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CL2008001674A1 - Dominio variable simple (dab) de inmunoglobulina anti-fator de crecimiento endotlial vascular (vegf); acido nucleoico que lo codifica; vector y celula huesped; metodo de produccion; antagonosta de vegf que comprende el dab; composiicon que comprende al antagonista; y uso del antagonista para prepara un medicamento. - Google Patents

Dominio variable simple (dab) de inmunoglobulina anti-fator de crecimiento endotlial vascular (vegf); acido nucleoico que lo codifica; vector y celula huesped; metodo de produccion; antagonosta de vegf que comprende el dab; composiicon que comprende al antagonista; y uso del antagonista para prepara un medicamento.

Info

Publication number
CL2008001674A1
CL2008001674A1 CL2008001674A CL2008001674A CL2008001674A1 CL 2008001674 A1 CL2008001674 A1 CL 2008001674A1 CL 2008001674 A CL2008001674 A CL 2008001674A CL 2008001674 A CL2008001674 A CL 2008001674A CL 2008001674 A1 CL2008001674 A1 CL 2008001674A1
Authority
CL
Chile
Prior art keywords
antagonist
vegf
dab
vector
host cell
Prior art date
Application number
CL2008001674A
Other languages
English (en)
Inventor
Malgorzata Pupecka
Ian Tomlinson
Carolyn Enever
Michael Steward
Thil Dinuk Batuwangala
Original Assignee
Domantis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0724331.4A external-priority patent/GB0724331D0/en
Application filed by Domantis Ltd filed Critical Domantis Ltd
Publication of CL2008001674A1 publication Critical patent/CL2008001674A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K2039/541—Mucosal route
    • A61K2039/544—Mucosal route to the airways
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Organic Chemistry (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Otolaryngology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Diabetes (AREA)
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Abstract

Dominio variable simple de la inmunoglobulina anti-factor de crecimiento endotelial vascular (vegf); ácido nucleico que lo codifica; vector y célula huésped; método de producción; antagonista de vegf que lo comprende; composición que comprende al antagonista; y uso del antagonista para tratar cáncer.
CL2008001674A 2007-06-06 2008-06-06 Dominio variable simple (dab) de inmunoglobulina anti-fator de crecimiento endotlial vascular (vegf); acido nucleoico que lo codifica; vector y celula huesped; metodo de produccion; antagonosta de vegf que comprende el dab; composiicon que comprende al antagonista; y uso del antagonista para prepara un medicamento. CL2008001674A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93363207P 2007-06-06 2007-06-06
GBGB0724331.4A GB0724331D0 (en) 2007-12-13 2007-12-13 Compositions for pulmonary delivery

Publications (1)

Publication Number Publication Date
CL2008001674A1 true CL2008001674A1 (es) 2008-11-21

Family

ID=39791116

Family Applications (3)

Application Number Title Priority Date Filing Date
CL2008001673A CL2008001673A1 (es) 2007-06-06 2008-06-06 Dominio variable simple de la inmunoglobulina del receptor tipo 1 de la anti-interleucina 1 (il-1r1); acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; antagonista de il-1r1 que lo comprende; composicion que comprende al antagonista; y uso del antagonista para tratar una condicion inflamatoria.
CL2008001676A CL2008001676A1 (es) 2007-06-06 2008-06-06 Dominio variable simple (dab) de inmunoglobulina anti-receptor 1 del factor de necrosis tumoral (tnfr1; p55) acido nucl eoico que lo codifica; vector y celula huesped; metodo de produccion; antagonista de tnrf que comprende el dab; composicion que comprende al antagonista; y uso del antagonista para preparar medicamento.
CL2008001674A CL2008001674A1 (es) 2007-06-06 2008-06-06 Dominio variable simple (dab) de inmunoglobulina anti-fator de crecimiento endotlial vascular (vegf); acido nucleoico que lo codifica; vector y celula huesped; metodo de produccion; antagonosta de vegf que comprende el dab; composiicon que comprende al antagonista; y uso del antagonista para prepara un medicamento.

Family Applications Before (2)

Application Number Title Priority Date Filing Date
CL2008001673A CL2008001673A1 (es) 2007-06-06 2008-06-06 Dominio variable simple de la inmunoglobulina del receptor tipo 1 de la anti-interleucina 1 (il-1r1); acido nucleico que lo codifica; vector y celula huesped; metodo de produccion; antagonista de il-1r1 que lo comprende; composicion que comprende al antagonista; y uso del antagonista para tratar una condicion inflamatoria.
CL2008001676A CL2008001676A1 (es) 2007-06-06 2008-06-06 Dominio variable simple (dab) de inmunoglobulina anti-receptor 1 del factor de necrosis tumoral (tnfr1; p55) acido nucl eoico que lo codifica; vector y celula huesped; metodo de produccion; antagonista de tnrf que comprende el dab; composicion que comprende al antagonista; y uso del antagonista para preparar medicamento.

Country Status (31)

Country Link
US (5) US8398979B2 (es)
EP (5) EP2162468A2 (es)
JP (3) JP5325211B2 (es)
KR (4) KR20100018040A (es)
CN (4) CN101802004A (es)
AR (3) AR066847A1 (es)
AU (4) AU2008259590A1 (es)
BR (3) BRPI0813899A2 (es)
CA (6) CA2688434A1 (es)
CL (3) CL2008001673A1 (es)
CO (2) CO6251322A2 (es)
CR (2) CR11194A (es)
CY (1) CY1116762T1 (es)
DK (1) DK2162467T3 (es)
DO (1) DOP2009000268A (es)
EA (5) EA200901494A1 (es)
ES (1) ES2546943T3 (es)
HR (1) HRP20151024T1 (es)
HU (1) HUE025899T2 (es)
IL (2) IL201398A0 (es)
MA (2) MA31403B1 (es)
MX (4) MX2009013137A (es)
NZ (1) NZ581372A (es)
PE (3) PE20090322A1 (es)
PL (1) PL2162467T3 (es)
PT (1) PT2162467E (es)
SG (2) SG182151A1 (es)
SI (1) SI2162467T1 (es)
TW (6) TW200911834A (es)
WO (3) WO2008149148A2 (es)
ZA (1) ZA200908470B (es)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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JP2005289809A (ja) 2001-10-24 2005-10-20 Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) 突然変異重鎖抗体
SI1888640T1 (sl) 2005-05-18 2012-07-31 Ablynx Nv Izboljšana nanotelesa proti faktorju nekroze tumorja alfa
DE102005023617A1 (de) 2005-05-21 2006-11-23 Aspre Ag Verfahren zum Mischen von Farben in einem Display
WO2009074634A2 (en) * 2007-12-13 2009-06-18 Glaxo Group Limited Compositions for pulmonary delivery
MX2009013137A (es) 2007-06-06 2010-04-30 Domantis Ltd Metodos para seleccionar polipeptidos resistentes a la proteasa.
MX2009012968A (es) * 2007-06-06 2010-04-01 Domantis Ltd Polipeptidos, dominios variables de anticuerpo y antagonistas.
GB0724331D0 (en) 2007-12-13 2008-01-23 Domantis Ltd Compositions for pulmonary delivery
EP2268668A1 (en) 2008-04-17 2011-01-05 Ablynx N.V. Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same
CA3020290A1 (en) 2008-06-25 2009-12-30 Esbatech, An Alcon Biomedical Research Unit Llc Stable and soluble antibodies inhibiting vegf
US8268314B2 (en) 2008-10-08 2012-09-18 Hoffmann-La Roche Inc. Bispecific anti-VEGF/anti-ANG-2 antibodies
EP2356147A1 (en) * 2008-11-26 2011-08-17 Glaxo Group Limited Polypeptides, antibody variable domains&antagonists
WO2010081787A1 (en) 2009-01-14 2010-07-22 Domantis Limited IMPROVED TNFα ANTAGONISM, PROPHYLAXIS & THERAPY WITH REDUCED ORGAN NECROSIS
EP2398827A2 (en) 2009-02-19 2011-12-28 Glaxo Group Limited Improved anti-tnfr1 polypeptides, antibody variable domains&antagonists
MX2011008749A (es) * 2009-02-19 2011-09-06 Glaxo Group Ltd Variantes de union a anti-albumina de suero mejoradas.
BRPI1008705B1 (pt) 2009-02-19 2021-05-25 Glaxo Group Limited Domínio variável único da imunoglobulina anti-soro albumina, ligante multiespecífico compreendendo o dito domínio, proteína de fusão fundida ao dito domínio, composição, ácido nucleico e vetor compreendendo o dito ácido nucleico
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