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BRPI0914926A2 - uso de benzotropolona e derivados da mesma, composição cosmética, compostos, e, método para sintetizar um derivado de benzotropolona - Google Patents

uso de benzotropolona e derivados da mesma, composição cosmética, compostos, e, método para sintetizar um derivado de benzotropolona

Info

Publication number
BRPI0914926A2
BRPI0914926A2 BRPI0914926A BRPI0914926A BRPI0914926A2 BR PI0914926 A2 BRPI0914926 A2 BR PI0914926A2 BR PI0914926 A BRPI0914926 A BR PI0914926A BR PI0914926 A BRPI0914926 A BR PI0914926A BR PI0914926 A2 BRPI0914926 A2 BR PI0914926A2
Authority
BR
Brazil
Prior art keywords
benzotropolone
synthesizing
derivatives
compounds
cosmetic composition
Prior art date
Application number
BRPI0914926A
Other languages
English (en)
Inventor
Barbara Wagner
Bernd Herzog
Gabriele Baisch
Kai Eichin
Reinhold Ohrlein
Stephanie Portmann
Original Assignee
Basf Se
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Se filed Critical Basf Se
Publication of BRPI0914926A2 publication Critical patent/BRPI0914926A2/pt
Publication of BRPI0914926B1 publication Critical patent/BRPI0914926B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35Ketones, e.g. benzophenone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/16Emollients or protectives, e.g. against radiation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/18Antioxidants, e.g. antiradicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00General protective or antinoxious agents
    • A61P39/06Free radical scavengers or antioxidants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00Preparations for care of the hair
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00Esters of sulfuric acids
    • C07C305/02Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/16Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
    • C07C305/18Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30Unsaturated compounds
    • C07C62/38Unsaturated compounds containing keto groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/67Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
    • C07C69/708Ethers
    • C07C69/712Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4006Esters of acyclic acids which can have further substituents on alkyl
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18Acyclic radicals, substituted by carbocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/203Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26Acyclic or carbocyclic radicals, substituted by hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04One of the condensed rings being a six-membered aromatic ring
    • C07C2602/12One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BRPI0914926-0A 2008-06-25 2009-06-18 Uso de benzotropolona e derivados da mesma BRPI0914926B1 (pt)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP08158977.2 2008-06-25
EP08158977 2008-06-25
EP08166349 2008-10-10
EP08166349.4 2008-10-10
EP09155560 2009-03-19
EP09155560.7 2009-03-19
PCT/EP2009/057587 WO2009156324A2 (en) 2008-06-25 2009-06-18 Use of benzotropolone derivatives as uv absorbers and antioxidants and their use in sunscreens and/or cosmetic compositions

Publications (2)

Publication Number Publication Date
BRPI0914926A2 true BRPI0914926A2 (pt) 2015-10-20
BRPI0914926B1 BRPI0914926B1 (pt) 2022-04-12

Family

ID=41445016

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0914926-0A BRPI0914926B1 (pt) 2008-06-25 2009-06-18 Uso de benzotropolona e derivados da mesma

Country Status (8)

Country Link
US (1) US9707417B2 (pt)
EP (1) EP2296760B1 (pt)
JP (2) JP2012500186A (pt)
KR (1) KR101346442B1 (pt)
CN (1) CN102238983B (pt)
BR (1) BRPI0914926B1 (pt)
ES (1) ES2570152T3 (pt)
WO (1) WO2009156324A2 (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010051138A2 (en) * 2008-10-06 2010-05-06 Pharma Cosmetix Research, Llc Skin treatments containing carboxylic acid-substituted idebenone derivatives and methods of preparation and use thereof
KR101701548B1 (ko) 2009-10-06 2017-02-01 바스프 에스이 벤조트로폴론을 함유하는 식물 추출물 및/또는 관련 벤조트로폴론 유도체의 사용에 의한 가정용 제품, 바디-관리 제품 및 식품의 안정화
EA024306B1 (ru) * 2010-04-06 2016-09-30 Юнилевер Н.В. Композиция для личной гигиены
US20110293543A1 (en) * 2010-05-27 2011-12-01 Wei Yu Anhydrous composition comprising a dibenzoylmethane compound and a color pigment
US8846723B2 (en) 2010-07-29 2014-09-30 Eastman Chemical Company Esters of O-substituted hydroxy carboxylic acids and preparations thereof
US8613940B2 (en) 2010-09-03 2013-12-24 Eastman Chemical Company Carbonate derivatives as skin care
WO2012086812A1 (ja) * 2010-12-22 2012-06-28 味の素株式会社 配糖体化合物
US8329938B2 (en) 2011-02-21 2012-12-11 Eastman Chemical Company Hydroxyalkanoic acid and hydroxyalkanoice acid oligomer esters of retinol
CN102559797A (zh) * 2012-02-15 2012-07-11 安徽大学 一种白藜芦醇多聚体的制备方法
WO2014022287A1 (en) * 2012-07-29 2014-02-06 The Regents Of The University Of Colorado, A Body Corporate Antagonists of the toll-like receptor 1/2 complex
KR101413232B1 (ko) 2012-08-31 2014-08-06 한국기계연구원 경조직 재생용 지지체 조성물 및 이를 포함하는 경조직 재생용 지지체 및 이들의 제조방법
CN103565852B (zh) * 2012-12-26 2015-10-28 中国辐射防护研究院 用于受照人体放射性核素促排的中药提取物及其提取方法
FR3004108B1 (fr) * 2013-04-09 2015-04-10 Jean-Noel Thorel Extrait d'arthrobacter agilis pour son utilisation en cosmetique
EP3177263B1 (en) * 2014-08-08 2020-10-28 L'Oréal Soap based sunscreen composition
KR101711603B1 (ko) * 2015-11-03 2017-03-03 윤철식 스티피탈리드를 유효성분으로 포함하는 조성물
EP3370523A4 (en) * 2015-11-04 2019-12-18 The Penn State Research Foundation CONNECTIONS, COMPOSITIONS AND METHOD FOR COLORING EDIBLE MATERIALS
EP3544578A1 (en) * 2016-11-23 2019-10-02 GOJO Industries, Inc. Antimicrobial peptide stimulating cleansing composition
WO2018096088A1 (en) * 2016-11-24 2018-05-31 Universiteit Antwerpen Halogenated benzotropolones as atg4b inhibitors
KR102040230B1 (ko) * 2017-09-25 2019-11-04 제주대학교 산학협력단 푸르푸로갈린을 포함하는, 활성산소종, 자외선 또는 미세먼지에 대한 피부 보호용 화장료 조성물
CN108276935B (zh) * 2018-01-18 2020-06-02 中国科学院理化技术研究所 一种基于丙烯酸类树脂的负离子环保胶及其制备方法
WO2020001166A1 (zh) * 2018-06-27 2020-01-02 上海和黄药业有限公司 糖苷类化合物、其制备方法、组合物、应用及中间体
KR102311011B1 (ko) * 2018-09-12 2021-10-08 주식회사 엘지생활건강 인간지방줄기세포의 증식 촉진용 조성물
KR102010211B1 (ko) * 2019-01-22 2019-08-12 이재현 하르가이 추출물을 함유하는 샴푸 조성물 및 그 제조 방법
KR20230035590A (ko) * 2020-06-30 2023-03-14 아미리스 인코퍼레이티드 금속 산화물 선스크린 제제
KR102614802B1 (ko) * 2021-02-02 2023-12-19 대구대학교 산학협력단 갈릭산 산화물로부터 분리된 화합물을 유효성분으로 함유하는 피부 주름 개선용 조성물
CN114369340B (zh) * 2021-11-23 2023-09-08 中国农业科学院农业环境与可持续发展研究所 含有紫外线吸收剂的材料及制备方法
CN114163322B (zh) * 2021-11-23 2023-09-12 中国农业科学院农业环境与可持续发展研究所 紫外线吸收剂、制备方法和用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2770545A (en) * 1953-10-02 1956-11-13 Universal Oil Prod Co Stabilization of organic compounds
DE1091114B (de) * 1959-02-07 1960-10-20 Hoechst Ag Verfahren zur Herstellung von Benzotropolonderivaten
JPS568309A (en) * 1979-06-29 1981-01-28 Yasuaki Fukuda White cosmetic
JP3019996B2 (ja) * 1990-03-01 2000-03-15 三井農林株式会社 白癬治療剤
JPH06507610A (ja) * 1991-05-16 1994-09-01 ウー,タイ−ウィン 酸化防止剤及び細胞保護剤として有用なプルプロガリンを含む医薬用組成物
US20050058709A1 (en) * 1997-06-04 2005-03-17 Fisher Gary J. Methods for inhibiting photoaging of human skin using orally-administered agent
US6602527B1 (en) * 2000-11-22 2003-08-05 Thomas J. Slaga Processing method for manufacturing black tea and an improved black tea
US6831191B2 (en) * 2001-12-20 2004-12-14 Em Industries Photo stable organic sunscreen compounds with antioxidant properties and compositions obtained therefrom
US7087790B2 (en) * 2003-08-29 2006-08-08 Rutgers, The State University Of New Jersey Benzotropolone derivatives and modulation of inflammatory response
JP2005281247A (ja) * 2004-03-30 2005-10-13 Hirobumi Nakano 新規フェノール性化合物及びその製造方法
GB2412866A (en) * 2004-04-02 2005-10-12 Ciba Sc Holding Ag Amino-benzophenone UV filter formulations for the prevention of tanning

Also Published As

Publication number Publication date
WO2009156324A3 (en) 2012-06-21
CN102238983B (zh) 2016-08-24
JP2014159446A (ja) 2014-09-04
US20110123468A1 (en) 2011-05-26
JP2012500186A (ja) 2012-01-05
JP5992010B2 (ja) 2016-09-14
WO2009156324A2 (en) 2009-12-30
KR101346442B1 (ko) 2014-01-15
KR20110023892A (ko) 2011-03-08
BRPI0914926B1 (pt) 2022-04-12
EP2296760B1 (en) 2016-03-16
CN102238983A (zh) 2011-11-09
US9707417B2 (en) 2017-07-18
EP2296760A2 (en) 2011-03-23
ES2570152T3 (es) 2016-05-17

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/06/2009, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2831 DE 08-04-2025 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.