BRPI1005169A2 - combinação de (a) metotrexato e (b) um inibidor de dhodh não-hepatotóxico, uso de uma combinação, produto, conjunto, embalagem e método de tratamento - Google Patents

combinação de (a) metotrexato e (b) um inibidor de dhodh não-hepatotóxico, uso de uma combinação, produto, conjunto, embalagem e método de tratamento

Info

Publication number: BRPI1005169A2
Authority: BR; Brazil
Prior art keywords: combination; nonhephototoxic; methotrexate; kit; package
Prior art date: 2009-01-21

Application number

BRPI1005169A

Other languages

English (en)

Inventor

Pilar Pizcueta Lalanza Maria

Godessart Marina Nuria

Original Assignee

Almirall Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-01-21

Filing date

2010-01-19

Publication date

2019-09-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40790917&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI1005169(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2010-01-19 Application filed by Almirall Sa filed Critical Almirall Sa

2019-09-24 Publication of BRPI1005169A2 publication Critical patent/BRPI1005169A2/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Virology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Pain & Pain Management (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Gastroenterology & Hepatology (AREA)
Toxicology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

BRPI1005169A 2009-01-21 2010-01-19 combinação de (a) metotrexato e (b) um inibidor de dhodh não-hepatotóxico, uso de uma combinação, produto, conjunto, embalagem e método de tratamento BRPI1005169A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP09382006A EP2210615A1 (en)	2009-01-21	2009-01-21	Combinations comprising methotrexate and DHODH inhibitors
PCT/EP2010/000270 WO2010083975A1 (en)	2009-01-21	2010-01-19	Combinations comprising methotrexate and dhodh inhibitors

Publications (1)

Publication Number	Publication Date
BRPI1005169A2 true BRPI1005169A2 (pt)	2019-09-24

Family

ID=40790917

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI1005169A BRPI1005169A2 (pt)	2009-01-21	2010-01-19	combinação de (a) metotrexato e (b) um inibidor de dhodh não-hepatotóxico, uso de uma combinação, produto, conjunto, embalagem e método de tratamento

Country Status (23)

Country	Link
US (1)	US20110280831A1 (pt)
EP (2)	EP2210615A1 (pt)
JP (1)	JP2012515737A (pt)
KR (1)	KR20110117658A (pt)
CN (1)	CN102292108A (pt)
AR (1)	AR075036A1 (pt)
AU (1)	AU2010206334A1 (pt)
BR (1)	BRPI1005169A2 (pt)
CA (1)	CA2748400A1 (pt)
CL (1)	CL2011001760A1 (pt)
CO (1)	CO6341575A2 (pt)
EA (1)	EA201101098A1 (pt)
EC (1)	ECSP11011201A (pt)
IL (1)	IL213625A0 (pt)
MX (1)	MX2011007446A (pt)
NZ (1)	NZ593413A (pt)
PE (1)	PE20120552A1 (pt)
SG (2)	SG172453A1 (pt)
TW (1)	TW201029652A (pt)
UA (1)	UA104449C2 (pt)
UY (1)	UY32380A (pt)
WO (1)	WO2010083975A1 (pt)
ZA (1)	ZA201104259B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2319596B1 (es)	2006-12-22	2010-02-08	Laboratorios Almirall S.A.	Nuevos derivados de los acidos amino-nicotinico y amino-isonicotinico.
UY31272A1 (es)	2007-08-10	2009-01-30	Almirall Lab	Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en)	2008-06-20	2009-12-23	Laboratorios Almirall, S.A.	Combination comprising DHODH inhibitors and methotrexate
EP2239256A1 (en)	2009-03-13	2010-10-13	Almirall, S.A.	Sodium salt of 5-cyclopropyl-2-{[2-(2,6-difluorophenyl)pyrimidin-5-yl]amino}benzoic acid as DHODH inhibitor
EP2314577A1 (en)	2009-10-16	2011-04-27	Almirall, S.A.	Process for manufacturing 2-[(3,5-difluoro-3'-methoxy-1,1'-biphenyl-4-yl)amino]nicotinic acid
EP2444086A1 (en) *	2010-10-22	2012-04-25	Almirall, S.A.	Combinations comprising DHODH inhibitors and COX inhibitors
EP2457900A1 (en)	2010-11-25	2012-05-30	Almirall, S.A.	New pyrazole derivatives having CRTh2 antagonistic behaviour
EP2672963A4 (en)	2011-02-08	2015-06-24	Childrens Medical Center	METHOD FOR THE TREATMENT OF MELANOMA
EP2518071A1 (en)	2011-04-29	2012-10-31	Almirall, S.A.	Imidazopyridine derivatives as PI3K inhibitors
EP2518070A1 (en)	2011-04-29	2012-10-31	Almirall, S.A.	Pyrrolotriazinone derivatives as PI3K inhibitors
EP2526945A1 (en)	2011-05-25	2012-11-28	Almirall, S.A.	New CRTH2 Antagonists
EP2548863A1 (en)	2011-07-18	2013-01-23	Almirall, S.A.	New CRTh2 antagonists.
EP2548876A1 (en)	2011-07-18	2013-01-23	Almirall, S.A.	New CRTh2 antagonists
EP2752190B1 (en) *	2011-08-30	2021-03-03	Toyama Chemical Co., Ltd.	Method for improving therapy for autoimmune diseases such as rheumatoid arthritis
WO2014060431A1 (en)	2012-10-16	2014-04-24	Almirall, S.A.	Pyrrolotriazinone derivatives as pi3k inhibitors
AR094797A1 (es)	2013-02-15	2015-08-26	Almirall Sa	Derivados de pirrolotriazina como inhibidores de pi3k
GB201809102D0 (en)	2018-06-04	2018-07-18	Univ Oxford Innovation Ltd	Compounds
EP3858361B1 (en)	2018-09-28	2025-10-08	FUJIFILM Corporation	Antitumor agent containing cytarabine, antitumor effect enhancer used in combination with cytarabine, antitumor kit, and antitumor agent used in combination with cytarabine
EP4037770A1 (en) *	2019-10-04	2022-08-10	Institut National De La Sante Et De La Recherche Medicale (Inserm)	Novel pyridin-2(1h)one derivatives, their preparation and their use for the treatment of pain
CN116056766A (zh) *	2020-07-30	2023-05-02	富士胶片株式会社	含氮杂环化合物或其盐、其利用以及其中间体

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4226869A (en) *	1979-02-02	1980-10-07	American Cyanamid Company	Method of stimulating the immune response with halogenated 10-(ω-dialkylaminopolymethyleneamino)-2-methoxypyrido[3,2-b]quinolines
BR9608997A (pt)	1995-06-21	1999-06-29	Asta Medica Ag	Cartucho para pó farmacêutico com dispositivo de medição integrado e intalador para medicamentos em pó
DE10129703A1 (de)	2001-06-22	2003-01-02	Sofotec Gmbh & Co Kg	Zerstäubungssystem für eine Pulvermischung und Verfahren für Trockenpulverinhalatoren
DE10202940A1 (de)	2002-01-24	2003-07-31	Sofotec Gmbh & Co Kg	Patrone für einen Pulverinhalator
TW200714289A (en) *	2005-02-28	2007-04-16	Genentech Inc	Treatment of bone disorders
AR055395A1 (es) *	2005-08-26	2007-08-22	Vertex Pharma	Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c
WO2008058288A2 (en) *	2006-11-09	2008-05-15	Proprius Pharmaceuticals, Inc.	Sustained release methotrexate formulations and methods of use thereof
UY31272A1 (es) *	2007-08-10	2009-01-30	Almirall Lab	Nuevos derivados de ácido azabifenilaminobenzoico
EP2135610A1 (en) *	2008-06-20	2009-12-23	Laboratorios Almirall, S.A.	Combination comprising DHODH inhibitors and methotrexate

2009
- 2009-01-21 EP EP09382006A patent/EP2210615A1/en not_active Withdrawn
2010
- 2010-01-11 UY UY0001032380A patent/UY32380A/es unknown
- 2010-01-13 TW TW099100843A patent/TW201029652A/zh unknown
- 2010-01-19 JP JP2011546677A patent/JP2012515737A/ja not_active Ceased
- 2010-01-19 NZ NZ593413A patent/NZ593413A/en not_active IP Right Cessation
- 2010-01-19 CA CA2748400A patent/CA2748400A1/en not_active Abandoned
- 2010-01-19 WO PCT/EP2010/000270 patent/WO2010083975A1/en not_active Ceased
- 2010-01-19 AU AU2010206334A patent/AU2010206334A1/en not_active Abandoned
- 2010-01-19 US US13/145,628 patent/US20110280831A1/en not_active Abandoned
- 2010-01-19 SG SG2011048337A patent/SG172453A1/en unknown
- 2010-01-19 UA UAA201110006A patent/UA104449C2/uk unknown
- 2010-01-19 SG SG2014003388A patent/SG196826A1/en unknown
- 2010-01-19 BR BRPI1005169A patent/BRPI1005169A2/pt not_active IP Right Cessation
- 2010-01-19 EP EP10701206.4A patent/EP2389197B1/en active Active
- 2010-01-19 EA EA201101098A patent/EA201101098A1/ru unknown
- 2010-01-19 MX MX2011007446A patent/MX2011007446A/es not_active Application Discontinuation
- 2010-01-19 CN CN2010800051639A patent/CN102292108A/zh active Pending
- 2010-01-19 PE PE2011001295A patent/PE20120552A1/es not_active Application Discontinuation
- 2010-01-19 KR KR1020117016969A patent/KR20110117658A/ko not_active Withdrawn
- 2010-01-20 AR ARP100100123A patent/AR075036A1/es not_active Application Discontinuation
2011
- 2011-06-08 ZA ZA2011/04259A patent/ZA201104259B/en unknown
- 2011-06-16 IL IL213625A patent/IL213625A0/en unknown
- 2011-07-13 EC EC2011011201A patent/ECSP11011201A/es unknown
- 2011-07-15 CO CO11088762A patent/CO6341575A2/es active IP Right Grant
- 2011-07-20 CL CL2011001760A patent/CL2011001760A1/es unknown

Also Published As

Publication number	Publication date
CL2011001760A1 (es)	2012-03-09
TW201029652A (en)	2010-08-16
CO6341575A2 (es)	2011-11-21
UA104449C2 (uk)	2014-02-10
CN102292108A (zh)	2011-12-21
EP2389197B1 (en)	2014-06-18
UY32380A (es)	2010-02-26
SG196826A1 (en)	2014-02-13
CA2748400A1 (en)	2010-07-29
WO2010083975A1 (en)	2010-07-29
EP2389197A1 (en)	2011-11-30
US20110280831A1 (en)	2011-11-17
IL213625A0 (en)	2011-07-31
PE20120552A1 (es)	2012-05-21
ZA201104259B (en)	2012-02-29
EP2210615A1 (en)	2010-07-28
JP2012515737A (ja)	2012-07-12
EA201101098A1 (ru)	2012-01-30
ECSP11011201A (es)	2011-08-31
AU2010206334A1 (en)	2011-07-07
NZ593413A (en)	2013-12-20
MX2011007446A (es)	2011-08-03
SG172453A1 (en)	2011-07-28
KR20110117658A (ko)	2011-10-27
AR075036A1 (es)	2011-03-02

Publication	Publication Date	Title
BRPI1005169A2 (pt)	2019-09-24	combinação de (a) metotrexato e (b) um inibidor de dhodh não-hepatotóxico, uso de uma combinação, produto, conjunto, embalagem e método de tratamento
IL210843A0 (en)	2011-04-28	Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
DK2276767T3 (da)	2014-07-14	Benzopyran- og benzoxepinforbindelser som pi3k-inhibitorer og anvendelsesfremgangsmåder
HUE054298T2 (hu)	2021-08-30	Készítmények és módszerek stroke kezelésére egy konkomittáns sztatin terápián tartott alanyban
DK2121614T3 (da)	2012-09-17	Aminonikotin og isonikotinsyrederivater som dhodh-inhibitorer
DK2178840T3 (da)	2012-03-26	Azabiphenylaminobenzoesyre-derivater som dhodh-hæmmere
DK2421825T3 (da)	2014-02-03	Azetidinyldiamider som monoacylglycerollipase-inhibitorer
ZA201008041B (en)	2011-06-29	Combinations comprising methotrexate and dhodh inhibitors
EP2272817A4 (en)	2011-12-14	PAI-1 INHIBITORS
BRPI1014316A2 (pt)	2016-04-05	composição, e, uso de uma composição
HUE046951T2 (hu)	2020-04-28	TFPI-inhibitorok és eljárás alkalmazásukra
BR112013003536A2 (pt)	2016-06-28	composição, e utilização de uma composição.
BRPI1015471A2 (pt)	2016-04-26	ativador de gel relaxante
EP2393776A4 (en)	2012-08-01	NEW TRIFLUOROMETHYLSULFONAMIDE INHIBITOR OF GAMMA-SECRETASE
EP2139883A4 (en)	2011-06-22	HIV-1 protease inhibitor
BR112013015891A2 (pt)	2016-10-04	uso de uma combinação, método de tratamento de um plasma e uso de uma combinação
BRPI0914793A2 (pt)	2015-08-04	Composição, e, uso de uma composição
IL208483A0 (en)	2010-12-30	Limk2 inhibitors, compositions comprising them, and methods of their use
HUE040085T2 (hu)	2019-02-28	PDE7 inhibitorok alkalmazása mozgási rendellenességek kezelésére
EP2237793A4 (en)	2013-07-31	INHIBITORS OF CATHEPSIN B
IL215835A0 (en)	2012-01-31	Carboxamide compounds and their use as calpain inhibitors
GB0820856D0 (en)	2008-12-24	Novel inhibitors of flavivirus replication
BRPI1006953A2 (pt)	2016-04-26	composição farmacêutica, e, uso de uma composição
ZA201204496B (en)	2013-02-27	Carboxamide compounds and their use as calpain inhibitors
BRPI0906721A2 (pt)	2015-06-30	Processo para fazer restauração dental, restauração dental, e processo para fazer uma restauração dental

Legal Events

Date	Code	Title	Description
2019-10-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
2020-01-21	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.