BRPI0812878A2 - Anticorpo isolado, sintético ou recombinante ou parte funcional, derivado e/ou análogo do mesmo, sequência de ácido nucleico isolada, sintética ou recombinante, ou uma parte funcional, derivado ou análogo da mesma, usos de um anticorpo, parte funcional, derivado ou análogo e de uma sequência de ácido nucleico, parte funcional, derivado e/ou análogo, célula que produz anticorpo isolado, métodos para produzir uma célula que produz anticorpo, para produzir anticorpos e para tratar ou prevenir pelo menos em parte um distúrbio relacionado com rsv - Google Patents
Anticorpo isolado, sintético ou recombinante ou parte funcional, derivado e/ou análogo do mesmo, sequência de ácido nucleico isolada, sintética ou recombinante, ou uma parte funcional, derivado ou análogo da mesma, usos de um anticorpo, parte funcional, derivado ou análogo e de uma sequência de ácido nucleico, parte funcional, derivado e/ou análogo, célula que produz anticorpo isolado, métodos para produzir uma célula que produz anticorpo, para produzir anticorpos e para tratar ou prevenir pelo menos em parte um distúrbio relacionado com rsvInfo
- Publication number
- BRPI0812878A2 BRPI0812878A2 BRPI0812878-2A BRPI0812878A BRPI0812878A2 BR PI0812878 A2 BRPI0812878 A2 BR PI0812878A2 BR PI0812878 A BRPI0812878 A BR PI0812878A BR PI0812878 A2 BRPI0812878 A2 BR PI0812878A2
- Authority
- BR
- Brazil
- Prior art keywords
- derivative
- analog
- antibody
- functional part
- isolated
- Prior art date
Links
Classifications
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- C07K16/11—
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Mycology (AREA)
- Urology & Nephrology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07109472.6 | 2007-06-01 | ||
| EP07109472A EP1997830A1 (en) | 2007-06-01 | 2007-06-01 | RSV specific binding molecules and means for producing them |
| PCT/NL2008/050333 WO2008147196A2 (en) | 2007-06-01 | 2008-05-30 | Rsv-specific binding molecules and means for producing them |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BRPI0812878A2 true BRPI0812878A2 (pt) | 2015-03-31 |
| BRPI0812878B1 BRPI0812878B1 (pt) | 2020-01-21 |
| BRPI0812878B8 BRPI0812878B8 (pt) | 2020-04-22 |
| BRPI0812878C1 BRPI0812878C1 (pt) | 2021-05-25 |
Family
ID=38578633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0812878A BRPI0812878C1 (pt) | 2007-06-01 | 2008-05-30 | anticorpo isolado ou parte funcional do mesmo, vetor, método para produzir um anticorpo ou uma parte funcional do mesmo, para produzir uma célula produtora de anticorpo e para produzir um anticorpo capaz de se ligar especificamente a rsv, composição, e, uso de um anticorpo ou parte funcional do mesmo ou de uma composição ou de vetor |
Country Status (22)
| Country | Link |
|---|---|
| US (5) | US8562996B2 (pt) |
| EP (3) | EP1997830A1 (pt) |
| JP (4) | JP5450395B2 (pt) |
| KR (2) | KR101599556B1 (pt) |
| CN (2) | CN104961825A (pt) |
| AU (1) | AU2008257801B8 (pt) |
| BR (1) | BRPI0812878C1 (pt) |
| CA (2) | CA2950515A1 (pt) |
| CY (1) | CY1117767T1 (pt) |
| DK (1) | DK2170952T3 (pt) |
| ES (1) | ES2575129T3 (pt) |
| HR (1) | HRP20160632T1 (pt) |
| HU (1) | HUE029225T2 (pt) |
| IL (1) | IL202288A (pt) |
| MX (2) | MX2009012843A (pt) |
| NZ (3) | NZ621824A (pt) |
| PL (1) | PL2170952T3 (pt) |
| PT (1) | PT2170952E (pt) |
| RU (2) | RU2628095C2 (pt) |
| SI (1) | SI2170952T1 (pt) |
| WO (1) | WO2008147196A2 (pt) |
| ZA (1) | ZA200908320B (pt) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2727425T3 (es) | 2000-12-12 | 2019-10-16 | Medimmune Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
| EP2540820B1 (en) | 2005-12-09 | 2018-01-10 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Means and methods for influencing the stability of antibody producing cells |
| US9005974B2 (en) | 2005-12-09 | 2015-04-14 | Academish Medisch Centrum Bij De Universiteit Van Amsterdam | Means and methods for influencing the stability of cells |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| WO2009042589A1 (en) * | 2007-09-24 | 2009-04-02 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses thereof |
| WO2010068722A1 (en) | 2008-12-12 | 2010-06-17 | Medimmune, Llc | Crystals and structure of a human igg fc variant with enhanced fcrn binding |
| AU2015200208B2 (en) * | 2009-07-15 | 2016-10-20 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| AU2010271583B2 (en) * | 2009-07-15 | 2015-02-12 | Kling Biotherapeutics B.V. | Means and methods for producing high affinity antibodies |
| NZ599148A (en) * | 2009-10-06 | 2014-08-29 | Medimmune Ltd | Rsv-specific binding molecule |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| CN104628850B (zh) * | 2009-10-06 | 2020-07-28 | 医学免疫有限公司 | Rsv-特异性结合分子 |
| CN103097412B (zh) * | 2010-07-09 | 2016-08-10 | 克鲁塞尔荷兰公司 | 抗人呼吸道合胞病毒(rsv)抗体以及使用方法 |
| US9206247B2 (en) * | 2010-12-02 | 2015-12-08 | Aimm Therapeutics B.V. | Means and methods for producing high affinity antibodies |
| CA2818781C (en) | 2010-12-17 | 2019-10-08 | Neurimmune Holding Ag | Human anti-sod1 antibodies |
| US9475862B2 (en) * | 2011-11-07 | 2016-10-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing GP41 antibodies and their use |
| EP2780366A2 (en) | 2011-11-17 | 2014-09-24 | AIMM Therapeutics B.V. | Rsv g protein specific antibodies |
| PL2828293T3 (pl) * | 2012-03-20 | 2018-03-30 | Humabs Biomed S.A. | Przeciwciała, które neutralizują RSV, MPV i PVM oraz ich zastosowania |
| US10017739B2 (en) * | 2012-09-06 | 2018-07-10 | Duke University | Methods of expanding and assessing B cells and using expanded B cells to treat disease |
| SI2950886T1 (sl) | 2013-02-01 | 2020-06-30 | Medimmune, Llc | Epitopi proteina F respiratornega sincicijskega virusa |
| HRP20240996T1 (hr) | 2013-03-13 | 2024-10-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefuzija rsv f proteina i njihova uporaba |
| US9738689B2 (en) | 2013-03-13 | 2017-08-22 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Prefusion RSV F proteins and their use |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒f蛋白質的人類抗體及其使用方法 |
| US9060975B2 (en) | 2013-03-14 | 2015-06-23 | Mucosis Bv | Heat-stable respiratory syncytial virus F protein oligomers and their use in immunological compositions |
| WO2014139476A1 (zh) * | 2013-03-15 | 2014-09-18 | 厦门大学 | Rsv融合蛋白的表位以及识别其的抗体 |
| US10047145B2 (en) | 2013-07-24 | 2018-08-14 | Humabs Biomed Sa | Antibodies that potently neutralize RSV and uses thereof |
| WO2015037992A1 (en) | 2013-09-11 | 2015-03-19 | Aimm Therapeutics B.V. | Parechovirus specific antibodies |
| EA201691130A8 (ru) | 2013-12-17 | 2018-08-31 | Аимм Терапьютикс Б.В. | Средства и способы противодействия миелопролиферативным или лимфопролиферативным расстройствам |
| AU2015206570A1 (en) * | 2014-01-15 | 2016-07-14 | Medimmune, Llc | RSV-specific antibodies and functional parts thereof |
| US10611829B2 (en) | 2014-01-31 | 2020-04-07 | Aimm Therapeutics B.V. | Means and methods for producing stable antibodies |
| EP2974739A1 (en) | 2014-07-15 | 2016-01-20 | Novartis AG | RSVF trimerization domains |
| US9340604B1 (en) * | 2014-10-29 | 2016-05-17 | Aridis Pharmaceuticals, Inc. | Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV) |
| JP5996707B2 (ja) * | 2015-04-15 | 2016-09-21 | メディミューン リミテド | Rsv特異的結合分子 |
| EP3124042A1 (en) | 2015-07-28 | 2017-02-01 | VIB, vzw | Immunoglobulin single variable domain antibody against rsv prefusion f protein |
| BR112017027303A2 (pt) | 2015-06-18 | 2018-09-04 | Vib Vzw | domínio variável único de imunoglobulina contra proteína f de rsv |
| MX2017016258A (es) | 2015-06-24 | 2018-04-20 | Aimm Therapeutics Bv | Antigenos de leucemia mieloide aguda (aml) y usos de los mismos. |
| KR20230074843A (ko) * | 2015-08-19 | 2023-05-31 | 화이자 인코포레이티드 | 조직 인자 경로 억제제 항체 및 그의 용도 |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| EP3393512B1 (en) | 2015-12-23 | 2025-11-19 | Pfizer Inc. | Rsv f protein mutants |
| US11174292B2 (en) | 2016-03-29 | 2021-11-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Substitutions-modified prefusion RSV F proteins and their use |
| JP7265984B2 (ja) | 2016-10-21 | 2023-04-27 | アディマブ, エルエルシー | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| BR112019008063A2 (pt) | 2016-10-21 | 2019-07-02 | Adimab, Llc | anticorpos contra o vírus sincicial anti-respiratório e métodos de sua geração e uso |
| EP3974447A3 (en) | 2016-10-21 | 2022-09-07 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US11084850B2 (en) | 2016-12-16 | 2021-08-10 | The Pirbright Institute | Recombinant prefusion RSV F proteins and uses thereof |
| TWI761453B (zh) | 2017-03-01 | 2022-04-21 | 英商梅迪繆思有限公司 | 抗rsv單株抗體配製物 |
| MA51230A (fr) | 2018-01-29 | 2021-05-05 | Merck Sharp & Dohme | Protéines f rsv stabilisées et leurs utilisations |
| US11623004B2 (en) | 2018-03-16 | 2023-04-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Compositions and methods for vaccination against respiratory syncytial virus infection |
| AU2019247034B2 (en) | 2018-04-03 | 2025-12-11 | Sanofi | Antigenic respiratory syncytial virus polypeptides |
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| EP3773708A2 (en) | 2018-04-03 | 2021-02-17 | Sanofi | Antigenic epstein barr virus polypeptides |
| EP3956351A1 (en) * | 2019-04-18 | 2022-02-23 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Biological and synthetic molecules inhibiting respiratory syncytial virus infection |
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| KR102467943B1 (ko) * | 2020-06-25 | 2022-11-16 | 재단법인 목암생명과학연구소 | 항-rsv 항체 및 이를 포함하는 약학적 조성물 |
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