CL2008000119A1 - Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. - Google Patents
Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia.Info
- Publication number
- CL2008000119A1 CL2008000119A1 CL200800119A CL2008000119A CL2008000119A1 CL 2008000119 A1 CL2008000119 A1 CL 2008000119A1 CL 200800119 A CL200800119 A CL 200800119A CL 2008000119 A CL2008000119 A CL 2008000119A CL 2008000119 A1 CL2008000119 A1 CL 2008000119A1
- Authority
- CL
- Chile
- Prior art keywords
- acetilcoline
- pirazol
- schizophrenia
- nicotinic
- alzheimer
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 206010039966 Senile dementia Diseases 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 201000000980 schizophrenia Diseases 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/38—Nitrogen atoms
- C07D231/40—Acylated on said nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Gynecology & Obstetrics (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88062907P | 2007-01-16 | 2007-01-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008000119A1 true CL2008000119A1 (es) | 2008-05-16 |
Family
ID=39345157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200800119A CL2008000119A1 (es) | 2007-01-16 | 2008-01-15 | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8163729B2 (es) |
| EP (1) | EP2118067B1 (es) |
| JP (1) | JP2010515770A (es) |
| KR (1) | KR20090116707A (es) |
| CN (1) | CN101679287B (es) |
| AR (1) | AR064921A1 (es) |
| AU (1) | AU2008206759B2 (es) |
| BR (1) | BRPI0806665A2 (es) |
| CA (1) | CA2675676A1 (es) |
| CL (1) | CL2008000119A1 (es) |
| CO (1) | CO6351782A2 (es) |
| CR (1) | CR10930A (es) |
| EA (1) | EA016948B1 (es) |
| EC (1) | ECSP099490A (es) |
| IL (1) | IL199889A0 (es) |
| MX (1) | MX2009007615A (es) |
| NZ (1) | NZ578411A (es) |
| PA (1) | PA8766201A1 (es) |
| SA (1) | SA08290018B1 (es) |
| SV (1) | SV2009003334A (es) |
| TW (1) | TW200901974A (es) |
| UA (1) | UA98317C2 (es) |
| WO (1) | WO2008087529A1 (es) |
| ZA (1) | ZA200904943B (es) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113925606A (zh) * | 2021-10-25 | 2022-01-14 | 四川大学华西医院 | 一种神经调控导航定位方法、装置和神经调控治疗系统 |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
| US20090181952A1 (en) * | 2008-01-14 | 2009-07-16 | Wyeth | Compounds useful as alpha7 nicotinic acetylcholine receptor agonists |
| WO2009091832A1 (en) * | 2008-01-14 | 2009-07-23 | Wyeth | Synthesis of pyrazoles |
| US20090181953A1 (en) * | 2008-01-14 | 2009-07-16 | Wyeth | Compound forms and uses thereof |
| TW201004941A (en) * | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| JP5731385B2 (ja) | 2008-08-22 | 2015-06-10 | バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ | ポリマーベンジルカルボネート誘導体 |
| US8865719B2 (en) * | 2009-03-09 | 2014-10-21 | The Regents Of The University Of California | Substituted heterocycles and their use as allosteric modulators of nicotinic and GABAA receptors |
| EP2456438A2 (en) * | 2009-07-23 | 2012-05-30 | Novartis AG | Use of azabicycloalkyl derivatives or pyrrolidine-2-one derivatives |
| JO3250B1 (ar) | 2009-09-22 | 2018-09-16 | Novartis Ag | إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7 |
| MX343905B (es) * | 2010-11-03 | 2016-11-28 | Dow Agrosciences Llc | Composiciones pesticidas y procesos relacionados a las mismas. |
| WO2012068553A2 (en) * | 2010-11-18 | 2012-05-24 | Dignity Health | Methods of diagnosing and treating neurodegenerative diseases |
| US20150259344A1 (en) * | 2012-10-02 | 2015-09-17 | Dainippon Sumitomo Pharma Co., Ltd. | Imidazole derivative |
| CN105254564A (zh) * | 2015-10-31 | 2016-01-20 | 丁玉琴 | 一种2-甲基-3,4-二硝基-5-(甲氧苯基)吡唑的合成方法 |
| CN105646358B (zh) * | 2016-03-01 | 2018-03-09 | 苏州艾缇克药物化学有限公司 | 一种3‑氨基‑5‑(4‑甲氧苯基)吡唑的合成方法 |
| CN112480005B (zh) * | 2017-11-08 | 2022-08-19 | 北京嘉林药业股份有限公司 | 化合物及其治疗癌症的用途 |
| TWI805699B (zh) | 2018-03-01 | 2023-06-21 | 日商日本煙草產業股份有限公司 | 甲基內醯胺環化合物及其用途 |
| CN111902408B (zh) | 2018-04-04 | 2023-11-14 | 日本烟草产业株式会社 | 杂芳基取代的吡唑化合物及其药物用途 |
| GB202006382D0 (en) | 2020-04-30 | 2020-06-17 | Spermatech As | Use |
| WO2023135978A1 (ja) * | 2022-01-14 | 2023-07-20 | 学校法人慈恵大学 | 新型コロナウイルス感染症後遺症の治療薬 |
Family Cites Families (100)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU167263B (es) * | 1973-02-12 | 1975-09-27 | ||
| DE2527677A1 (de) * | 1975-06-21 | 1977-01-20 | Bayer Ag | Verfahren zur herstellung von 2,4- dioxo-1,2,3,4-tetrahydro-s-triazino- eckige klammer auf 1,2-a eckige klammer zu -benzimidazolen |
| US4624954A (en) | 1985-12-20 | 1986-11-25 | American Home Products Corporation | 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments |
| US4665183A (en) * | 1985-12-20 | 1987-05-12 | American Home Products Corp. | Process for preparing 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof useful for the treatment of cognitive impairments |
| US5219857A (en) * | 1986-10-16 | 1993-06-15 | American Cyanamid Company | Method of treating cognitive and related neural behavioral problems |
| US4904658A (en) | 1988-04-15 | 1990-02-27 | American Cyanamid Company | Substituted-6H,8H-pyrimido-[1,2,3-cd]purine-8,10-(9H)-diones and substituted-6H,10H-pyrimido[1,2-cd]purin-10-ones |
| US5260331A (en) | 1989-01-02 | 1993-11-09 | John Wyeth & Brother Limited | Composition for treating depression with (S- or O-heteroaryl)alkyl amines |
| US5422355A (en) | 1989-06-02 | 1995-06-06 | John Wyeth & Brother, Limited | Composition for treating depression with (N-heteroaryl)alkylamines |
| FR2655988B1 (fr) | 1989-12-20 | 1994-05-20 | Adir Cie | Nouveaux derives de la napht-1-yl piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| IE911774A1 (en) | 1990-06-11 | 1991-12-18 | Akzo Nv | Pyridinylpiperazine derivatives |
| AU645681B2 (en) * | 1991-05-02 | 1994-01-20 | John Wyeth & Brother Limited | Piperazine derivatives |
| GB9125615D0 (en) * | 1991-12-02 | 1992-01-29 | Wyeth John & Brother Ltd | Amines |
| WO1993013083A1 (en) | 1991-12-31 | 1993-07-08 | Fujisawa Pharmaceutical Co., Ltd. | Oxadiazole derivatives having acetylcholinesterase-inhibitory and muscarinic agonist activity |
| JPH0616638A (ja) | 1992-03-30 | 1994-01-25 | Yoshitomi Pharmaceut Ind Ltd | ピリジン化合物およびその医薬用途 |
| EP0651746B1 (en) | 1992-07-24 | 2002-03-27 | The Regents of the University of California | Drugs that enhance synaptic responses mediated by ampa receptors |
| CA2150016C (en) | 1992-12-17 | 2000-02-08 | Yuhpyng L. Chen | Pyrrolopyrimidines as crf antagonists |
| JP2862374B2 (ja) | 1992-12-17 | 1999-03-03 | フアイザー・インコーポレイテツド | Ｃｒｆアンタゴニスト活性を有するピラゾール及びピラゾロピリミジン |
| TW336932B (en) | 1992-12-17 | 1998-07-21 | Pfizer | Amino-substituted pyrazoles |
| DE69327254T2 (de) | 1992-12-17 | 2000-03-30 | Pfizer, Inc. | Substituierte pyrazole als crf antagonisten |
| TW370529B (en) | 1992-12-17 | 1999-09-21 | Pfizer | Pyrazolopyrimidines |
| GB9302622D0 (en) | 1993-02-10 | 1993-03-24 | Wellcome Found | Heteroaromatic compounds |
| KR100327270B1 (ko) | 1994-01-14 | 2002-08-01 | 닛뽕쇼지가부시끼가이샤 | 디아자시클로알킨알킬술폰아미드유도체 |
| JP3319651B2 (ja) * | 1994-04-26 | 2002-09-03 | 富士写真フイルム株式会社 | 感光性転写シート |
| US5650409A (en) | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| GB9514901D0 (en) | 1995-07-20 | 1995-09-20 | American Home Prod | Piperazine derivatives |
| US6288091B1 (en) * | 1995-12-29 | 2001-09-11 | Boehringer Ingelheim Ltd. | Antiherpes virus compounds and methods for their preparation and use |
| SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Astra Ab | Azabicyclic esters of carbamic acids useful in therapy |
| US5736543A (en) | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| NZ332477A (en) | 1996-05-11 | 2000-07-28 | Smithkline Beecham Plc | Tetrahydroisoquinoline derivatives as modulators of dopamine D3 receptors |
| GB9708694D0 (en) | 1997-04-30 | 1997-06-18 | Smithkline Beecham Plc | Compounds |
| GB9708805D0 (en) | 1997-05-01 | 1997-06-25 | Smithkline Beecham Plc | Compounds |
| US6329368B1 (en) * | 1997-05-09 | 2001-12-11 | The Regents Of The University Of California | Endocrine modulation with positive modulators of AMPA type glutamate receptors |
| KR100247563B1 (ko) | 1997-07-16 | 2000-04-01 | 박영구 | 키랄3,4-에폭시부티르산및이의염의제조방법 |
| NZ502252A (en) * | 1997-07-25 | 2001-09-28 | H | Indole and 2,3-dihydroindole derivatives useful for inhibiting serotonin reuptake and antagonism of 5-HT1a receptors |
| US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| RU2214405C2 (ru) | 1998-02-18 | 2003-10-20 | НьюроСёрч А/С | Новые соединения и их применение в качестве положительных модуляторов амра-рецепторов |
| BR9909277A (pt) | 1998-03-31 | 2001-10-16 | Acadia Pharm Inc | Compostos com atividade em receptores muscarìnicos |
| US6124278A (en) | 1998-04-03 | 2000-09-26 | The Regents Of The University Of California | Acylbenzoxazines for enhancing synaptic response |
| EP1083889B1 (en) | 1998-06-01 | 2003-12-10 | Ortho-McNeil Pharmaceutical, Inc. | Tetrahydronaphtalene compounds and their use for the treatment of neurodegenerative diseases |
| US6605623B1 (en) | 1998-12-18 | 2003-08-12 | Bristol-Myers Squibb Pharma Co. | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
| US6313126B1 (en) * | 1999-01-07 | 2001-11-06 | American Home Products Corp | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression |
| SE9900100D0 (sv) | 1999-01-15 | 1999-01-15 | Astra Ab | New compounds |
| KR20010101675A (ko) | 1999-01-26 | 2001-11-14 | 우에노 도시오 | 2ｈ-프탈라진-1-온 유도체 및 그 유도체를 유효 성분으로하는 약제 |
| US20010044445A1 (en) * | 1999-04-08 | 2001-11-22 | Bamaung Nwe Y. | Azole inhibitors of cytokine production |
| US6387900B1 (en) | 1999-08-12 | 2002-05-14 | Pharmacia & Upjohn S.P.A. | 3(5)-ureido-pyrazole derivatives process for their preparation and their use as antitumor agents |
| AU1161601A (en) | 1999-11-05 | 2001-05-14 | University College London | Activators of soluble guanylate cyclase |
| SE9904176D0 (sv) | 1999-11-18 | 1999-11-18 | Astra Ab | New use |
| CA2398754A1 (en) * | 2000-02-07 | 2001-08-09 | Abbott Gmbh & Co. Kg | 2-benzothiazolyl urea derivatives and their use as protein kinase inhibitors |
| ATE361297T1 (de) | 2000-03-31 | 2007-05-15 | Ortho Mcneil Pharm Inc | Phenyl-substituierte imidazopyridine |
| EP1268421B1 (en) | 2000-03-31 | 2009-05-06 | Ortho-McNeil Pharmaceutical, Inc. | Phenyl-substituted indoles as histamine h3-receptor antagonists |
| SK13942002A3 (sk) | 2000-04-10 | 2004-03-02 | Pfizer Products Inc. | Benzoamidové piperidínové zlúčeniny a príbuzné zlúčeniny |
| US6448276B1 (en) * | 2000-05-17 | 2002-09-10 | Inspire Pharmaceuticals, Inc. | Method for treating vaginal dryness with nicotinic acetylcholine receptor agonists |
| JP2004516237A (ja) | 2000-06-21 | 2004-06-03 | ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー | ケモカイン受容体活性調節剤としてのピペリジンアミド類 |
| JP2002030073A (ja) | 2000-07-19 | 2002-01-29 | Ono Pharmaceut Co Ltd | ４−（３−（４−モルホリノブチリルアミノ）フェニル）−２ｈ−フタラジン−１−オン・メタンスルホン酸塩・１水和物およびその製造方法。 |
| US7211594B2 (en) * | 2000-07-31 | 2007-05-01 | Signal Pharmaceuticals, Llc | Indazole compounds and compositions thereof as JNK inhibitors and for the treatment of diseases associated therewith |
| US20020173507A1 (en) | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
| IL145209A0 (en) * | 2000-09-06 | 2002-06-30 | Pfizer Prod Inc | Pharmaceutical combinations for the treatment of stroke and traumatic brain injury |
| AU2001287898A1 (en) | 2000-09-22 | 2002-04-02 | Stephen Garland | Pyrazolopyridines and pyrazolopyridazines as antidiabetics |
| US6469007B2 (en) | 2000-11-28 | 2002-10-22 | Wyeth | Serotonergic agents |
| HUP0303857A3 (en) * | 2000-12-13 | 2007-07-30 | Wyeth Corp | Heterocyclic sulifonamide inhibitors of beta amyloid production |
| UA73619C2 (en) * | 2000-12-13 | 2005-08-15 | Pfizer Prod Inc | Stable pharmaceutical compositions of nmda receptor agonist (variants) and method of treatment |
| MXPA03006843A (es) | 2001-02-16 | 2003-11-13 | Aventis Pharma Inc | Derivados heterociclicos novedosos de ureas y su uso como ligandos para receptor d3 de dopamina. |
| EP1362039B1 (en) | 2001-02-16 | 2005-12-21 | Aventis Pharmaceuticals Inc. | Heterocyclic substituted carbonyl derivatives and their use as dopamine d3 receptor ligands |
| HUP0103986A2 (hu) | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| HUP0103987A3 (en) | 2001-09-28 | 2004-11-29 | Richter Gedeon Vegyeszet | Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates |
| KR100579813B1 (ko) | 2001-10-16 | 2006-05-12 | 주식회사 에스티씨나라 | 피페리딘 유도체, 이의 제조방법 및 이를 포함하는 치매치료용 약학적 조성물 |
| US7402580B2 (en) | 2002-02-19 | 2008-07-22 | Ono Pharmaceutical Co., Ltd. | Fused pyridazine derivative compounds and drugs containing these compounds as the active ingredient |
| DE10211415A1 (de) | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
| UA78999C2 (en) * | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| UA77814C2 (en) | 2002-07-03 | 2007-01-15 | Lundbeck & Co As H | Spirocyclic piperidines as antagonists of mch1 and use thereof |
| WO2004007459A2 (en) * | 2002-07-12 | 2004-01-22 | Janssen Pharmaceutica N.V. | Naphthol, quinoline and isoquinoline-derivatives as modulators of vanilloid vr1 receptor |
| GB0216233D0 (en) | 2002-07-12 | 2002-08-21 | Glaxo Group Ltd | Compounds |
| TW200401641A (en) * | 2002-07-18 | 2004-02-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylindole or-indazole derivatives as 5-hydroxytryptamine-6 ligands |
| AU2003253686A1 (en) | 2002-08-01 | 2004-02-23 | Pharmacia & Upjohn Company Llc | 1h-pyrazole and 1h-pyrrole-azabicyclic compounds with alfa-7 nachr activity |
| WO2004039366A1 (en) | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Nicotinic acetylcholine agonists in the treatment of glaucoma and retinal neuropathy |
| US7186832B2 (en) * | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| US7157460B2 (en) * | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
| TWI334868B (en) * | 2003-06-03 | 2010-12-21 | Nippon Kayaku Kk | [1,2,4] triazoro [1,5-a] pyrimidine-2-ylurea derivative and use thereof |
| DK1648904T3 (da) * | 2003-07-31 | 2007-10-22 | Wyeth Corp | N-sulfonylheterocyclopyrrolalkylaminforbindelser som 5-hydroxytryptamin-6-ligander |
| US7572914B2 (en) | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US7674899B2 (en) | 2004-02-04 | 2010-03-09 | Neurosearch A/S | Dimeric azacyclic compounds and their use |
| EP1720548A1 (en) * | 2004-03-02 | 2006-11-15 | Wyeth | Non-immunosuppressive immunophilin ligands as neuroprotective and/or neuroregenerative agents |
| KR20070009578A (ko) * | 2004-03-02 | 2007-01-18 | 와이어쓰 | 마크롤라이드 및 이의 제조 방법 |
| EP1758907B1 (en) | 2004-06-16 | 2009-02-18 | Wyeth | Diphenylimidazopyrimidine and -imidazole amines as inhibitors of b-secretase |
| NZ552031A (en) | 2004-06-16 | 2009-06-26 | Wyeth Corp | Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase |
| RU2403247C2 (ru) * | 2004-07-20 | 2010-11-10 | СЬЕНА БИОТЕК С.п.А. | Модуляторы никотиновых ацетилхолиновых рецепторов альфа 7 и их терапевтические применения |
| CA2576971A1 (en) | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| EP1845973B1 (en) | 2005-01-21 | 2015-08-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
| US7776847B2 (en) | 2005-02-25 | 2010-08-17 | Rigel Pharmaceuticals, Inc. | Benzisothiazoles useful for treating or preventing HCV infection |
| WO2007057750A2 (en) * | 2005-11-15 | 2007-05-24 | Inverness Medical Switzerland Gmbh | Assays |
| BRPI0706610A2 (pt) | 2006-01-18 | 2011-04-05 | Siena Biotech Spa | moduladores de receptores alfa 7 nicotìnico acetilcolina e usos terapêuticos destes |
| TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
| GB0723815D0 (en) | 2007-12-05 | 2008-01-16 | Glaxo Group Ltd | Compounds |
| US20090181952A1 (en) | 2008-01-14 | 2009-07-16 | Wyeth | Compounds useful as alpha7 nicotinic acetylcholine receptor agonists |
| US20090181953A1 (en) * | 2008-01-14 | 2009-07-16 | Wyeth | Compound forms and uses thereof |
| WO2009091832A1 (en) | 2008-01-14 | 2009-07-23 | Wyeth | Synthesis of pyrazoles |
| US20100016598A1 (en) * | 2008-07-16 | 2010-01-21 | Wyeth | Alpha7 nicotinic acetylcholine receptor inhibitors |
| US20100016360A1 (en) * | 2008-07-16 | 2010-01-21 | Wyeth | Alpha7 nicotinic acetylcholine receptor inhibitors |
| TW201004941A (en) | 2008-07-16 | 2010-02-01 | Wyeth Corp | Alpha7 nicotinic acetylcholine receptor inhibitors |
| US20100016343A1 (en) * | 2008-07-16 | 2010-01-21 | Wyeth | Alpha7 nicotinic acetylcholine receptor inhibitors |
-
2008
- 2008-01-15 TW TW097101453A patent/TW200901974A/zh unknown
- 2008-01-15 CL CL200800119A patent/CL2008000119A1/es unknown
- 2008-01-16 KR KR1020097014828A patent/KR20090116707A/ko not_active Ceased
- 2008-01-16 PA PA20088766201A patent/PA8766201A1/es unknown
- 2008-01-16 EA EA200900831A patent/EA016948B1/ru not_active IP Right Cessation
- 2008-01-16 US US12/523,189 patent/US8163729B2/en not_active Expired - Fee Related
- 2008-01-16 BR BRPI0806665-5A patent/BRPI0806665A2/pt not_active IP Right Cessation
- 2008-01-16 JP JP2009546013A patent/JP2010515770A/ja active Pending
- 2008-01-16 EP EP08702252.1A patent/EP2118067B1/en active Active
- 2008-01-16 MX MX2009007615A patent/MX2009007615A/es active IP Right Grant
- 2008-01-16 AR ARP080100189A patent/AR064921A1/es not_active Application Discontinuation
- 2008-01-16 UA UAA200907422A patent/UA98317C2/ru unknown
- 2008-01-16 SA SA08290018A patent/SA08290018B1/ar unknown
- 2008-01-16 CN CN200880008464XA patent/CN101679287B/zh not_active Expired - Fee Related
- 2008-01-16 NZ NZ578411A patent/NZ578411A/en not_active IP Right Cessation
- 2008-01-16 CA CA002675676A patent/CA2675676A1/en not_active Abandoned
- 2008-01-16 AU AU2008206759A patent/AU2008206759B2/en not_active Ceased
- 2008-01-16 WO PCT/IB2008/000090 patent/WO2008087529A1/en not_active Ceased
- 2008-01-16 ZA ZA200904943A patent/ZA200904943B/xx unknown
-
2009
- 2009-07-03 EC EC2009009490A patent/ECSP099490A/es unknown
- 2009-07-08 CO CO09070527A patent/CO6351782A2/es not_active Application Discontinuation
- 2009-07-15 CR CR10930A patent/CR10930A/es unknown
- 2009-07-15 SV SV2009003334A patent/SV2009003334A/es unknown
- 2009-07-16 IL IL199889A patent/IL199889A0/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113925606A (zh) * | 2021-10-25 | 2022-01-14 | 四川大学华西医院 | 一种神经调控导航定位方法、装置和神经调控治疗系统 |
| CN113925606B (zh) * | 2021-10-25 | 2023-07-07 | 四川大学华西医院 | 一种神经调控导航定位方法、装置和神经调控治疗系统 |
Also Published As
| Publication number | Publication date |
|---|---|
| SA08290018B1 (ar) | 2013-01-17 |
| HK1142335A1 (en) | 2010-12-03 |
| CN101679287A (zh) | 2010-03-24 |
| CR10930A (es) | 2013-02-12 |
| ECSP099490A (es) | 2009-09-29 |
| AU2008206759B2 (en) | 2013-09-05 |
| EP2118067B1 (en) | 2013-05-08 |
| AU2008206759A1 (en) | 2008-07-24 |
| CO6351782A2 (es) | 2011-12-20 |
| CA2675676A1 (en) | 2008-07-24 |
| BRPI0806665A2 (pt) | 2011-09-06 |
| EA200900831A1 (ru) | 2010-02-26 |
| US8163729B2 (en) | 2012-04-24 |
| EA016948B1 (ru) | 2012-08-30 |
| ZA200904943B (en) | 2010-09-29 |
| AR064921A1 (es) | 2009-05-06 |
| KR20090116707A (ko) | 2009-11-11 |
| PA8766201A1 (es) | 2008-11-19 |
| TW200901974A (en) | 2009-01-16 |
| SV2009003334A (es) | 2010-08-09 |
| CN101679287B (zh) | 2013-03-27 |
| UA98317C2 (ru) | 2012-05-10 |
| EP2118067A1 (en) | 2009-11-18 |
| WO2008087529A1 (en) | 2008-07-24 |
| MX2009007615A (es) | 2009-07-27 |
| JP2010515770A (ja) | 2010-05-13 |
| IL199889A0 (en) | 2010-04-15 |
| NZ578411A (en) | 2011-06-30 |
| US20100029606A1 (en) | 2010-02-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2008000119A1 (es) | Compuestos derivados de pirazol, antagonistas del receptor nicotinico de acetilcolina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como demencia senil, alzheimer y esquizofrenia. | |
| CL2008000307A1 (es) | Compuestos derivados de cromen-2-ona sustituido; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como ateroesclerosis, asma, rinitis alergica y epoc. | |
| CL2008002689A1 (es) | Compuestos derivados de heterociclo 1,4 piperidina sustituida; compuestos intermediarios; composicion farmaceutica; proceso de preparacion; y su uso en el tratamiento del alzheimer y esquizofrenia. | |
| SMT201600164B (it) | Nuove n-acil-5, 6, 7, ( 8-s0stituito )-tetraidro-[1, 2, 4]triazolo[4, 3-a]pirazine chirali come antagonisti selettivi del recettore nk-3, composizione farmaceutica, e metodi per l'uso in disturbi mediati dal recettore nk-3 | |
| IL214425A (en) | Converted metastatic heterocyclic compounds, their pharmaceutical preparations and their uses | |
| CL2007003879A1 (es) | Compuestos derivados de aril-carboxamida; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como alzheimer, epilepsia y parkinson. | |
| MY193728A (en) | Muscarinic receptor agonists | |
| CL2007002996A1 (es) | Compuestos derivados de quinolina sustituido, moduladores de los receptores x del higado; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como sindrome coronario agudo, alzheimer, diabetes y aterosclerosis. | |
| IL214208A (en) | Preserved heterotromatic bicycles, containing pharmaceutical preparations and their use in preventing the jak process | |
| WO2014106238A8 (en) | Heterocyclic compounds and methods of use thereof | |
| CL2012003604A1 (es) | Compuestos heterociclicos derivados de piridina carboxamida sustituida; proceso de preparacion; composicion farmaceutica; combinacion farmaceutica; uso en el tratamiento de trastornos proliferativos celulares, enfermedad de parkinson, cancer, entre otros. | |
| CL2014000395A1 (es) | Compuestos derivados de piridazinona sustituida; compuesto intermediario; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de la esquizofrenia, trastorno esquizoafectivo, trastornos cognitivos o dolor. | |
| CL2008001215A1 (es) | Compuestos derivados de heterociclos nitrogenados condensados; composicion farmaceutica; procedimiento para preparar la composicion farmaceutica; y uso en el tratamiento de enfermedades tales como diabetes, dislipidemia, obesidad y alzheimer. | |
| CL2008000875A1 (es) | Compuestos derivados de imidazolidin-2-ona; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento y/o profilaxis de enfermedades tales como dislipidemia, diabetes, enfermedades inflamatorias, entre otras. | |
| WO2013056070A3 (en) | Heterocyclic compounds and use thereof as modulators of type iii receptor tyrosine kinases | |
| CL2007001042A1 (es) | Compuestos derivados de tioxantina; composicion farmaceutica que comprende a dicho compuesto; y uso en el tratamiento de desordenes neuroinflamatorios como esclerosis multiple, parkinson, en desordenes ateroscleroticos, cardio- y cerebrovascular, des | |
| CL2008002864A1 (es) | Compuestos derivados de 2-amino-quinolina, antagonistas del receptor de serotonina 5-ht 5a; procedimiento de preparacion;composicion farmaceutica; y uso de los compuestos en la prevencion o el tratamiento de depresion,trastornos de ansiedad,esquizofrenia,trastornos de panico,trastornos de memoria,demencia,entre otros. | |
| BRPI1014039A2 (pt) | 6-(3-aza-biciclo[3.1.0]hex-3-il)-2-fenil-pirimidinas | |
| CL2014000641A1 (es) | Compuestos derivados de triazolo[1,5-a]piridina, inhibidores de la ped10a; proceso de obtencion; composicion farmaceutica; y uso en el tratamiento o profilaxis de enfermedades tales como esquizofrenia, parkinson, alzheimer, entre otras. | |
| UA102857C2 (en) | Quinuclidine carbonate derivatives and use thereof | |
| CL2007003765A1 (es) | Compuestos derivados de 2-oxo-4-hidroxi-benzotiazol; procesode preparacion; composicion farmaceutica; combinacion farmaceutica; y uso en el tratamiento de enfermedades tales como epoc, bronquitis, asma y bronquiectasias. | |
| CR20130209A (es) | Derivados de carboxamida como antagonistas del receptor muscarinico | |
| CL2008000629A1 (es) | Compuestos macrociclicos derivados de 6-aril-4-mercapto-[1.3.5]triazina/[1.3]pirimidin-2-amina; composicion farmaceutica, utiles en el tratamiento del cancer. | |
| CL2014003325A1 (es) | Compuestos derivados de difluoro-hexahidro-ciclopentaoxacinilos y difluoro-hexahidro-benzooxacinilos, inhibidores de bace 1; composicion farmaceutica; y su uso en el tratamiento de enfermedades con niveles elevados de beta-amiloide, tal como la enfermedad de alzheimer | |
| CL2008002088A1 (es) | Compuestos derivados de fenilo sustituido, moduladores del receptor de histamina 3; proceso de preparacion; composicion farmaceutica; y uso en el tratamiento de trastornos cognitivos tales como demencia, alzheimer, entre otros. |