CL2007002017A1 - Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple. - Google Patents

Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.

Info

Publication number: CL2007002017A1
Authority: CL; Chile
Prior art keywords: cancer; vejiga; bipirimidinil; cinasa; mieloma
Prior art date: 2006-07-12

Application number

CL200702017A

Other languages

English (en)

Inventor

Pamela A He Yun Jiang Albaugh

Original Assignee

Irm Llc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-07-12

Filing date

2007-07-11

Publication date

2008-06-13

2007-07-11 Application filed by Irm Llc filed Critical Irm Llc

2008-06-13 Publication of CL2007002017A1 publication Critical patent/CL2007002017A1/es

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

CL200702017A 2006-07-12 2007-07-11 Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple. CL2007002017A1 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US83049206P	2006-07-12	2006-07-12

Publications (1)

Publication Number	Publication Date
CL2007002017A1 true CL2007002017A1 (es)	2008-06-13

Family

ID=38617203

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CL200702017A CL2007002017A1 (es)	2006-07-12	2007-07-11	Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.

Country Status (21)

Country	Link
US (1)	US8026243B2 (es)
EP (1)	EP2044036B1 (es)
JP (1)	JP2009543798A (es)
KR (1)	KR20090029832A (es)
CN (1)	CN101511798B (es)
AR (1)	AR061867A1 (es)
AT (1)	ATE508119T1 (es)
AU (1)	AU2007272646A1 (es)
BR (1)	BRPI0714291A2 (es)
CA (1)	CA2657381A1 (es)
CL (1)	CL2007002017A1 (es)
DE (1)	DE602007014374D1 (es)
ES (1)	ES2367666T3 (es)
MX (1)	MX2009000429A (es)
PE (1)	PE20080548A1 (es)
PL (1)	PL2044036T3 (es)
PT (1)	PT2044036E (es)
RU (1)	RU2009104340A (es)
TW (1)	TW200811134A (es)
UY (1)	UY30477A1 (es)
WO (1)	WO2008008747A1 (es)

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GB0720038D0 (en)	2007-10-12	2007-11-21	Astex Therapeutics Ltd	New compounds
GB0810902D0 (en)	2008-06-13	2008-07-23	Astex Therapeutics Ltd	New compounds
GB0906470D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
GB0906472D0 (en)	2009-04-15	2009-05-20	Astex Therapeutics Ltd	New compounds
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WO2011076725A1 (en)	2009-12-21	2011-06-30	Bayer Cropscience Ag	Thienylpyri (mi) dinylazole and their use for controlling phytopathogenic fungi
US8754114B2 (en)	2010-12-22	2014-06-17	Incyte Corporation	Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
AR086992A1 (es)	2011-06-20	2014-02-05	Bayer Ip Gmbh	Tienilpiri(mi)dinilpirazoles
IN2014CN02475A (es)	2011-10-06	2015-06-19	Bayer Ip Gmbh
PL2763987T3 (pl)	2011-10-06	2019-01-31	Bayer Cropscience Ag	Heterocyklilopiry(mi)dynylopirazole jako środki grzybobójcze
CN106986863B (zh)	2012-04-24	2019-12-31	沃泰克斯药物股份有限公司	Dna-pk抑制剂
PH12019502809B1 (en)	2012-06-13	2024-04-24	Incyte Holdings Corp	Substituted tricyclic compounds as fgfr inhibitors
US9388185B2 (en)	2012-08-10	2016-07-12	Incyte Holdings Corporation	Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors
HK1210500A1 (en) *	2012-09-27	2016-04-22	中外制药株式会社	Fgfr3 fusion gene and pharmaceutical drug targeting same
US9266892B2 (en)	2012-12-19	2016-02-23	Incyte Holdings Corporation	Fused pyrazoles as FGFR inhibitors
AR094812A1 (es)	2013-02-20	2015-08-26	Eisai R&D Man Co Ltd	Derivado de piridina monocíclico como inhibidor del fgfr
HUE041544T2 (hu)	2013-03-12	2019-05-28	Vertex Pharma	DNS-PK inhibitorok
SMT201800127T1 (it)	2013-04-19	2018-05-02	Incyte Holdings Corp	Eterocilci biciclici come inibitori di fgfr
WO2015058067A1 (en)	2013-10-17	2015-04-23	Vertex Pharmaceuticals Incorporated	Co-crystals of (s)-n-methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl)amino)propan-2-yl)quinoline-4-carboxamide and deuterated derivatives thereof as dna-pk inhibitors
US9951047B2 (en)	2014-08-18	2018-04-24	Eisai R&D Management Co., Ltd.	Salt of monocyclic pyridine derivative and crystal thereof
US10851105B2 (en)	2014-10-22	2020-12-01	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
MA41551A (fr)	2015-02-20	2017-12-26	Incyte Corp	Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
SG10201913036RA (en)	2015-02-20	2020-02-27	Incyte Corp	Bicyclic heterocycles as fgfr inhibitors
US9580423B2 (en)	2015-02-20	2017-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR4 inhibitors
RU2712222C2 (ru)	2015-03-25	2020-01-27	Нэшнл Кэнсер Сентер	Терапевтическое средство против рака желчных протоков
CN115177619A (zh)	2015-12-17	2022-10-14	卫材R&D管理有限公司	用于乳腺癌的治疗剂
AU2017335648B2 (en)	2016-09-27	2022-02-17	Vertex Pharmaceuticals Incorporated	Method for treating cancer using a combination of DNA-damaging agents and DNA-PK inhibitors
AR111960A1 (es)	2017-05-26	2019-09-04	Incyte Corp	Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
KR102613433B1 (ko) *	2017-10-11	2023-12-13	주식회사 대웅제약	신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
JPWO2019189241A1 (ja)	2018-03-28	2021-03-18	エーザイ・アール・アンド・ディー・マネジメント株式会社	肝細胞癌治療剤
JP2021523121A (ja)	2018-05-04	2021-09-02	インサイト・コーポレイションＩｎｃｙｔｅＣｏｒｐｏｒａｔｉｏｎ	Ｆｇｆｒ阻害剤の固体形態及びその調製プロセス
MA52493A (fr)	2018-05-04	2021-03-10	Incyte Corp	Sels d'un inhibiteur de fgfr
US11628162B2 (en)	2019-03-08	2023-04-18	Incyte Corporation	Methods of treating cancer with an FGFR inhibitor
KR102133595B1 (ko)	2019-05-31	2020-07-13	에이치케이이노엔 주식회사	단백질 키나제 억제제로서의 헤테로고리 화합물
US11591329B2 (en)	2019-07-09	2023-02-28	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
KR102112336B1 (ko)	2019-08-12	2020-05-18	에이치케이이노엔 주식회사	단백질 키나제 억제제로서의 헤테로고리 화합물
US12122767B2 (en)	2019-10-01	2024-10-22	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
JOP20220083A1 (ar)	2019-10-14	2023-01-30	Incyte Corp	حلقات غير متجانسة ثنائية الحلقة كمثبطات لـ fgfr
WO2021076728A1 (en)	2019-10-16	2021-04-22	Incyte Corporation	Bicyclic heterocycles as fgfr inhibitors
IL293001A (en)	2019-12-04	2022-07-01	Incyte Corp	Derivatives of fgfr repressors
EP4069696A1 (en)	2019-12-04	2022-10-12	Incyte Corporation	Tricyclic heterocycles as fgfr inhibitors
US12012409B2 (en)	2020-01-15	2024-06-18	Incyte Corporation	Bicyclic heterocycles as FGFR inhibitors
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JP2024522188A (ja)	2021-06-09	2024-06-11	インサイト・コーポレイション	Ｆｇｆｒ阻害剤としての三環式ヘテロ環
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2007
- 2007-07-04 TW TW096124311A patent/TW200811134A/zh unknown
- 2007-07-10 EP EP07812739A patent/EP2044036B1/en not_active Not-in-force
- 2007-07-10 US US12/373,441 patent/US8026243B2/en not_active Expired - Fee Related
- 2007-07-10 DE DE602007014374T patent/DE602007014374D1/de active Active
- 2007-07-10 MX MX2009000429A patent/MX2009000429A/es not_active Application Discontinuation
- 2007-07-10 AR ARP070103061A patent/AR061867A1/es unknown
- 2007-07-10 AT AT07812739T patent/ATE508119T1/de active
- 2007-07-10 CN CN2007800337140A patent/CN101511798B/zh not_active Expired - Fee Related
- 2007-07-10 ES ES07812739T patent/ES2367666T3/es active Active
- 2007-07-10 AU AU2007272646A patent/AU2007272646A1/en not_active Abandoned
- 2007-07-10 CA CA002657381A patent/CA2657381A1/en not_active Abandoned
- 2007-07-10 PL PL07812739T patent/PL2044036T3/pl unknown
- 2007-07-10 PE PE2007000885A patent/PE20080548A1/es not_active Application Discontinuation
- 2007-07-10 BR BRPI0714291-9A2A patent/BRPI0714291A2/pt not_active Application Discontinuation
- 2007-07-10 KR KR1020097002815A patent/KR20090029832A/ko not_active Withdrawn
- 2007-07-10 PT PT07812739T patent/PT2044036E/pt unknown
- 2007-07-10 RU RU2009104340/04A patent/RU2009104340A/ru not_active Application Discontinuation
- 2007-07-10 JP JP2009519623A patent/JP2009543798A/ja active Pending
- 2007-07-10 WO PCT/US2007/073111 patent/WO2008008747A1/en not_active Ceased
- 2007-07-11 UY UY30477A patent/UY30477A1/es not_active Application Discontinuation
- 2007-07-11 CL CL200702017A patent/CL2007002017A1/es unknown

Also Published As

Publication number	Publication date
KR20090029832A (ko)	2009-03-23
WO2008008747A1 (en)	2008-01-17
CN101511798B (zh)	2011-11-02
EP2044036A1 (en)	2009-04-08
EP2044036B1 (en)	2011-05-04
JP2009543798A (ja)	2009-12-10
RU2009104340A (ru)	2010-08-20
ES2367666T3 (es)	2011-11-07
US20100234376A1 (en)	2010-09-16
MX2009000429A (es)	2009-01-29
PE20080548A1 (es)	2008-06-24
CA2657381A1 (en)	2008-01-17
ATE508119T1 (de)	2011-05-15
DE602007014374D1 (de)	2011-06-16
US8026243B2 (en)	2011-09-27
TW200811134A (en)	2008-03-01
AR061867A1 (es)	2008-09-24
PT2044036E (pt)	2011-08-23
CN101511798A (zh)	2009-08-19
PL2044036T3 (pl)	2011-09-30
AU2007272646A1 (en)	2008-01-17
BRPI0714291A2 (pt)	2014-10-21
UY30477A1 (es)	2009-04-30

Publication	Publication Date	Title
CL2007002017A1 (es)	2008-06-13	Compuestos derivados de [4,5']-bipirimidinil-6,4'-diamina; composicion farmaceutica; y uso como inhibidor de la actividad de cinasa en cancer de vejiga, cancer cervical y mieloma multiple.
CL2007000161A1 (es)	2008-05-30	Compuestos derivados de 2,4-dioxoimidazolidina sustituida, inhibidores de proteinas cinasas; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer.
BRPI0614205A2 (pt)	2016-11-22	composto, composição farmacêutica, e, uso de composto
BRPI0618904A2 (pt)	2016-09-13	composto, composição farmacêutica, e, uso do composto
CL2007002377A1 (es)	2008-04-04	Compuestos derivados de quinazolina; procedimiento de preparacion; composicion farmaceutica; y su uso como anticancerigeno.
BRPI0806531A2 (pt)	2014-04-22	Composto, composição farmacêutica, agente terapêutico, e, uso do composto.
IL188050A (en)	2015-10-29	The history of azaindazole, their medicinal preparations and their uses
IL195488A (en)	2017-04-30	Compounds, pharmaceuticals containing them and their uses
CL2007002316A1 (es)	2008-02-01	Compuestos derivados de pirimidina, inhibidores de pi3k; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto en enfermedades proliferativas como cancer.
CL2007002640A1 (es)	2008-06-20	Compuestos derivados de 3-(6-oxo-1,6-dihidro-piridin-3-il)-benzamida; composicion farmaceutica; y uso en el tratamiento del cancer.
CL2007002642A1 (es)	2008-07-18	Compuestos derivados de 3-(6-oxo-1,6-dihidro-piridin-3-il)-benzamida; composicion farmaceutica; y uso en el tratamiento del cancer.
IL225206A (en)	2017-11-30	A derivative of multinuclear carbamoylpyridone, its pharmaceutical composition and its use
IL192298A (en)	2016-02-29	Heterocyclic Compounds, Their Acceptable Salts, Pharmaceuticals Containing and Using Them
IL199151A (en)	2017-01-31	Pyrimidine derivatives, their pharmaceutical preparations, their use in cancer treatment and their kits
BRPI0814593A2 (pt)	2015-01-20	Composto, composição farmacêutica que o contém e uso do composto.
BRPI0908504A2 (pt)	2015-08-11	Compostos derivados de 3-metil-imidazo[1,2-b]piridazina, uso dos mesmos e composição farmacêutica
BRPI0814529A2 (pt)	2015-01-27	Derivados de 2-3-dihidrobenzo[1,4]dioxin-2-ilmetil como antagonistas alfa2c para o uso no tratamento de doenças do sistema nervoso periférico e central.
IL185484A0 (en)	2008-01-06	Aminopyrazole derivatives, their manufacture and use as pharmaceutical agents
CL2007003672A1 (es)	2008-07-25	Compuestos derivados de heteroaril-pirrolidinil-cetona y heteroaril-piperidinil-cetona; composicion farmaceutica; y uso en el tratamiento de la depresion y ansiedad.
ITMI20031570A1 (it)	2005-02-01	Composizione per uso dietetico, farmaceutico o cosmetico
CL2007001630A1 (es)	2008-02-08	Compuestos derivados de pirrolidinamida; composicion farmaceutica; y uso para el tratamiento de la hepatitis c.
CL2007002376A1 (es)	2008-04-04	Compuestos derivados de pirrol sustituido; proceso de preparacion; composicion farmaceutica; y uso en enfermedades bacterianas.
CL2007003038A1 (es)	2008-06-06	Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos.
CL2007002619A1 (es)	2008-04-18	Compuestos derivados de 3-aza-biciclo[4.1.0]heptano; composicion farmaceutica; y uso en el tratamiento de la depresion.
CL2008002353A1 (es)	2008-10-24	Compuestos derivados de 7h-indolo[2,1-a][2]benzazepina; composicion farmaceutica; y uso en el tratamiento de la hepatitis c.