BRPI0819696A2 - Compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto - Google Patents
Compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um compostoInfo
- Publication number
- BRPI0819696A2 BRPI0819696A2 BRPI0819696-6A BRPI0819696A BRPI0819696A2 BR PI0819696 A2 BRPI0819696 A2 BR PI0819696A2 BR PI0819696 A BRPI0819696 A BR PI0819696A BR PI0819696 A2 BRPI0819696 A2 BR PI0819696A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- compound
- pharmaceutical composition
- phenylpyrimidine derivatives
- phenylpyrimidine
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- OXPDQFOKSZYEMJ-UHFFFAOYSA-N 2-phenylpyrimidine Chemical class C1=CC=CC=C1C1=NC=CC=N1 OXPDQFOKSZYEMJ-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
- C07F9/65846—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring the phosphorus atom being part of a six-membered ring which may be condensed with another ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2007054850 | 2007-11-29 | ||
| PCT/IB2008/055002 WO2009069100A1 (en) | 2007-11-29 | 2008-11-28 | Phosphonic acid derivates and their use as p2y12 receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0819696A2 true BRPI0819696A2 (pt) | 2015-06-16 |
| BRPI0819696A8 BRPI0819696A8 (pt) | 2017-12-26 |
| BRPI0819696B1 BRPI0819696B1 (pt) | 2018-10-23 |
Family
ID=40445499
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819696A BRPI0819696B1 (pt) | 2007-11-29 | 2008-11-28 | compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8518912B2 (pt) |
| EP (1) | EP2225253B1 (pt) |
| JP (1) | JP4729133B2 (pt) |
| KR (1) | KR101178319B1 (pt) |
| CN (1) | CN101868469B (pt) |
| AR (1) | AR069494A1 (pt) |
| AU (1) | AU2008331163B2 (pt) |
| BR (1) | BRPI0819696B1 (pt) |
| CA (1) | CA2706475C (pt) |
| CY (1) | CY1113151T1 (pt) |
| DK (1) | DK2225253T3 (pt) |
| ES (1) | ES2388958T3 (pt) |
| HR (1) | HRP20120735T1 (pt) |
| IL (1) | IL205947A (pt) |
| MA (1) | MA31983B1 (pt) |
| MX (1) | MX2010005519A (pt) |
| MY (1) | MY153749A (pt) |
| NZ (1) | NZ586445A (pt) |
| PL (1) | PL2225253T3 (pt) |
| PT (1) | PT2225253E (pt) |
| RU (1) | RU2483072C2 (pt) |
| SI (1) | SI2225253T1 (pt) |
| TW (1) | TWI361690B (pt) |
| WO (1) | WO2009069100A1 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200640877A (en) | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| CL2007003038A1 (es) | 2006-10-25 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos. |
| DK2225238T3 (en) | 2007-11-29 | 2014-11-24 | Boehringer Ingelheim Int | Derivatives of 6,7-dihydro-5H-imidazoý1,2- imidazol-3-carboxylic acid amides. |
| AR071653A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AR071652A1 (es) | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AU2010233378A1 (en) | 2009-04-08 | 2011-11-24 | Actelion Pharmaceuticals Ltd. | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as ADP receptor antagonists |
| NZ596388A (en) | 2009-04-22 | 2013-05-31 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
| EP2750676B1 (en) | 2011-08-30 | 2018-01-10 | University of Utah Research Foundation | Methods and compositions for treating nephrogenic diabetes insipidus |
| US10034892B2 (en) | 2014-08-21 | 2018-07-31 | Srx Cardio, Llc | Composition and methods of use of small molecules as binding ligands for the modulation of proprotein convertase subtilisin/kexin type 9(PCSK9) protein activity |
| WO2017063757A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
| WO2017063755A1 (en) | 2015-10-12 | 2017-04-20 | Polyphor Ag | Conformationally constrained macrocyclic compounds |
| CN109715639B (zh) | 2016-09-22 | 2022-04-19 | 爱杜西亚药品有限公司 | 结晶形式 |
| CN106831867A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一种腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| CN106831871A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一类硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| CN106749408A (zh) * | 2017-02-09 | 2017-05-31 | 广东赛博科技有限公司 | 一种硝基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| CN106831866A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一类烷氧噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| CN106831868A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一种胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| JOP20190193A1 (ar) | 2017-02-09 | 2019-08-08 | Bayer Pharma AG | ممركبات 2-أريل غير متجانس-3-أكسو-2، 3-ثنائي هيدرو بيريدازين-4-كربوكساميد لمعالجة السرطان |
| CN106831869A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 胺基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| CN106831870A (zh) * | 2017-02-09 | 2017-06-13 | 广东赛博科技有限公司 | 一类腈基噻吩芳基氧化膦p2y12受体拮抗剂及其用途 |
| TWI765002B (zh) | 2017-03-15 | 2022-05-21 | 瑞士商愛杜西亞製藥有限公司 | 受體拮抗劑之皮下投藥 |
| EP3713923B1 (en) | 2017-11-21 | 2021-12-01 | Bayer Aktiengesellschaft | 2-phenylpyrimidine-4-carboxamides as ahr inhibitors |
| CN115968372A (zh) | 2020-05-08 | 2023-04-14 | 通尼克斯医药有限公司 | 辐射保护和化疗保护化合物 |
| US20230255987A1 (en) | 2020-07-15 | 2023-08-17 | Idorsia Pharmaceuticals Ltd | Aqueous pharmaceutical composition comprising a p2y12 receptor antagonist |
| CN112500354A (zh) * | 2020-12-08 | 2021-03-16 | 烟台凯博医药科技有限公司 | 一种4-氯-6-环丙基嘧啶-5-胺的合成方法 |
| IL309948A (en) | 2021-07-13 | 2024-03-01 | Idorsia Pharmaceuticals Ltd | A process for the synthesis of 4-((R)-2-{[6-((S)-3-methoxy-pyrrolidin-1-yl)-2-phenyl-pyrimidin-4-carbonyl]-amino}-3-phosphono- Propionyl)-piperazine-1-carboxylic acid butyl ester |
| CN118871446A (zh) | 2022-03-14 | 2024-10-29 | 晖致亚太私人有限公司 | (r)-2-((叔丁氧基羰基)氨基)-3-(二乙氧基磷酰基)丙酸或其膦酸酯衍生物的合成方法 |
Family Cites Families (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1003M (fr) | 1960-03-09 | 1961-12-18 | Erba Carlo Spa | Dérivés d'antibiotiques a base de tétracycline. |
| US3338963A (en) | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| USRE26253E (en) | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3341585A (en) | 1966-05-06 | 1967-09-12 | American Cyanamid Co | Substituted 7-and/or 9-amino-6-deoxytetracyclines |
| US3345410A (en) | 1966-12-01 | 1967-10-03 | American Cyanamid Co | Substituted 7- and/or 9-amino tetracyclines |
| US3373196A (en) | 1967-03-21 | 1968-03-12 | American Cyanamid Co | 7-and/or 9-(lower alkyl) amino-5a, 6-anhydrotetracyclines |
| US3518306A (en) | 1968-02-19 | 1970-06-30 | American Cyanamid Co | 7- and/or 9-(n-nitrosoalkylamino)-6-demethyl-6-deoxytetracyclines |
| US3579579A (en) | 1968-04-18 | 1971-05-18 | American Cyanamid Co | Substituted 7- and/or 9-amino-6-demethyl-6-deoxytetracyclines |
| GB1469384A (en) | 1974-06-25 | 1977-04-06 | Farmaceutici Italia | Tetracyclines |
| JPS5373586A (en) | 1976-12-09 | 1978-06-30 | Mitsubishi Chem Ind Ltd | New penicillin derivatives |
| IT1135476B (it) | 1981-02-16 | 1986-08-20 | Brionvega Spa | Disposizione per l'orientamento automatico di una antenna in un radioricevitore o televisore per mezzo d'un telecomando |
| CA2020437A1 (en) | 1989-07-05 | 1991-01-06 | Yoshihide Fuse | Cinnamamide derivative |
| US5281628A (en) | 1991-10-04 | 1994-01-25 | American Cyanamid Company | 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines |
| PT536515E (pt) | 1991-10-04 | 2002-05-31 | American Cyanamid Co | Novas 7-substituido-9-(amino substitido)-6-desmetil-6-desoxitetraciclinas |
| US5494903A (en) | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| SG47520A1 (en) | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5328902A (en) | 1992-08-13 | 1994-07-12 | American Cyanamid Co. | 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines |
| US5284963A (en) | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
| US6693130B2 (en) | 1999-02-18 | 2004-02-17 | Regents Of The University Of California | Inhibitors of epoxide hydrolases for the treatment of hypertension |
| US6258822B1 (en) | 1997-08-06 | 2001-07-10 | Abbott Laboratories | Urokinase inhibitors |
| WO1999037307A1 (en) | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| WO1999067288A1 (en) | 1998-06-25 | 1999-12-29 | Sumitomo Pharmaceuticals Company, Limited | Tumor antigen peptides originating in cyclophilin b |
| AU766200B2 (en) | 1998-11-18 | 2003-10-09 | Collagenex Pharmaceuticals, Inc. | Novel 4-dedimethy laminotetra cycline derivatives |
| US6855715B1 (en) * | 1999-06-14 | 2005-02-15 | Eli Lilly And Company | Serine protease inhibitors |
| US8106225B2 (en) | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| JP5093953B2 (ja) | 1999-09-14 | 2012-12-12 | トラスティーズ オブ タフツ カレッジ | 遷移金属を用いた化学反応による置換テトラサイクリンの調製方法 |
| WO2001052858A1 (en) | 2000-01-24 | 2001-07-26 | Trustees Of Tufts College | Tetracycline compounds for treatment of cryptosporidium parvum related disorders |
| US6818634B2 (en) | 2000-03-31 | 2004-11-16 | Paratek Pharmaceuticals, Inc. | 7-and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline compounds |
| WO2001087824A2 (en) | 2000-05-15 | 2001-11-22 | Paratek Pharmaceuticals, Inc. | 7-substituted fused ring tetracycline compounds |
| US20020128237A1 (en) | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-N-substituted phenyl tetracycline compounds |
| US20020128238A1 (en) | 2000-06-16 | 2002-09-12 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| ATE504562T1 (de) | 2000-07-07 | 2011-04-15 | Tufts College | 7-, 8- und 9-substitutierte tetracyclinverbindungen |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| EA013908B1 (ru) | 2000-07-07 | 2010-08-30 | Трастис Оф Тафтс Коллидж | Замещенные соединения миноциклина (варианты), фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния млекопитающего |
| US7018985B1 (en) * | 2000-08-21 | 2006-03-28 | Inspire Pharmaceuticals, Inc. | Composition and method for inhibiting platelet aggregation |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| EP2298732A1 (en) | 2001-03-13 | 2011-03-23 | Paratek Pharmaceuticals, Inc. | 7,9-Substituted tetracycline compounds |
| AU2002250331A1 (en) | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| WO2002072022A2 (en) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as antifungal agents |
| WO2002072031A2 (en) | 2001-03-14 | 2002-09-19 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| JP2004529927A (ja) | 2001-04-24 | 2004-09-30 | パラテック ファーマシューティカルズ， インク． | マラリアの治療のための置換されたテトラサイクリン化合物 |
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US6861424B2 (en) | 2001-06-06 | 2005-03-01 | Schering Aktiengesellschaft | Platelet adenosine diphosphate receptor antagonists |
| WO2003005971A2 (en) | 2001-07-13 | 2003-01-23 | Paratek Pharmaceuticals, Inc. | Tetracycline compounds having target therapeutic activities |
| EP2311798A1 (en) | 2002-01-08 | 2011-04-20 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| EP1327903A1 (de) | 2002-01-14 | 2003-07-16 | Alcatel | Optischer Wellenleiterphasenschieber |
| JP2005526754A (ja) | 2002-03-08 | 2005-09-08 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノメチル置換されたテトラサイクリン化合物 |
| CN1653037A (zh) | 2002-03-21 | 2005-08-10 | 帕拉特克药品公司 | 取代的四环素化合物 |
| KR20050059162A (ko) | 2002-09-03 | 2005-06-17 | 솔베이 어드밴스트 폴리머스 엘.엘.씨. | 열전도성 액정 중합체 조성물과 이로 형성된 물품 |
| DE10241156A1 (de) | 2002-09-05 | 2004-03-18 | Infineon Technologies Ag | Verfahren zum Herstellen einer integrierten pin-Diode und zugehörige Schaltungsanordnung |
| RU2351586C2 (ru) * | 2002-10-03 | 2009-04-10 | Таргеджен, Инк. | Васкулостатические агенты и способы их применения |
| US8173624B2 (en) | 2002-10-24 | 2012-05-08 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate RNA |
| AP2005003363A0 (en) | 2002-12-11 | 2005-09-30 | Schering Ag | 2-Aminocarbonyl-quinoline componds as platelet ad enosine diphosphate receptor antagonists. |
| ATE481103T1 (de) | 2003-04-09 | 2010-10-15 | Wyeth Llc | Derivate von 2-(8,9-dioxo-2,6- diazabicyclo(5.2.0)non-1(7)-en-2- yl)alkylphosphonsäure und deren verwendung als n- methyl-d-aspartat- (nmda-) rezeptorantagonisten |
| CA2531732C (en) | 2003-07-09 | 2012-04-10 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| EP2295404A3 (en) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US7488739B2 (en) * | 2003-07-24 | 2009-02-10 | Astellas Pharma Inc. | Quinolone derivative or salt thereof |
| WO2005070878A1 (en) | 2004-01-15 | 2005-08-04 | Paratek Pharmaceuticals, Inc. | Aromatic a-ring derivatives of tetracycline compounds |
| TW200640877A (en) * | 2005-04-28 | 2006-12-01 | Actelion Pharmaceuticals Ltd | Pyrimidine derivatives |
| NZ568335A (en) * | 2005-10-21 | 2011-07-29 | Actelion Pharmaceuticals Ltd | Piperazine derivatives as antimalarial agents |
| CL2007002920A1 (es) | 2006-10-13 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-aminocarbonilpiridina; composicion farmaceutica; y uso para el tratamiento de trastornos vasculares oclusivos. |
| CL2007003038A1 (es) * | 2006-10-25 | 2008-06-06 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 2-fenil-6-aminocarbonil-pirimidina; composicion farmaceutica; y uso en el tratamiento de trastornos vasculares oclusivos. |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| EP2148871A1 (en) | 2007-04-23 | 2010-02-03 | Sanofi-Aventis | Quinoline-carboxamide derivatives as p2y12 antagonists |
| WO2009080227A2 (en) | 2007-12-26 | 2009-07-02 | Sanofi-Aventis | Pyrazole-carboxamide derivatives as p2y12 antagonists |
| EP2238128B1 (en) | 2007-12-26 | 2012-08-22 | Sanofi | Heterocyclic pyrazole-carboxamides as p2y12 antagonists |
| AR071653A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2-fenil-4-ciclopropil-pirimidina |
| AR071652A1 (es) * | 2008-04-11 | 2010-07-07 | Actelion Pharmaceuticals Ltd | Derivados 2- fenil-piridina substituidos |
| AU2010233378A1 (en) | 2009-04-08 | 2011-11-24 | Actelion Pharmaceuticals Ltd. | 6-(3-aza-bicyclo[3.1.0]hex-3-yl)-2-phenyl-pyrimidines as ADP receptor antagonists |
| NZ596388A (en) * | 2009-04-22 | 2013-05-31 | Actelion Pharmaceuticals Ltd | Thiazole derivatives and their use as p2y12 receptor antagonists |
-
2008
- 2008-11-28 US US12/745,358 patent/US8518912B2/en active Active
- 2008-11-28 KR KR1020107012062A patent/KR101178319B1/ko active Active
- 2008-11-28 RU RU2010126048/04A patent/RU2483072C2/ru active
- 2008-11-28 MY MYPI2010002493A patent/MY153749A/en unknown
- 2008-11-28 HR HRP20120735AT patent/HRP20120735T1/hr unknown
- 2008-11-28 WO PCT/IB2008/055002 patent/WO2009069100A1/en not_active Ceased
- 2008-11-28 PL PL08855100T patent/PL2225253T3/pl unknown
- 2008-11-28 JP JP2010535498A patent/JP4729133B2/ja active Active
- 2008-11-28 NZ NZ586445A patent/NZ586445A/en unknown
- 2008-11-28 MX MX2010005519A patent/MX2010005519A/es active IP Right Grant
- 2008-11-28 SI SI200830722T patent/SI2225253T1/sl unknown
- 2008-11-28 BR BRPI0819696A patent/BRPI0819696B1/pt active IP Right Grant
- 2008-11-28 AR ARP080105205A patent/AR069494A1/es active IP Right Grant
- 2008-11-28 DK DK08855100.7T patent/DK2225253T3/da active
- 2008-11-28 CN CN200880116983.8A patent/CN101868469B/zh active Active
- 2008-11-28 ES ES08855100T patent/ES2388958T3/es active Active
- 2008-11-28 EP EP08855100A patent/EP2225253B1/en active Active
- 2008-11-28 PT PT08855100T patent/PT2225253E/pt unknown
- 2008-11-28 TW TW097146477A patent/TWI361690B/zh active
- 2008-11-28 AU AU2008331163A patent/AU2008331163B2/en active Active
- 2008-11-28 CA CA2706475A patent/CA2706475C/en active Active
-
2010
- 2010-05-25 IL IL205947A patent/IL205947A/en active IP Right Grant
- 2010-06-08 MA MA32897A patent/MA31983B1/fr unknown
-
2012
- 2012-09-27 CY CY20121100884T patent/CY1113151T1/el unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BRPI0819696A2 (pt) | Compostos de derivados de 2-fenil-pirimidina, composição farmacêutica e uso de um composto | |
| BRPI0810696A2 (pt) | Composto, composição farmacêutica, e, uso de um composto | |
| BRPI0810161A2 (pt) | Composto, preparação farmacêutica, composição farmacêutica, e, uso de um composto | |
| BRPI0919942A2 (pt) | Composto, composição farmacêutica, e, uso de um composto | |
| BRPI0907562A2 (pt) | composto, composição farmacêutica, e, uso de um composto | |
| BRPI0921375A2 (pt) | composto, composição farmacêutica, e, uso de um composto | |
| BRPI0815709A2 (pt) | composro, composição farmacêutica, e, uso de um composto. | |
| BRPI0716171A2 (pt) | composto, composiÇço farmacÊutica e uso de um composto. | |
| BRPI0921879A2 (pt) | composto, composição farmacêutica , e, uso de um composto | |
| BRPI0821301A2 (pt) | Composto de aspirinato de isossorbida, composto carregador, composto medicamentoso, composição farmacêutica, e, uso de um composto | |
| BRPI0810019A2 (pt) | Composto, composição farmacêutica, e, uso de um composto | |
| BRPI0812942A2 (pt) | Composto, composição farmacêutica e uso de um composto | |
| BRPI0917579A2 (pt) | composto, composição farmacêutica, métodos, e, uso de um composto | |
| BRPI1016219A2 (pt) | composto, composição farmacêutica, e, uso de um composto | |
| BRPI1008793A2 (pt) | composto, uso de um composto, e, composição farmacêutica | |
| BRPI0809977A2 (pt) | Uso de um composto, compostos e composição farmacêutica que o contém | |
| BRPI0609802A2 (pt) | composto, composição farmacêutica e uso de um composto | |
| BRPI0821115A2 (pt) | Composto derivado de aminotriazol, medicamento, composição farmacêutica e uso do composto | |
| BRPI0716698A2 (pt) | Composto, composição farmacêutica e uso de um composto | |
| BRPI0818193A2 (pt) | composto, sal farmacêuticamente aceitável de um composto, composição farmacêutica, e, uso de um composto | |
| BRPI1007018A2 (pt) | composto, composição farmacêutica, e , uso de um composto. | |
| BRPI0906937A2 (pt) | composto, composição farmacêutica, e, uso de um composto | |
| BRPI1008906A2 (pt) | composto, composição farmacêutica, e, uso de um composto. | |
| BRPI0917001A2 (pt) | composto, composição farmacêutica, e, uso de um composto ou uma composição farmacêutica | |
| BRPI0915473A2 (pt) | composto, composição farmacêutica, e, uso de um composto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
| B25L | Entry of change of name and/or headquarter and transfer of application, patent and certificate of addition of invention: publication cancelled |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
| B25C | Requirement related to requested transfer of rights |
Owner name: ACTELION PHARMACEUTICALS LTD (CH) |
|
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: IDORSIA PHARMACEUTICALS LTD (CH) |
|
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 28/11/2008, OBSERVADAS AS CONDICOES LEGAIS. |