[go: up one dir, main page]

CL2008003037A1 - Anticuerpo que se une especificamente a il-4; moleculas de acido nucleico, celulas huesped; composicion farmaceutica que comprende dicho anticuerpo; uso del anticuerpo para tratar cancer, entre otras enfermedades. - Google Patents

Anticuerpo que se une especificamente a il-4; moleculas de acido nucleico, celulas huesped; composicion farmaceutica que comprende dicho anticuerpo; uso del anticuerpo para tratar cancer, entre otras enfermedades.

Info

Publication number
CL2008003037A1
CL2008003037A1 CL2008003037A CL2008003037A CL2008003037A1 CL 2008003037 A1 CL2008003037 A1 CL 2008003037A1 CL 2008003037 A CL2008003037 A CL 2008003037A CL 2008003037 A CL2008003037 A CL 2008003037A CL 2008003037 A1 CL2008003037 A1 CL 2008003037A1
Authority
CL
Chile
Prior art keywords
antibody
diseases
nucleic acid
pharmaceutical composition
host cells
Prior art date
Application number
CL2008003037A
Other languages
English (en)
Inventor
Vincent Mikol
Ercole Rao
Danxi Li
Jochen Kruip
Matthew Davison
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39313041&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2008003037(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed filed Critical
Publication of CL2008003037A1 publication Critical patent/CL2008003037A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6845—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a cytokine, e.g. growth factors, VEGF, TNF, a lymphokine or an interferon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/247—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS ANTICUERPOS ANTI-IL-4 Y IL-13 HUMANIZADOS Y A FRAGMENTOS DE LOS MISMOS, Y A NUEVOS ANTICUERPOS BIESPECÍFICOS Y FRAGMENTOS DE LOS MISMOS QUE SE UNEN ESPECÍFICAMENTE A IL-4 Y A IL-13. LA INVENCIÓN TAMBIÉN INCLUYE USOS DE LOS ANTICUERPOS PARA TRATAR O PREVENIR ENFERMEDADES O TRASTORNOS MEDIADOS POR IL-4 Y/O IL-13, INCLUYENDO ASMA ALÉRGICA Y DERMATITIS.
CL2008003037A 2007-10-15 2008-10-14 Anticuerpo que se une especificamente a il-4; moleculas de acido nucleico, celulas huesped; composicion farmaceutica que comprende dicho anticuerpo; uso del anticuerpo para tratar cancer, entre otras enfermedades. CL2008003037A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP07291259A EP2050764A1 (en) 2007-10-15 2007-10-15 Novel polyvalent bispecific antibody format and uses thereof
US3712808P 2008-03-17 2008-03-17

Publications (1)

Publication Number Publication Date
CL2008003037A1 true CL2008003037A1 (es) 2009-03-06

Family

ID=39313041

Family Applications (4)

Application Number Title Priority Date Filing Date
CL2008003037A CL2008003037A1 (es) 2007-10-15 2008-10-14 Anticuerpo que se une especificamente a il-4; moleculas de acido nucleico, celulas huesped; composicion farmaceutica que comprende dicho anticuerpo; uso del anticuerpo para tratar cancer, entre otras enfermedades.
CL2012003196A CL2012003196A1 (es) 2007-10-15 2012-11-15 Anticuerpo aislado o fragmento del mismo que se une específicamente a interleuquina-4 (il-4); molécula de ácido nucleico aislado que lo codifica y vector que la comprende; célula que comprende dicho vector; composición farmacéutica que comprende dicho anticuerpo; y su uso parar tratar una enfermedad alérgica, cáncer y asma.
CL2013002040A CL2013002040A1 (es) 2007-10-15 2013-07-12 Anticuerpo biespecifico o fragmento del mismo que se une especificamente a il-13 e il-14; molecula de acido nucleico que lo codifica; vector; celula; composicion farmaceutica; y sus usos (div.sol.n°3037-08).
CL2013002039A CL2013002039A1 (es) 2007-10-15 2013-07-12 Anticuerpo aislado o fragmento del mismo que se une especificamente a il-13; molecula de acido nucleico que lo codifica; vector; celula; composicion farmaceutica que lo comprende; y su uso (div.sol.n°3037-08).

Family Applications After (3)

Application Number Title Priority Date Filing Date
CL2012003196A CL2012003196A1 (es) 2007-10-15 2012-11-15 Anticuerpo aislado o fragmento del mismo que se une específicamente a interleuquina-4 (il-4); molécula de ácido nucleico aislado que lo codifica y vector que la comprende; célula que comprende dicho vector; composición farmacéutica que comprende dicho anticuerpo; y su uso parar tratar una enfermedad alérgica, cáncer y asma.
CL2013002040A CL2013002040A1 (es) 2007-10-15 2013-07-12 Anticuerpo biespecifico o fragmento del mismo que se une especificamente a il-13 e il-14; molecula de acido nucleico que lo codifica; vector; celula; composicion farmaceutica; y sus usos (div.sol.n°3037-08).
CL2013002039A CL2013002039A1 (es) 2007-10-15 2013-07-12 Anticuerpo aislado o fragmento del mismo que se une especificamente a il-13; molecula de acido nucleico que lo codifica; vector; celula; composicion farmaceutica que lo comprende; y su uso (div.sol.n°3037-08).

Country Status (43)

Country Link
US (18) US8388965B2 (es)
EP (12) EP2050764A1 (es)
JP (5) JP5858616B2 (es)
KR (5) KR101681909B1 (es)
CN (3) CN113480647B (es)
AR (3) AR068861A1 (es)
AU (5) AU2008312655B2 (es)
BR (1) BRPI0818677B8 (es)
CA (3) CA2702473C (es)
CL (4) CL2008003037A1 (es)
CR (5) CR11337A (es)
CY (5) CY1114987T1 (es)
DK (5) DK2205640T3 (es)
DO (3) DOP2010000109A (es)
ES (5) ES2660152T3 (es)
GT (1) GT201000067A (es)
HN (1) HN2010000710A (es)
HR (5) HRP20140150T1 (es)
HU (4) HUE038556T2 (es)
IL (2) IL205005A (es)
LT (4) LT2573119T (es)
MA (1) MA31838B1 (es)
MX (6) MX363901B (es)
MY (1) MY171214A (es)
NI (7) NI201000405A (es)
NO (2) NO2574629T3 (es)
NZ (3) NZ601342A (es)
PA (1) PA8799001A1 (es)
PE (1) PE20091382A1 (es)
PH (2) PH12013501033B1 (es)
PL (5) PL2573121T3 (es)
PT (5) PT2573121T (es)
RS (5) RS56553B1 (es)
RU (4) RU2580049C2 (es)
SG (4) SG185303A1 (es)
SI (5) SI2574629T1 (es)
TN (1) TN2010000126A1 (es)
TR (2) TR201802225T4 (es)
TW (4) TW201825117A (es)
UA (2) UA118949C2 (es)
UY (1) UY31394A1 (es)
WO (1) WO2009052081A2 (es)
ZA (1) ZA201002069B (es)

Families Citing this family (197)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
CN101842387B (zh) 2007-09-26 2014-05-07 Ucb医药有限公司 双特异性抗体融合物
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
DE112008003232T5 (de) * 2007-11-30 2011-02-24 Glaxo Group Limited, Greenford Antigen-Bindungskonstrukte
US20090162359A1 (en) 2007-12-21 2009-06-25 Christian Klein Bivalent, bispecific antibodies
US9266967B2 (en) 2007-12-21 2016-02-23 Hoffmann-La Roche, Inc. Bivalent, bispecific antibodies
JP5529869B2 (ja) * 2008-08-14 2014-06-25 メルク・シャープ・アンド・ドーム・コーポレーション プロテインａアフィニティークロマトグラフィーを用いる抗体の精製方法
EP2334705B1 (en) 2008-09-26 2016-12-14 UCB Biopharma SPRL Biological products
CA2757931C (en) 2009-04-07 2019-03-26 Roche Glycart Ag Trivalent, bispecific antibodies
US9676845B2 (en) 2009-06-16 2017-06-13 Hoffmann-La Roche, Inc. Bispecific antigen binding proteins
WO2011030107A1 (en) * 2009-09-10 2011-03-17 Ucb Pharma S.A. Multivalent antibodies
EP2478013B1 (en) 2009-09-16 2018-10-24 F.Hoffmann-La Roche Ag Coiled coil and/or tether containing protein complexes and uses thereof
GB201000467D0 (en) * 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
AR080793A1 (es) 2010-03-26 2012-05-09 Roche Glycart Ag Anticuerpos biespecificos
FR2958936A1 (fr) 2010-04-14 2011-10-21 Sanofi Aventis Proteine de fusion robo1-fc et son utilisation dans le traitement des tumeurs
US20130115215A1 (en) * 2010-07-14 2013-05-09 Hongxing Zhou Domain insertion immunoglobulin
MY172618A (en) * 2010-08-02 2019-12-06 Regeneron Pharma Mice that make binding proteins comprising vl domains
JP2013537415A (ja) 2010-08-03 2013-10-03 アッヴィ・インコーポレイテッド 二重可変ドメイン免疫グロブリンおよびその使用
RU2013110876A (ru) 2010-08-24 2014-09-27 Рош Гликарт Аг Активируемые биспецифические антитела
BR112013001847A2 (pt) 2010-08-24 2016-05-31 Hoffmann La Roche anticorpo biespecífico, método de preparação do anticorpo biespecífico, do anticorpo biespecífico trivalente, métodos e composição farmacêutica
EP2655413B1 (en) 2010-12-23 2019-01-16 F.Hoffmann-La Roche Ag Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
JP5768147B2 (ja) 2011-02-28 2015-08-26 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 一価抗原結合タンパク質
CN102675460B (zh) * 2011-02-28 2015-08-19 珠海市丽珠单抗生物技术有限公司 抗肿瘤坏死因子α的人源化抗体
CN103502271B (zh) 2011-02-28 2016-10-26 霍夫曼-拉罗奇有限公司 抗原结合蛋白
TWI700093B (zh) * 2011-03-16 2020-08-01 法商賽諾菲公司 雙重ｖ區類抗體蛋白質之用途
TWI588156B (zh) * 2011-03-28 2017-06-21 賽諾菲公司 具有交叉結合區定向之雙重可變區類抗體結合蛋白
HUE053139T2 (hu) * 2011-03-28 2021-06-28 Sanofi Sa Kettõs variábilis régióval rendelkezõ ellenanyag-szerû fehérjék keresztezett kötõrégiós orientációval
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CN107936121B (zh) * 2011-05-16 2022-01-14 埃泰美德(香港)有限公司 多特异性fab融合蛋白及其使用方法
UY34105A (es) * 2011-06-03 2012-07-31 Lg Life Sciences Ltd Formulación líquida estable de etanercept
SMT202100357T1 (it) 2011-08-05 2021-07-12 Regeneron Pharma Topi di catena leggera universale umanizzata
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
KR102024066B1 (ko) 2011-11-23 2019-09-24 비오벤 쓰리 리미티드 재조합 단백질 및 그들의 치료적 용도
WO2013103783A1 (en) * 2012-01-04 2013-07-11 Sanofi Us Murine il-13 antibodies
MX2014009565A (es) 2012-02-10 2014-11-10 Genentech Inc Anticuerpos monocatenarios y otros heteromultimeros.
RU2014139546A (ru) * 2012-03-27 2016-05-20 Дженентек, Инк. Методы прогнозирования, диагностики и лечения идиопатического легочного фиброза
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
RU2015100656A (ru) 2012-06-27 2016-08-20 Ф. Хоффманн-Ля Рош Аг Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения
ES2597228T3 (es) 2012-06-27 2017-01-17 F. Hoffmann-La Roche Ag Procedimiento para la selección y la producción de entidades de objetivación, como dianas, altamente selectivas y multiespecíficas, personalizadas, las cuales contienen por lo menos dos entidades de unión diferentes, y utilización de éstas
NZ631562A (en) 2012-08-21 2017-03-31 Regeneron Pharma Methods for treating or preventing asthma by administering an il-4r antagonist
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
US9790268B2 (en) 2012-09-12 2017-10-17 Genzyme Corporation Fc containing polypeptides with altered glycosylation and reduced effector function
PL3366705T3 (pl) 2012-09-12 2023-09-18 Genzyme Corporation FC zawierające polipeptydy o zmienionej glikozylacji i zmniejszonej funkcji efektorowej
SG11201503324WA (en) 2012-11-01 2015-05-28 Abbvie Inc Stable dual variable domain immunoglobulin protein formulations
TW202037609A (zh) 2012-11-01 2020-10-16 美商艾伯維有限公司 抗-vegf/dll4雙重可變區域免疫球蛋白及其用途
KR102661801B1 (ko) 2012-11-20 2024-04-26 사노피 항-ceacam5 항체 및 이의 용도
CN105007941B (zh) 2012-12-27 2019-01-25 赛诺菲 抗-lamp1抗体和抗体药物偶联物及其用途
EP2983701A2 (en) 2013-03-11 2016-02-17 Genzyme Corporation Site-specific antibody-drug conjugation through glycoengineering
AU2013381687A1 (en) 2013-03-12 2015-09-24 Abbvie Inc. Human antibodies that bind human TNF-alpha and methods of preparing the same
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
CN105530959B (zh) * 2013-03-15 2021-09-17 纪念斯隆-凯特琳癌症中心 多聚化技术
WO2014151910A1 (en) * 2013-03-15 2014-09-25 Amgen Inc. Heterodimeric bispecific antibodies
US20140302037A1 (en) 2013-03-15 2014-10-09 Amgen Inc. BISPECIFIC-Fc MOLECULES
JP2016522168A (ja) * 2013-04-05 2016-07-28 ジェネンテック， インコーポレイテッド 抗ｉｌ−４抗体及び二重特異性抗体及びその使用
TWI679019B (zh) * 2013-04-29 2019-12-11 法商賽諾菲公司 抗ｉｌ－４／抗ｉｌ－１３之雙特異性抗體調配物
WO2015051293A2 (en) 2013-10-04 2015-04-09 Abbvie, Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
BR112016006929A2 (pt) 2013-10-11 2017-09-19 Hoffmann La Roche Anticorpo, ácido nucleico, vetor de expressão, célula hospedeira, métodos de preparação de anticorpo, de tratamento de pacientes e de geração de um anticorpo, composição farmacêutica e uso do anticorpo
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
EP3065769A4 (en) * 2013-11-08 2017-05-31 Biogen MA Inc. Procoagulant fusion compound
WO2015073884A2 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
BR112016011027A2 (pt) 2013-12-20 2017-12-05 Genentech Inc método de produção de um anticorpo, anticorpos, composição farmacêutica, polinucleotídeo, vetor, célula hospedeira, método de tratamento de asma e método de tratamento de um distúrbio
EP2893939A1 (en) 2014-01-10 2015-07-15 Netris Pharma Anti-netrin-1 antibody
US20150225479A1 (en) * 2014-02-12 2015-08-13 Sanofi Anti-IL-4/Anti-IL-13 Bispecific Antibody/Polyglutamate Formulations
IL315136A (en) * 2014-02-21 2024-10-01 Sanofi Biotechnology Methods for treating or preventing asthma by administering an il-4rantagonist
WO2015127405A2 (en) * 2014-02-21 2015-08-27 Genentech, Inc. Anti-il-13/il-17 bispecific antibodies and uses thereof
ES3051373T3 (en) 2014-03-19 2025-12-26 Genzyme Corp Site-specific glycoengineering of targeting moieties
EP3895528A1 (en) 2014-03-21 2021-10-20 Regeneron Pharmaceuticals, Inc. Non-human animals that make single domain binding proteins
SG11201607015VA (en) 2014-03-21 2016-09-29 Regeneron Pharma V<sb>L</sb> ANTIGEN BINDING PROTEINS EXHIBITING DISTINCT BINDING CHARACTERISTICS
TW201628647A (zh) 2014-06-27 2016-08-16 賽諾菲公司 抗－ｉｌ４－ｉｌ１３雙特異性抗體
HUE048667T2 (hu) 2014-07-11 2020-08-28 Genmab As AXL-hez kötõdõ ellenanyagok
MA39070A1 (fr) 2014-07-31 2017-11-30 Sanofi Sa Anticorps anti-cd38 spécifiques pour le traitement de cancers humains
WO2016044707A1 (en) 2014-09-18 2016-03-24 Cedars-Sinai Medical Center Compositions and methods for treating fibrosis
EP3799887A1 (en) 2014-10-09 2021-04-07 Genzyme Corporation Glycoengineered antibody drug conjugates
CA2967602C (en) 2014-11-14 2024-09-24 Regeneron Pharmaceuticals, Inc. METHODS OF TREATMENT OF CHRONIC SINUSITIS WITH NASAL POLYPOSIS BY ADMINISTRATION OF AN IL-4R ANTAGONIST
EP3222637A4 (en) * 2014-11-21 2018-10-31 Astellas Pharma Inc. Novel bispecific antibody format
WO2016087416A1 (en) 2014-12-03 2016-06-09 F. Hoffmann-La Roche Ag Multispecific antibodies
US10093733B2 (en) 2014-12-11 2018-10-09 Abbvie Inc. LRP-8 binding dual variable domain immunoglobulin proteins
HRP20201517T1 (hr) 2015-01-23 2020-12-11 Sanofi Anti-cd3 protutijela, anti-cd123 protutijela i bispecifična protutijela koja se specifično vežu na cd3 i/ili cd123
MA41414A (fr) 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
EP3067062A1 (en) 2015-03-13 2016-09-14 Ipsen Pharma S.A.S. Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament
WO2016149276A1 (en) * 2015-03-16 2016-09-22 Genentech, Inc. Methods of detecting and quantifying il-13 and uses in diagnosing and treating th2-associated diseases
AU2016232715A1 (en) 2015-03-19 2017-09-28 Regeneron Pharmaceuticals, Inc. Non-human animals that select for light chain variable regions that bind antigen
TW201710286A (zh) 2015-06-15 2017-03-16 艾伯維有限公司 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白
JP6892431B2 (ja) 2015-07-10 2021-06-23 ゲンマブ エー／エス 癌治療用のａｘｌ特異的抗体−薬物コンジュゲート
PE20240096A1 (es) 2015-10-02 2024-01-18 Hoffmann La Roche Anticuerpos biespecificos especificos para un receptor de tnf coestimulador
CR20180288A (es) 2015-10-25 2018-09-11 Us Health Proteínas de union triespecíficas y/o trivalentes para la prevención o el tratamiento de la infección por vih
TW201720459A (zh) 2015-11-02 2017-06-16 妮翠斯製藥公司 Ntn1中和劑與抑制後生控制之藥物之組合治療
US20170233480A1 (en) 2015-12-31 2017-08-17 Development Center For Biotechnology Anti-vegfr antibody and uses thereof
JP7078536B2 (ja) 2016-01-08 2022-05-31 アルトゥルバイオ， インコーポレイテッド 四価抗ｐｓｇｌ－１抗体とその使用
CA3017776A1 (en) 2016-03-15 2017-09-21 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
JP7195929B2 (ja) 2016-04-13 2022-12-26 サノフイ 三重特異性および／または三価結合タンパク質
DK3443006T5 (da) 2016-04-13 2024-09-16 Sanofi Sa Trispecifikke og/eller trivalente bindingsproteiner
IL297519B2 (en) 2016-04-27 2024-06-01 Abbvie Inc Methods for treating diseases in which IL-13 activity is harmful using antibodies to IL-13
TW201808336A (zh) 2016-05-11 2018-03-16 賽諾菲公司 用抗ｍｕｃ１類美登素免疫綴合物抗體治療腫瘤的治療方案
EP3484922A1 (en) 2016-07-14 2019-05-22 Genmab A/S Multispecific antibodies against cd40 and cd137
TWI790206B (zh) 2016-07-18 2023-01-21 法商賽諾菲公司 特異性結合至ｃｄ３和ｃｄ１２３的雙特異性抗體樣結合蛋白
ES2975750T3 (es) 2016-08-26 2024-07-12 Sanofi Sa Anticuerpos multiespecíficos que facilitan el emparejamiento selectivo de las cadenas ligeras
TWI778985B (zh) 2016-10-20 2022-10-01 法商賽諾菲公司 抗chikv抗體及其用途
BR112019008702A2 (pt) 2016-11-01 2019-07-16 Genmab B.V. polipeptídeo, método de diminuição de uma função fc efetora de um polipeptídeo, composição, método de tratamento, kit de partes, e, uso de um polipeptídeo ou composição.
EP3551034A1 (en) 2016-12-07 2019-10-16 Progenity, Inc. Gastrointestinal tract detection methods, devices and systems
EA039433B1 (ru) 2017-01-05 2022-01-27 Нетрис Фарма Комбинированное лечение лекарственными средствами, интерферирующими с нетрином-1, и лекарственными средствами, ингибиторами контрольных точек иммуного ответа
EP4659808A2 (en) 2017-02-17 2025-12-10 Sanofi Multispecific binding molecules having specificity to dystroglycan and laminin-2
CA3053774A1 (en) 2017-02-17 2018-08-23 Sanofi Multispecific binding molecules having specificity to dystroglycan and laminin-2
WO2018151841A1 (en) 2017-02-17 2018-08-23 Sanofi Multispecific binding molecules having specificity to dystroglycan and laminin-2
KR101961871B1 (ko) * 2017-02-20 2019-07-17 주식회사 와이바이오로직스 신규 다중특이적 결합 단백질
WO2018183932A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor
WO2018224609A1 (en) 2017-06-07 2018-12-13 Genmab B.V. Therapeutic antibodies based on mutated igg hexamers
EP3648757A4 (en) * 2017-07-03 2020-11-25 Development Center for Biotechnology ANTI-VEGFR ANTIBODIES AND ITS USES
WO2019028367A1 (en) 2017-08-04 2019-02-07 Regeneron Pharmaceuticals, Inc. METHODS OF TREATING ESOPHAGITIS WITH ACTIVE EOSINOPHILES
WO2019051204A1 (en) 2017-09-08 2019-03-14 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services SYNERGISTIC COMBINATION OF IL4, INTERFERON GAMMA AND INTERFERON ALPHA RECEPTOR AGENTS FOR USE IN THE TREATMENT OF OVARIAN CANCER
CN120058938A (zh) 2017-10-10 2025-05-30 赛诺菲 抗cd38抗体及与抗cd3和抗cd28抗体的组合
CN109705217B (zh) * 2017-10-25 2020-09-11 北京智仁美博生物科技有限公司 抗il-13抗体及其用途
ES2969049T3 (es) 2017-10-30 2024-05-16 Sanofi Biotechnology Antagonista de IL-4R para uso en un método para tratar o prevenir el asma
US11067584B2 (en) 2018-01-12 2021-07-20 Genzyme Corporation Methods for the quantitation of polypeptides
WO2019145455A1 (en) 2018-01-24 2019-08-01 Genmab B.V. Polypeptide variants and uses thereof
KR20250008975A (ko) 2018-01-26 2025-01-16 젠자임 코포레이션 FcRn에 대한 증진된 결합 및 연장된 반감기를 갖는 Fc 변이체
US20210024632A1 (en) * 2018-03-05 2021-01-28 Etablissement Francais Du Sang Recombinant single chain immunoglobulins
SG11202008718UA (en) * 2018-03-09 2020-10-29 Brigham & Womens Hospital Inc Combination therapy for cardiovascular diseases
EP3788074A1 (en) 2018-05-03 2021-03-10 Genmab B.V. Antibody variant combinations and uses thereof
EP3574915A1 (en) 2018-05-29 2019-12-04 Neovacs Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity
WO2019243636A1 (en) 2018-06-22 2019-12-26 Genmab Holding B.V. Anti-cd37 antibodies and anti-cd20 antibodies, compositions and methods of use thereof
MX2020013631A (es) 2018-07-13 2021-03-25 Genmab As Variantes de anticuerpo grupo de diferenciacion (cd38) y usos de las mismas.
JP7534281B2 (ja) 2018-07-13 2024-08-14 ジェンマブ エー／エス Ｃｄ３８抗体を使用したトロゴサイトーシスを介した治療
JP7548587B2 (ja) 2018-09-07 2024-09-10 アイタブメッド （エイチケイ） リミテッド 二重特異性抗原結合タンパク質及びその使用
BR112021006055A2 (pt) 2018-10-04 2021-07-20 Genmab Holding B.V. composição farmacêutica, uso da composição farmacêutica, e, métodos para induzir a morte celular ou para inibir o crescimento e/ou proliferação de uma célula tumoral e para tratar um indivíduo.
BR112021006558A2 (pt) 2018-10-09 2021-07-13 Sanofi proteínas de ligação triespecíficas anti-cd38, anti-cd28 e anti-cd3 e métodos de uso para o tratamento de infecção viral
CN113166259A (zh) * 2018-11-09 2021-07-23 亚洲大学校产学协力团 对人IL-4受体α具有高亲和力的人抗体及其用途
US20240252795A1 (en) 2018-11-19 2024-08-01 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
MX2021007565A (es) 2018-12-21 2021-10-13 Aim Immunotech Inc Composiciones y metodos para la terapia contra el cancer.
CN111514292B (zh) * 2018-12-25 2023-06-20 江苏荃信生物医药股份有限公司 抗人白介素4受体α单克隆抗体的制药用途
MA55204A (fr) 2019-03-06 2022-01-12 Regeneron Pharma Inhibiteurs de la voie il-4/il-13 pour une efficacité améliorée dans le traitement du cancer
MA55372A (fr) 2019-03-21 2022-01-26 Regeneron Pharma Combinaison d'inhibiteurs de la voie il-4/il-13 et d'ablation de plasmocytes pour traiter une allergie
JP7575401B2 (ja) 2019-04-03 2024-10-29 ジェンザイム・コーポレーション 断片化が低減した抗アルファベータｔｃｒ結合ポリペプチド
US11613576B2 (en) 2019-04-09 2023-03-28 Sanofi Trispecific binding proteins, methods, and uses thereof
EP3976181A1 (en) 2019-05-24 2022-04-06 Sanofi Methods for treating systemic sclerosis
EP3753954A1 (en) 2019-06-21 2020-12-23 Université de Franche-Comté Anti-cd123 antibodies, anti-cd123 chimeric antigen receptors and anti-cd123 chimeric antigen receptors t cells
MX2022000649A (es) 2019-07-16 2022-06-08 Sanofi Biotechnology Metodos para tratar o prevenir el asma mediante la administracion de un antagonista de il-4r.
JP7685985B2 (ja) 2019-07-16 2025-05-30 サノフイ アルツハイマー病の処置のための中和抗アミロイドベータ抗体
EP4004039A2 (en) 2019-07-25 2022-06-01 Genzyme Corporation Methods of treating antibody-mediated disorders with fcrn antagonists
EP3870261B1 (en) 2019-12-13 2024-01-31 Biora Therapeutics, Inc. Ingestible device for delivery of therapeutic agent to the gastrointestinal tract
GB201919062D0 (en) * 2019-12-20 2020-02-05 Ucb Biopharma Sprl Antibody
WO2021144020A1 (en) 2020-01-15 2021-07-22 Immatics Biotechnologies Gmbh Antigen binding proteins specifically binding prame
CN115397394A (zh) 2020-01-31 2022-11-25 赛诺菲 抗体的肺部递送
CA3169521A1 (en) 2020-02-28 2021-09-02 Marie-Priscille Brun Modified binding polypeptides for optimized drug conjugation
WO2021175924A1 (en) 2020-03-03 2021-09-10 Active Biotech Ab Tasquinimod or a pharmaceutically acceptable salt thereof for use in combination therapy
TW202146463A (zh) 2020-03-05 2021-12-16 法商賽諾菲公司 蛋白酶加工的分子
AU2021236906A1 (en) 2020-03-18 2022-08-18 Genmab A/S Antibodies binding to B7H4
WO2021214221A1 (en) 2020-04-24 2021-10-28 Sanofi Antitumor combinations containing anti-ceacam5 antibody conjugates and folfiri
WO2021214223A1 (en) 2020-04-24 2021-10-28 Sanofi Antitumor combinations containing anti-ceacam5 antibody conjugates and folfox
MX2022013404A (es) 2020-04-24 2022-11-14 Sanofi Sa Combinaciones antitumorales que contienen productos conjugados de anticuerpos anti-ceacam5, trifluridina y tipirazilo.
EP4138927A1 (en) 2020-04-24 2023-03-01 Sanofi Antitumor combinations containing anti-ceacam5 antibody conjugates and cetuximab
CN111690066B (zh) * 2020-06-22 2022-07-22 南京融捷康生物科技有限公司 抗IL-4Rα的单域抗体以及应用和药物
WO2021263075A1 (en) * 2020-06-26 2021-12-30 St. Jude Children's Research Hospital, Inc. Methods of generating an activation inducible expression system in immune cells
WO2022018294A1 (en) 2020-07-23 2022-01-27 Genmab B.V. A combination of anti-dr5 antibodies and an immunomodulatory imide drug for use in treating multiple myeloma
JP2023539525A (ja) 2020-09-02 2023-09-14 ジェンマブ エー／エス 抗体療法
MX2023002330A (es) 2020-09-04 2023-03-21 Merck Patent Gmbh Anticuerpos anti molecula de adhesion celular 5 relacionada con el antigeno carcinoembrionario (ceacam5) y conjugados y usos de los mismos.
AU2021395729A1 (en) * 2020-12-07 2023-07-13 UCB Biopharma SRL Multi-specific antibodies and antibody combinations
WO2022184805A1 (en) 2021-03-03 2022-09-09 Immatics Biotechnologies Gmbh Antigen binding proteins specifically binding sars-cov-2 antigenic peptides in complex with a major histocompatibility complex protein
BR112023021089A2 (pt) 2021-05-07 2023-12-12 Genmab As Composição farmacêutica, método para tratar uma doença, método para tratar câncer em um indivíduo, uso da composição farmacêutica, forma de dosagem unitária, kit de partes, e, método para preparar uma composição farmacêutica
CA3216005A1 (en) 2021-05-27 2022-12-01 Jochen Beninga Fc variant with enhanced affinity to fc receptors and improved thermal stability
US20250312468A1 (en) 2021-07-02 2025-10-09 Merck Patent Gmbh Anti-protac antibodies and complexes
EP4372009A4 (en) * 2021-07-26 2025-06-11 Denka Company Limited REAGENT CONTAINING A HUMANIZED ANTIBODY
JP2024531390A (ja) * 2021-08-20 2024-08-29 ネオヴァクス ＩＬ－４および／またはＩＬ－１３ＲＮＡを含むｍＲＮＡワクチンおよびその使用
MX2024005484A (es) 2021-11-05 2024-07-19 Sanofi Sa Combinaciones antineoplásicas que contienen conjugados de anticuerpo-fármaco anti-ceacam5 y anticuerpos anti-vegfr-2.
IL313897A (en) 2021-12-30 2024-08-01 Regeneron Pharma Methods for reducing atopic dermatitis by administering an IL-4/IL-13 antagonist
CN119998316A (zh) * 2022-03-03 2025-05-13 辉瑞大药厂 多特异性抗体及其用途
JP2025509365A (ja) 2022-03-09 2025-04-11 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 抗ｃｅａｃａｍ５抗体および抱合体ならびにその使用
EP4245772A1 (en) 2022-03-18 2023-09-20 Netris Pharma Anti-netrin-1 antibody to treat liver inflammation
EP4249509A1 (en) 2022-03-22 2023-09-27 Netris Pharma Anti-netrin-1 antibody against arthritis-associated pain
KR20250017240A (ko) 2022-05-27 2025-02-04 사노피 FC-조작을 갖는 NKp46 및 BCMA 변이체에 결합하는 자연 살해(NK) 세포 관여자
WO2023245187A2 (en) 2022-06-17 2023-12-21 Apogee Biologics, Inc. Antibodies that bind interleukin 13 and methods of use
IL320455A (en) 2022-10-25 2025-06-01 Ablynx Nv Glyco-engineered polypeptide variants of FC with enhanced effector function
EP4642482A1 (en) 2022-12-27 2025-11-05 Merck Patent GmbH Vhh anti-protac antibodies and complexes
EP4413995A1 (en) 2023-02-07 2024-08-14 Université de Franche-Comté Anti-cd123 chimeric antigen receptors t cells for use in the treatement of autoimmune diseases
WO2024180085A1 (en) 2023-02-27 2024-09-06 Netris Pharma Anti-netrin-1 monoclonal antibody for treating endometriosis and associated pains
CN120813387A (zh) 2023-03-01 2025-10-17 赛诺菲 抗ceacam5免疫缀合物用于治疗表达ceacam5的神经内分泌癌症的用途
EP4427763A1 (en) 2023-03-06 2024-09-11 Sanofi Antitumor combinations containing anti-ceacam5 antibody-drug conjugates, anti-vegfr-2 antibodies and anti-pd1/pd-l1 antibodies
EP4434586A1 (en) 2023-03-23 2024-09-25 Xenothera Combination of antibodies, or antigen-binding fragments thereof, for the treatment of cancer and composition thereof
KR20250169564A (ko) 2023-03-23 2025-12-03 사노피 암 치료법에서 환자 선택을 위한 CEACAM5 mRNA 검정
AU2024271605A1 (en) 2023-05-12 2025-11-13 BioNTech SE Antibodies capable of binding to ox40, variants thereof and uses thereof
WO2024238614A2 (en) * 2023-05-15 2024-11-21 Sthria Sciences Limited Liability Company A method of treating autoimmune disease
CN121443320A (zh) 2023-06-05 2026-01-30 赛诺菲 含有抗ceacam5抗体-药物缀合物、抗pd1/pd-l1抗体和抗ctla4抗体的抗肿瘤组合
WO2025049347A1 (en) * 2023-08-25 2025-03-06 Triveni Bio, Inc. Klk5/7 + il-4 targeting antibodies and uses thereof
WO2025049348A1 (en) * 2023-08-25 2025-03-06 Triveni Bio, Inc. Klk5/7 + il-13 targeting antibodies and uses thereof
WO2025049346A1 (en) * 2023-08-25 2025-03-06 Triveni Bio, Inc. Klk5/7 + th2 targeting antibodies and uses thereof
WO2025049345A1 (en) 2023-08-25 2025-03-06 Proteologix Us Inc. Anti-il-13 multispecific antibody constructs and uses thereof
JP2025036273A (ja) * 2023-08-30 2025-03-14 ファイザー・インク 多重特異性抗体およびその使用
WO2025073856A1 (en) 2023-10-04 2025-04-10 Xenothera Combination of antibodies, or antigen-binding fragments thereof, for the treatment of cancers
TW202535925A (zh) 2023-10-25 2025-09-16 比利時商艾伯霖克斯公司 具有增強的Ｆｃ受體結合之Ｆｃ結構域變體
WO2025166146A1 (en) * 2024-02-02 2025-08-07 Triveni Bio, Inc. Klk5/7 + ox40 targeting antibodies and uses thereof
WO2025166138A1 (en) * 2024-02-02 2025-08-07 Triveni Bio, Inc. Klk5/7 + tslp targeting antibodies and uses thereof
WO2025242845A1 (en) 2024-05-22 2025-11-27 Merck Patent Gmbh Colorectal cancer treatment
WO2026022712A1 (en) 2024-07-23 2026-01-29 Sanofi Cereblon ligase modulator and bcma nk cell engager combination therapy

Family Cites Families (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4307016A (en) 1978-03-24 1981-12-22 Takeda Chemical Industries, Ltd. Demethyl maytansinoids
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4256746A (en) 1978-11-14 1981-03-17 Takeda Chemical Industries Dechloromaytansinoids, their pharmaceutical compositions and method of use
JPS55102583A (en) 1979-01-31 1980-08-05 Takeda Chem Ind Ltd 20-acyloxy-20-demethylmaytansinoid compound
JPS55162791A (en) 1979-06-05 1980-12-18 Takeda Chem Ind Ltd Antibiotic c-15003pnd and its preparation
JPS6023084B2 (ja) 1979-07-11 1985-06-05 味の素株式会社 代用血液
JPS5645483A (en) 1979-09-19 1981-04-25 Takeda Chem Ind Ltd C-15003phm and its preparation
EP0028683A1 (en) 1979-09-21 1981-05-20 Takeda Chemical Industries, Ltd. Antibiotic C-15003 PHO and production thereof
JPS5645485A (en) 1979-09-21 1981-04-25 Takeda Chem Ind Ltd Production of c-15003pnd
US4444887A (en) 1979-12-10 1984-04-24 Sloan-Kettering Institute Process for making human antibody producing B-lymphocytes
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
WO1982001188A1 (en) 1980-10-08 1982-04-15 Takeda Chemical Industries Ltd 4,5-deoxymaytansinoide compounds and process for preparing same
US4450254A (en) 1980-11-03 1984-05-22 Standard Oil Company Impact improvement of high nitrile resins
US4315929A (en) 1981-01-27 1982-02-16 The United States Of America As Represented By The Secretary Of Agriculture Method of controlling the European corn borer with trewiasine
US4313946A (en) 1981-01-27 1982-02-02 The United States Of America As Represented By The Secretary Of Agriculture Chemotherapeutically active maytansinoids from Trewia nudiflora
JPS57192389A (en) 1981-05-20 1982-11-26 Takeda Chem Ind Ltd Novel maytansinoid
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4716111A (en) 1982-08-11 1987-12-29 Trustees Of Boston University Process for producing human antibodies
US4560655A (en) 1982-12-16 1985-12-24 Immunex Corporation Serum-free cell culture medium and process for making same
US4657866A (en) 1982-12-21 1987-04-14 Sudhir Kumar Serum-free, synthetic, completely chemically defined tissue culture media
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
AU584417B2 (en) 1985-04-01 1989-05-25 Lonza Group Ag Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
US4737456A (en) 1985-05-09 1988-04-12 Syntex (U.S.A.) Inc. Reducing interference in ligand-receptor binding assays
EP0206448B1 (en) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5618920A (en) 1985-11-01 1997-04-08 Xoma Corporation Modular assembly of antibody genes, antibodies prepared thereby and use
GB8601597D0 (en) 1986-01-23 1986-02-26 Wilson R H Nucleotide sequences
WO1987005330A1 (en) 1986-03-07 1987-09-11 Michel Louis Eugene Bergh Method for enhancing glycoprotein stability
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
GB8717430D0 (en) 1987-07-23 1987-08-26 Celltech Ltd Recombinant dna product
IL89489A0 (en) 1988-03-09 1989-09-10 Hybritech Inc Chimeric antibodies directed against human carcinoembryonic antigen
JPH02503867A (ja) 1988-04-15 1990-11-15 プロテイン　デザイン　ラブズ　インコーポレーテッド Ｉｌ‐２レセプター特異的キメラ抗体
JP3105898B2 (ja) 1988-04-16 2000-11-06 セルテック リミテッド 組換えｄｎａタンパクの製造方法
ATE120454T1 (de) 1988-06-14 1995-04-15 Cetus Oncology Corp Kupplungsmittel und sterisch gehinderte, mit disulfid gebundene konjugate daraus.
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US6048728A (en) 1988-09-23 2000-04-11 Chiron Corporation Cell culture medium for enhanced cell growth, culture longevity, and product expression
US5534617A (en) 1988-10-28 1996-07-09 Genentech, Inc. Human growth hormone variants having greater affinity for human growth hormone receptor at site 1
WO1990005144A1 (en) 1988-11-11 1990-05-17 Medical Research Council Single domain ligands, receptors comprising said ligands, methods for their production, and use of said ligands and receptors
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
IE63847B1 (en) 1989-05-05 1995-06-14 Res Dev Foundation A novel antibody delivery system for biological response modifiers
CA2018228C (en) 1989-06-05 1996-02-27 Nancy L. Parenteau Cell culture systems and media
US5413923A (en) 1989-07-25 1995-05-09 Cell Genesys, Inc. Homologous recombination for universal donor cells and chimeric mammalian hosts
FR2650598B1 (fr) 1989-08-03 1994-06-03 Rhone Poulenc Sante Derives de l'albumine a fonction therapeutique
GB8928874D0 (en) 1989-12-21 1990-02-28 Celltech Ltd Humanised antibodies
ES2284161T3 (es) 1990-01-12 2007-11-01 Amgen Fremont Inc. Generacion de anticuerpos xenogenicos.
US5314995A (en) 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
ATE158615T1 (de) 1990-03-20 1997-10-15 Univ Columbia Chimäre antikörper mit rezeptor-bindenden liganden anstelle ihrer konstanten region
GB9015198D0 (en) 1990-07-10 1990-08-29 Brien Caroline J O Binding substance
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
CA2089661C (en) 1990-08-29 2007-04-03 Nils Lonberg Transgenic non-human animals capable of producing heterologous antibodies
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5122469A (en) 1990-10-03 1992-06-16 Genentech, Inc. Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
JPH09506761A (ja) 1990-11-09 1997-07-08 ステファン ディー．ギリーズ サイトカインの免疫複合体
DE69233482T2 (de) 1991-05-17 2006-01-12 Merck & Co., Inc. Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
US5565332A (en) 1991-09-23 1996-10-15 Medical Research Council Production of chimeric antibodies - a combinatorial approach
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
ES2165851T3 (es) 1991-11-25 2002-04-01 Enzon Inc Proteinas multivalentes que se unen a antigenos.
US5885793A (en) 1991-12-02 1999-03-23 Medical Research Council Production of anti-self antibodies from antibody segment repertoires and displayed on phage
US5869619A (en) 1991-12-13 1999-02-09 Xoma Corporation Modified antibody variable domains
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686901A1 (fr) 1992-01-31 1993-08-06 Rhone Poulenc Rorer Sa Nouveaux polypeptides antithrombotiques, leur preparation et compositions pharmaceutiques les contenant.
DE69334351D1 (de) 1992-02-06 2011-05-12 Novartis Vaccines & Diagnostic Biosynthetisches Bindeprotein für Tumormarker
EP0563475B1 (en) 1992-03-25 2000-05-31 Immunogen Inc Cell binding agent conjugates of derivatives of CC-1065
WO1993021319A1 (en) 1992-04-08 1993-10-28 Cetus Oncology Corporation HUMANIZED C-erbB-2 SPECIFIC ANTIBODIES
ZA932522B (en) 1992-04-10 1993-12-20 Res Dev Foundation Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens
CA2102401A1 (en) 1992-06-09 1993-12-10 Friedrich Hoppe Latch and lockset system
EP0749475A4 (en) 1992-08-26 1997-05-07 Harvard College USE OF CYTOKINE IP-10 AS ANTI-TUMOR AGENT
US5639641A (en) 1992-09-09 1997-06-17 Immunogen Inc. Resurfacing of rodent antibodies
DE69427974T2 (de) 1993-04-29 2001-12-06 Unilever N.V., Rotterdam Herstellung von antikörpern oder funktionstüchtig gemachten teilen davon, abgeleitet von schweren ketten von immunglobulinen von camelidae
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
ZA946875B (en) * 1993-09-07 1995-07-06 Smithkline Beecham Corp Recombinant il4 antibodies useful in treatment of il4 mediated disorders
US5928904A (en) * 1993-09-07 1999-07-27 Smithkline Beecham Corporation DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
AP583A (en) 1993-09-07 1997-04-14 Smithkline Beecham Corp Recombination IL4 antibodies useful in treatment of IL4 mediated disorders.
WO1995009917A1 (en) * 1993-10-07 1995-04-13 The Regents Of The University Of California Genetically engineered bispecific tetravalent antibodies
US5597710A (en) 1994-03-10 1997-01-28 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US5705154A (en) 1995-03-08 1998-01-06 Schering Corporation Humanized monoclonal antibodies against human interleukin-4
US6165463A (en) 1997-10-16 2000-12-26 Inhale Therapeutic Systems, Inc. Dispersible antibody compositions and methods for their preparation and use
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
AU2466895A (en) 1995-04-28 1996-11-18 Abgenix, Inc. Human antibodies derived from immunized xenomice
BR9606706A (pt) * 1995-10-16 1999-04-06 Unilever Nv Análogo de fragmento de anticorpo biespecífico ou bivalente uso processo para produzir o mesmo
US6664227B1 (en) 1996-03-01 2003-12-16 Genetics Institute, Llc Treatment of fibrosis by antagonism of IL-13 and IL-13 receptor chains
AU5711196A (en) 1996-03-14 1997-10-01 Human Genome Sciences, Inc. Apoptosis inducing molecule i
CA2249195A1 (en) 1996-03-18 1997-09-25 Board Of Regents, The University Of Texas System Immunoglobin-like domains with increased half lives
KR20030096450A (ko) 1996-03-22 2003-12-31 휴먼 게놈 사이언시즈, 인코포레이티드 고사 유도 분자 ⅱ
WO1997035991A1 (en) 1996-03-28 1997-10-02 The Johns Hopkins University Soluble divalent and multivalent heterodimeric analogs of proteins
US5916771A (en) 1996-10-11 1999-06-29 Abgenix, Inc. Production of a multimeric protein by cell fusion method
WO1998023289A1 (en) 1996-11-27 1998-06-04 The General Hospital Corporation MODULATION OF IgG BINDING TO FcRn
DE69738539T2 (de) 1996-12-03 2009-03-26 Amgen Fremont Inc. Vollkommen humane Antikörper die EGFR binden
GB9625899D0 (en) * 1996-12-13 1997-01-29 Glaxo Group Ltd Substances and their uses
US6277375B1 (en) 1997-03-03 2001-08-21 Board Of Regents, The University Of Texas System Immunoglobulin-like domains with increased half-lives
CN100387621C (zh) 1997-04-14 2008-05-14 麦可麦脱股份公司 抗人抗原受体的新的生产方法及其用途
US6235883B1 (en) 1997-05-05 2001-05-22 Abgenix, Inc. Human monoclonal antibodies to epidermal growth factor receptor
MXPA00004256A (es) 1997-11-03 2005-07-01 Human Genome Sciences Inc Inhibidor de las celulas endoteliales vasculares, un inhibidor de la angiogenesis y crecimiento del tumor.
US6994853B1 (en) 1998-09-25 2006-02-07 Trion Pharma Gmbh Time-staggered utilization of tumor cells in combination with intact antibodies for immunization
TR200603997T1 (tr) * 1999-03-25 2010-01-21 Abbott Gmbh & Co. Kg Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler.
CN100390288C (zh) 2000-04-11 2008-05-28 杰南技术公司 多价抗体及其应用
EP2298355A3 (en) 2000-04-12 2011-06-29 Human Genome Sciences, Inc. Albumin fusion proteins
AU2001264946A1 (en) * 2000-05-24 2001-12-03 Imclone Systems Incorporated Bispecific immunoglobulin-like antigen binding proteins and method of production
ATE545703T1 (de) * 2000-07-25 2012-03-15 Immunomedics Inc Multivalentes zielbindendes protein
US6333410B1 (en) 2000-08-18 2001-12-25 Immunogen, Inc. Process for the preparation and purification of thiol-containing maytansinoids
RU2295537C2 (ru) * 2000-10-20 2007-03-20 Тугаи Сейяку Кабусики Кайся Модифицированное агонистическое антитело
EP1578912A4 (en) 2001-10-26 2007-12-26 Centocor Inc IL-13 MUTEIN PROTEINS, ANTIBODIES, COMPOSITIONS, METHODS AND USES
US20040023338A1 (en) 2001-10-26 2004-02-05 Heavner George A. IL-4 mutein proteins, antibodies, compositions, methods and uses
US6811780B2 (en) 2002-05-01 2004-11-02 Regeneron Pharmaceuticals, Inc. Methods of using cytokine antagonists to treat HIV infection and AIDS
US20070104710A1 (en) * 2002-06-28 2007-05-10 Domants Limited Ligand that has binding specificity for IL-4 and/or IL-13
US20050003403A1 (en) 2003-04-22 2005-01-06 Rossi Edmund A. Polyvalent protein complex
GB0407315D0 (en) * 2003-07-15 2004-05-05 Cambridge Antibody Tech Human antibody molecules
US7638606B2 (en) * 2003-11-07 2009-12-29 Immunex Corporation Antibodies that bind interleukin-4 receptor
SG10201404273QA (en) * 2003-12-23 2014-10-30 Genentech Inc Novel anti-il 13 antibodies and uses thereof
US7652146B2 (en) 2004-02-06 2010-01-26 Bristol-Myers Squibb Company Process for preparing 2-aminothiazole-5-carboxamides useful as kinase inhibitors
PL1729795T3 (pl) 2004-02-09 2016-08-31 Human Genome Sciences Inc Białka fuzyjne albuminy
CN1922490B (zh) * 2004-02-19 2012-07-04 耶鲁大学 使用蛋白质组学技术鉴定癌症蛋白生物标志物的方法
AU2005219837A1 (en) 2004-02-27 2005-09-15 Regeneron Pharmaceuticals, Inc. IL-4/IL-13 sepecific polypetides and therapeutic uses thereof
GB0411186D0 (en) * 2004-05-19 2004-06-23 Celltech R&D Ltd Biological products
PT1765397E (pt) * 2004-05-25 2013-02-04 Tactic Pharma Llc Anticorpos inibidores que se ligam ao complexo ativador plasminogénico do tipo uroquinasa (upa) e seu receptor (upar)
AR049390A1 (es) * 2004-06-09 2006-07-26 Wyeth Corp Anticuerpos contra la interleuquina-13 humana y usos de los mismos
GB0414799D0 (en) * 2004-07-01 2004-08-04 Glaxo Group Ltd Immunoglobulins
US20060148009A1 (en) 2004-10-12 2006-07-06 Xencor, Inc. Prediction and assessment of immunogenicity
TW200902555A (en) * 2005-01-03 2009-01-16 Hoffmann La Roche Antibodies against IL-13 receptor alpha 1 and uses thereof
US20090041783A1 (en) * 2005-04-28 2009-02-12 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
GB0514319D0 (en) * 2005-07-13 2006-06-14 Secr Defence Antibodies for anthrax
US7612181B2 (en) * 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
BRPI0616359B8 (pt) 2005-09-30 2022-08-30 Medimmune Ltd Composição farmacêutica, processo para purificação de um anticorpo de il-13 e uso de uma composição farmacêutica contendo um anticorpo
NZ567124A (en) * 2005-10-21 2011-08-26 Novartis Ag Human antibodies against Interleukin-13 and therapeutic uses to treat asthma
GB0600488D0 (en) * 2006-01-11 2006-02-22 Glaxo Group Ltd Immunoglobulins
AU2007209202A1 (en) * 2006-01-24 2007-08-02 Domantis Limited Ligands that bind IL-4 and/or IL-13
CA2646626A1 (en) * 2006-03-22 2007-09-27 Apogenix Gmbh Antibody specific for human il-4 for the treatment of cancer
EP2050764A1 (en) 2007-10-15 2009-04-22 sanofi-aventis Novel polyvalent bispecific antibody format and uses thereof
TWI700093B (zh) * 2011-03-16 2020-08-01 法商賽諾菲公司 雙重ｖ區類抗體蛋白質之用途
TWI679019B (zh) * 2013-04-29 2019-12-11 法商賽諾菲公司 抗ｉｌ－４／抗ｉｌ－１３之雙特異性抗體調配物
TW201628647A (zh) * 2014-06-27 2016-08-16 賽諾菲公司 抗－ｉｌ４－ｉｌ１３雙特異性抗體

Also Published As

Publication number Publication date
LT2573119T (lt) 2018-04-10
EP2573116A1 (en) 2013-03-27
EP2574629A1 (en) 2013-04-03
AU2013202389B9 (en) 2017-02-02
LT2573121T (lt) 2017-12-11
EP2574630B1 (en) 2018-04-18
US11453727B2 (en) 2022-09-27
CA3015470C (en) 2022-01-18
MX363638B (es) 2019-03-28
US9732162B2 (en) 2017-08-15
KR20100067669A (ko) 2010-06-21
US20230235088A1 (en) 2023-07-27
US20130209469A1 (en) 2013-08-15
HN2010000710A (es) 2013-07-22
AU2013203324B2 (en) 2017-01-19
AR122833A2 (es) 2022-10-12
PE20091382A1 (es) 2009-10-14
RS56914B1 (sr) 2018-05-31
HUE038444T2 (hu) 2018-10-29
NZ601342A (en) 2014-02-28
MX363634B (es) 2019-03-28
KR20190022928A (ko) 2019-03-06
US20250313651A1 (en) 2025-10-09
AU2013203339A1 (en) 2013-05-02
DK2574629T3 (en) 2018-02-26
US20140023649A1 (en) 2014-01-23
AU2013203339B2 (en) 2017-01-05
US20180030156A1 (en) 2018-02-01
NO2574629T3 (es) 2018-04-21
EP2573121B1 (en) 2017-08-23
HRP20180517T1 (hr) 2018-05-04
HRP20140150T1 (hr) 2014-03-28
DOP2013000301A (es) 2014-02-16
KR20180014189A (ko) 2018-02-07
SI2574629T1 (en) 2018-03-30
HUE036530T2 (hu) 2018-07-30
CL2013002040A1 (es) 2014-01-24
KR101823859B1 (ko) 2018-02-01
ZA201002069B (en) 2010-12-29
JP6280526B2 (ja) 2018-02-14
HRP20181085T1 (hr) 2018-09-07
PL2573119T3 (pl) 2018-07-31
TR201802225T4 (tr) 2018-03-21
NI201000406A (es) 2010-09-07
DK2574630T3 (en) 2018-07-30
PL2573121T3 (pl) 2018-01-31
CA3071750C (en) 2022-06-14
US20130236461A1 (en) 2013-09-12
EP2573119A1 (en) 2013-03-27
RU2721236C2 (ru) 2020-05-18
IL249289A0 (en) 2017-01-31
UY31394A1 (es) 2009-05-29
MX363901B (es) 2019-04-08
UA104130C2 (uk) 2014-01-10
US20130236460A1 (en) 2013-09-12
JP2018078907A (ja) 2018-05-24
RU2015141428A (ru) 2017-04-04
TWI616205B (zh) 2018-03-01
CY1120887T1 (el) 2019-12-11
EP2574629B1 (en) 2017-11-22
GT201000067A (es) 2012-04-12
HRP20171765T1 (hr) 2017-12-29
JP2015231382A (ja) 2015-12-24
TWI616206B (zh) 2018-03-01
AR068861A1 (es) 2009-12-09
US20130251716A1 (en) 2013-09-26
TW200932263A (en) 2009-08-01
EP2573119B1 (en) 2018-01-03
AU2013202389B2 (en) 2017-01-05
TW201536322A (zh) 2015-10-01
RU2015141428A3 (es) 2019-04-30
TW201536321A (zh) 2015-10-01
PT2574629T (pt) 2018-02-23
EP2574626A1 (en) 2013-04-03
CA3071750A1 (en) 2009-04-23
CN106986938A (zh) 2017-07-28
CN113480647A (zh) 2021-10-08
US20130236463A1 (en) 2013-09-12
DOP2010000109A (es) 2010-05-31
KR101954596B1 (ko) 2019-03-07
IL205005A (en) 2016-11-30
KR20160142889A (ko) 2016-12-13
NI201000401A (es) 2010-09-07
TW201825117A (zh) 2018-07-16
EP2573115A1 (en) 2013-03-27
CA2702473A1 (en) 2009-04-23
EP2050764A1 (en) 2009-04-22
RS53175B (sr) 2014-06-30
HRP20180320T1 (hr) 2018-04-06
US20130251718A1 (en) 2013-09-26
UA118949C2 (uk) 2019-04-10
CL2012003196A1 (es) 2013-01-25
SI2573119T1 (en) 2018-05-31
DK2205640T3 (en) 2014-02-24
WO2009052081A4 (en) 2009-07-23
EP2574630A1 (en) 2013-04-03
EP2573118A1 (en) 2013-03-27
RU2010119521A (ru) 2011-11-27
SG10201913836SA (en) 2020-03-30
DK2573121T3 (en) 2017-12-04
SG10201913838RA (en) 2020-03-30
JP6126652B2 (ja) 2017-05-10
NZ729148A (en) 2021-12-24
AU2013203324A1 (en) 2013-05-02
MX354150B (es) 2018-02-15
AR122834A2 (es) 2022-10-12
US20130243777A1 (en) 2013-09-19
BRPI0818677A2 (pt) 2015-04-14
SI2574630T1 (en) 2018-08-31
US20130259866A1 (en) 2013-10-03
RS57060B1 (sr) 2018-05-31
CY1119875T1 (el) 2018-06-27
PT2573121T (pt) 2017-11-21
US20130236462A1 (en) 2013-09-12
PH12013501033B1 (en) 2018-12-14
JP2016006086A (ja) 2016-01-14
BRPI0818677B1 (pt) 2019-11-12
TN2010000126A1 (en) 2011-09-26
MX354666B (es) 2018-03-15
AU2013203328B2 (en) 2017-01-05
NI201000040A (es) 2010-09-07
NZ584658A (en) 2012-08-31
TWI619508B (zh) 2018-04-01
NI201000403A (es) 2010-09-07
EP2573121A1 (en) 2013-03-27
RS56553B1 (sr) 2018-02-28
RS57396B1 (sr) 2018-09-28
CL2013002039A1 (es) 2014-03-07
JP2011501671A (ja) 2011-01-13
CN113480647B (zh) 2025-03-28
RU2580049C2 (ru) 2016-04-10
CA2702473C (en) 2018-10-09
ES2660152T3 (es) 2018-03-21
US8388965B2 (en) 2013-03-05
CN101827863B (zh) 2017-03-22
JP2016006087A (ja) 2016-01-14
CR20150101A (es) 2015-04-14
US20210047437A1 (en) 2021-02-18
SI2573121T1 (en) 2018-01-31
LT2574629T (lt) 2018-03-12
CR20150654A (es) 2016-02-08
ES2447915T3 (es) 2014-03-13
SI2205640T1 (sl) 2014-04-30
MX2010003290A (es) 2010-04-30
DOP2013000302A (es) 2014-02-16
US10759871B2 (en) 2020-09-01
AU2013203339B9 (en) 2017-02-02
HUE037205T2 (hu) 2018-08-28
KR101681909B1 (ko) 2016-12-05
KR20140112574A (ko) 2014-09-23
US20130251717A1 (en) 2013-09-26
TR201810005T4 (tr) 2018-08-27
ES2664476T3 (es) 2018-04-19
CR20150103A (es) 2015-04-14
NI201000404A (es) 2010-09-07
RU2013120318A (ru) 2014-11-10
JP5858616B2 (ja) 2016-02-10
RU2015141418A (ru) 2017-04-04
NZ709353A (en) 2018-06-29
CA3015470A1 (en) 2009-04-23
CY1114987T1 (el) 2016-12-14
CR11337A (es) 2010-04-21
WO2009052081A3 (en) 2009-06-04
EP2205640A2 (en) 2010-07-14
IL205005A0 (en) 2010-11-30
PL2574630T3 (pl) 2018-09-28
PA8799001A1 (es) 2009-07-23
CN101827863A (zh) 2010-09-08
PT2205640E (pt) 2014-02-25
AU2008312655B2 (en) 2013-05-02
AU2013203328B9 (en) 2017-02-02
ES2679281T3 (es) 2018-08-23
AU2013203324C1 (en) 2017-03-30
PL2574629T3 (pl) 2018-05-30
KR101682373B1 (ko) 2016-12-06
WO2009052081A2 (en) 2009-04-23
NO2573121T3 (es) 2018-01-20
AU2013203328A1 (en) 2013-05-02
AU2013202389A1 (en) 2013-05-02
ES2647872T3 (es) 2017-12-27
SG10201602770UA (en) 2016-05-30
CN106986938B (zh) 2021-07-09
LT2574630T (lt) 2018-07-25
CR20150102A (es) 2015-04-30
NI201000405A (es) 2010-09-07
CY1120033T1 (el) 2018-12-12
RU2488595C2 (ru) 2013-07-27
US20130243776A1 (en) 2013-09-19
EP2205640B1 (en) 2013-11-20
RU2705551C2 (ru) 2019-11-07
DK2573119T3 (en) 2018-04-16
US9738728B2 (en) 2017-08-22
US20130243778A1 (en) 2013-09-19
CY1120108T1 (el) 2018-12-12
PT2574630T (pt) 2018-07-17
SG185303A1 (en) 2012-11-29
PH12013501032A1 (en) 2015-05-18
HUE038556T2 (hu) 2018-10-29
PH12013501032B1 (en) 2015-05-18
NI201000402A (es) 2010-09-07
PT2573119T (pt) 2018-04-04
EP3686220A1 (en) 2020-07-29
US20100226923A1 (en) 2010-09-09
BRPI0818677B8 (pt) 2021-05-25
AU2008312655A1 (en) 2009-04-23
MA31838B1 (fr) 2010-11-01
MY171214A (en) 2019-10-02
JP6126653B2 (ja) 2017-05-10
EP2573117A1 (en) 2013-03-27
PL2205640T3 (pl) 2014-05-30
PH12013501033A1 (en) 2015-05-25
RU2015141418A3 (es) 2019-05-14

Similar Documents

Publication Publication Date Title
CL2008003037A1 (es) Anticuerpo que se une especificamente a il-4; moleculas de acido nucleico, celulas huesped; composicion farmaceutica que comprende dicho anticuerpo; uso del anticuerpo para tratar cancer, entre otras enfermedades.
AR066198A1 (es) Anticuerpos anti ige apoptoticos
BR112015006060A2 (pt) agentes de ligação kir3dl2
BR112012001984B8 (pt) anticorpos humanos com alta afinidade para angiopoietina-2 humana, uso dos mesmos e composição farmacêutica
CO6460768A2 (es) Anticuerpos específicos para dkk-1 y sus usos
CL2008000935A1 (es) Anticuerpo monoclonal humano anti-ige o fragmento del mismo; acido nucleico que lo codifica; vector y celula huesped; metodo de preparacion; composicion farmaceutica que lo comprende; y su uso en el tratamiento de trastornos relacionados con ige.
BR112013025304A2 (pt) moléculas de ligação biespecíficas que ligam a vegf e ang2
BR112013021134A8 (pt) Anticorpo isolado que se liga especificamente a ptk7 humano, seu uso, composição farmacêutica que o compreende, e ácido nucleico
BR112021023048A2 (pt) Moléculas de ligação a cd19 e usos das mesmas
BR112014010383A2 (pt) proteína de ligação a antígeno e uso do mesmo como produto direcionado a alvo para o tratamento de câncer
BR112014028785A2 (pt) proteínas de ligação a antígeno de st2
CL2007003807A1 (es) Anticuerpos humanos anti-cd44 o fragmentos de los mismos; acidos nucleicos que los codifican; vector y celula huesped que los comprende; composicion farmaceutica que comprende a los anticuerpos; y su uso para tratar los sintomas de trastornos mediado
BR112015014751A2 (pt) anticorpos anti-tau humanos
BR112012024710A8 (pt) moléculas que se ligam ao antígeno, seus processos de produção, bem como composição farmacêutica que as compreendem
ECSP14001260A (es) Inmunoligantes biespecificos dirigidos contra tnf e il-17 referencia cruzada a solicitudes relacionadas
BR112015018203A2 (pt) Anti-corpos biespecíficos anti-tnf-anti-il-17
CL2013001468A1 (es) Anticuerpo humano aislado que se une especificamente al receptor de glucagon humano o fragmento de union a antigeno del mismo; molecula de acido nucleico que lo codifica; vector de expresion; metodo de produccion; composicion farmaceutica que lo comprende; y su uso para tratar una enfermedad o afeccion asociada con altos niveles de glucosa o cetona en sangre.
BR112014023415A2 (pt) moléculas que se ligam a ang2
CL2013002811A1 (es) Anticuerpo monoclonal aislado que se une a un epitopo del inhibidor de la ruta del factor tisular humano; molecula de acido nucleico que lo codifica; composicion farmaceutica que lo comprende; y su uso para tratar deficiencias o defectos geneticos o adquiridos en la coagulacion.
UY30927A1 (es) Miembros de union para moleculas ige
CL2012001143A1 (es) Anticuerpo anti-fractalkina (anti-fkn); composicion farmaceutica que comprende dicho anticuerpo anti-fkn; acido nucleico; vector; celula huesped; uso del anticuerpo anti-fkn para tratar trastornos inflamatorios.
BR112013025294A2 (pt) moléculas de ligação biespecífica ligando a dll4 e ang2
BR112015029300A2 (pt) Anticorpo biespecífico, composição farmacêutica compreendendo o mesmo, seus usos, usos de um anticorpo anti-ccl2, e um anticorpo anti-loxl2, ou seus fragmentos e kit
EA201591898A1 (ru) Антитела, направленные на m-csf
TH159436A (th) แอนติบอดี้ชนิดต้าน egfr และการใช้ประโยชน์ของมัน