BRPI0820519A2 - intermediário para a síntese do análogo de halicondrina b e reação de dessulfonilação usada para o intermediário - Google Patents
intermediário para a síntese do análogo de halicondrina b e reação de dessulfonilação usada para o intermediárioInfo
- Publication number
- BRPI0820519A2 BRPI0820519A2 BRPI0820519A BRPI0820519A BRPI0820519A2 BR PI0820519 A2 BRPI0820519 A2 BR PI0820519A2 BR PI0820519 A BRPI0820519 A BR PI0820519A BR PI0820519 A BRPI0820519 A BR PI0820519A BR PI0820519 A2 BRPI0820519 A2 BR PI0820519A2
- Authority
- BR
- Brazil
- Prior art keywords
- halicondrin
- analogue
- synthesis
- reaction used
- desulfonylation reaction
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98849607P | 2007-11-16 | 2007-11-16 | |
| JP2007298074 | 2007-11-16 | ||
| PCT/JP2008/071167 WO2009064029A1 (en) | 2007-11-16 | 2008-11-14 | Novel intermediate for halichondrin b analog synthesis and novel desulfonylation reaction used for the intermediate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0820519A2 true BRPI0820519A2 (pt) | 2017-05-23 |
Family
ID=40344710
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0820519A BRPI0820519A2 (pt) | 2007-11-16 | 2008-11-14 | intermediário para a síntese do análogo de halicondrina b e reação de dessulfonilação usada para o intermediário |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20090203771A1 (pt) |
| EP (1) | EP2220094A1 (pt) |
| JP (1) | JP5134686B2 (pt) |
| CN (1) | CN101910180A (pt) |
| BR (1) | BRPI0820519A2 (pt) |
| CA (1) | CA2705383A1 (pt) |
| IL (1) | IL205761A0 (pt) |
| MX (1) | MX2010005340A (pt) |
| RU (1) | RU2010118063A (pt) |
| WO (1) | WO2009064029A1 (pt) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4454151B2 (ja) * | 1998-06-17 | 2010-04-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 大環状類似体及びそれらの使用並びに調製方法 |
| RS54054B1 (sr) | 2004-06-03 | 2015-10-30 | Eisai R&D Management Co. Ltd. | Intermedijeri za pripremu halihondrina b |
| EP2200992B1 (en) | 2007-10-03 | 2014-02-26 | Eisai R&D Management Co., Ltd. | Intermediates and methods for the synthesis of halichondrin b analogs |
| CN102056930B (zh) * | 2008-04-04 | 2016-04-20 | 卫材R&D管理有限公司 | 软海绵素b类似物 |
| SG182612A1 (en) | 2010-01-26 | 2012-08-30 | Eisai R&D Man Co Ltd | Furo [3, 2 -b] pyrane derivatives useful in the synthesis of halichondrin b analogs |
| WO2012147900A1 (en) | 2011-04-28 | 2012-11-01 | Eisai R&D Management Co., Ltd. | Microreactor process for halichondrin b analog synthesis |
| WO2015066729A1 (en) | 2013-11-04 | 2015-05-07 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b |
| MX384292B (es) | 2013-12-06 | 2025-03-14 | Eisai R&D Man Co Ltd | Metodos utiles en la sintesis de analogos de halicondrina b. |
| JP2017520586A (ja) | 2014-06-30 | 2017-07-27 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハリコンドリン類似体の合成およびその使用 |
| JP2017206439A (ja) * | 2014-08-27 | 2017-11-24 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ホモジナイザーを用いる抗腫瘍剤の製造方法 |
| US10344038B2 (en) | 2015-04-30 | 2019-07-09 | President And Fellows Of Harvard College | Chromium-mediated coupling and application to the synthesis of halichondrins |
| WO2016179607A1 (en) | 2015-05-07 | 2016-11-10 | Eisai R&D Management Co., Ltd. | Macrocyclization reactions and intermediates and other fragments useful in the synthesis of halichondrin macrolides |
| US10676481B2 (en) | 2016-02-12 | 2020-06-09 | Eisai R&D Management Co., Ltd. | Intermediates in the synthesis of eribulin and related methods of synthesis |
| KR102404629B1 (ko) | 2016-06-30 | 2022-06-02 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체 |
| JP6978758B2 (ja) | 2016-11-11 | 2021-12-08 | プレジデント アンド フェローズ オブ ハーバード カレッジ | パラジウム媒介ケトール化 |
| TWI863657B (zh) | 2017-04-05 | 2024-11-21 | 哈佛大學校長及研究員協會 | 巨環化合物及其用途 |
| US9938288B1 (en) | 2017-04-05 | 2018-04-10 | President And Fellows Of Harvard College | Macrocyclic compound and uses thereof |
| CN106946906A (zh) * | 2017-05-05 | 2017-07-14 | 重庆泰濠制药有限公司 | 一种化合物及其制备方法和应用 |
| WO2018217894A1 (en) * | 2017-05-24 | 2018-11-29 | Eisai R&D Management Co., Ltd. | Fluorine-labelled halichondrin derivatives and related methods of synthesis |
| US11498892B2 (en) | 2017-07-06 | 2022-11-15 | President And Fellows Of Harvard College | Fe/Cu-mediated ketone synthesis |
| ES2940688T3 (es) | 2017-07-06 | 2023-05-10 | Harvard College | Síntesis de halicondrinas |
| EP3710454B1 (en) | 2017-11-15 | 2024-01-03 | President And Fellows Of Harvard College | Macrocyclic compounds and uses thereof |
| JP7469226B2 (ja) | 2018-01-03 | 2024-04-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ハリコンドリンマクロライドとそのアナログの合成に有用なプリンス反応及び化合物 |
| US11447499B2 (en) | 2019-06-14 | 2022-09-20 | Rk Pharma Inc. | Process for the preparation of eribulin mesylate intermediate |
| WO2020255164A1 (en) | 2019-06-21 | 2020-12-24 | Council Of Scientific And Industrial Research | A chemo-enzymatic process for the preparation of homopropargylic alcohol |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS54054B1 (sr) * | 2004-06-03 | 2015-10-30 | Eisai R&D Management Co. Ltd. | Intermedijeri za pripremu halihondrina b |
-
2008
- 2008-11-14 BR BRPI0820519A patent/BRPI0820519A2/pt not_active IP Right Cessation
- 2008-11-14 CN CN2008801240310A patent/CN101910180A/zh active Pending
- 2008-11-14 US US12/271,731 patent/US20090203771A1/en not_active Abandoned
- 2008-11-14 CA CA2705383A patent/CA2705383A1/en not_active Abandoned
- 2008-11-14 JP JP2010519043A patent/JP5134686B2/ja not_active Expired - Fee Related
- 2008-11-14 RU RU2010118063/04A patent/RU2010118063A/ru unknown
- 2008-11-14 EP EP08850157A patent/EP2220094A1/en not_active Withdrawn
- 2008-11-14 WO PCT/JP2008/071167 patent/WO2009064029A1/en not_active Ceased
- 2008-11-14 MX MX2010005340A patent/MX2010005340A/es not_active Application Discontinuation
-
2010
- 2010-05-13 IL IL205761A patent/IL205761A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2010118063A (ru) | 2011-12-27 |
| CN101910180A (zh) | 2010-12-08 |
| JP5134686B2 (ja) | 2013-01-30 |
| JP2011504166A (ja) | 2011-02-03 |
| EP2220094A1 (en) | 2010-08-25 |
| WO2009064029A1 (en) | 2009-05-22 |
| MX2010005340A (es) | 2010-12-21 |
| IL205761A0 (en) | 2010-11-30 |
| US20090203771A1 (en) | 2009-08-13 |
| CA2705383A1 (en) | 2009-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |