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EA200801428A1 - Производные пиридиазинона для лечения опухолей - Google Patents

Производные пиридиазинона для лечения опухолей

Info

Publication number
EA200801428A1
EA200801428A1 EA200801428A EA200801428A EA200801428A1 EA 200801428 A1 EA200801428 A1 EA 200801428A1 EA 200801428 A EA200801428 A EA 200801428A EA 200801428 A EA200801428 A EA 200801428A EA 200801428 A1 EA200801428 A1 EA 200801428A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pyridiazinone
tumors
derivatives
treatment
compounds
Prior art date
Application number
EA200801428A
Other languages
English (en)
Other versions
EA014667B1 (ru
Inventor
Дитер Дорш
Оливер Шадт
Андрее Блаукат
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA200801428A1 publication Critical patent/EA200801428A1/ru
Publication of EA014667B1 publication Critical patent/EA014667B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Соединения формулы (I), в которой R
EA200801428A 2005-12-05 2006-11-07 Производные пиридазинона для лечения опухолей EA014667B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102005057924A DE102005057924A1 (de) 2005-12-05 2005-12-05 Pyridazinonderivate
PCT/EP2006/010668 WO2007065518A1 (de) 2005-12-05 2006-11-07 Pyridiazinonderivate zur behandlung von tumoren

Publications (2)

Publication Number Publication Date
EA200801428A1 true EA200801428A1 (ru) 2008-10-30
EA014667B1 EA014667B1 (ru) 2010-12-30

Family

ID=37775213

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801428A EA014667B1 (ru) 2005-12-05 2006-11-07 Производные пиридазинона для лечения опухолей

Country Status (27)

Country Link
US (1) US8173653B2 (ru)
EP (1) EP1960370B1 (ru)
JP (1) JP5210172B2 (ru)
KR (1) KR101367447B1 (ru)
CN (1) CN101326167B (ru)
AR (1) AR057214A1 (ru)
AT (1) ATE527241T1 (ru)
AU (1) AU2006322364B2 (ru)
BR (1) BRPI0619407A2 (ru)
CA (1) CA2632217C (ru)
CY (1) CY1112206T1 (ru)
DE (1) DE102005057924A1 (ru)
DK (1) DK1960370T3 (ru)
EA (1) EA014667B1 (ru)
EC (1) ECSP088598A (ru)
ES (1) ES2373117T3 (ru)
IL (1) IL191832A (ru)
MY (1) MY153261A (ru)
NZ (1) NZ569568A (ru)
PE (1) PE20070832A1 (ru)
PL (1) PL1960370T3 (ru)
PT (1) PT1960370E (ru)
SI (1) SI1960370T1 (ru)
TW (1) TWI395741B (ru)
UA (1) UA95934C2 (ru)
WO (1) WO2007065518A1 (ru)
ZA (1) ZA200805877B (ru)

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MY148634A (en) * 2006-07-25 2013-05-15 Cephalon Inc Pyridazinone derivatives
DE102006037478A1 (de) * 2006-08-10 2008-02-14 Merck Patent Gmbh 2-(Heterocyclylbenzyl)-pyridazinonderivate
EP2094662B1 (en) * 2006-12-14 2012-04-11 Astellas Pharma Inc. Polycyclic acid compounds useful as crth2 antagonists and antiallergic agents
US8283351B2 (en) * 2007-04-02 2012-10-09 Institute For Oneworld Health Cyclic and acyclic hydrazine derivatives compositions including them and uses thereof
DE102007025718A1 (de) 2007-06-01 2008-12-04 Merck Patent Gmbh Pyridazinonderivate
DE102007025717A1 (de) 2007-06-01 2008-12-11 Merck Patent Gmbh Arylether-pyridazinonderivate
DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) * 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007038957A1 (de) * 2007-08-17 2009-02-19 Merck Patent Gmbh 6-Thioxo-pyridazinderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
CN101537006B (zh) * 2008-03-18 2012-06-06 中国科学院上海药物研究所 哒嗪酮类化合物在制备抗肿瘤药物中的用途
DE102008019907A1 (de) * 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
DE102008037790A1 (de) 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
US8586599B2 (en) * 2008-12-22 2013-11-19 Merck Patent Gmbh Polymorphic forms of 6-(1-methyl-1H-pyrazol-4-yl)-2-{3-[5-(2-morpholin-4-yl-ethoxy)-pyrimidin-2-yl]-benzyl}-2H-pyridazin-3-one dihydrogenphosphate and processes of manufacturing thereof
DE102008062826A1 (de) 2008-12-23 2010-07-01 Merck Patent Gmbh Pyridazinonderivate
DE102009003954A1 (de) 2009-01-07 2010-07-08 Merck Patent Gmbh Pyridazinonderivate
MX350894B (es) * 2009-01-08 2017-09-22 Merck Patent Gmbh * Nuevas formas polimorficas de sal de clorhidrato de 3-(1-{3-[5-(1-metil-piperidin-4-ilmetoxi)-pirimidin-2-il]-bencil} -6-oxo-1,6-dihidro-piridazin-3-il)-benzonitrilo y sus procesos de preparacion.
DE102009004061A1 (de) 2009-01-08 2010-07-15 Merck Patent Gmbh Pyridazinonderivate
CN102731409A (zh) * 2011-04-08 2012-10-17 中国科学院上海药物研究所 一类哒嗪酮类化合物，其药物组合物、制备方法及用途
KR101842645B1 (ko) * 2012-04-12 2018-03-29 한국화학연구원 신규한 히드라진온이 치환된 피리미딘 유도체 및 그의 용도
HUE035483T2 (hu) * 2012-11-02 2018-05-02 Merck Patent Gmbh 6-oxo-1,6-dihidro-piridazin-származék hepatocelluláris karcinóma (HCC) kezelésében történõ alkalmazásra
EP3640241B1 (en) 2013-10-18 2022-09-28 Celgene Quanticel Research, Inc. Bromodomain inhibitors
CN103772352B (zh) * 2014-01-16 2017-01-18 四川百利药业有限责任公司 哒嗪酮类衍生物及其制备方法和用途
JP6791855B2 (ja) * 2014-12-11 2020-11-25 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ 抗がん活性を有する６−オキソ−１，６−ジヒドロ−ピリダジン誘導体とキナゾリン誘導体との組み合わせ
EP3532467A1 (en) * 2016-10-26 2019-09-04 Proteostasis Therapeutics, Inc. Pyridazine derivatives, compositions and methods for modulating cftr
CN107334767B (zh) * 2017-06-08 2019-03-05 中国医学科学院医药生物技术研究所 一种哒嗪酮类化合物在肿瘤治疗中的应用
CN118206529A (zh) * 2017-09-04 2024-06-18 C4医药公司 二氢苯并咪唑酮
JP7671245B2 (ja) * 2018-11-06 2025-05-01 エッジワイズ セラピューティクス， インコーポレイテッド ピリダジノン化合物およびその使用
EP4248972A3 (en) 2018-11-06 2023-12-06 Edgewise Therapeutics, Inc. Pyridazinone compounds and uses thereof
MX2021005350A (es) 2018-11-06 2021-08-11 Edgewise Therapeutics Inc Compuestos de piridazinona y usos de los mismos.
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JPS5826802A (ja) * 1981-08-10 1983-02-17 Sankyo Co Ltd 農園芸用殺菌剤
DE3321012A1 (de) * 1983-06-10 1984-12-13 A. Nattermann & Cie GmbH, 5000 Köln Substituierte 4,5-dihydro-6-(thien-2-yl)-3(2h)-pyridazinone und 6-(thien-2-yl)-3(2h)-pyridazinone sowie verfahren zu ihrer herstellung
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CN101410120A (zh) * 2003-04-25 2009-04-15 吉里德科学公司 抗炎的膦酸酯化合物
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US7763617B2 (en) * 2005-03-07 2010-07-27 Kyorin Pharmaceutical Co., Ltd. Pyrazolopyridine-4-yl pyridazinone derivatives and addition salts thereof, and PDE inhibitors comprising the same derivatives or salts as active ingredient

Also Published As

Publication number Publication date
JP5210172B2 (ja) 2013-06-12
PE20070832A1 (es) 2007-08-27
AR057214A1 (es) 2007-11-21
MY153261A (en) 2015-01-29
TWI395741B (zh) 2013-05-11
EA014667B1 (ru) 2010-12-30
EP1960370B1 (de) 2011-10-05
ECSP088598A (es) 2008-08-29
KR20080077664A (ko) 2008-08-25
BRPI0619407A2 (pt) 2011-10-04
AU2006322364A1 (en) 2007-06-14
CA2632217C (en) 2014-07-08
CN101326167A (zh) 2008-12-17
CA2632217A1 (en) 2007-06-14
US8173653B2 (en) 2012-05-08
AU2006322364B2 (en) 2012-01-12
JP2009518323A (ja) 2009-05-07
NZ569568A (en) 2011-05-27
EP1960370A1 (de) 2008-08-27
WO2007065518A1 (de) 2007-06-14
PL1960370T3 (pl) 2012-01-31
TW200804303A (en) 2008-01-16
HK1127489A1 (en) 2009-09-25
CN101326167B (zh) 2011-03-09
PT1960370E (pt) 2012-01-11
IL191832A0 (en) 2008-12-29
ZA200805877B (en) 2009-07-29
DE102005057924A1 (de) 2007-06-06
KR101367447B1 (ko) 2014-02-25
ES2373117T3 (es) 2012-01-31
ATE527241T1 (de) 2011-10-15
DK1960370T3 (da) 2012-01-02
IL191832A (en) 2013-09-30
US20080293719A1 (en) 2008-11-27
SI1960370T1 (sl) 2011-12-30
UA95934C2 (ru) 2011-09-26
CY1112206T1 (el) 2015-12-09

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM