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2013002029A CL2013002029A1 (es) | 2011-01-12 | 2013-07-12 | Celula progenitora y no diferenciada neural humana expandible aislada; composicion que la comprende; metodo de cultivo in vitro; dicho cultivo in vitro; y su uso para tratar una condicion causada por perdida de mielina o de oligodendrocitos. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8993320B2 (es) |
| EP (1) | EP2663638B1 (es) |
| JP (1) | JP5649745B2 (es) |
| KR (1) | KR102099807B1 (es) |
| CN (2) | CN103687941A (es) |
| AR (1) | AR084835A1 (es) |
| AU (2) | AU2012206411B2 (es) |
| BR (1) | BR112013017685A2 (es) |
| CA (1) | CA2821065C (es) |
| CL (1) | CL2013002029A1 (es) |
| DK (1) | DK2663638T3 (es) |
| EA (1) | EA034058B1 (es) |
| ES (1) | ES2732938T3 (es) |
| IL (1) | IL227361B (es) |
| MX (1) | MX364742B (es) |
| MY (1) | MY173219A (es) |
| PH (1) | PH12013501496B1 (es) |
| PL (1) | PL2663638T3 (es) |
| SG (1) | SG191729A1 (es) |
| TW (1) | TWI586805B (es) |
| WO (1) | WO2012095730A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003070171A2 (en) | 2002-02-15 | 2003-08-28 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
| CA2723382A1 (en) | 2008-05-08 | 2009-11-12 | University Of Rochester | Treating myelin diseases with optimized cell preparations |
| US10450546B2 (en) | 2013-02-06 | 2019-10-22 | University Of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| IL281665B (en) * | 2013-04-17 | 2022-07-01 | Salk Inst For Biological Studi | Media compositions for neuronal cell culture |
| JP6615616B2 (ja) * | 2014-01-21 | 2019-12-04 | 国立研究開発法人科学技術振興機構 | アダルト型オリゴデンドロサイト前駆細胞の製造方法 |
| CN105154386B (zh) * | 2014-05-30 | 2018-04-24 | 中国人民解放军第二军医大学东方肝胆外科医院 | 人肝细胞长期维持和增殖传代培养的专用培养基和培养方法 |
| KR101675123B1 (ko) * | 2014-06-27 | 2016-11-14 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물 |
| KR101793722B1 (ko) | 2014-08-25 | 2017-11-03 | 한국생명공학연구원 | 성상세포의 생산방법 |
| KR102635212B1 (ko) * | 2015-03-04 | 2024-02-13 | 메조블라스트 인터내셔널 에스에이알엘 | 중간엽 줄기 세포를 위한 세포 배양 방법 |
| JP6780638B2 (ja) * | 2015-03-30 | 2020-11-04 | 味の素株式会社 | ヒト血清アルブミンを含む神経幹細胞増殖培地 |
| CA2982959C (en) * | 2015-04-16 | 2021-08-31 | The Board Of Regents, The University Of Texas System | Cd133+ cells and method for expanding |
| JP6844953B2 (ja) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | アルツハイマー病研究を標的にしたグリア細胞システム |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| CN107921068A (zh) * | 2015-06-26 | 2018-04-17 | S生物医药公司 | 包含神经前体细胞的分泌蛋白质组作为有效成分的用于治疗缺血性疾病或神经炎症疾病的组合物 |
| CA2995634A1 (en) * | 2015-08-15 | 2017-02-23 | Asterias Biotherapeutics, Inc. | Stem cell-derived oligodendrocyte progenitor cells for the treatment of white matter stroke |
| WO2017156762A1 (en) | 2016-03-18 | 2017-09-21 | Institute Of Biophysics, Chinese Academy Of Sciences | A cell culture medium and culture medium supplement |
| CA3019514A1 (en) | 2016-03-30 | 2017-10-05 | Asterias Biotherapeutics, Inc. | Oligodendrocyte progenitor cell compositions |
| CN106929474B (zh) * | 2017-03-31 | 2021-09-14 | 北京恒峰铭成生物科技有限公司 | 一种m2巨噬细胞诱导剂 |
| WO2018209022A2 (en) | 2017-05-10 | 2018-11-15 | University Of Rochester | Methods of treating neuropsychiatric disorders |
| KR101889228B1 (ko) * | 2017-09-29 | 2018-08-16 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 척수손상 치료용 조성물 |
| CN107760649B (zh) * | 2017-11-02 | 2021-03-30 | 北京全式金生物技术有限公司 | 一种用于人神经系统细胞培养和人多能性干细胞向神经系统细胞分化的营养添加剂 |
| CN108070558B (zh) * | 2017-11-24 | 2022-01-28 | 吉林省拓华生物科技有限公司 | 一种临床级神经干细胞的制备方法 |
| KR101994640B1 (ko) | 2018-03-16 | 2019-07-02 | (주)메디노 | 신경줄기세포의 고효율 분리배양 방법 |
| MA52540A (fr) * | 2018-04-17 | 2021-02-24 | Univ Case Western Reserve | Induction d'oligodendrocytes myélinisants dans des sphéroïdes corticaux humains |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| EP3853345A4 (en) | 2018-09-19 | 2022-07-13 | Lineage Cell Therapeutics, Inc. | Methods for differentiating pluripotent stem cells in dynamic suspension culture |
| CN120060141A (zh) | 2019-01-23 | 2025-05-30 | 阿斯特里亚斯生物疗法股份有限公司 | 来自人多能干细胞的背源性少突胶质祖细胞 |
| US20230123863A1 (en) * | 2020-06-30 | 2023-04-20 | National Yang-Ming University | A glia cell and neuron co-culture system and method |
| CN114540301B (zh) * | 2020-11-20 | 2024-02-27 | 上海纽仁生物医药科技有限公司 | 少突胶质前体细胞亚群及其用途 |
| IL316055A (en) | 2022-04-15 | 2024-11-01 | Aspen Neuroscience Inc | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
| CN117821382A (zh) * | 2023-12-29 | 2024-04-05 | 广州赛莱拉干细胞科技股份有限公司 | 一种毛囊干细胞无血清培养基和培养方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1990003430A1 (en) * | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| DE19756864C5 (de) * | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten |
| US7504257B2 (en) * | 2000-03-14 | 2009-03-17 | Es Cell International Pte Ltd. | Embryonic stem cells and neural progenitor cells derived therefrom |
| GB2379447B (en) * | 2000-05-17 | 2004-12-29 | Geron Corp | Neural progenitor cell populations |
| EP1367899A4 (en) * | 2001-02-14 | 2004-07-28 | Leo T Furcht | TOTIPOTENT ADULT STEM CELLS, SOURCES OF SUCH CELLS, METHODS FOR OBTAINING AND MAINTAINING SAME, METHODS FOR DIFFERENTIATING THESE CELLS, METHODS OF USING SAME, AND CELLS DERIVED FROM THE ABOVE-MENTIONED CELLS |
| US9446073B2 (en) * | 2005-05-15 | 2016-09-20 | Biodontos, Llc | Non-lineage committed precursor cells from the dental papillary tissue of teeth |
| US20080153167A1 (en) * | 2006-06-21 | 2008-06-26 | The Trustees Of Columbia University In The City Of New York | In vivo amplification of neural progenitor cells |
| WO2008003042A2 (en) * | 2006-06-28 | 2008-01-03 | The University Of Medicine And Dentistry Of New Jersey | Amnion-derived stem cells and uses thereof |
| US20110236971A2 (en) | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
| EP2379711B8 (en) | 2008-12-23 | 2017-03-22 | BOCO Silicon Valley, Inc. | Target populations of oligodendrocyte precursor cells and methods of making and using same |
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2012
- 2012-01-12 US US13/349,089 patent/US8993320B2/en active Active
- 2012-01-12 AR ARP120100101A patent/AR084835A1/es not_active Application Discontinuation
- 2012-01-12 CN CN201280004915.9A patent/CN103687941A/zh active Pending
- 2012-01-12 WO PCT/IB2012/000030 patent/WO2012095730A1/en not_active Ceased
- 2012-01-12 CA CA2821065A patent/CA2821065C/en active Active
- 2012-01-12 PL PL12701024T patent/PL2663638T3/pl unknown
- 2012-01-12 DK DK12701024.7T patent/DK2663638T3/da active
- 2012-01-12 MX MX2013008208A patent/MX364742B/es active IP Right Grant
- 2012-01-12 CN CN201811129309.5A patent/CN109749996A/zh active Pending
- 2012-01-12 MY MYPI2013701211A patent/MY173219A/en unknown
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- 2012-01-12 KR KR1020137018381A patent/KR102099807B1/ko active Active
- 2012-01-12 ES ES12701024T patent/ES2732938T3/es active Active
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