CL2007002017A1 - Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple. - Google Patents

Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.

Info

Publication number: CL2007002017A1
Authority: CL; Chile
Prior art keywords: cancer; vejiga; bipirimidinil; cinasa; mieloma
Prior art date: 2006-07-12

Application number

CL200702017A

Other languages

English (en)

Inventor

Pamela A He Yun Jiang Albaugh

Original Assignee

Irm Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-12

Filing date

2007-07-11

Publication date

2008-06-13

2007-07-11 Application filed by Irm Llc filed Critical Irm Llc

2008-06-13 Publication of CL2007002017A1 publication Critical patent/CL2007002017A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CL200702017A 2006-07-12 2007-07-11 Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple. CL2007002017A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83049206P	2006-07-12	2006-07-12

Publications (1)

Publication Number	Publication Date
CL2007002017A1 true CL2007002017A1 (es)	2008-06-13

Family

ID=38617203

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200702017A CL2007002017A1 (es)	2006-07-12	2007-07-11	Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.

Country Status (21)

Country	Link
US (1)	US8026243B2 (es)
EP (1)	EP2044036B1 (es)
JP (1)	JP2009543798A (es)
KR (1)	KR20090029832A (es)
CN (1)	CN101511798B (es)
AR (1)	AR061867A1 (es)
AT (1)	ATE508119T1 (es)
AU (1)	AU2007272646A1 (es)
BR (1)	BRPI0714291A2 (es)
CA (1)	CA2657381A1 (es)
CL (1)	CL2007002017A1 (es)
DE (1)	DE602007014374D1 (es)
ES (1)	ES2367666T3 (es)
MX (1)	MX2009000429A (es)
PE (1)	PE20080548A1 (es)
PL (1)	PL2044036T3 (es)
PT (1)	PT2044036E (es)
RU (1)	RU2009104340A (es)
TW (1)	TW200811134A (es)
UY (1)	UY30477A1 (es)
WO (1)	WO2008008747A1 (es)

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GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
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RU2616293C2 (ru)	2011-10-06	2017-04-14	Байер Интеллектуэль Проперти Гмбх	Гетероциклилпиридинилпиразолы в качестве фунгицидного средства
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RS61664B1 (sr)	2012-04-24	2021-04-29	Vertex Pharma	Inhibitori dna-pk
NZ702747A (en)	2012-06-13	2017-03-31	Incyte Holdings Corp	Substituted tricyclic compounds as fgfr inhibitors
WO2014026125A1 (en)	2012-08-10	2014-02-13	Incyte Corporation	Pyrazine derivatives as fgfr inhibitors
ES2643571T3 (es) *	2012-09-27	2017-11-23	Chugai Seiyaku Kabushiki Kaisha	Gen de fusión FGFR3 y fármaco que se dirige al mismo
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
AR094812A1 (es)	2013-02-20	2015-08-26	Eisai R&D Man Co Ltd	Derivado de piridina monocíclico como inhibidor del fgfr
HUE057527T2 (hu)	2013-03-12	2022-05-28	Vertex Pharma	DNS-PK inhibitorok
LT2986610T (lt)	2013-04-19	2018-04-10	Incyte Holdings Corporation	Bicikliniai heterociklai, kaip fgfr inhibitoriai
HRP20181841T1 (hr)	2013-10-17	2019-01-11	Vertex Pharmaceuticals Incorporated	Sukristali (s)-n-metil-8-(1-((2′-metil-[4,5′-bipirimidin]-6-il)amino)propan-2-il)kinolin-4-karboksamida i njegovih deuteriranih derivata kao inhibitora dna-pk
WO2016027781A1 (ja)	2014-08-18	2016-02-25	エーザイ・アール・アンド・ディー・マネジメント株式会社	単環ピリジン誘導体の塩およびその結晶
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US9580423B2 (en)	2015-02-20	2017-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
SG10201913036RA (en)	2015-02-20	2020-02-27	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
RU2712222C2 (ru)	2015-03-25	2020-01-27	Нэшнл Кэнсер Сентер	Терапевтическое средство против рака желчных протоков
AU2016374441B2 (en)	2015-12-17	2021-10-21	Eisai R&D Management Co., Ltd.	Therapeutic agent for breast cancer
JP2019529475A (ja)	2016-09-27	2019-10-17	バーテックスファーマシューティカルズインコーポレイテッドＶｅｒｔｅｘＰｈａｒｍａｃｅｕｔｉｃａｌｓＩｎｃｏｒｐｏｒａｔｅｄ	Ｄｎａ損傷剤とｄｎａ−ｐｋ阻害剤との組合せ物を使用する、がんを処置するための方法
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR102613433B1 (ko) *	2017-10-11	2023-12-13	주식회사 대웅제약	신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
BR112020017922A2 (pt)	2018-03-28	2020-12-22	Eisai R&D Management Co., Ltd.	Agente terapêutico para carcinoma hepatocelular
EP4309737A3 (en)	2018-05-04	2024-03-27	Incyte Corporation	Solid forms of an fgfr inhibitor and processes for preparing the same
EP3788046B1 (en)	2018-05-04	2025-12-10	Incyte Corporation	Salts of an fgfr inhibitor
US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
KR102133595B1 (ko)	2019-05-31	2020-07-13	에이치케이이노엔 주식회사	단백질 키나제 억제제로서의 헤테로고리 화합물
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
KR102112336B1 (ko)	2019-08-12	2020-05-18	에이치케이이노엔 주식회사	단백질 키나제 억제제로서의 헤테로고리 화합물
WO2021067374A1 (en)	2019-10-01	2021-04-08	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
CR20220169A (es)	2019-10-14	2022-10-27	Incyte Corp	Heterociclos bicíclicos como inhibidores de fgfr
WO2021076728A1 (en)	2019-10-16	2021-04-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
CA3163875A1 (en)	2019-12-04	2021-06-10	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
KR20220131900A (ko)	2019-12-04	2022-09-29	인사이트 코포레이션	Fgfr 억제제의 유도체
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
US12065494B2 (en)	2021-04-12	2024-08-20	Incyte Corporation	Combination therapy comprising an FGFR inhibitor and a Nectin-4 targeting agent
AR126102A1 (es)	2021-06-09	2023-09-13	Incyte Corp	Heterociclos tricíclicos como inhibidores de fgfr
AR126101A1 (es)	2021-06-09	2023-09-13	Incyte Corp	Heterociclos tricíclicos como inhibidores de fgfr

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2007
- 2007-07-04 TW TW096124311A patent/TW200811134A/zh unknown
- 2007-07-10 ES ES07812739T patent/ES2367666T3/es active Active
- 2007-07-10 BR BRPI0714291-9A2A patent/BRPI0714291A2/pt not_active Application Discontinuation
- 2007-07-10 CA CA002657381A patent/CA2657381A1/en not_active Abandoned
- 2007-07-10 EP EP07812739A patent/EP2044036B1/en not_active Not-in-force
- 2007-07-10 KR KR1020097002815A patent/KR20090029832A/ko not_active Withdrawn
- 2007-07-10 AR ARP070103061A patent/AR061867A1/es unknown
- 2007-07-10 CN CN2007800337140A patent/CN101511798B/zh not_active Expired - Fee Related
- 2007-07-10 WO PCT/US2007/073111 patent/WO2008008747A1/en not_active Ceased
- 2007-07-10 AT AT07812739T patent/ATE508119T1/de active
- 2007-07-10 DE DE602007014374T patent/DE602007014374D1/de active Active
- 2007-07-10 AU AU2007272646A patent/AU2007272646A1/en not_active Abandoned
- 2007-07-10 PT PT07812739T patent/PT2044036E/pt unknown
- 2007-07-10 MX MX2009000429A patent/MX2009000429A/es not_active Application Discontinuation
- 2007-07-10 PL PL07812739T patent/PL2044036T3/pl unknown
- 2007-07-10 RU RU2009104340/04A patent/RU2009104340A/ru not_active Application Discontinuation
- 2007-07-10 JP JP2009519623A patent/JP2009543798A/ja active Pending
- 2007-07-10 US US12/373,441 patent/US8026243B2/en not_active Expired - Fee Related
- 2007-07-10 PE PE2007000885A patent/PE20080548A1/es not_active Application Discontinuation
- 2007-07-11 CL CL200702017A patent/CL2007002017A1/es unknown
- 2007-07-11 UY UY30477A patent/UY30477A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
PE20080548A1 (es)	2008-06-24
DE602007014374D1 (de)	2011-06-16
JP2009543798A (ja)	2009-12-10
WO2008008747A1 (en)	2008-01-17
PT2044036E (pt)	2011-08-23
US8026243B2 (en)	2011-09-27
EP2044036B1 (en)	2011-05-04
AU2007272646A1 (en)	2008-01-17
CA2657381A1 (en)	2008-01-17
RU2009104340A (ru)	2010-08-20
MX2009000429A (es)	2009-01-29
TW200811134A (en)	2008-03-01
ES2367666T3 (es)	2011-11-07
EP2044036A1 (en)	2009-04-08
UY30477A1 (es)	2009-04-30
PL2044036T3 (pl)	2011-09-30
CN101511798A (zh)	2009-08-19
ATE508119T1 (de)	2011-05-15
KR20090029832A (ko)	2009-03-23
AR061867A1 (es)	2008-09-24
BRPI0714291A2 (pt)	2014-10-21
US20100234376A1 (en)	2010-09-16
CN101511798B (zh)	2011-11-02

Publication	Publication Date	Title
CL2007002017A1 (es)	2008-06-13	Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.
CL2007000161A1 (es)	2008-05-30	Compuestos derivados de 2,4-dioxoimidazolidina sustituida, inhibidores de proteinas cinasas; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer.
BRPI0614205A2 (pt)	2016-11-22	composto, composição farmacêutica, e, uso de composto
BRPI0618904A2 (pt)	2016-09-13	composto, composição farmacêutica, e, uso do composto
CL2007002377A1 (es)	2008-04-04	Compuestos derivados de quinazolina; procedimiento de preparacion; composicion farmaceutica; y su uso como anticancerigeno.
BRPI0806531A2 (pt)	2014-04-22	Composto, composição farmacêutica, agente terapêutico, e, uso do composto.
IL188050A (en)	2015-10-29	The history of azaindazole, their medicinal preparations and their uses
IL195488A (en)	2017-04-30	Compounds, pharmaceuticals containing them and their uses
CL2007002316A1 (es)	2008-02-01	Compuestos derivados de pirimidina, inhibidores de pi3k; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades proliferativas como cancer.
CL2007002640A1 (es)	2008-06-20	Compuestos derivados de 3-(6-oxo-1,6-dihidro-piridin-3-il)-benzamida; composicion farmaceutica; y uso en el tratamiento del cancer.
CL2007002642A1 (es)	2008-07-18	Compuestos derivados de 3-(6-oxo-1,6-dihidro-piridin-3-il)-benzamida; composicion farmaceutica; y uso en el tratamiento del cancer.
IL192298A (en)	2016-02-29	Heterocyclic Compounds, Their Acceptable Salts, Pharmaceuticals Containing and Using Them
IL199151A (en)	2017-01-31	Pyrimidine derivatives, their pharmaceutical preparations, their use in cancer treatment and their kits
BRPI0814593A2 (pt)	2015-01-20	Composto, composição farmacêutica que o contém e uso do composto.
BRPI0908504A2 (pt)	2015-08-11	Compostos derivados de 3-metil-imidazo[1,2-b]piridazina, uso dos mesmos e composição farmacêutica
BRPI0814529A2 (pt)	2015-01-27	Derivados de 2-3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas alfa2c para o uso no tratamento de doenças do sistema nervoso periférico e central.
IL185484A0 (en)	2008-01-06	Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
CL2007003672A1 (es)	2008-07-25	Compuestos derivados de heteroaril-pirrolidinil-cetona y heteroaril-piperidinil-cetona; composicion farmaceutica; y uso en el tratamiento de la depresion y ansiedad.
ITMI20031570A1 (it)	2005-02-01	Composizione per uso dietetico, farmaceutico o cosmetico
CL2007001630A1 (es)	2008-02-08	Compuestos derivados de pirrolidinamida; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
CL2007002376A1 (es)	2008-04-04	Compuestos derivados de pirrol sustituido; proceso de preparacion; composicion farmaceutica; y uso en enfermedades bacterianas.
CL2007003038A1 (es)	2008-06-06	Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos.
CL2007002619A1 (es)	2008-04-18	Compuestos derivados de 3-aza-biciclo[4.1.0]heptano; composicion farmaceutica; y uso en el tratamiento de la depresion.
CL2008002353A1 (es)	2008-10-24	Compuestos derivados de 7h-indolo[2,1-a][2]benzazepina; composicion farmaceutica; y uso en el tratamiento de la hepatitis c.
ZA200711105B (en)	2009-08-26	Novel physiological substance nesfatin substance relevant thereto, and use of the substances