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CL2009000923A1 - Compuestos derivados de 1-(aminoacetil)-n-(1-cicloalquil)pirrolidina-2-carboxamida sustituidas; composicion farmaceutica; utiles para tratar la hepatitis c. - Google Patents

Compuestos derivados de 1-(aminoacetil)-n-(1-cicloalquil)pirrolidina-2-carboxamida sustituidas; composicion farmaceutica; utiles para tratar la hepatitis c.

Info

Publication number
CL2009000923A1
CL2009000923A1 CL2009000923A CL2009000923A CL2009000923A1 CL 2009000923 A1 CL2009000923 A1 CL 2009000923A1 CL 2009000923 A CL2009000923 A CL 2009000923A CL 2009000923 A CL2009000923 A CL 2009000923A CL 2009000923 A1 CL2009000923 A1 CL 2009000923A1
Authority
CL
Chile
Prior art keywords
aminoacetyl
pyrrolidine
cycloalkyl
substituted
useful
Prior art date
Application number
CL2009000923A
Other languages
English (en)
Inventor
Ny Sin
Brian Lee Venables
Paul Michael Scola
Alan Xiangdong Wang
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2009000923A1 publication Critical patent/CL2009000923A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Compuestos derivados de 1-(aminoacetil)-n-(1-cicloalquil) pirrolidina-2-carboxamida sustituidas; composición farmacéutica; útiles para tratar la hepatitis C.
CL2009000923A 2008-04-16 2009-04-16 Compuestos derivados de 1-(aminoacetil)-n-(1-cicloalquil)pirrolidina-2-carboxamida sustituidas; composicion farmaceutica; utiles para tratar la hepatitis c. CL2009000923A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4543408P 2008-04-16 2008-04-16
US12/418,677 US8163921B2 (en) 2008-04-16 2009-04-06 Hepatitis C virus inhibitors

Publications (1)

Publication Number Publication Date
CL2009000923A1 true CL2009000923A1 (es) 2009-09-11

Family

ID=40666703

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2009000923A CL2009000923A1 (es) 2008-04-16 2009-04-16 Compuestos derivados de 1-(aminoacetil)-n-(1-cicloalquil)pirrolidina-2-carboxamida sustituidas; composicion farmaceutica; utiles para tratar la hepatitis c.

Country Status (11)

Country Link
US (1) US8163921B2 (es)
EP (2) EP2813500B1 (es)
JP (1) JP5512655B2 (es)
KR (1) KR101610418B1 (es)
CN (2) CN103936819B (es)
AR (1) AR071370A1 (es)
CL (1) CL2009000923A1 (es)
MX (1) MX2010010974A (es)
PE (1) PE20091841A1 (es)
TW (1) TW200946523A (es)
WO (1) WO2009129109A1 (es)

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Also Published As

Publication number Publication date
WO2009129109A1 (en) 2009-10-22
JP2011518163A (ja) 2011-06-23
EP2265606A1 (en) 2010-12-29
AR071370A1 (es) 2010-06-16
US20090274652A1 (en) 2009-11-05
EP2265606B1 (en) 2015-10-21
JP5512655B2 (ja) 2014-06-04
CN102083821B (zh) 2014-09-17
EP2813500A1 (en) 2014-12-17
CN103936819B (zh) 2016-11-16
AU2009236467A1 (en) 2009-10-22
US8163921B2 (en) 2012-04-24
CN103936819A (zh) 2014-07-23
EP2813500B1 (en) 2016-08-17
KR20100132078A (ko) 2010-12-16
PE20091841A1 (es) 2009-12-04
TW200946523A (en) 2009-11-16
MX2010010974A (es) 2010-11-01
CN102083821A (zh) 2011-06-01
KR101610418B1 (ko) 2016-04-07

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