AR084835A1 - Metodo de cultivo para obtener y mantener una poblacion pura o enriquecida de celulas madre neurales y/o celulas progenitoras neurales de mamifero que tienden a diferenciarse in vitro en celulas del linaje de oligodendrocitos - Google Patents
Metodo de cultivo para obtener y mantener una poblacion pura o enriquecida de celulas madre neurales y/o celulas progenitoras neurales de mamifero que tienden a diferenciarse in vitro en celulas del linaje de oligodendrocitosInfo
- Publication number
- AR084835A1 AR084835A1 ARP120100101A ARP120100101A AR084835A1 AR 084835 A1 AR084835 A1 AR 084835A1 AR P120100101 A ARP120100101 A AR P120100101A AR P120100101 A ARP120100101 A AR P120100101A AR 084835 A1 AR084835 A1 AR 084835A1
- Authority
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- Argentina
- Prior art keywords
- cell
- differentiate
- cells
- neural stem
- ability
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title abstract 7
- 210000001178 neural stem cell Anatomy 0.000 title abstract 4
- 238000012136 culture method Methods 0.000 title abstract 2
- 238000000338 in vitro Methods 0.000 title abstract 2
- 210000005155 neural progenitor cell Anatomy 0.000 title 1
- 210000004248 oligodendroglia Anatomy 0.000 abstract 5
- 210000000130 stem cell Anatomy 0.000 abstract 4
- 210000001130 astrocyte Anatomy 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 210000002569 neuron Anatomy 0.000 abstract 2
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 abstract 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102000006386 Myelin Proteins Human genes 0.000 abstract 1
- 108010083674 Myelin Proteins Proteins 0.000 abstract 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 abstract 1
- 102100040120 Prominin-1 Human genes 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 210000004748 cultured cell Anatomy 0.000 abstract 1
- 210000005012 myelin Anatomy 0.000 abstract 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0622—Glial cells, e.g. astrocytes, oligodendrocytes; Schwann cells
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- A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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Abstract
Una célula madre o progenitora neural humana aislada expandible, donde la célula es una célula progenitora o una célula madre, que conserva su capacidad para diferenciarse en neuronas, astrocitos y oligodendrocitos, conserva su capacidad para diferenciarse en células del linaje de oligodendrocitos de manera eficaz durante todos los pasajes subsiguientes, y la célula expresa por lo menos los antígenos de la superficie celular, CD133 y CD140a. También se provee un método de cultivo in vitro de una célula progenitora o madre neural expandible aislada de un sistema nervioso central de mamífero, y el propio cultivo, en donde dicha célula conserva su capacidad para diferenciarse en neuronas, astrocitos y oligodendrocitos y su capacidad para diferenciarse en células del linaje de oligodendrocitos de una manera eficiente. Además, se provee un método de tratamiento de una condición causada por la pérdida de mielina o la pérdida de oligodendrocitos, así como una composición que comprende una célula madre neural aislada expandible o una célula cultivada mediante los métodos divulgados.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161431944P | 2011-01-12 | 2011-01-12 | |
| US201161558527P | 2011-11-11 | 2011-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084835A1 true AR084835A1 (es) | 2013-06-26 |
Family
ID=45529155
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120100101A AR084835A1 (es) | 2011-01-12 | 2012-01-12 | Metodo de cultivo para obtener y mantener una poblacion pura o enriquecida de celulas madre neurales y/o celulas progenitoras neurales de mamifero que tienden a diferenciarse in vitro en celulas del linaje de oligodendrocitos |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8993320B2 (es) |
| EP (1) | EP2663638B1 (es) |
| JP (1) | JP5649745B2 (es) |
| KR (1) | KR102099807B1 (es) |
| CN (2) | CN109749996A (es) |
| AR (1) | AR084835A1 (es) |
| AU (2) | AU2012206411B2 (es) |
| BR (1) | BR112013017685A2 (es) |
| CA (1) | CA2821065C (es) |
| CL (1) | CL2013002029A1 (es) |
| DK (1) | DK2663638T3 (es) |
| EA (1) | EA034058B1 (es) |
| ES (1) | ES2732938T3 (es) |
| IL (1) | IL227361B (es) |
| MX (1) | MX364742B (es) |
| MY (1) | MY173219A (es) |
| PH (1) | PH12013501496B1 (es) |
| PL (1) | PL2663638T3 (es) |
| SG (1) | SG191729A1 (es) |
| TW (1) | TWI586805B (es) |
| WO (1) | WO2012095730A1 (es) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003211063A1 (en) | 2002-02-15 | 2003-09-09 | Cornell Research Foundation, Inc. | Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells |
| KR20110011658A (ko) | 2008-05-08 | 2011-02-08 | 유니버시티 오브 로체스터 | 최적화된 세포 제제에 의한 수초 질환의 치료 |
| EP2954046B1 (en) * | 2013-02-06 | 2025-10-15 | University Of Rochester | Induced pluripotent cell-derived oligodendrocyte progenitor cells for the treatment of myelin disorders |
| WO2014172580A1 (en) * | 2013-04-17 | 2014-10-23 | Salk Institute For Biological Studies | Media compositions for neuronal cell culture |
| JP6615616B2 (ja) * | 2014-01-21 | 2019-12-04 | 国立研究開発法人科学技術振興機構 | アダルト型オリゴデンドロサイト前駆細胞の製造方法 |
| CN105154386B (zh) * | 2014-05-30 | 2018-04-24 | 中国人民解放军第二军医大学东方肝胆外科医院 | 人肝细胞长期维持和增殖传代培养的专用培养基和培养方法 |
| KR101675123B1 (ko) * | 2014-06-27 | 2016-11-14 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 허혈성 질환 또는 신경염증 질환 치료용 조성물 |
| KR101793722B1 (ko) | 2014-08-25 | 2017-11-03 | 한국생명공학연구원 | 성상세포의 생산방법 |
| BR112017018885A2 (pt) | 2015-03-04 | 2018-04-17 | Mesoblast Int Sarl | método de cultura celular para células-tronco mesenquimais |
| EP3279318A4 (en) * | 2015-03-30 | 2018-08-29 | Ajinomoto Co., Inc. | Human serum albumin-containing culture medium for growth of neural stem cells |
| CA2982959C (en) * | 2015-04-16 | 2021-08-31 | The Board Of Regents, The University Of Texas System | Cd133+ cells and method for expanding |
| JP6844953B2 (ja) * | 2015-04-22 | 2021-03-17 | 公益財団法人東京都医学総合研究所 | アルツハイマー病研究を標的にしたグリア細胞システム |
| US9724432B2 (en) | 2015-04-30 | 2017-08-08 | University Of Rochester | Non-human mammal model of human degenerative disorder, uses thereof, and method of treating human degenerative disorder |
| CN107921068A (zh) * | 2015-06-26 | 2018-04-17 | S生物医药公司 | 包含神经前体细胞的分泌蛋白质组作为有效成分的用于治疗缺血性疾病或神经炎症疾病的组合物 |
| US20180236004A1 (en) * | 2015-08-15 | 2018-08-23 | Asterias Biotherapeutics, Inc. | Stem cell-derived oligodendrocyte progenitor cells for the treatment of white matter stroke |
| CN108779436A (zh) | 2016-03-18 | 2018-11-09 | 中国科学院生物物理研究所 | 一种细胞培养基和培养基补充物 |
| EP3436567A4 (en) | 2016-03-30 | 2019-10-30 | Asterias Biotherapeutics, Inc. | COMPOSITIONS FROM OLIGOD DRO CYTOMATOR CELLARS |
| CN106929474B (zh) * | 2017-03-31 | 2021-09-14 | 北京恒峰铭成生物科技有限公司 | 一种m2巨噬细胞诱导剂 |
| CN110913689A (zh) | 2017-05-10 | 2020-03-24 | 罗切斯特大学 | 治疗神经精神病症的方法 |
| KR101889228B1 (ko) * | 2017-09-29 | 2018-08-16 | 연세대학교 산학협력단 | Psa-ncam-양성 신경전구세포를 유효성분으로 포함하는 척수손상 치료용 조성물 |
| CN107760649B (zh) * | 2017-11-02 | 2021-03-30 | 北京全式金生物技术有限公司 | 一种用于人神经系统细胞培养和人多能性干细胞向神经系统细胞分化的营养添加剂 |
| CN108070558B (zh) * | 2017-11-24 | 2022-01-28 | 吉林省拓华生物科技有限公司 | 一种临床级神经干细胞的制备方法 |
| KR101994640B1 (ko) | 2018-03-16 | 2019-07-02 | (주)메디노 | 신경줄기세포의 고효율 분리배양 방법 |
| JP2021521790A (ja) * | 2018-04-17 | 2021-08-30 | ケース ウェスタン リザーブ ユニバーシティＣａｓｅ Ｗｅｓｔｅｒｎ Ｒｅｓｅｒｖｅ Ｕｎｉｖｅｒｓｉｔｙ | ヒト皮質スフェロイドでのミエリン形成オリゴデンドロサイトの誘導 |
| CN108624560B (zh) * | 2018-06-01 | 2022-04-08 | 南京艾尔普再生医学科技有限公司 | 一种分化培养基及少突胶质前体细胞的制备方法 |
| KR20210068050A (ko) * | 2018-09-19 | 2021-06-08 | 리니지 셀 테라퓨틱스, 인크. | 동적 현탁 배양에서 만능 줄기 세포를 분화시키는 방법 |
| WO2020154533A1 (en) | 2019-01-23 | 2020-07-30 | Asterias Biotherapeutics, Inc. | Dorsally-derived oligodendrocyte progenitor cells from human pluripotent stem cells |
| WO2022005463A1 (en) * | 2020-06-30 | 2022-01-06 | National Yang-Ming University | A glia cell and neuron co-culture system and method |
| CN114540301B (zh) * | 2020-11-20 | 2024-02-27 | 上海纽仁生物医药科技有限公司 | 少突胶质前体细胞亚群及其用途 |
| US20230377685A1 (en) | 2022-04-15 | 2023-11-23 | Aspen Neuroscience, Inc. | Methods of classifying the differentiation state of cells and related compositions of differentiated cells |
| CN117821382A (zh) * | 2023-12-29 | 2024-04-05 | 广州赛莱拉干细胞科技股份有限公司 | 一种毛囊干细胞无血清培养基和培养方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO1990003430A1 (en) * | 1988-09-23 | 1990-04-05 | Cetus Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| DE19756864C5 (de) * | 1997-12-19 | 2014-07-10 | Oliver Brüstle | Neurale Vorläuferzellen, Verfahren zu ihrer Herstellung und ihre Verwendung zur Therapie von neuralen Defekten |
| WO2002064748A2 (en) * | 2001-02-14 | 2002-08-22 | Furcht Leo T | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
| IL151170A0 (en) * | 2000-03-14 | 2003-04-10 | Es Cell Int Pte Ltd | Embryonic stem cells and neural progenitor cells derived therefrom |
| JP5943533B2 (ja) * | 2000-05-17 | 2016-07-06 | アステリアス バイオセラピューティクス インコーポレイテッド | 神経前駆細胞の集団 |
| US9446073B2 (en) * | 2005-05-15 | 2016-09-20 | Biodontos, Llc | Non-lineage committed precursor cells from the dental papillary tissue of teeth |
| US20080153167A1 (en) * | 2006-06-21 | 2008-06-26 | The Trustees Of Columbia University In The City Of New York | In vivo amplification of neural progenitor cells |
| WO2008003042A2 (en) * | 2006-06-28 | 2008-01-03 | The University Of Medicine And Dentistry Of New Jersey | Amnion-derived stem cells and uses thereof |
| US20110236971A2 (en) | 2007-09-25 | 2011-09-29 | Maksym Vodyanyk | Generation of Clonal Mesenchymal Progenitors and Mesenchymal Stem Cell Lines Under Serum-Free Conditions |
| WO2010075500A1 (en) * | 2008-12-23 | 2010-07-01 | Stemcells California, Inc | Target populations of oligodendrocyte precursor cells and methods of making and using same |
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