BRPI0912411A2 - uso de uma muteína de interleucina humana-2 (muteína de hil-2) ou de um fragmento da mesma, composição farmacêutica para o tratamento e/ou profilaxia de uma doença autoimune, uso de muteína de interleucina humana-2 (muteína de hil-2) ou de uma seção da mesma, agete para formação de células t regulatórias (treg) em um organismo, método para tratamento e/ou profilaxia de uma doença autoimune em um organismo, método para formação de células t regulatórias (treg) em um organismo, método para formação de células t regulatórias (treg) in vitro. - Google Patents
uso de uma muteína de interleucina humana-2 (muteína de hil-2) ou de um fragmento da mesma, composição farmacêutica para o tratamento e/ou profilaxia de uma doença autoimune, uso de muteína de interleucina humana-2 (muteína de hil-2) ou de uma seção da mesma, agete para formação de células t regulatórias (treg) em um organismo, método para tratamento e/ou profilaxia de uma doença autoimune em um organismo, método para formação de células t regulatórias (treg) em um organismo, método para formação de células t regulatórias (treg) in vitro.Info
- Publication number
- BRPI0912411A2 BRPI0912411A2 BRPI0912411A BRPI0912411A BRPI0912411A2 BR PI0912411 A2 BRPI0912411 A2 BR PI0912411A2 BR PI0912411 A BRPI0912411 A BR PI0912411A BR PI0912411 A BRPI0912411 A BR PI0912411A BR PI0912411 A2 BRPI0912411 A2 BR PI0912411A2
- Authority
- BR
- Brazil
- Prior art keywords
- mutein
- organism
- treg
- regulatory
- cells
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 3
- 238000000034 method Methods 0.000 title 3
- 210000003289 regulatory T cell Anatomy 0.000 title 3
- 208000023275 Autoimmune disease Diseases 0.000 title 2
- 101100506090 Caenorhabditis elegans hil-2 gene Proteins 0.000 title 2
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 title 2
- 102000055277 human IL2 Human genes 0.000 title 2
- 238000011321 prophylaxis Methods 0.000 title 2
- 238000011282 treatment Methods 0.000 title 2
- 239000012634 fragment Substances 0.000 title 1
- 238000000338 in vitro Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
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- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2013—IL-2
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- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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- C12N2501/23—Interleukins [IL]
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- Zoology (AREA)
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- Biotechnology (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Virology (AREA)
- Developmental Biology & Embryology (AREA)
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- Mycology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102008023820.1 | 2008-05-08 | ||
| DE102008023820A DE102008023820A1 (de) | 2008-05-08 | 2008-05-08 | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| PCT/EP2009/003076 WO2009135615A2 (de) | 2008-05-08 | 2009-04-28 | Mittel zur behandlung und/oder prophylaxe einer autoimmunerkrankung und zur bildung von regulatorischen t-zellen |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0912411A2 true BRPI0912411A2 (pt) | 2016-09-13 |
| BRPI0912411A8 BRPI0912411A8 (pt) | 2019-05-14 |
| BRPI0912411B1 BRPI0912411B1 (pt) | 2020-02-18 |
| BRPI0912411B8 BRPI0912411B8 (pt) | 2021-05-25 |
Family
ID=41152787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0912411A BRPI0912411B8 (pt) | 2008-05-08 | 2009-04-28 | uso de uma muteína de interleucina humana-2 (muteína de hil-2) e composição farmacêutica para o tratamento e/ou profilaxia de uma doença autoimune |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US20110150826A1 (pt) |
| EP (1) | EP2288372B1 (pt) |
| JP (2) | JP5651583B2 (pt) |
| KR (3) | KR101554056B1 (pt) |
| CN (2) | CN102088996A (pt) |
| AR (1) | AR071756A1 (pt) |
| AT (1) | ATE544465T1 (pt) |
| AU (1) | AU2009244039B2 (pt) |
| BR (1) | BRPI0912411B8 (pt) |
| CA (1) | CA2723761C (pt) |
| CL (1) | CL2009001099A1 (pt) |
| CY (1) | CY1112469T1 (pt) |
| DE (1) | DE102008023820A1 (pt) |
| DK (1) | DK2288372T3 (pt) |
| ES (1) | ES2378957T3 (pt) |
| HR (1) | HRP20120296T1 (pt) |
| IL (3) | IL209128A (pt) |
| MX (1) | MX2010012214A (pt) |
| PE (1) | PE20091967A1 (pt) |
| PL (1) | PL2288372T3 (pt) |
| PT (1) | PT2288372E (pt) |
| RU (1) | RU2531936C2 (pt) |
| SI (1) | SI2288372T1 (pt) |
| TW (1) | TWI510622B (pt) |
| UA (1) | UA102099C2 (pt) |
| UY (1) | UY31816A (pt) |
| WO (1) | WO2009135615A2 (pt) |
| ZA (1) | ZA201008129B (pt) |
Families Citing this family (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008023820A1 (de) | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
| EP2382228B2 (en) | 2009-01-21 | 2026-01-07 | Amgen Inc. | Compositions and methods of treating inflammatory and autoimmune diseases |
| WO2011006029A1 (en) | 2009-07-10 | 2011-01-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Artificial cell constructs for inducing immunological tolerance |
| US11090363B2 (en) | 2009-07-10 | 2021-08-17 | University of Pittsburgh—of the Commonwealth System of Higher Education | Vasoactive intestinal peptide release from microparticles |
| CU23734A1 (es) * | 2009-11-27 | 2011-11-15 | Centro Inmunologia Molecular | Polipéptidos inmunomoduladores derivados de la il-2 con actividad antagonista de esta citocina útiles en la terapia del cáncer y enfermedades infecciosas crónicas |
| WO2012012737A2 (en) * | 2010-07-23 | 2012-01-26 | The University Of Toledo | Stable tregs and related materials and methods |
| CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
| MX384095B (es) | 2011-03-11 | 2025-03-14 | Hopitaux Paris Assist Publique | Uso de dosis bajas de il-2 para tratar trastornos inflamatorios o relacionados con la autoinmunidad. |
| BR112013023151A2 (pt) | 2011-03-11 | 2020-09-15 | Assistance Publique - Hôpitaux De Paris | interleucina-2 para uso no tratamento de desordem auto-imune, !muno-relacionada ou inflamatória e método para determinar se um regime ou dose de il-2 tem de ser modificado |
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