MX2010002044A - Metodos para produccion recombinante de anticuerpos anti-virus sincitial respiratorio (anti-rsv). - Google Patents
Metodos para produccion recombinante de anticuerpos anti-virus sincitial respiratorio (anti-rsv).Info
- Publication number
- MX2010002044A MX2010002044A MX2010002044A MX2010002044A MX2010002044A MX 2010002044 A MX2010002044 A MX 2010002044A MX 2010002044 A MX2010002044 A MX 2010002044A MX 2010002044 A MX2010002044 A MX 2010002044A MX 2010002044 A MX2010002044 A MX 2010002044A
- Authority
- MX
- Mexico
- Prior art keywords
- rsv
- collection
- antibodies
- cells
- rsv antibodies
- Prior art date
Links
Classifications
-
- C07K16/11—
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La invención se refiere a un método para producir anticuerpos anti-RSV recombinantes y composiciones de anticuerpo. El método comprende obtener una colección de células transfectadas con una colección de secuencias variantes de ácido nucleico, en donde cada célula en la colección se transfecta con y es capaz de expresar un distinto anticuerpo anti-RSV. Las células se cultivan bajo condiciones adecuadas para la expresión del anticuerpo/anticuerpos anti-RSV. La secuencia de ácido nucleico se introduce en las células por transfección con vectores de expresión, que evitan la integración específica al sitio. El presente método es adecuado para producir anticuerpos anti-RSV monoclonales y policlonales recombinantes para usos terapéuticos.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200701289 | 2007-09-07 | ||
| US97140407P | 2007-09-11 | 2007-09-11 | |
| PCT/DK2008/050218 WO2009030237A2 (en) | 2007-09-07 | 2008-09-04 | Methods for recombinant manufacturing of anti-rsv antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010002044A true MX2010002044A (es) | 2010-03-18 |
Family
ID=40297785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010002044A MX2010002044A (es) | 2007-09-07 | 2008-09-04 | Metodos para produccion recombinante de anticuerpos anti-virus sincitial respiratorio (anti-rsv). |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20090137003A1 (es) |
| EP (1) | EP2185590A2 (es) |
| JP (1) | JP2011514139A (es) |
| KR (1) | KR20100087283A (es) |
| CN (1) | CN101821289A (es) |
| AU (1) | AU2008295248A1 (es) |
| BR (1) | BRPI0817079A2 (es) |
| CA (1) | CA2695309A1 (es) |
| MX (1) | MX2010002044A (es) |
| RU (1) | RU2010113510A (es) |
| TW (1) | TW200925279A (es) |
| WO (1) | WO2009030237A2 (es) |
| ZA (1) | ZA201000756B (es) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2655933C (en) * | 2006-06-23 | 2014-09-09 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
| JP5669397B2 (ja) * | 2007-03-01 | 2015-02-12 | シムフォゲン・アクティーゼルスカブＳｙｍｐｈｏｇｅｎ Ａ／Ｓ | 同族抗体をクローニングするための方法 |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| RU2011111725A (ru) * | 2008-08-29 | 2012-10-10 | Симфоген А/С (Dk) | Способ клонирования антител птиц |
| CN104829714A (zh) | 2008-11-03 | 2015-08-12 | 阿莱斯亚生物疗法股份有限公司 | 特异性地阻滞肿瘤抗原的生物活性的抗体 |
| GB0905023D0 (en) | 2009-03-24 | 2009-05-06 | Univ Erasmus Medical Ct | Binding molecules |
| ES2553440T3 (es) | 2009-08-13 | 2015-12-09 | Crucell Holland B.V. | Anticuerpos contra el virus sincitial respiratorio humano (VSR) y método de uso |
| CN104628850B (zh) * | 2009-10-06 | 2020-07-28 | 医学免疫有限公司 | Rsv-特异性结合分子 |
| NZ599148A (en) * | 2009-10-06 | 2014-08-29 | Medimmune Ltd | Rsv-specific binding molecule |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| ES2595376T3 (es) | 2009-12-10 | 2016-12-29 | Regeneron Pharmaceuticals, Inc. | Ratones que producen anticuerpos de cadena pesada |
| CN103097412B (zh) | 2010-07-09 | 2016-08-10 | 克鲁塞尔荷兰公司 | 抗人呼吸道合胞病毒(rsv)抗体以及使用方法 |
| MX352373B (es) | 2011-03-31 | 2017-11-22 | Adc Therapeutics Sa | Anticuerpos contra antigeno 1 asociado con riñon y sus fragmentos de union de antigeno. |
| IN2014CN04690A (es) | 2012-01-09 | 2015-09-18 | Alethia Biotherapeutics Inc | |
| MX364265B (es) * | 2012-08-23 | 2019-04-17 | Agensys Inc | Conjugados de anticuerpo farmaco (adc) que enlazan a las proteinas 158p1d7. |
| JP5996707B2 (ja) * | 2015-04-15 | 2016-09-21 | メディミューン リミテド | Ｒｓｖ特異的結合分子 |
| HK1250513A1 (zh) | 2015-05-07 | 2018-12-21 | 阿吉纳斯公司 | 抗ox40抗体及其使用方法 |
| EP3383914A4 (en) * | 2015-12-02 | 2019-10-30 | Agenus Inc. | ANTI-OX40 ANTIBODIES AND METHOD OF USE THEREOF |
| WO2017096182A1 (en) * | 2015-12-03 | 2017-06-08 | Agenus Inc. | Anti-ox40 antibodies and methods of use thereof |
| JP7265984B2 (ja) | 2016-10-21 | 2023-04-27 | アディマブ， エルエルシー | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| BR112019008063A2 (pt) | 2016-10-21 | 2019-07-02 | Adimab, Llc | anticorpos contra o vírus sincicial anti-respiratório e métodos de sua geração e uso |
| EP3974447A3 (en) | 2016-10-21 | 2022-09-07 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP3538152A4 (en) | 2016-11-09 | 2020-09-30 | Agenus Inc. | ANTI-OX40 ANTIBODIES, ANTI-GITR ANTIBODIES, AND PROCESSES FOR USE |
| WO2018150029A1 (en) * | 2017-02-17 | 2018-08-23 | Institut Pasteur | Generation of monoclonal antibodies targeting respiratory syncytial virus (rsv) using regulatory b cells from newborns (nbregs) |
| WO2021202463A1 (en) | 2020-03-30 | 2021-10-07 | Danisco Us Inc | Anti-rsv antibodies |
| WO2021253002A1 (en) | 2020-06-12 | 2021-12-16 | Gigagen, Inc. | Recombinant polyclonal proteins targeting covid-19 and methods of use thereof |
| WO2022031834A1 (en) | 2020-08-05 | 2022-02-10 | Gigagen, Inc. | Recombinant polyclonal proteins targeting zika and methods of use thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060275766A1 (en) * | 2003-01-07 | 2006-12-07 | Haurum John S | Method for manufacturing recombinant polyclonal proteins |
| TWI333977B (en) * | 2003-09-18 | 2010-12-01 | Symphogen As | Method for linking sequences of interest |
| JP4870667B2 (ja) * | 2004-07-20 | 2012-02-08 | シムフォゲン・アクティーゼルスカブ | 組換えポリクローナルタンパク質またはポリクローナル細胞株を構造上特徴付ける方法 |
| MX2007000644A (es) * | 2004-07-20 | 2007-03-28 | Symphogen As | Anticuerpo policlonal recombinante anti-rhesus d y metodos de fabricacion. |
| US7850965B2 (en) * | 2005-12-05 | 2010-12-14 | Symphogen A/S | Anti-orthopoxvirus recombinant polyclonal antibody |
| US20100040606A1 (en) * | 2006-03-06 | 2010-02-18 | Symphogen A/S | Recombinant polyclonal antibody for treatment of respiratory syncytial virus infections |
| BRPI0808673A2 (pt) * | 2007-03-06 | 2014-08-12 | Symphogen A/S | Anticorpos recombinantes para tratamento de infecções com vírus sinciciais respiratórios. |
| BRPI0812091A2 (pt) * | 2007-05-25 | 2014-10-14 | Symphogen As | Método para fabricar uma proteína policlonal recombinante |
-
2008
- 2008-09-04 MX MX2010002044A patent/MX2010002044A/es not_active Application Discontinuation
- 2008-09-04 CA CA2695309A patent/CA2695309A1/en not_active Abandoned
- 2008-09-04 AU AU2008295248A patent/AU2008295248A1/en not_active Abandoned
- 2008-09-04 EP EP08784476A patent/EP2185590A2/en not_active Withdrawn
- 2008-09-04 KR KR1020107007563A patent/KR20100087283A/ko not_active Withdrawn
- 2008-09-04 WO PCT/DK2008/050218 patent/WO2009030237A2/en not_active Ceased
- 2008-09-04 CN CN200880106131A patent/CN101821289A/zh active Pending
- 2008-09-04 BR BRPI0817079A patent/BRPI0817079A2/pt not_active IP Right Cessation
- 2008-09-04 RU RU2010113510/10A patent/RU2010113510A/ru not_active Application Discontinuation
- 2008-09-04 JP JP2010523277A patent/JP2011514139A/ja active Pending
- 2008-09-05 TW TW097134053A patent/TW200925279A/zh unknown
- 2008-09-05 US US12/230,885 patent/US20090137003A1/en not_active Abandoned
-
2010
- 2010-02-01 ZA ZA2010/00756A patent/ZA201000756B/en unknown
-
2011
- 2011-09-23 US US13/243,768 patent/US20120009623A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0817079A2 (pt) | 2016-10-11 |
| WO2009030237A2 (en) | 2009-03-12 |
| CN101821289A (zh) | 2010-09-01 |
| WO2009030237A3 (en) | 2009-04-30 |
| KR20100087283A (ko) | 2010-08-04 |
| JP2011514139A (ja) | 2011-05-06 |
| AU2008295248A1 (en) | 2009-03-12 |
| RU2010113510A (ru) | 2011-10-20 |
| ZA201000756B (en) | 2010-10-27 |
| CA2695309A1 (en) | 2009-03-12 |
| US20120009623A1 (en) | 2012-01-12 |
| TW200925279A (en) | 2009-06-16 |
| US20090137003A1 (en) | 2009-05-28 |
| EP2185590A2 (en) | 2010-05-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |