BRPI0914927A2 - composto, composição farmacêutica, métodos para inibir a função de fak e de tratamento de um câncer, uso de um composto, e, processo para preparar um composto - Google Patents
composto, composição farmacêutica, métodos para inibir a função de fak e de tratamento de um câncer, uso de um composto, e, processo para preparar um compostoInfo
- Publication number
- BRPI0914927A2 BRPI0914927A2 BRPI0914927A BRPI0914927A BRPI0914927A2 BR PI0914927 A2 BRPI0914927 A2 BR PI0914927A2 BR PI0914927 A BRPI0914927 A BR PI0914927A BR PI0914927 A BRPI0914927 A BR PI0914927A BR PI0914927 A2 BRPI0914927 A2 BR PI0914927A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- preparing
- methods
- pharmaceutical composition
- cancer treatment
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 3
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7305508P | 2008-06-17 | 2008-06-17 | |
| US61/073055 | 2008-06-17 | ||
| PCT/GB2009/050675 WO2009153589A1 (en) | 2008-06-17 | 2009-06-15 | Pyridine compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0914927A2 true BRPI0914927A2 (pt) | 2017-06-20 |
| BRPI0914927B1 BRPI0914927B1 (pt) | 2020-10-06 |
| BRPI0914927B8 BRPI0914927B8 (pt) | 2021-05-25 |
Family
ID=40896110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0914927A BRPI0914927B8 (pt) | 2008-06-17 | 2009-06-15 | composto, composição farmacêutica e uso de um composto |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8569298B2 (pt) |
| EP (1) | EP2303861B1 (pt) |
| JP (1) | JP5551689B2 (pt) |
| KR (1) | KR101695501B1 (pt) |
| CN (1) | CN102124000B (pt) |
| AU (1) | AU2009261764B2 (pt) |
| BR (1) | BRPI0914927B8 (pt) |
| CA (1) | CA2726508C (pt) |
| CR (1) | CR11854A (pt) |
| DO (1) | DOP2010000390A (pt) |
| EA (1) | EA020807B1 (pt) |
| EC (1) | ECSP10010695A (pt) |
| ES (1) | ES2472323T3 (pt) |
| IL (1) | IL209727A0 (pt) |
| MX (1) | MX2010014057A (pt) |
| WO (1) | WO2009153589A1 (pt) |
| ZA (1) | ZA201100388B (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3384482B2 (ja) | 1997-03-18 | 2003-03-10 | 本田技研工業株式会社 | ピストンリング供給装置 |
| JO3067B1 (ar) | 2008-10-27 | 2017-03-15 | Glaxosmithkline Llc | بيرميدينات بيرازولو امينو كمثبطات ل fak |
| US20140155410A1 (en) * | 2008-10-27 | 2014-06-05 | Glaxosmithkline Llc | Pyrazolylaminopyridines as inhibitors of fak |
| WO2010068947A2 (en) * | 2008-12-12 | 2010-06-17 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Nuclear export inhibitors of topoisomerase ii alpha |
| LT2464645T (lt) | 2009-07-27 | 2017-10-25 | Gilead Sciences, Inc. | Kondensuoti heterocikliniai junginiai, kaip jonų kanalų moduliatoriai |
| RU2528386C2 (ru) | 2010-05-21 | 2014-09-20 | Кемилиа Аб | Новые производные пиримидина |
| JP5936609B2 (ja) | 2010-06-29 | 2016-06-22 | ベラステム インコーポレイテッド | キナーゼインヒビターの経口製剤 |
| NZ604801A (en) * | 2010-06-30 | 2015-03-27 | Verastem Inc | Synthesis and use of focal adhesion kinase inhibitors |
| US8703759B2 (en) | 2010-07-02 | 2014-04-22 | Gilead Sciences, Inc. | Fused heterocyclic compounds as ion channel modulators |
| US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
| CA2825790A1 (en) * | 2011-01-26 | 2012-08-02 | Board Of Regents The University Of Texas System | Combinations |
| WO2012110773A1 (en) | 2011-02-17 | 2012-08-23 | Cancer Therapeutics Crc Pty Limited | Fak inhibitors |
| CA2827172C (en) | 2011-02-17 | 2019-02-26 | Cancer Therapeutics Crc Pty Limited | Selective fak inhibitors |
| CA2830129C (en) | 2011-03-24 | 2016-07-19 | Chemilia Ab | Novel pyrimidine derivatives |
| KR20140033377A (ko) | 2011-05-10 | 2014-03-18 | 길리애드 사이언시즈, 인코포레이티드 | 나트륨 채널 조절제로서의 융합된 헤테로시클릭 화합물 |
| NO3175985T3 (pt) | 2011-07-01 | 2018-04-28 | ||
| UY34171A (es) | 2011-07-01 | 2013-01-31 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal iónico |
| CN104302640A (zh) | 2012-03-16 | 2015-01-21 | 埃克希金医药品有限公司 | 3,5-二氨基吡唑激酶抑制剂 |
| NZ631142A (en) | 2013-09-18 | 2016-03-31 | Axikin Pharmaceuticals Inc | Pharmaceutically acceptable salts of 3,5-diaminopyrazole kinase inhibitors |
| BR112016029612B1 (pt) * | 2014-06-17 | 2021-01-19 | Pfizer Inc. | compostos de di-hidroisoquinolinona substituídos |
| US9442005B2 (en) * | 2014-07-30 | 2016-09-13 | Corning Optical Communications LLC | Non-contact methods of measuring insertion loss in optical fiber connectors |
| HUE049801T2 (hu) | 2014-12-23 | 2020-10-28 | Sma Therapeutics Inc | 3,5-diaminopirazol kináz inhibitorok |
| GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
| CA3244408A1 (en) | 2015-06-29 | 2025-06-13 | Verastem, Inc. | Therapeutic compositions, combinations, and methods of use |
| US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
| GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
| KR102730587B1 (ko) | 2018-02-28 | 2024-11-14 | 바스프 에스이 | 질화작용 저해제로서의 n-관능화 알콕시 피라졸 화합물의 용도 |
| WO2019166558A1 (en) | 2018-02-28 | 2019-09-06 | Basf Se | Use of pyrazole propargyl ethers as nitrification inhibitors |
| CN112218658A (zh) | 2018-03-12 | 2021-01-12 | 国家健康科学研究所 | 热量限制模拟物用于增强癌症治疗的化学免疫疗法的用途 |
| CN108912095B (zh) * | 2018-08-09 | 2019-08-20 | 广州安岩仁医药科技有限公司 | 苯并咪唑类化合物及其制备方法和应用 |
| CN113811300B (zh) * | 2019-03-15 | 2024-10-29 | 总医院公司 | Tead转录因子的新型小分子抑制剂 |
| AU2020365108A1 (en) * | 2019-10-18 | 2022-04-21 | Atengen, Inc. | 3-phenylsulphonyl-quinoline derivatives as agents for treating pathogenic blood vessels disorders |
| US20240270658A1 (en) | 2021-05-21 | 2024-08-15 | Basf Se | Use of an N-Functionalized Alkoxy Pyrazole Compound as Nitrification Inhibitor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0004890D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0305929D0 (en) | 2003-03-14 | 2003-04-23 | Novartis Ag | Organic compounds |
| DE10336184A1 (de) | 2003-08-07 | 2005-02-24 | Bayer Materialscience Ag | Neue Katalysatoren für die selektive Isocyanatdimerisierung |
| EP2287156B1 (en) * | 2003-08-15 | 2013-05-29 | Novartis AG | 2,4-Di(phenylamino)-pyrimidines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders |
| CA2571482A1 (en) | 2004-06-21 | 2005-12-29 | Pharmacia & Upjohn Company Llc | Pyk2 inhibitors for stimulation of osteoblast function |
| GB0419160D0 (en) | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| GB0419161D0 (en) * | 2004-08-27 | 2004-09-29 | Novartis Ag | Organic compounds |
| US8211929B2 (en) | 2004-12-30 | 2012-07-03 | Exelixis, Inc. | Pyrimidine derivatives as kinase modulators and method of use |
| US8722884B2 (en) * | 2005-12-01 | 2014-05-13 | Verastem, Inc. | Pyrimidine derivatives for the treatment of abnormal cell growth |
| RS20080272A (sr) | 2005-12-21 | 2009-07-15 | Pfizer Products Inc., | Derivati pirimidina za tretman neprirodnog rasta ćelija |
| PL2091918T3 (pl) | 2006-12-08 | 2015-02-27 | Novartis Ag | Związki i kompozycje jako inhibitory kinazy białkowej |
| DK2134689T3 (da) * | 2007-03-16 | 2014-06-30 | Scripps Research Inst | Inhibitorer af fokal adhæsionskinase |
| AU2008276063B2 (en) * | 2007-07-17 | 2013-11-28 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| JP2011512413A (ja) * | 2008-02-19 | 2011-04-21 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Ｆａｋの阻害剤としてのアニリノピリジン |
-
2009
- 2009-06-15 WO PCT/GB2009/050675 patent/WO2009153589A1/en not_active Ceased
- 2009-06-15 MX MX2010014057A patent/MX2010014057A/es active IP Right Grant
- 2009-06-15 AU AU2009261764A patent/AU2009261764B2/en active Active
- 2009-06-15 ES ES09766150.8T patent/ES2472323T3/es active Active
- 2009-06-15 CN CN200980132565.2A patent/CN102124000B/zh active Active
- 2009-06-15 CA CA2726508A patent/CA2726508C/en active Active
- 2009-06-15 BR BRPI0914927A patent/BRPI0914927B8/pt active IP Right Grant
- 2009-06-15 EA EA201100032A patent/EA020807B1/ru not_active IP Right Cessation
- 2009-06-15 US US12/999,025 patent/US8569298B2/en active Active
- 2009-06-15 EP EP09766150.8A patent/EP2303861B1/en active Active
- 2009-06-15 KR KR1020117001022A patent/KR101695501B1/ko active Active
- 2009-06-15 JP JP2011514125A patent/JP5551689B2/ja active Active
-
2010
- 2010-12-02 IL IL209727A patent/IL209727A0/en unknown
- 2010-12-17 DO DO2010000390A patent/DOP2010000390A/es unknown
- 2010-12-17 EC EC2010010695A patent/ECSP10010695A/es unknown
- 2010-12-17 CR CR11854A patent/CR11854A/es not_active Application Discontinuation
-
2011
- 2011-01-14 ZA ZA2011/00388A patent/ZA201100388B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US8569298B2 (en) | 2013-10-29 |
| EA201100032A1 (ru) | 2012-01-30 |
| BRPI0914927B1 (pt) | 2020-10-06 |
| EP2303861A1 (en) | 2011-04-06 |
| DOP2010000390A (es) | 2011-01-15 |
| AU2009261764B2 (en) | 2013-01-10 |
| BRPI0914927B8 (pt) | 2021-05-25 |
| MX2010014057A (es) | 2011-03-21 |
| KR101695501B1 (ko) | 2017-01-11 |
| CA2726508C (en) | 2016-06-07 |
| WO2009153589A1 (en) | 2009-12-23 |
| ECSP10010695A (es) | 2011-01-31 |
| KR20110023884A (ko) | 2011-03-08 |
| IL209727A0 (en) | 2011-02-28 |
| AU2009261764A1 (en) | 2009-12-23 |
| CR11854A (es) | 2011-02-25 |
| JP5551689B2 (ja) | 2014-07-16 |
| CN102124000A (zh) | 2011-07-13 |
| ES2472323T3 (es) | 2014-06-30 |
| HK1155170A1 (en) | 2012-05-11 |
| CA2726508A1 (en) | 2009-12-23 |
| US20110166139A1 (en) | 2011-07-07 |
| JP2011524411A (ja) | 2011-09-01 |
| CN102124000B (zh) | 2014-09-17 |
| EP2303861B1 (en) | 2014-04-23 |
| ZA201100388B (en) | 2011-10-26 |
| EA020807B1 (ru) | 2015-01-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 06/10/2020, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/06/2009 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |