CA1195244A - Flea collars for animals - Google Patents
Flea collars for animalsInfo
- Publication number
- CA1195244A CA1195244A CA000419250A CA419250A CA1195244A CA 1195244 A CA1195244 A CA 1195244A CA 000419250 A CA000419250 A CA 000419250A CA 419250 A CA419250 A CA 419250A CA 1195244 A CA1195244 A CA 1195244A
- Authority
- CA
- Canada
- Prior art keywords
- chosen
- necklace according
- methyl
- acid
- substance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
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- 239000000126 substance Substances 0.000 claims abstract description 38
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- 235000004626 essential fatty acids Nutrition 0.000 claims abstract description 11
- 239000004014 plasticizer Substances 0.000 claims abstract description 6
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- 239000004416 thermosoftening plastic Substances 0.000 claims abstract description 4
- 239000002781 deodorant agent Substances 0.000 claims abstract description 3
- 239000000945 filler Substances 0.000 claims abstract description 3
- 239000003381 stabilizer Substances 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 26
- 239000002917 insecticide Substances 0.000 claims description 22
- -1 2-chloro (2,4,5-trichlorophenyl) vinyl Chemical group 0.000 claims description 18
- 239000000654 additive Substances 0.000 claims description 18
- 150000004665 fatty acids Chemical class 0.000 claims description 14
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 12
- 239000000194 fatty acid Substances 0.000 claims description 12
- 229930195729 fatty acid Natural products 0.000 claims description 12
- 229940088594 vitamin Drugs 0.000 claims description 12
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- 235000013343 vitamin Nutrition 0.000 claims description 11
- 229930003231 vitamin Natural products 0.000 claims description 11
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- 239000002253 acid Substances 0.000 claims description 8
- 241000607479 Yersinia pestis Species 0.000 claims description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 7
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- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims description 4
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- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
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- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims description 2
- 235000021342 arachidonic acid Nutrition 0.000 claims description 2
- 229940114079 arachidonic acid Drugs 0.000 claims description 2
- CVXBEEMKQHEXEN-UHFFFAOYSA-N carbaryl Chemical compound C1=CC=C2C(OC(=O)NC)=CC=CC2=C1 CVXBEEMKQHEXEN-UHFFFAOYSA-N 0.000 claims description 2
- OEBRKCOSUFCWJD-UHFFFAOYSA-N dichlorvos Chemical compound COP(=O)(OC)OC=C(Cl)Cl OEBRKCOSUFCWJD-UHFFFAOYSA-N 0.000 claims description 2
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims description 2
- 229960004488 linolenic acid Drugs 0.000 claims description 2
- KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 claims description 2
- DSWNRHCOGVRDOE-UHFFFAOYSA-N n,n-dimethylmethanimidamide Chemical compound CN(C)C=N DSWNRHCOGVRDOE-UHFFFAOYSA-N 0.000 claims description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 2
- 125000003944 tolyl group Chemical group 0.000 claims description 2
- 238000003466 welding Methods 0.000 claims description 2
- 125000005023 xylyl group Chemical group 0.000 claims description 2
- XSXIVVZCUAHUJO-AVQMFFATSA-N (11e,14e)-icosa-11,14-dienoic acid Chemical compound CCCCC\C=C\C\C=C\CCCCCCCCCC(O)=O XSXIVVZCUAHUJO-AVQMFFATSA-N 0.000 claims 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 claims 1
- KHBCHWFRVFRJED-UHFFFAOYSA-N 2,2-dichloroethenylcyclopropane Chemical compound ClC(Cl)=CC1CC1 KHBCHWFRVFRJED-UHFFFAOYSA-N 0.000 claims 1
- IDVSZKGRCBMUQW-UHFFFAOYSA-N 2-(2,2-dichloroethenyl)-1,1-dimethylcyclopropane Chemical compound CC1(C)CC1C=C(Cl)Cl IDVSZKGRCBMUQW-UHFFFAOYSA-N 0.000 claims 1
- XSXIVVZCUAHUJO-UHFFFAOYSA-N Homo-gamma-linoleic acid Natural products CCCCCC=CCC=CCCCCCCCCCC(O)=O XSXIVVZCUAHUJO-UHFFFAOYSA-N 0.000 claims 1
- DLAWHUHRMLAWJP-UHFFFAOYSA-N O1C=C(C=C1)CC1C(C1C=C1C(SCC1)=O)(C)C Chemical compound O1C=C(C=C1)CC1C(C1C=C1C(SCC1)=O)(C)C DLAWHUHRMLAWJP-UHFFFAOYSA-N 0.000 claims 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 229960002969 oleic acid Drugs 0.000 claims 1
- 235000021313 oleic acid Nutrition 0.000 claims 1
- 150000004045 organic chlorine compounds Chemical class 0.000 claims 1
- 150000002903 organophosphorus compounds Chemical class 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 230000003071 parasitic effect Effects 0.000 claims 1
- 230000002141 anti-parasite Effects 0.000 abstract description 6
- 239000003096 antiparasitic agent Substances 0.000 abstract description 6
- 238000009792 diffusion process Methods 0.000 abstract description 6
- 229920000915 polyvinyl chloride Polymers 0.000 description 19
- 239000004800 polyvinyl chloride Substances 0.000 description 18
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 15
- 239000008116 calcium stearate Substances 0.000 description 15
- 235000013539 calcium stearate Nutrition 0.000 description 15
- 229920001519 homopolymer Polymers 0.000 description 15
- 235000012424 soybean oil Nutrition 0.000 description 13
- 239000003549 soybean oil Substances 0.000 description 13
- 230000000996 additive effect Effects 0.000 description 12
- 239000004156 Azodicarbonamide Substances 0.000 description 10
- XOZUGNYVDXMRKW-AATRIKPKSA-N azodicarbonamide Chemical compound NC(=O)\N=N\C(N)=O XOZUGNYVDXMRKW-AATRIKPKSA-N 0.000 description 10
- 235000019399 azodicarbonamide Nutrition 0.000 description 10
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000012360 testing method Methods 0.000 description 8
- 239000013543 active substance Substances 0.000 description 7
- WTFXARWRTYJXII-UHFFFAOYSA-N iron(2+);iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+2].[Fe+3].[Fe+3] WTFXARWRTYJXII-UHFFFAOYSA-N 0.000 description 7
- SZVJSHCCFOBDDC-UHFFFAOYSA-N iron(II,III) oxide Inorganic materials O=[Fe]O[Fe]O[Fe]=O SZVJSHCCFOBDDC-UHFFFAOYSA-N 0.000 description 7
- 230000007935 neutral effect Effects 0.000 description 7
- 241000282472 Canis lupus familiaris Species 0.000 description 6
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 6
- 229920003023 plastic Polymers 0.000 description 6
- 239000004033 plastic Substances 0.000 description 6
- 241000282326 Felis catus Species 0.000 description 5
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 239000004593 Epoxy Substances 0.000 description 4
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- WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 4
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- WTTJVINHCBCLGX-UHFFFAOYSA-N (9trans,12cis)-methyl linoleate Natural products CCCCCC=CCC=CCCCCCCCC(=O)OC WTTJVINHCBCLGX-UHFFFAOYSA-N 0.000 description 3
- LNJCGNRKWOHFFV-UHFFFAOYSA-N 3-(2-hydroxyethylsulfanyl)propanenitrile Chemical compound OCCSCCC#N LNJCGNRKWOHFFV-UHFFFAOYSA-N 0.000 description 3
- PKIXXJPMNDDDOS-UHFFFAOYSA-N Methyl linoleate Natural products CCCCC=CCCC=CCCCCCCCC(=O)OC PKIXXJPMNDDDOS-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- UOBSVARXACCLLH-UHFFFAOYSA-N monomethyl adipate Chemical compound COC(=O)CCCCC(O)=O UOBSVARXACCLLH-UHFFFAOYSA-N 0.000 description 3
- 229920002554 vinyl polymer Polymers 0.000 description 3
- NIQCNGHVCWTJSM-UHFFFAOYSA-N Dimethyl phthalate Chemical compound COC(=O)C1=CC=CC=C1C(=O)OC NIQCNGHVCWTJSM-UHFFFAOYSA-N 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
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- 150000007513 acids Chemical class 0.000 description 2
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- BJQHLKABXJIVAM-UHFFFAOYSA-N bis(2-ethylhexyl) phthalate Chemical compound CCCCC(CC)COC(=O)C1=CC=CC=C1C(=O)OCC(CC)CCCC BJQHLKABXJIVAM-UHFFFAOYSA-N 0.000 description 2
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- 235000001510 limonene Nutrition 0.000 description 1
- 229940040452 linolenate Drugs 0.000 description 1
- DTOSIQBPPRVQHS-PDBXOOCHSA-M linolenate Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC([O-])=O DTOSIQBPPRVQHS-PDBXOOCHSA-M 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- DVWSXZIHSUZZKJ-YSTUJMKBSA-N methyl linolenate Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(=O)OC DVWSXZIHSUZZKJ-YSTUJMKBSA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
- ALIFPGGMJDWMJH-UHFFFAOYSA-N n-phenyldiazenylaniline Chemical compound C=1C=CC=CC=1NN=NC1=CC=CC=C1 ALIFPGGMJDWMJH-UHFFFAOYSA-N 0.000 description 1
- 150000002829 nitrogen Chemical class 0.000 description 1
- 125000002347 octyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- 229960000490 permethrin Drugs 0.000 description 1
- RLLPVAHGXHCWKJ-UHFFFAOYSA-N permethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 RLLPVAHGXHCWKJ-UHFFFAOYSA-N 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- BSCCSDNZEIHXOK-UHFFFAOYSA-N phenyl carbamate Chemical compound NC(=O)OC1=CC=CC=C1 BSCCSDNZEIHXOK-UHFFFAOYSA-N 0.000 description 1
- 150000003014 phosphoric acid esters Chemical class 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
- 150000003021 phthalic acid derivatives Chemical class 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920000131 polyvinylidene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940095050 propylene Drugs 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229940015367 pyrethrum Drugs 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 238000005494 tarnishing Methods 0.000 description 1
- UBCKGWBNUIFUST-YHYXMXQVSA-N tetrachlorvinphos Chemical compound COP(=O)(OC)O\C(=C/Cl)C1=CC(Cl)=C(Cl)C=C1Cl UBCKGWBNUIFUST-YHYXMXQVSA-N 0.000 description 1
- CXBMCYHAMVGWJQ-UHFFFAOYSA-N tetramethrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCN1C(=O)C(CCCC2)=C2C1=O CXBMCYHAMVGWJQ-UHFFFAOYSA-N 0.000 description 1
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
- 235000012141 vanillin Nutrition 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 239000012463 white pigment Substances 0.000 description 1
- 239000001043 yellow dye Substances 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K27/00—Leads or collars, e.g. for dogs
- A01K27/007—Leads or collars, e.g. for dogs with insecticide-dispensing means
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K27/00—Leads or collars, e.g. for dogs
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Environmental Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- Health & Medical Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
La présente invention est relative à des perfectionnements apportés aux colliers antiparasitaires pour animaux. Ces colliers antiparasitaires se caractérisent en ce qu'ils comportent un dispositif insecticide formé d'au moins une substance insecticide associée à au moins une substance choisie parmi les acides gras essentiels insaturés de C18 é C22, ledit dispositif se composant en outre d'un support macromoléculaire solide thermoplastique et d'au moins un adjuvant choisi dans le groupe comprenant les plastifiants, les charges inertes, les colorants, les désodorisants, les stabilisants et les régulateurs de diffusion. Ce collier peut se présenter soit sous la forme d'une lanière, soit sous la forme d'une double lanière mixte formée de deux lanières accolées latéralement, une lanière contenant la substance insecticide, l'autre, l'acide gras essentiel insaturé.The present invention relates to improvements made to antiparasitic collars for animals. These antiparasitic collars are characterized in that they include an insecticidal device formed from at least one insecticidal substance associated with at least one substance chosen from unsaturated essential fatty acids from C18 to C22, said device further comprising a support macromolecular solid thermoplastic and at least one adjuvant chosen from the group comprising plasticizers, inert fillers, dyes, deodorants, stabilizers and diffusion regulators. This collar can be presented either in the form of a thong, or in the form of a double mixed thong formed by two thongs joined laterally, one thong containing the insecticidal substance, the other, the unsaturated essential fatty acid.
Description
La présente invention est relative à des perfec-tionnements apportes aux colliers anti-parasitaires pour animaux. On utilise depuis un certain temps déjà, des dispositifs aptes a libérer progressivement un insecticide de contact destiné à la protection des animaux contre les parasites, et en particulier contre les ectoparasites. La plupart de ces dispositifs sont constitues par un insecti-cide inclus dans une matrice en matiere plastique. La libé-ration lente du produit ectoparasiticide (qu'il agisse par sa vapeur ou qu'il se dépose sur les poils de l'animal), permet une protection efficace contre les parasites pendant plusieurs mois.
Ces différents dispositifs antiparasitaires et qui ont fait l'objet de tres nombreux brevets (notamment les Brevets français de la Demanderesse , 447 679, , 69 859, 307 ~66, ~ 436 563, 370 57~ `13 01~ 374 853, ~ 386 ~53, ` 386 ~5~, ~ 39. 606), sont essentiellement com-posés de trois éléments de base :
- l'insecticide (ou mélange d'insecticides), GO - le support (généralement a base d'une résine thermo-plastique), - les adjuvants (comme les plastifiants, regulateurs de diffusion, etc...) Le choix de chacun de ces trois constituants de `5 base est tres important. Il est en effet impératif d'avoir un dispositif efficace contre les parasites, diffusant d'une maniere lente et réguliere et d'une inocuité parfaite aussi bien pour l'animal que pour son entourage, et notam-ment pour les jeunes enfants.
Si la plupart des inconvénients de ces colliers anti-parasitai-res ont pu être elir~nés et les difficultés de toutes sortes surmontées, il reste pourtant un inconvenient et de grande ir~ortance.L'anir~,tres rapidement ou apres une certaine përiode d'utilisation,presente des pheno-~ menes allergiques se traduisant par des troubles locaux:rougeurs de la ; 35 peau,eczemas,ternissement du poil,perte de la souplesse de la peau etc et/ou par des troubles aenera~:v ~ ssements,perte de poids,etc...
,~.
z~
La présente invention s'est par consé~uent fixé pour but de pourvoir à des dispositifs et colliers ectoparasiticides qui réponaent mieux aux nécessités de la pratique que les dispositifs visant au même but anterieurement connus, notamment en ce qulils suppriment en totalite les troubles cutanes de l'animal, tout en gardant une grande efficacite d'action pendant une longue periode.
La presente invention a pour objet un collier antiparasitaire pour animaux,caractérisé en qu'il comporte undispositif insecticide ~ormé d'au moins une substance insecticide associee à au moins une substance choisie parmi les acides gras essentiels insatures de C18 à C2~, ledit dispositif se composant en outre d'un support macromoleculaire solide thermoplastique et d'au moins un adjuvant choisi dans le groupe comprenant les plasti-fiants, les charges i~ertes, les colorants, les deso-dorisants, les stabilisants et les régulateurs de di~fu-sion.
La très grande experience de la Demanderesse dans le domaine de la lutte contre les parasites des animaux, lui a permis de constater qu'à la longue l'into-lerance au collier insecticide etait due à la carence en certains acides gras necessaires au système epithelial de l'animal.
Selon un mode de realisation avantageux de l'objet de l'invention, la substance insecticide est ; choisie parmi les composes organochlores et/ou organo-phosphores et/ou carbamates, et/ou pyrèthres et/ou : 30 formamidines.
Selon une modalite particulière de ce mode de realisation, les substances organochloreessont choisies dans le groupe ~ui comprend:
:
~ . . .
S2~
- 2a -- le phosphate de 2,2-dichlorovinyle et de diméthyle(DDVP) - le phosphate de l,2-dibromo-2,2-dichloroethyle et de méthyle (NALED)*, - le phosphate de 2-chloro, 12,4,5-trichlorophenyl)-vinyle S et de dimethyle (STIRIFoS~.
*(marque de commerce) ~-`D .
.
~s~
5elon une autre modalite particulièxe, la subst n-ce organophosphor~e est choisie dans le groupe qui comprend le thionophosphate de 0,0'-diéthyl,0-(isopropyl-~ m~thyl-4 pyrimidinyl--6) ~DIMPYLATE) et le phosphate de 0,0 di~thyl O~(isopropyl-~ méthyl-4 pyrimidinyl-6) (DIAZOXON).
Selon une autre modalité particulière, les carbamates sont choisis parmi le N-méthyl carbamate de diméthyl~ benzodioxol-1,3 ol~4 (BENDIOCA ~ , le N-methyl carbamate d'isopropoxy-~ phenyl (PROPOXU~ , le N-méthyl carbamate de l-naphtyl (CARBARYL~.
Selon une autre modalité particuliere, les substances de type pyrethre sont choisies parmi l'~-cyano-3 phénoxybenzyl ~,~-diméthyl 3-~ -dichlorovinyl~ cyclo~
propane carboxylate lCYPERMETHRIN3, 1 ' ~-cyano-3 phénoxy benzyl ~ -chlorophenyl) 3 methyl butyrate (FEl~VALERAT~, le 5-benzyl,3 furylméthyl `,~-dimethyl 3-(--oxo ~,3,4,5 tetrahydro 3-thienylidènemethyl) cyclopropane carboxylate (KADETHRIN~, le 3-pheno~ybenzyl ,,~-dimethyl, 3-(-,~-di-chlorovinyl) cyclopropane carboxylate (PERMETHRINE~, le ~0 (3,4,5,6 tetrahydrophtalimidomethyl) chrysanthemate (NEOPYNAMIN~.
Selon une autre modalité particuliere, les for-mamidines sont choisies parmi le N'-(4-chloro 0 tolyl) NN, diméthylformamidine (CHLORDIMEFO ~, et le N méthyl, N' ~5 ~,4 ~ylyl N (1~ ~, 4 xyllylformamidoyl) formamidine ~AMITRA~).
Conformément à l'invention, les acides gras essentiels insatures libres ou estérifiés, sont choisis dans le groupe qui comprend l'acide oléique, l'acide linolëique, l'acide linolénique, l'acide arachidonique, l'acide 11,14 eicosadiénolque, l'acide docosahexaénoique et leurs esters linéaires ou ramifiés de Cl à C4.
* ~marque de commerce~
p,; ~, ,~i,'^:.';~ `;
. .
Selon un autre mode de réalisation particulière-ment avantageu~, on utilise en tant qu'acides ~ras, de la vitamine F.
Comme support macromoléculaire solide thermo-plastique, on peut utiliser par exemple le polyethylène,le polypropylène, les copolymères d'éthylène et de propyl-ène, les polyacrylates, les polymères vinyliques, les halo-génures de polyvinyle, les acétals de polyvinyle, les com-posés du type polyvinylidène, les polyuréthanes, les poly-10 aldéhydes, etc..., et de preférence les homopolym~-res des chlorures de polyvinyle ou leurs copolymères avec d'autres polymères.
Comme plastifiants nécessaires pour conférer de la souplesse, la résistance mécanique et les caractéristi-15 ques superficielles désirées, on peut utiliser par exempleles esters d'acide phosphorique, telsque le phosphate de tricrésyle, les esters d'acide phtalique tels que le phtalate de méthyle, de butyle, d'octyle, d'éthyle-~-hexyle, les esters d'acides adipique, azéla~que, sébacique, 20 malélque, etc...
Les additifs les plus communément ajoutés,sont des colorants ou pigments, des désodorisants tels que l'éthylvanille, la vanilline, le limonène, etc...; des s t a b i 1 1 s a n t s, I u ~ L' i f i a n t s, 1 e s ~5 c o m p 1 e x e s m é t a 1 1 i q u e s ~de cad~ium, de baryum et de zinc, par exemple) ; d e s r é-gulateurs de diffusion qui ayissent en modifiant la poro-sité de la lanière plastique, par vaporisation ou décompo-sition lors de la fabrication, comme par exemple les 30 dérivés azotés (benzènesulfonylhydrazine, trihydrazino-triazine, etc...) et les dérivés azoïques (azodiisobutyro-nitrile, diazoaminobenzène, azodicarbonamide,etc...).
Comme charges nécessaires pour diminuer la quan-tité de résine et faciliter la mise en oeuvre de la laniere 35 thermoplastique, on peut utiliser le talc, la silice,etc..
~s~
Conformément à l'invention, la composition du dis-positif antiparasitaire comprend de 5 ~ 25 ~ de substance insecticide, de 1 à 10 ~ d'acide gras essentiel insature, de 10 à 50 ~ de support macromoleculaire et de 1 à 15 de divers adjuvants.
Selon un mode de réalisation particulièrement avan-tageux de llobjet de llinvention 7 la substance insecticide associée à l'acide gras est le DIMPYLATE associe à la vitamine F.
En poursuivant plus en avant les recherches, la Demanderesse a constaté que dans certains cas, la nature physicochimique des substances actives telles que notam-ment l'aspect physique-solide ou liquide-, le point de fusion, le point d'ebullition, la tension de vapeur, la stabilité thermique ou chimique etc... ne permettaient pas une diffusion regulière et identique des deux substances à la fois.
Cette vitesse de diffusion pouvait varier meme dans certains cas dans des proportions importantes. Il devenait indispensable, dans certains cas, de tenir compte des propriétés physicochimiques des substances actives (l'insecticide et l'acide gras) afin de choisix un support macromoléculaire convenable, de plastifiants, d'additifs, des charges et des regulateurs de diffusions appropxies, de manière a réaliser un compromis et avoir les vitesses d'élimination des deux substances actives aussi proches que possible sinon sensiblement identiques.
Un des buts de la présente invention est de réali-ser un collier antiparasitaire de manière à pouvoir se libérer des contraintes que pouvait constituer dans cer-tains cas l'incompatibilité entre une substance active et un acide gras essentiel insaturé.
La présente invention a egalement pour objet un collier antiparasitaire pour animaux comportant un dispo-sitif insecticide formé d'au moins une substance insecti-* (marque de commerce) z~
6cide associée a au moins une substance choisie parmi les acides gra~ essentiels insatures de C18 à C22, caracte-rise par le ~ait qu'il se presen~e sous la forme de deux lanieres accolees lateralement pour former une double laniexe mixte, une lanière contenant la substance insec-ticide, l'autre, l'acide gras, chacune des deux parties de lanière contenant des supportset additifs appropries à la substance insecticide et à l'acide gras essentiel insature choisi.
La réalisation de deux lanières de matières plas-tiques contenant chacune l'une des substances actives - les lanières etant accolees lateralement - a permis de satisfaire au maximum aux exigences de diffusion et d'eli-mination.
Selon un mode de realisation particulièrement avan-tageux de l'objet de l'invention, la lanière mixte est obtenue par co-extrusion à chaud.
Selon un autre mode de realisation de l'objet de l'invention, la lanière mixte est obtenue par moulage.
Mais quelque soit le moyen technique d9obtention des la-nières (co-extrusion ou le moulage), il est très facile d'adapter la nature des excipients et du support aux proprietes physicochimiques de chacune des deux substan-ces actives et de fixer ainsi les conditions operatoires.
Il en resulte ~ue tout en conservant la qualite de tolerance decrite, on ameliore grandement l'efficacite du dispositif antiparasitaire et on reduit au maximum les contraintes de fabrication, donc le prix de revient.
Parmi les différentes techniques d'obtention pos-sibles de ces dispositifs conformes à la presente inven-tion, 1.a technique dite de co-extrusion à chaud constitue, à l'echelle de production industrielle, la methode la plus adaptée.
Ce dernier procede - actuellement très utilise dans l'industrie du caoutchouc et des matières plastiques -4~
7conduit à l'obtention par co-extrusion par le passa~e dans une filiere unique ~'une laniere ~ixte ~ partir de l'extru-sion séparée de deux mélanges différents.
En procédant ainsi à la préparation de deux mélanges distincts et appropriés chacun dans leur composition à la nature de la substance active, on réalise un dispositif final plus efficace. Ce type de préparation s'avère surtout souhai-table quand les deux substances actives sont très différentes par ~eu~s pro~riét~s ph~sicochimiques.
C'est ainsi que si les acides gras essentiels insaturés de C-a à C~ ou leurs dérivés estérifiés se présentent sous la for~e de liquides visqueux, les subs-tances insecticides retenues dans cette invention peuvent être des composés liquides (organo-chlorés, organophosphorés, pyrethrinoïdes) ou solides (car-15 bamates, formamidines).
Par ailleurs, chaque groupe de composés se carac-térise également par des points d'ébullition ou de fusion différents, par des tensions de vapeur très éloignées ainsi que par des critères de stabilité thermique ou chimique dif^-20 férentS.
Or, il est connu de l'homme de l'art que la naturedu support macromoléculaire, la nature des plastifiants, la nature des additifs,influent de fa~on considérable sur les vitesses de diffusion donc d'élimination~ donc sur l~acti~
25té mesurée.
A l'évidence, il ressort aue l'association d'un car-bamate et/ou d'une formamidine avec un ester d'acide gras, ne donnera des résultats optimaux que si la composition de chacune des parties est différente.
3~ Le résultat est jugé optimal quand les vitesses de diffusion de chacun des composés sont voisines.
Pour chaque t~pe de substance utilisé, il est donc nécessaire d'adapter la nature des adjuvants et/ou des sup-ports de façon à accélérer ou à freiner l'élimination de l'un 8~Z~
des composés par rapport ~ l'autre pris comme référence.
Dans leur aspect, les nouveaux dispositifs se présentent sous la forme ~'une lanière mixte dorlt les di-mensions respectives de chague partie sont établies sur la base d'éléments divers tels que le pourcentage en ma~tière active, l'activité insecticide et/ou protectrice de la substance ; généralement, elles doivent etre compatibles avec les impératifs de l'obtention d'une lanière pouvant etre utilisée comme collier antiparasitaire pour les ani-maux domestiques (chiens ou chats).
D'une manière générale les dimensions de la lanièrefinale se situent aux environs de 15 à 30 mm pour la largeur et aux environs de 2 à 5 mm pour l'épaisseur, la lon- ~
gueur étant calculée de ~açon à pouvoir etre fixée sur le cou des animaux les plus gros.
Il est évident que des dispositifs adaptés en di-mensions pour chaque type d'animal, chat, chiot, chien, grand chien sont préférables.
Compte-tenu des pourcentages différents, à savoir de 5 à 25 % pour la substance insecticide et de 1 à 10 %
pour les acides gras, les largeurs respectives de chacune des parties seront di~férentes.
En général, les largeurs sont de 10 à 20 mm pour la partie insecticide et de 5 à 10 mm pour la partie acide gras.
La fabrication séparée de chacun des deux mélanges permet l'incorporation de substances colorantes, de pigments, de substances photo--réfléchissantes ou luminescentes dif-férentes pour chacune des parties~
3U Outre les dispositions qui précëdent, l'inven-tion comprend encore d'autres dispositions qul ressorti-ront de la description qui va suivre.
La présente invention vise particulièrement les colliers antiparasitaires pour animaux, conformes aux dis-positions qui precèdent, ainsi que les moyens propres à
5'~
la realisation de ces colliers.
L'invention pourra etre mieux comprise à l'aide du complément de description qui va suivre, qui se r~f~re ~ des exemples de réalisation des dispositifs conformes à la présente invention, ~ des exemples de composition desdits dispositifsl ainsi qu'à un compte-rendu des es-sais cliniques effectués sur animaux.
Il doit ~tre bien entendu, toutefois, que les exemples de mise en oeuvre qui seront décrits ci-après, ainsi que le compte-rendu clinique, sont donnes unique-ment à titre d'illustration de l'objet de l'invention, mais n'en constituent en aucune manière une limitation.
E~EMPLES DE COMPOSITIO~
E~EMP~E 1 ~ Parties en poids 15 DI~PYLATE* ~ principe 15 Linoléate de methyle ~ actif Linolénate de méthyle Adipate d'éthyl-2 hexyle ,0 Huile de soja époxydée Additif -5 20 Stéarate de calcium Oxyde de fer noir 0,5 Silice micronis~e ~ 1,5 Azodicarbonamide ~ , Homopolymère de çhlorure de polyvinyle ~ 49 EXEI~PLE ~ ~
Dll~YLA~L I principe 18 I actif Vitamine F neutre ~ 6 Adipate d'isooctyle ~ ,3 Huile de soja epoxydée / 3 30 Stéarate de calcium ~ Additif Oxyde de fer rou~e 0,5 Silice micronisée Azodicarbonamide Homopolymère de PVC / ~3,5 * (marque de commerce) ~-~ .
....
BE~DI~CAPD ~ 10 Linoléate de methyle ~ principe 1,5 Linolén~te de méthyle ) actif 1,5 Oleate de methyle .
Phtalate de butyle ~ 15 Phtalate de methyle / 10 Huile de soja epoxydee / 5 Stearate de calcium \ Additif 10 Oxyde de fer rouge 0,~5 Oxyde de fer noir 0,,5 Azodicarbonamide Homopolymere de PVC ~ 50,5 EXEMPLE ~ ~
15 ~EI~IOC~ principe 8 ~ actif Vitamine F neutre J 6 Adipate d'isooctyle 10 Adipate de methyle ~ 15 Huile de soja epoxydee ¦Additif 5 20 Stearate de calcium ¦
Azodicarbonamide Homopolymère de PVC ) 5 CYrE?`'ETHRI,'* ~ p~ Ci~ 5 25 Acide docosahexanoate de m'athyle~ actif 6 .
Adipate de butyle ~ 10 Adipate de méthyle 10 Stéarate de calcium Additif Complexe cadmium/baryum ( 30 Silice micronisee ¦ ~
Oxyde de fer noir J 0,5 Homopolymere de PVC 63,5 * (marque de commerce~
sz~
~E~l~ALERATE ~ p-incipe 6 Linolenate de methvle ) actif 3 .
Adipate d'isooctyle ~ 10 Adipate de methyle ¦ 15 Huile de soja epoxydée ( 3 Stéarate de calcium ~ Additif ~omopolymère ae PVC J 6 EXE~IPLE 7 10 AMITRAZ principe 10 Vitamine F neutre~ actif 5 Phtalate d'éthyl-~-hexyl ~ 1~,5 Phtalate de butyle 1 1 ,5 Huile de soja epoxyd-ee ~ Additif 5 15 Stearate de calcium ~ 1,5 Oxyde de fer noir~ 0,5 Oxyde de fer rouge ~ 0,5 Azodicarbonamide J ~,5 Homopolymere de PVC 50 20 EXEMPLE DE FABRICATION D'UN COLLIER
On utilise les substances de l'Exemple `
Dans un recipient approprie, on melange intime-ment 36 kg de DI~'~LATE~*1, kg de vitamine ~ neutre, 46 kg d'adipate d'isooctyle, 6 kg d'huile de soja epoxydee et on 25 colore la solution par l'oxyde de fer rouge (environ 1 kg).
Dans un melangeur chauffant, on introduit 47 kg d'homopolymère de PVC, 4 kg de stearate de calcium, 4 kg de silice micronisee et 4 kg d'azodicarbonamide.
On verse sous agitation la solution precedente dans le m.~lanaeu~ ci-dessu~. nn l;~lange la p9te obtenlie ~usqu'à obtention d'une couleur rouge uniforme. On porte le meIange à une temperature de 70~C environ, et on melange 30 minutes. La poudre ainsi obtenue est introduite dans la tremie d'une extrudeuse à vis. Les paramètres d'extrusion, à savoir la temperature de la filière, la pression de la *(marque de commerce) b . j~
filière, la vitesse d'ex-trusion et la temperature de re-froidissement, sont fixés de fa~on à obtenir une lanière uniforme en aspect et en dimension.
La lanière est ensuite coupée à la longueur`; un système de fermeture est agraffé à l'une des extrémités.
Le collier insecticide obtenu est conditionné
dans des sachets à triple épaisseur (PVC - al~ninium -papier) et soudé.
Ce protocole de fabrication est valable pour tous les Exemples, en y apportant les modifications dues à la nature physique des constituants.
EXEMPLE DE FABRICATION D'UNE DOUBLE LANIERE MIXTE
_ .
On prépare deux mélanges : le mélange A contenant la substance insecticide et le mélange B contenant l'acide gras.
Ces deux mélanges (dont quelques différentes com-positions seront décrites ci-après) sont, après homogé-néisation, in-troduits séparément dans les deux trémies d'une extrudeuse à double système. En sortie, les deux lanières précalibrées en dimensions passent dans une tête de filière commune a l'intérieur de laquelle sleffec-tue le soudage latéral.
Cette étape de fabrication peut etre également réalisée avec l'emploi de deux extrudeuses différentes, reliées en sortie par une tête de filière unique permet-tant l'accolement latéral des deux lanières initiales et leur calibrage définitif au format de la la~ière unique.
Ce système a l'avantage de pouvoir régler, indé-pendamment, les paramètres d'extrusion tels que la tempé-rature de la filière, la pression et la vitesse d'extrusion.
~5~
Exemples'de composition :
Exem~le_~
. Mélanqe A ~ parties en poids Dimpylate [Thionophosphate principe q5 de 0,0'-diethyl,O-(isopropyl-2 acti' méthyl-4 pyrimidinyl-6~
Huile de soja epoxydée ~ 3 Stéarate de Calcium 1 2 Ethyl-2 hexyl phtalate ~ Additif 20 Azodicarbonamide ~ 2 Oxyde de fer rouge ¦ 0,25 Oxyde de fer noir ¦ 0,25 Homopolymère de P.V.C. ~ 57,50 . Mlanqe B ~ ir._ipe Vitamine F neutre ) actif 12 Huile de soja époxydee ~ 3 Phtalate de butyle 25 Pigment jaune Additif 0,5 Carbonate de calcium 5 Stéarate de calcium ~ 2 Homopolymère de P.V.C, J 52,~0 Mél_n~e A
Dans un premier récipient on mélange intimement 32 kg de Dimpylate à 95 %, 6 kg d'huile de soja epoxydée, 40 kg d'ethyl-2 hexyl phtalate et on colore la solution par le mélange des deux oxydes de fer.
Dans un melangeur chauffant, on introduit 50 kg d~omopclymère de P.V.C. et 4 kg d'azodicarbonamide.
On introduit ensuite sous agitation la solution précédente dans le mélangeur, on chauffe pendant 30 ~n à
70 C, puis on compléte par la quantité restante d'homo-polymère de P.V.C. On agite en refroidissant jusgu'à l'ob-tention d'une poudre sèche et homogène de coloration uni-forme marron.
* (marque de commerce) ~,, .,,,, ~
~s~
M~lan~e B
_ _ _ _ _ _ _ _ On procéde de la m~me façon qu'en A, en prenant la précaution de travailler à une température n'excéaant pas 40~ C. On introduit la poudre du mélange A dans la tremie d'une extrudeuse et la poudre du mélange B dans la trémie de l'autre extrudeuse.
Les températ~res des ilières sont, respectivement, de 100 C pour A et de 90D C pour B, la filière de coex-trusion étant réglée à une température de 9oD C.
l0 ~n sortie de filière, la lanière mixte obtenue est refroidie par passage dans un bain ~'eau froide.
La lanière est ensuite coupee aux longueur_ souhaitées~ un système de fermeture (boucle) est agrafé à
l'une des extrémités.
15 Les critères de ~imensions fixés par la forme de la filière sont lessuivants :
. Largeur totale 15 mm . Largeur de la partie insecticide ~marron) 1o mm . Largeur de la partie acide gras (jaune) 5 mm . ~paisseur 3 mm Exemple g . M~lan~e A ~ partie~ en poids Amitraze~[N-méthyl, N' 2,4 ~ principe 8 xylyl N (N 2,~ xylylforma- J actif midovl) formamidine~
Adipate d'octyle ~ 25 Stéarate de calcium ( 2 Huile de SOja époxydée J Aclditif 12,5 Pigment blanc Homopolymère de P.V.C. 46,5 * (marque de commerce) ?
,. .~ . ..
~sz~
, M~l~n~e B
Linoléate de méthyle \ principe Linol~énate de méthyle J actif t,5 Oléate de méthyle 2 Phtalate ~e butyle ~ 20 Huile de soja époxydée ~ 5 Stéarate de calcium ~ Additif 2 Carbonate f3e calcium ~ 15 Oxyde de fer noir l 0,5 Homopolymère de P.V.C. J 52~5 On procéde ensuite à la fabrication et à l'extru-sion comme décrit dans l'exemple 8.
Avec les sp~cifications de la filière de co-extru-sion, on obtient une lanière blanche et noire dont les di-lS mencions sont les suivantes :
. Largeur totale 20 ~m . Largeur de la partie insecticide (blanche) 15 mm . La~geur de la partie acide gras (noire) 5 mm . Epaicseur totale 2,5 mm 20 Exemple lf . Mélan~e A ~ parties en poids Propo~ur*lN-~éthyl carbamateJ principe 1o d'isopropoxy-2 phényle Diéthylphtalate ~ 20 Dibutylphtalate / 5 Stéarate de calcium ~ Additif 5 Huile de soja époxydée ~ 5 ~zodicarbonamide ~ I
Oxyde de fer noir ~ 0,5 Homopolymère de P.V.C. . 53,5 .
* (marque de co~merce) s,~,,, . Mélan~e B
Llnoléate de méthyle j P~ctifP l5 Dibutylphtalate ~ 2 Stéarate de calcium ¦ 5 I Additif Carbonate de calcium 'l l5 Colorant jaune Homopolymère de P.V.C. J 44 La lanière mixte oDtenue après co-extrusion, a les spécifications suivantes :
. Largeur totale ~5 mm . Largeur de la partie insecticide (noire) 1~ mm . Largeur de la partie acide gras (jaune) 5 mm . Epaisseur totale 3 mm ESSAIS CLINIQUES
Sur une population animale comportant des chiens et des chats, d'âge et de race différents, de nombreuses constatations cliniques ont montré l'apparition d'affec-tions cutanées diverses dues au port du collier insec-ticide.
L'incorporation d'acides gras essentiels insatu-rés de C18 à C2~ libres ou estérifiés, et en particulier d'acides en C18 constitutifs de la vitamine F à un collier insecticide, permet de minimiser ces manifestations cuta-nées.
PREMIER ESSAI DE COMPARAISON
L'essai consiste a traiter deux populations (P
et P2), de chiens de sexe, d'âge et de race différents.
Chaque population comprend 500 individus.
L'essai est conduit pendant une période de 10 semaines, l'état des animaux étant vérifié toutes les deux semaines après la fixation du collier.
Les affectations cutanées prises en considération durant l'expérience sont :
- les desquamations - les érythèmes ~52~
- le prurit - la chute de poils au niveau du cou.
La Composition des colliers (% en poids) étudiée, est la sui~ante : .
Collier Cl Collier C2 (conforme a l'invention) DIMPYLATE* 15 15 Vitamine F neutre 6 10 Adipate d'isooctyle 20 20 Huile de soja époxydée 5 5 Stéarate de calcium 2 ?
Oxyde de fer rouge 0,5 0,5 Silice micronisée 2 2 15 Azodicarbonamide 2 2 Homopolymère de PVC 47,5 53,5 ~ es colliers de type Cl sont fixes sur les ani-maux de la population Pl.
Les colliers de type C2 sont fixés sur les ani-maux de la population P2.
Le tableau I regroupe les resultats des observa-tions, les chiffres indiquant le nombre d'animaux presen-tant les signes d'intolerance locale.
TABLEAU I
_ I t 1 2eme 1 4eme ¦6eme l8eme 1 10ème Isemaine~ semaine~semaine+semaine~semaine Population P1 j 0 j 0 1 1 ¦ 1 j 2 ----~-- , , t Population P2 j 3 j 3 j 4 1 5 j 6 _________________~_______I________~_______~_______~_______ DE~XIEME ESSAI DE COMP~RAISON
~ n essai comparatif identique est effectué avec deux populations de chats Pl et P2 portant les colliers C
et C2 de l'Exemple précédent.
* (marque de commerce) t~
~s~
Les résultats sont reqroupes dans le Tableau II.
TABLEAU II
__ ~ème ~eme 6eme 8ème 10eme semaine semaine semaine semaine semaine Population ~1 1 1 1 10 Population P~ 4 4 5 5 - 7 Dans les essais 1 et -`, les deux compositions de colliers C1 et C~ sont efficaces a 95 % pour éliminer les parasites présents sur les animaux (puces et tiques).
Les animaux exempts de parasites sont protéges a 100 % pendant les 10 semaines de l'expérience.
Dans ce cas, les phénomenes d'intolérance locale sont dûs uniquement au port du collier et non d~s au grat-tage excessif ou aux mutilations provoqués par la présence des puces.
T~OISI~ME ESSAI
On selectionne les six chiens ayant porte le col-lier C~ (cf. essai 1), et les sept chats ayant porté le collier C (cf. essai ~`).
Tous les animaux présentent des réactions cuta-nées. On leur enleve le collier C~ et on leur place le col-lier Cl.
On observe ces animaux pendan~ cinq semaines.
Les résultats (cf. Tableau III) montrent que la formulation conforme a l'invention (enrichie à la vitamine F neutre), permet la disparition des réactions cutanées en très peu de temps.
TABLEA~ III
n~brç lère ~eme 3eme ~eme 5eme d ndl- semaine semaine semaine semaine semaine Chiens P~ 6 ~ ~ 1 1 Chats P~ 7 3 ~ _ ~
Ainsi que cela ressort de ce qui precede, l'in-vention ne se limite nullement à ceux de ses modes de realisation et d'application qui viennent d'etre decrits de façon plus explicite ; elle en embrasse, au contraire, toutes les variantes qui peuvent venir à l'esprit du tech-nicien en la matière, sans s'ecarter du cadre, ni de la portee, de la presente invention. The present invention relates to perfec-of the anti-parasitic collars for animals. For some time now, we have been using devices capable of gradually releasing an insecticide for the protection of animals against parasites, and in particular against ectoparasites. The most of these devices are constituted by an insecti-cide included in a plastic matrix. Liberation slow ration of the ectoparasiticide product (whether it acts by its vapor or that it is deposited on the animal's hair), provides effective protection against parasites during several months.
These different pest control devices and which have been the subject of numerous patents (in particular the Applicant's French patents, 447,679,, 69,859, 307 ~ 66, ~ 436 563, 370 57 ~ `13 01 ~ 374 853, ~ 386 ~ 53, `386 ~ 5 ~, ~ 39. 606), are essentially com-posed of three basic elements:
- insecticide (or mixture of insecticides), GO - the support (generally based on a thermo-resin plastic), - adjuvants (such as plasticizers, regulators of diffusion, etc ...) The choice of each of these three constituents of `5 base is very important. It is indeed imperative to have an effective device against parasites, diffusing slowly and steadily and perfectly harmless as well for the animal as for its entourage, and in particular-ment for young children.
If most of the disadvantages of these anti-parasitic collars res could be elir ~ born and difficulties of all kinds overcome, there remains, however, a drawback and of great ir ~ ortance.L'anir ~, very quickly or after a certain period of use, has pheno-~ allergic symptoms resulting in local disorders: redness of the ; 35 skin, eczema, tarnishing of the hair, loss of flexibility of the skin, etc.
and / or by aenera ~ disorders: clothing, weight loss, etc ...
, ~.
z ~
The present invention is therefore cons ~ uent set to provide devices and collars ectoparasiticides that better respond to the needs of practice that devices aimed at the same goal previously known, in particular in that they suppress in total animal skin disorders, while keeping a high efficiency of action for a long time period.
The subject of the present invention is a necklace antiparasitic for animals, characterized in that it comprises insecticide device ~ with at least one substance insecticide associated with at least one selected substance among the unsaturated essential fatty acids from C18 to C2 ~, said device further comprising a support macromolecular solid thermoplastic and at least an adjuvant chosen from the group comprising plastics fiants, inert fillers, dyes, deso-dorisants, stabilizers and flow regulators if we.
The Claimant's very great experience in the field of pest control animals, enabled him to note that in the long run the into-the resistance to the insecticide collar was due to the deficiency in certain fatty acids necessary for the epithelial system of the animal.
According to an advantageous embodiment of object of the invention, the insecticidal substance is ; chosen from organochlorine and / or organo-phosphorus and / or carbamate, and / or pyrethrum and / or : 30 formamidines.
According to a particular modality of this mode of realization, organochlorine substances are chosen in the group ~ ui includes:
:
~. . .
S2 ~
- 2a -- 2,2-dichlorovinyl and dimethyl phosphate (DDVP) - 1,2-dibromo-2,2-dichloroethyl phosphate and methyl (NALED) *, - 2-chloro, 12,4,5-trichlorophenyl) -vinyl phosphate S and dimethyl (STIRIFoS ~.
*(trademark) ~ -`D.
.
~ s ~
5According to another particular modality, the substance n-this organophosphor ~ e is chosen from the group which comprises 0,0'-diethyl thionophosphate, 0- (isopropyl- ~ m ~ thyl-4 pyrimidinyl - 6) ~ DIMPYLATE) and 0.0 diethyl phosphate O ~ (isopropyl- ~ methyl-4 pyrimidinyl-6) (DIAZOXON).
According to another particular modality, the carbamates are chosen from N-methyl carbamate dimethyl ~ benzodioxol-1,3 ol ~ 4 (BENDIOCA ~, N-methyl isopropoxy- ~ phenyl carbamate (PROPOXU ~, N-methyl l-naphthyl carbamate (CARBARYL ~.
According to another particular modality, the pyrethrum-type substances are chosen from ~ -cyano-3 phenoxybenzyl ~, ~ -dimethyl 3- ~ -dichlorovinyl ~ cyclo ~
propane carboxylate lCYPERMETHRIN3, 1 '~ -cyano-3 phenoxy benzyl ~ -chlorophenyl) 3 methyl butyrate (FEl ~ VALERAT ~, 5-benzyl, 3 furylmethyl `, ~ -dimethyl 3 - (- oxo ~, 3,4,5 tetrahydro 3-thienylidènemethyl) cyclopropane carboxylate (KADETHRIN ~, 3-pheno ~ ybenzyl ,, ~ -dimethyl, 3 - (-, ~ -di-chlorovinyl) cyclopropane carboxylate (PERMETHRIN ~, the ~ 0 (3,4,5,6 tetrahydrophthalimidomethyl) chrysanthemate (NEOPYNAMIN ~.
According to another particular modality, the mamidines are chosen from N '- (4-chloro 0 tolyl) NN, dimethylformamidine (CHLORDIMEFO ~, and N methyl, N ' ~ 5 ~, 4 ~ ylyl N (1 ~ ~, 4 xyllylformamidoyl) formamidine ~ AMITRA ~).
According to the invention, the fatty acids essential free or esterified insatures, are chosen in the group that includes oleic acid, acid linolenic, linolenic acid, arachidonic acid, 11.14 eicosadienolic acid, docosahexaenoic acid and their linear or branched esters from C1 to C4.
* ~ trademark ~
p ,; ~, , ~ i, '^ :.'; ~ `;
. .
According to another particular embodiment-ment advantageous ~, we use as acids ~ ras, the vitamin F.
As a solid macromolecular support plastic, one can use for example polyethylene, polypropylene, copolymers of ethylene and propyl-ene, polyacrylates, vinyl polymers, halo-polyvinyl genides, polyvinyl acetals, polyvinylidene type, polyurethanes, poly-10 aldehydes, etc ..., and preferably homopolymers ~ -res polyvinyl chlorides or their copolymers with others polymers.
As plasticizers necessary to impart flexibility, mechanical strength and characteristics As desired, there may be used, for example, phosphoric acid esters, such as phosphate tricresyl, phthalic acid esters such as methyl phthalate, butyl, octyl, ethyl- ~ -hexyl, esters of adipic acids, azéla ~ que, sebacique, 20 Malelque, etc ...
The most commonly added additives are dyes or pigments, deodorants such as ethyl vanilla, vanillin, limonene, etc ...; of stabi 1 1 sants, I u ~ L 'ifiants, 1 es ~ 5 comp 1 exesm é ta 1 1 iques ~ of cad ~ ium, barium and zinc, for example); desr é-diffusion gulators which have by modifying the poro-plastic strap, by spraying or decomposing sition during manufacture, such as for example 30 nitrogen derivatives (benzenesulfonylhydrazine, trihydrazino-triazine, etc.) and azo derivatives (azodiisobutyro-nitrile, diazoaminobenzene, azodicarbonamide, etc.).
As charges necessary to decrease the amount resin and facilitate the implementation of the strap 35 thermoplastic, talc, silica, etc. can be used ~ s ~
According to the invention, the composition of the dis-pest control positive includes 5 ~ 25 ~ of substance insecticide, from 1 to 10 ~ of unsaturated essential fatty acid, from 10 to 50 ~ of macromolecular support and from 1 to 15 various additives.
According to a particularly advantageous embodiment the object of the invention 7 the insecticidal substance associated with fatty acid is DIMPYLATE associated with vitamin F.
By pursuing research further, the Applicant has found that in certain cases, the nature physicochemical of active substances such as in particular the physical aspect - solid or liquid -, the point of melting, boiling point, vapor pressure, thermal or chemical stability etc ... did not allow regular and identical distribution of the two substances at a time.
This diffusion speed could vary even in some cases in significant proportions. he became essential, in some cases, to take into account physicochemical properties of active substances (insecticide and fatty acid) in order to choose a support suitable macromolecular, plasticizers, additives, loads and appropriate broadcast regulators, so as to achieve a compromise and have the speeds elimination of the two active substances as close together as possible if not substantially identical.
One of the aims of the present invention is to realize wear a pest control collar so that you can free from the constraints that could constitute in certain some cases the incompatibility between an active substance and an unsaturated essential fatty acid.
The present invention also relates to a pest control collar for animals with a provision insecticide spray consisting of at least one insecticidal substance * (trademark) z ~
6cide associated with at least one substance chosen from essential fatty acids ~ unsaturated from C18 to C22, character-made by the ~ that it is presented in the form of two straps joined laterally to form a double mixed laniexe, a lanyard containing the substance ticide, the other, fatty acid, each of the two parts of strap containing suitable supports and additives insecticide and essential fatty acid insature chosen.
The production of two strips of plastics-ticks each containing one of the active substances - the straps being joined laterally - allowed to meet as much as possible the distribution and eli-mination.
According to a particularly advantageous embodiment tagging the subject of the invention, the mixed strap is obtained by hot co-extrusion.
According to another embodiment of the object of the invention, the mixed strap is obtained by molding.
But whatever the technical means of obtaining the ners (co-extrusion or molding), it is very easy to adapt the nature of the excipients and of the support to physicochemical properties of each of the two substances these assets and thus to set the operating conditions.
This results while maintaining the quality of tolerance described, the efficiency is greatly improved of the pest control device and reduce as much as possible manufacturing constraints, therefore the cost price.
Among the different techniques for obtaining pos-of these devices in accordance with the present invention tion, 1.a so-called hot co-extrusion technique constitutes, on the industrial production scale, the most adapted.
The latter process - currently widely used in rubber and plastics industry -4 ~
7 leads to obtaining by co-extrusion by the pass ~ e in a single die ~ 'a strap ~ ixte ~ from the extru-separate separation of two different mixtures.
By doing so preparing two mixtures distinct and appropriate each in their composition to the nature of the active substance, a final device is produced more efficient. This type of preparation is especially desirable.
table when the two active substances are very different by ~ eu ~ s pro ~ riét ~ s ph ~ sicochemicals.
This is how if unsaturated essential fatty acids Ca to C ~ or their esterified derivatives are in the form of ~
viscous liquids, insecticidal substances retained in this invention can be liquid compounds (organo-chlorinated, organophosphorous, pyrethrinoid) or solid (car-15 bamates, formamidines).
In addition, each group of compounds is characterized also terrifies by boiling or melting points different, by very distant vapor pressures as well only by criteria of thermal or chemical stability dif ^ -20 férentS.
However, it is known to those skilled in the art that the nature of the macromolecular support, the nature of the plasticizers, the nature of the additives, have a considerable influence on the diffusion speeds therefore elimination ~ therefore on the acti ~
25ty measured.
Obviously, it emerges from the association of a bamate and / or a formamidine with a fatty acid ester, will only give optimal results if the composition of each part is different.
3 ~ The result is considered optimal when the diffusion of each of the compounds are neighboring.
For each t ~ pe of substance used, it is therefore necessary to adapt the nature of the adjuvants and / or the ports so as to speed up or slow the elimination of one 8 ~ Z ~
compounds compared to the other taken as a reference.
In their appearance, the new devices are have the form ~ 'a mixed strap dorlt the di-respective chague part mensions are established on the base of various elements such as the percentage in ma ~ tiere active, the insecticidal and / or protective activity of the substance; generally they must be compatible with the imperatives of obtaining a strap that can be used as a pest control collar for animals domestic ailments (dogs or cats).
Generally the dimensions of the end strap are around 15 to 30 mm for the width and around 2 to 5 mm for the thickness, the length ~
gueur being calculated from ~ açon to be able to be fixed on the neck of the largest animals.
It is obvious that devices adapted in di-mensions for each type of animal, cat, puppy, dog, large dogs are preferable.
Given the different percentages, namely from 5 to 25% for the insecticide substance and from 1 to 10%
for fatty acids, the respective widths of each parts will be different.
In general, the widths are 10 to 20 mm for the insecticide part and 5 to 10 mm for the acid part bold.
The separate production of each of the two mixtures allows the incorporation of coloring substances, pigments, of diffuse photo-reflective or luminescent substances for each of the parties ~
3U In addition to the foregoing, the invention tion also includes other provisions which from the description which follows.
The present invention particularly relates to antiparasitic collars for animals, compliant with preceding positions, as well as the means specific to 5 '~
making these necklaces.
The invention can be better understood using of the additional description which follows, which is referred to ~ examples of implementation of compliant devices to the present invention, ~ examples of composition said devicesl as well as a report of the know clinical performed on animals.
It should be understood, however, that examples of implementation which will be described below, as well as the clinical report, are given only-by way of illustration of the subject of the invention, but in no way constitute a limitation.
E ~ EMPLES OF COMPOSITIO ~
E ~ EMP ~ E 1 ~ Parts by weight 15 DI ~ PYLATE * ~ principle 15 Methyl linoleate ~ active Methyl linolenate 2-ethylhexyl adipate, 0 Epoxidized soybean oil Additive -5 20 Calcium stearate Black iron oxide 0.5 Micronis silica ~ e ~ 1.5 Azodicarbonamide ~, Polyvinyl chloride homopolymer ~ 49 EXEI ~ PLE ~ ~
Dll ~ YLA ~ LI principle 18 I active Vitamin F neutral ~ 6 Isooctyle adipate ~, 3 Epoxidized soybean oil / 3 30 Calcium stearate ~ Additive Red iron oxide 0.5 Micronized silica Azodicarbonamide PVC homopolymer / ~ 3.5 * (trademark) ~ - ~.
....
BE ~ DI ~ CAPD ~ 10 Methyl linoleate ~ principle 1.5 Linolén ~ te de methyl) active 1,5 Methyl oleate .
Butyl phthalate ~ 15 Methyl phthalate / 10 Epoxy soybean oil / 5 Calcium stearate \ Additive 10 Red iron oxide 0, ~ 5 Black iron oxide 0, 5 Azodicarbonamide PVC homopolymer ~ 50.5 EXAMPLE ~ ~
15 ~ EI ~ IOC ~ principle 8 ~ active Vitamin F neutral J 6 Isooctyle adipate 10 Methyl adipate ~ 15 Epoxy soybean oil ¦Additive 5 20 Calcium stearate ¦
Azodicarbonamide PVC homopolymer) 5 CYrE? `` ETHRI, '* ~ p ~ Ci ~ 5 25 Docosahexanoate acid from m'athyle ~ active 6 .
Butyl adipate ~ 10 Methyl adipate 10 Calcium stearate Additive Cadmium / barium complex ( 30 Micronized silica ¦ ~
Black iron oxide J 0.5 PVC homopolymer 63.5 * (trademark ~
sz ~
~ E ~ l ~ ALERATE ~ p-incipe 6 Methvle linolenate) active 3 .
Isooctyle adipate ~ 10 Methyl adipate ¦ 15 Epoxidized soybean oil (3 Calcium stearate ~ Additive ~ PVC J 6 omopolymer EXE ~ IPLE 7 10 AMITRAZ principle 10 Vitamin F neutral ~ active 5 Ethyl phthalate ~ ~ -hexyl ~ 1 ~, 5 Butyl phthalate 1 1, 5 Epoxidized soybean oil ~ Additive 5 15 Calcium stearate ~ 1.5 Black iron oxide ~ 0.5 Red iron oxide ~ 0.5 Azodicarbonamide J ~, 5 Homopolymer of PVC 50 We use the substances of Example `
In a suitable container, mix intimately ment 36 kg DI ~ '~ LATE ~ * 1, kg of vitamin ~ neutral, 46 kg isooctyl adipate, 6 kg of epoxy soybean oil and 25 colors the solution with red iron oxide (about 1 kg).
47 kg are introduced into a heated mixer PVC homopolymer, 4 kg calcium stearate, 4 kg micronized silica and 4 kg of azodicarbonamide.
The previous solution is poured with stirring in the m. ~ lanaeu ~ above ~. nn l; ~ lange la p9te obtlie ~ until a uniform red color is obtained. We wear mix at a temperature of around 70 ~ C, and mix 30 minutes. The powder thus obtained is introduced into the hopper of a screw extruder. Extrusion parameters, namely the die temperature, the pressure of the *(trademark) b. i ~
die, the extrusion speed and the return temperature cooling, are fixed in a way to obtain a strap uniform in appearance and size.
The strap is then cut to length; a closure system is stapled at one end.
The insecticide collar obtained is conditioned in triple thickness bags (PVC - al ~ ninium -paper) and welded.
This manufacturing protocol is valid for all Examples, making changes due to the physical nature of the constituents.
EXAMPLE OF MANUFACTURE OF A DOUBLE MIXED STRAP
_.
Two mixtures are prepared: mixture A containing the insecticidal substance and the mixture B containing the acid bold.
These two mixtures (some of which are different positions will be described below) are, after homogeneous-neization, introduced separately in the two hoppers of a dual system extruder. On exit, the two precalibrated strips in dimensions pass in a common die head inside which sleffec-kills side welding.
This manufacturing step can also be produced using two different extruders, connected at the output by a single die head allows both the lateral joining of the two initial strips and their final calibration in the format of the single ~ ière.
This system has the advantage of being able to adjust, independently meanwhile, extrusion parameters such as temperature erasure of the die, pressure and speed of extrusion.
~ 5 ~
Examples of composition:
Example ~ le_ ~
. Mixture A ~ parts by weight Dimpylate [Thionophosphate principle q5 of 0,0'-diethyl, O- (isopropyl-2 acti ' 4-methylpyrimidinyl-6 ~
Epoxidized soybean oil ~ 3 Calcium stearate 1 2 2-Ethyl hexyl phthalate ~ Additive 20 Azodicarbonamide ~ 2 Red iron oxide ¦ 0.25 Black iron oxide ¦ 0.25 PVC homopolymer ~ 57.50 . Mlanqe B ~ ir._ipe Vitamin F neutral) active 12 Epoxy soybean oil ~ 3 Butyl phthalate 25 Yellow pigment Additive 0.5 Calcium carbonate 5 Calcium stearate ~ 2 Homopolymer of PVC, J 52, ~ 0 E-mail A
In a first container we mix intimately 32 kg of 95% Dimpylate, 6 kg of epoxidized soybean oil, 40 kg of ethyl-2 hexyl phthalate and the solution is colored by mixing the two iron oxides.
50 kg are introduced into a heated mixer d ~ omopclymère of PVC and 4 kg of azodicarbonamide.
The solution is then introduced with stirring previous in the mixer, heating for 30 ~ n to 70 C, then complete with the remaining amount of homo-PVC polymer Agitate while cooling until it reaches use of a dry and homogeneous powder of uniform coloring brown shape.
* (trademark) ~ ,,. ,,,, ~
~ s ~
M ~ lan ~ e B
_ _ _ _ _ _ _ _ We proceed in the same way as in A, taking the precaution of working at a temperature not exceeding step 40 ~ C. The powder of mixture A is introduced into the hopper of an extruder and the powder of mixture B in the hopper of the other extruder.
The temperatures of the islands are, respectively, 100 C for A and 90 C for B, the coex-trusion being set at a temperature of 9oD C.
l0 ~ n outlet of the die, the mixed strap obtained is cooled by passage through a bath ~ 'cold water.
The strap is then cut to length_ desired ~ a closure system (loop) is stapled to one of the ends.
15 The criteria of ~ imensions fixed by the form of the sector are the following:
. Total width 15 mm . Width of insecticide part ~ brown) 1o mm . Width of the fatty acid part (yellow) 5 mm . ~ thickness 3 mm Example g . M ~ lan ~ e A ~ part ~ by weight Amitraz ~ [N-methyl, N '2,4 ~ principle 8 xylyl N (N 2, ~ xylylforma- J active midovl) formamidine ~
Octyl adipate ~ 25 Calcium stearate (2 Epoxidized SOJ Oil J Aclditive 12.5 White pigment Homopolymer of PVC 46.5 * (trademark) ?
,. . ~. ..
~ sz ~
, M ~ l ~ n ~ e B
Methyl linoleate \ principle Linol ~ methyl enate J active t, 5 Methyl oleate 2 Phthalate ~ butyl ~ 20 Epoxidized soybean oil ~ 5 Calcium stearate ~ Additive 2 Carbonate f3e calcium ~ 15 Black iron oxide l 0.5 PVC homopolymer J 52 ~ 5 We then proceed to manufacture and extrude sion as described in Example 8.
With the specifications of the co-extrusion sector zion, we get a white and black strap whose di-They are as follows:
. Total width 20 ~ m . Width of insecticide part (white) 15 mm . The size of the fatty acid part (black) 5 mm . 2.5mm total thickness 20 Example lf . Melan ~ e A ~ parts by weight Propo ~ ur * lN- ~ ethyl carbamateJ principle 1o 2-isopropoxyphenyl Diethylphthalate ~ 20 Dibutylphthalate / 5 Calcium stearate ~ Additive 5 Epoxidized soybean oil ~ 5 ~ zodicarbonamide ~ I
Black iron oxide ~ 0.5 PVC homopolymer. 53.5 .
* (trade mark) s, ~ ,,, . Melan ~ e B
Methyl lloleate j P ~ ctifP l5 Dibutylphthalate ~ 2 Calcium stearate ¦ 5 I Additive Calcium carbonate 'l l5 Yellow dye Homopolymer of PVC J 44 The mixed strap obtained after co-extrusion has the following specifications:
. Total width ~ 5 mm . Width of insecticide part (black) 1 ~ mm . Width of the fatty acid part (yellow) 5 mm . Total thickness 3 mm CLINICAL TESTS
On an animal population comprising dogs and cats, of different ages and breeds, many clinical findings have shown the onset of affect various skin conditions due to the wearing of the insect collar ticide.
The incorporation of unsaturated essential fatty acids res from C18 to C2 ~ free or esterified, and in particular of C18 acids that make up vitamin F on a necklace insecticide, can minimize these cutaneous manifestations born.
FIRST COMPARISON TEST
The trial consists of treating two populations (P
and P2), dogs of different sex, age and breed.
Each population includes 500 individuals.
The test is conducted for a period of 10 weeks, the condition of the animals being checked every two weeks after attaching the collar.
Skin conditions taken into consideration during the experience are:
- flaking - erythema ~ 52 ~
- pruritus - hair loss at the neck.
The Composition of the necklaces (% by weight) studied, is the following:.
Cl necklace C2 necklace (conform to the invention) DIMPYLATE * 15 15 Vitamin F neutral 6 10 Isooctyle adipate 20 20 Epoxidized soybean oil 5 5 Calcium stearate 2?
Red iron oxide 0.5 0.5 Micronized silica 2 2 15 Azodicarbonamide 2 2 PVC homopolymer 47.5 53.5 ~ Cl type collars are fixed on the ani-ills of the population Pl.
Type C2 collars are attached to the ani-ills of the P2 population.
Table I groups the results of the observations the figures showing the number of animals presented both the signs of local intolerance.
TABLE I
_ I t 1 2nd 1 4th 4th l 6th 18th 1 10th Week ~ week ~ week + week ~ week Population P1 d 0 d 0 1 1 ¦ 1 d 2 ---- ~ -,, t Population P2 d 3 d 3 d 4 1 5 d 6 _________________ ~ _______ I ________ ~ _______ ~ _______ ~ _______ OF ~ XITH COMPETATION TEST ~ REASON
~ n identical comparative test is carried out with two populations of cats Pl and P2 wearing the collars C
and C2 of the previous Example.
* (trademark) t ~
~ s ~
The results are grouped in Table II.
TABLE II
__ ~ th ~ th 6th 8th 10th week week week week week Population ~ 1 1 1 1 10 Population P ~ 4 4 5 5 - 7 In tests 1 and -`, the two compositions of C1 and C ~ collars are 95% effective in eliminating parasites present on animals (fleas and ticks).
Pest-free animals are protected 100% during the 10 weeks of the experiment.
In this case, the phenomena of local intolerance are due only to the wearing of the necklace and not due to the excessive age or mutilation caused by the presence lice or fleas.
T ~ OISI ~ TRY ME
We select the six dogs having worn the collar-link C ~ (cf. test 1), and the seven cats which carried the collar C (see test ~ `).
All animals show skin reactions born. We remove the collar C ~ and we place the collar link Cl.
These animals are observed for five weeks.
The results (cf. Table III) show that the formulation in accordance with the invention (enriched with vitamin F neutral), allows the disappearance of skin reactions in very little time.
TABLEA ~ III
n ~ brç lère ~ eme 3rd ~ eme 5th d ndl- week week week week week Dogs P ~ 6 ~ ~ 1 1 Cats P ~ 7 3 ~ _ ~
As is clear from the above, the information vention is by no means limited to those of its modes of realization and application which have just been described more explicitly; on the contrary, it embraces all the variations that can come to mind from tech-nician in the matter, without departing from the framework, nor from the scope, of the present invention.
Claims (18)
au moins une substance choisie parmi les acides gras essentiels insaturés de C18 à C22, ledit dispositif se composant en outre d'un support macromoléculaire solide thermoplastique et d'au moins un adjuvant choisi dans le groupe comprenant les plastifiants, les charges inertes, les colorants, les désodorisants, les stabilisants et les régulateurs de diffusion. 1. Pest control collar for animals characterized in that it includes an insecticide device formed from at least one insecticidal substance associated with at least one substance chosen from fatty acids unsaturated essentials from C18 to C22, said device is further component of a solid macromolecular support thermoplastic and at least one adjuvant chosen from the group comprising plasticizers, inert fillers, dyes, deodorants, stabilizers and broadcast regulators.
en ce que les carbamates sont choisis dans le groupe comprenant le N-méthyl carbamate de diméthyl-2,2 benzo-dioxol-1,3 ol-4, le N-méthyl carbamate d'isopropoxy-2 phényl et le N-méthyl carbamate de 1-naphtyl. 5. Necklace according to claim 2, characterized in that the carbamates are chosen from the group including 2,2-dimethylbenzo- N-methyl carbamate 1,3-dioxol ol-4, isopropoxy-2 N-methyl carbamate phenyl and 1-naphthyl N-methyl carbamate.
en ce que les substances du type pyrèthre sont choisies dans le groupe comprenant l'.alpha.-cyano-3 phénoxybenzyl 2,2-diméthyl 3-(2,2-dichlorovinyl)cyclopropane carboxylate, l'.alpha.-cyano-3 phénoxybenzyl 2-(4-chlorophényl) 3-méthyl butyrate, le 5-benzyl, 3-furylméthyl 2,2-diméthyl 3-(2-oxo 2,3,4,5 tétrahydro 3-thiénylidèneméthyl) cyclopropane carboxylate, le 3-phénoxybenzyl, 2,2-diméthyl,3-(2,2-dichlorovinyl) cyclopropane carboxylate et le (3,4,5,6 tétrahydrophtalimidométhyl) chrysantémate. 6. Necklace according to claim 2, characterized in that pyrethrum-like substances are chosen in the group comprising alpha.-3-cyano-phenoxybenzyl 2,2-dimethyl 3- (2,2-dichlorovinyl) cyclopropane carboxylate, alpha.-3-cyano-phenoxybenzyl 2- (4-chlorophenyl) 3-methyl butyrate, 5-benzyl, 3-furylmethyl 2,2-dimethyl 3- (2-oxo 2,3,4,5 tetrahydro 3-thienylidenemethyl) cyclopropane carboxylate, 3-phenoxybenzyl, 2,2-dimethyl, 3- (2,2-dichlorovinyl) cyclopropane carboxylate and (3,4,5,6 tetrahydrophthalimidomethyl) chrysantemate.
en ce que les formamidines sont choisies dans le groupe comprenant le N'-(4-chloro 0 tolyl) NN, diméthylformami-dine et le N-méthyl, N' 2,4 xylyl N (N 2,4-xylyformamidoyl) formamidine. 7. Necklace according to claim 2, characterized in that formamidines are selected from the group comprising N '- (4-chloro 0 tolyl) NN, dimethylformami-dine and N-methyl, N '2,4 xylyl N (N 2,4-xylyformamidoyl) formamidine.
en ce que les acides gras essentiels insaturés libres ou estérifiés, sont choisis dans le groupe comprenant l'acide oléique, l'acide linoléïque, l'acide linolénique, l'acide arachidonique, l'acide 11,14 eicosadiénoïque, l'acide docosahexanoïque et leurs esters linéaires ou ramifiés de C1 à C4. 8. Necklace according to claim 1, characterized in that the free unsaturated essential fatty acids or esterified, are chosen from the group comprising oleic acid, linoleic acid, linolenic acid, arachidonic acid, 11,14 eicosadienoic acid, docosahexanoic acid and their linear esters or branched from C1 to C4.
en ce que l'on utilise en tant qu'acides gras, de la vitamine F. 9. Necklace according to claim 1, characterized in what is used as fatty acids, vitamin F.
en ce qu'il comprend de 5 à 25% de substance insecti-cide, de 1 à 10% d'acide gras essentiel insaturé, de 10 à 50% de support macromoléculaire et de 1 à 15%
de divers adjuvants. 10. Necklace according to claim 1, characterized in that it comprises from 5 to 25% of insecticidal substance cide, from 1 to 10% of unsaturated essential fatty acid, 10 to 50% macromolecular support and 1 to 15%
various additives.
en ce que le dispositf est essentiellement constitué
par l'association thionophosphate de 0,0'-diéthyl, 0-(isopropyl-2 méthyl-4 pyrimidinyl-6)-Vitamine F. 11. Necklace according to claim 1, characterized in that the device is essentially constituted by the 0.0'-diethyl thionophosphate association, 0- (2-isopropyl-4-methylpyrimidinyl-6) -Vitamin F.
en ce que la lanière mixte est obtenue par co-extrusion à chaud. 13. Necklace according to claim 12, characterized in that the mixed strip is obtained by co-extrusion hot.
en ce que la lanière mixte est obtenue par moulage. 14. Necklace according to claim 12, characterized in that the mixed strap is obtained by molding.
en ce qu'il contient entre 5 et 25% de substance insec-ticide et de 1 a 10% d'acides gras. 15. Necklace according to claim 12, characterized in that it contains between 5 and 25% of insecticidal substance ticide and 1 to 10% fatty acids.
en ce que chacune des deux parties de la lanière mixte contient des substances colorantes et/ou des pigments et/ou des substances photo-réfléchissantes et/ou des substances luminescentes différentes. 16. Necklace according to claim 12, characterized in that each of the two parts of the mixed thong contains coloring substances and / or pigments and / or photo-reflective substances and / or different luminescent substances.
en ce que les deux mélanges sont extrudés dans deux extrudeuses différentes reliées en sortie par une tête de filière unique. 18. Method according to claim 17, characterized in that the two mixtures are extruded into two different extruders connected at the output by a head single sector.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8200362 | 1982-01-12 | ||
| FR8200362A FR2519515B1 (en) | 1982-01-12 | 1982-01-12 | IMPROVEMENTS ON PEST CONTROL COLLARS FOR ANIMALS |
| FR8216089 | 1982-09-24 | ||
| FR8216089A FR2533412B2 (en) | 1982-01-12 | 1982-09-24 | IMPROVEMENTS ON PEST CONTROL COLLARS FOR ANIMALS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1195244A true CA1195244A (en) | 1985-10-15 |
Family
ID=26222704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000419250A Expired CA1195244A (en) | 1982-01-12 | 1983-01-11 | Flea collars for animals |
Country Status (8)
| Country | Link |
|---|---|
| AU (1) | AU560927B2 (en) |
| CA (1) | CA1195244A (en) |
| DE (1) | DE3300579C2 (en) |
| ES (1) | ES8400002A1 (en) |
| FR (1) | FR2533412B2 (en) |
| GB (1) | GB2114442B (en) |
| IT (1) | IT1213011B (en) |
| NL (1) | NL191137C (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4803956A (en) * | 1984-10-15 | 1989-02-14 | A. H. Robins Company, Incorporated | Co-extrustion of multi-component insecticidal pet collars |
| FR2592277B1 (en) * | 1985-12-27 | 1989-05-26 | Viguie Jean | INSECTICIDE PERCH FOR CAGE BIRDS |
| AU700100B2 (en) * | 1995-07-10 | 1998-12-24 | Sumitomo Chemical Company, Limited | Resin composition and molded product thereof |
| AUPN569895A0 (en) * | 1995-09-29 | 1995-10-26 | Victorian Chemicals International Pty Ltd | Insecticide adjuvants |
| US20060288955A1 (en) * | 2005-05-24 | 2006-12-28 | Wyeth | Device and method for controlling insects |
| NL1033350C2 (en) * | 2007-02-07 | 2008-08-11 | Ver Bedrijven Beaphar B V | Animal collar containing insecticide, comprises band with cavity in one side for housing insecticide strip |
| JP5258115B2 (en) * | 2009-12-24 | 2013-08-07 | 住化ライフテク株式会社 | Insect repellent resin composition and sustained-release insect repellent molded article obtained therefrom |
| FR3070619B1 (en) * | 2017-09-01 | 2024-10-04 | Ab7 Innovation | MONOLITHIC CAST PART IN MULTIPLE MATRIX FOR THE DIFFUSION OF ACTIVE INGREDIENTS AND METHOD FOR OBTAINING SAME |
| ES2982583T3 (en) * | 2021-07-30 | 2024-10-16 | Bioiberica S A U | Dermatological collar for non-human animals |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2213014A1 (en) * | 1972-12-20 | 1974-08-02 | Aries Robert | Phosphoric ester - chrysanthemic ester compsns. - synergistic insecticides, formulated as solns., powders, animal collars etc. |
| DE2414479C3 (en) * | 1974-03-26 | 1979-11-22 | Zoecon Corp., Pulo Alto, Calif. (V.St.A.) | Animal collar for combating ticks and fleas |
| FR2269859A1 (en) * | 1974-05-07 | 1975-12-05 | Dick Pierre | Insecticidal collars for animals - contg diazinone or diazoxone in a plasticised vinyl (idene) polymer |
| FR2307466A2 (en) * | 1975-04-16 | 1976-11-12 | Dick Pierre | Insecticidal collars for animals - contg diazinone or diazoxone in a plasticised vinyl (idene) polymer |
| GB1594737A (en) * | 1976-11-10 | 1981-08-05 | Robins Co Inc A H | Method for producing insect-combating device |
| DE2658725A1 (en) * | 1976-12-24 | 1978-07-06 | Bayer Ag | AGENT FOR CONTROLLING ANIMAL EECTOPARASITES WITH A STRONG RESIDUAL EFFECT |
| CA1057144A (en) * | 1977-01-10 | 1979-06-26 | A.H. Robins Company | Pet collar |
| CA1105832A (en) * | 1977-04-07 | 1981-07-28 | Miklos Von Bittera | Animal collars having ectoparasiticidal activity |
| US4189467A (en) * | 1977-04-07 | 1980-02-19 | Bayer Aktiengesellschaft | Polyurethanes having ectoparasiticidal activity |
| US4195075A (en) * | 1978-09-20 | 1980-03-25 | Shell Oil Company | Method and device for controlling insects on livestock |
| FR2447679A2 (en) * | 1979-01-30 | 1980-08-29 | Dick Pierre | Insecticidal animal collars - contg. bendiocarb, vinyl! polymer, and a plasticiser |
| DE3039881A1 (en) * | 1980-10-22 | 1982-05-27 | Bayer Ag, 5090 Leverkusen | EECTROPARASITICIDE CONTAINERS FOR PETS |
-
1982
- 1982-09-24 FR FR8216089A patent/FR2533412B2/en not_active Expired
-
1983
- 1983-01-04 AU AU10011/83A patent/AU560927B2/en not_active Ceased
- 1983-01-06 GB GB08300273A patent/GB2114442B/en not_active Expired
- 1983-01-10 DE DE3300579A patent/DE3300579C2/en not_active Expired - Fee Related
- 1983-01-11 NL NL8300075A patent/NL191137C/en not_active IP Right Cessation
- 1983-01-11 CA CA000419250A patent/CA1195244A/en not_active Expired
- 1983-01-12 ES ES518940A patent/ES8400002A1/en not_active Expired
- 1983-01-12 IT IT8383305A patent/IT1213011B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| AU1001183A (en) | 1983-07-21 |
| GB2114442B (en) | 1985-07-17 |
| IT1213011B (en) | 1989-12-07 |
| DE3300579C2 (en) | 1995-04-20 |
| ES518940A0 (en) | 1983-10-16 |
| NL8300075A (en) | 1983-08-01 |
| DE3300579A1 (en) | 1983-07-21 |
| AU560927B2 (en) | 1987-04-30 |
| GB8300273D0 (en) | 1983-02-09 |
| IT8383305A0 (en) | 1983-01-12 |
| FR2533412A2 (en) | 1984-03-30 |
| NL191137C (en) | 1995-02-16 |
| GB2114442A (en) | 1983-08-24 |
| FR2533412B2 (en) | 1986-05-09 |
| NL191137B (en) | 1994-09-16 |
| ES8400002A1 (en) | 1983-10-16 |
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