BRPI0819092A2 - Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. - Google Patents
Evolução direcionada usando proteínas que compreendem aminoácidos não naturais.Info
- Publication number
- BRPI0819092A2 BRPI0819092A2 BRPI0819092A BRPI0819092A2 BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2 BR PI0819092 A BRPI0819092 A BR PI0819092A BR PI0819092 A2 BRPI0819092 A2 BR PI0819092A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acids
- unnatural amino
- directed evolution
- proteins
- understanding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1058—Directional evolution of libraries, e.g. evolution of libraries is achieved by mutagenesis and screening or selection of mixed population of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/67—General methods for enhancing the expression
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
- C40B40/08—Libraries containing RNA or DNA which encodes proteins, e.g. gene libraries
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Ecology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US168107P | 2007-11-02 | 2007-11-02 | |
| US12726208P | 2008-05-08 | 2008-05-08 | |
| US19477308P | 2008-09-29 | 2008-09-29 | |
| PCT/US2008/012363 WO2009061369A2 (en) | 2007-11-02 | 2008-10-31 | Directed evolution using proteins comprising unnatural amino acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0819092A2 true BRPI0819092A2 (pt) | 2014-10-14 |
Family
ID=40626380
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0819092 BRPI0819092A2 (pt) | 2007-11-02 | 2008-10-31 | Evolução direcionada usando proteínas que compreendem aminoácidos não naturais. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9150849B2 (pt) |
| EP (1) | EP2217702A4 (pt) |
| JP (1) | JP5513398B2 (pt) |
| KR (1) | KR20100091997A (pt) |
| CN (1) | CN101878303B (pt) |
| AU (1) | AU2008325239A1 (pt) |
| BR (1) | BRPI0819092A2 (pt) |
| CA (1) | CA2704494A1 (pt) |
| IL (1) | IL205238A0 (pt) |
| MX (1) | MX2010004807A (pt) |
| WO (1) | WO2009061369A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2128246B1 (en) | 2001-04-19 | 2014-03-12 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-Aminoacyl-tRNA synthetase pairs |
| CN103215228A (zh) | 2003-04-17 | 2013-07-24 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| ATE386133T1 (de) * | 2003-07-07 | 2008-03-15 | Scripps Research Inst | Zusammensetzungen der orthogonalen lysyl-trna und aminoacyl-trna synthetase paaren und ihre verwendungen |
| JP6193570B2 (ja) | 2009-07-17 | 2017-09-13 | バイオアトラ、エルエルシー | 産生宿主における抗体／タンパク質パフォーマンス及び発現の同時で統合された選択及び進化 |
| US9567386B2 (en) | 2010-08-17 | 2017-02-14 | Ambrx, Inc. | Therapeutic uses of modified relaxin polypeptides |
| SMT201900495T1 (it) * | 2010-08-17 | 2019-11-13 | Ambrx Inc | Polipeptidi di relaxina modificati e loro usi |
| KR101901467B1 (ko) | 2010-11-08 | 2018-11-02 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 안정성이 증가되고 보유 촉매 활성이 증가된 변종 재조합 베타-글루코세레브로시다제 단백질 |
| DE102013106462B3 (de) * | 2013-06-20 | 2014-10-09 | Airbus Defence and Space GmbH | Detektionsverfahren zur Detektion von Bakterien, Verfahren zur Herstellung von Fusionsproteinen und Fusionsprotein |
| US20160272957A1 (en) * | 2013-11-20 | 2016-09-22 | Danisco Us Inc. | Variant alpha-amylases having reduced susceptibility to protease cleavage, and methods of use, thereof |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| US11608570B2 (en) | 2016-07-29 | 2023-03-21 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Targeted in situ protein diversification by site directed DNA cleavage and repair |
| TW201837051A (zh) | 2017-02-08 | 2018-10-16 | 美商必治妥美雅史谷比公司 | 包含藥物動力學增強劑之經修飾之鬆弛素(relaxin)多肽及其用途 |
| US12404512B2 (en) | 2018-05-01 | 2025-09-02 | Ambrx, Inc. | Method for optimizing antibody expression |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| EP3935166A4 (en) * | 2019-03-04 | 2022-11-23 | The Texas A&M University System | METHODS OF MAKING AND USING IMPOSED AMBER BACTERIOPHAGE DISPLAY LIBRARIES |
| EP4045636A4 (en) * | 2019-10-15 | 2023-11-29 | University of Massachusetts | STRATEGY FOR AAV PRODUCTION USING A CELL LINE EXPRESSING AN INDUCTIBLE REP GENE |
| WO2021164694A1 (zh) * | 2020-02-17 | 2021-08-26 | 中国科学院生物物理研究所 | 抗体筛选方法 |
| WO2024216066A1 (en) * | 2023-04-12 | 2024-10-17 | The Board Of Trustees Of The Leland Stanford Junior University | Orthogonalized human protease |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE269401T1 (de) | 1991-04-10 | 2004-07-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| US6190908B1 (en) * | 1998-08-12 | 2001-02-20 | The Scripps Research Institute | Modulation of polypeptide display on modified filamentous phage |
| EP2128246B1 (en) | 2001-04-19 | 2014-03-12 | The Scripps Research Institute | Methods and compositions for the production of orthogonal tRNA-Aminoacyl-tRNA synthetase pairs |
| DK1402025T3 (da) * | 2001-06-15 | 2006-06-06 | Crucell Holland Bv | Kimære fager |
| FI20021726A0 (fi) * | 2002-09-27 | 2002-09-27 | Ctt Cancer Targeting Tech Oy | Menetelmä peptidien tuottamiseksi |
| MXPA05003978A (es) | 2002-10-16 | 2005-06-22 | Scripps Research Inst | Sintesis de glicoproteinas. |
| EP1583816A4 (en) | 2002-12-22 | 2007-06-13 | Scripps Research Inst | PROTEIN ARRAYS |
| CN103215228A (zh) | 2003-04-17 | 2013-07-24 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| CA2527877A1 (en) | 2003-06-18 | 2005-01-13 | The Scripps Research Institute | Unnatural reactive amino acid genetic code additions |
| WO2005007870A2 (en) | 2003-07-07 | 2005-01-27 | The Scripps Research Institute | COMPOSITIONS OF ORTHOGONAL LEUCYL-tRNA AND AMINOACYL-tRNA SYNTHETASE PAIRS AND USES THEREOF |
| EP1658366A4 (en) | 2003-07-07 | 2006-08-09 | Scripps Research Inst | COMPOSITIONS OF ORTHOGONAL GLUTAMYL-TRNA AND AMINOACYL-TRNA-SYNTHETASEPAARES AND THEIR USES |
| ATE386133T1 (de) | 2003-07-07 | 2008-03-15 | Scripps Research Inst | Zusammensetzungen der orthogonalen lysyl-trna und aminoacyl-trna synthetase paaren und ihre verwendungen |
| EP1687401B1 (en) | 2003-10-14 | 2012-11-21 | The Scripps Research Institute | Site-specific incorporation of redox active amino acids into proteins |
| CA2549830A1 (en) | 2003-12-18 | 2006-01-05 | The Scripps Research Institute | Selective incorporation of 5-hyroxytryptophan into proteins in mammalian cells |
| JP2008500050A (ja) | 2004-05-25 | 2008-01-10 | ザ スクリップス リサーチ インスティテュート | 結晶構造決定のための重原子含有非天然アミノ酸の部位特異的蛋白質組込み |
| EP1797177A4 (en) | 2004-09-21 | 2008-07-09 | Scripps Research Inst | ADDITION OF PHOTOREGULATED AMINO ACIDS TO THE GENETIC CODE |
| MX2007003142A (es) | 2004-09-21 | 2007-07-04 | Scripps Research Inst | Incorporacion in vivo de alquinil aminoacidos a proteinas en eubacterias. |
| US20060110784A1 (en) | 2004-09-22 | 2006-05-25 | The Scripps Research Institute | Site-specific labeling of proteins for NMR studies |
| JP2008516637A (ja) | 2004-10-20 | 2008-05-22 | ザ スクリップス リサーチ インスティテュート | 真正細菌へのｎ−アセチルガラクトサミンアミノ酸のインビボ部位特異的組込み |
| US20080227205A1 (en) * | 2005-06-03 | 2008-09-18 | Ambrx, Inc. | Incorporation on Non-Naturally Encoded Amino Acids Into Proteins |
| JP2008541769A (ja) | 2005-06-03 | 2008-11-27 | アンブレツクス・インコーポレイテツド | 改善されたヒトインターフェロン分子及びそれらの使用 |
| AU2006304110B2 (en) * | 2005-10-12 | 2012-02-02 | The Scripps Research Institute | Selective posttranslational modification of phage-displayed polypeptides |
| US20070178554A1 (en) | 2006-02-01 | 2007-08-02 | Nima Shiva | Orthogonal Aminoacyl Synthetase-tRNA Pairs for Incorporating Unnatural Amino Acids Into Proteins |
| CN101405401B (zh) | 2006-03-16 | 2013-03-27 | 斯克利普斯研究院 | 含非天然氨基酸苯基硒代半胱氨酸的蛋白质的遗传编程表达 |
| BRPI0716963A2 (pt) * | 2006-09-21 | 2013-11-05 | Scripps Research Inst | Expressão geneticamente programada de proteínas seletivamente sulfatadas em eubactéria |
-
2008
- 2008-10-31 KR KR20107011772A patent/KR20100091997A/ko not_active Withdrawn
- 2008-10-31 US US12/290,673 patent/US9150849B2/en active Active
- 2008-10-31 JP JP2010533076A patent/JP5513398B2/ja not_active Expired - Fee Related
- 2008-10-31 AU AU2008325239A patent/AU2008325239A1/en not_active Abandoned
- 2008-10-31 EP EP20080847822 patent/EP2217702A4/en not_active Withdrawn
- 2008-10-31 CN CN200880118668.9A patent/CN101878303B/zh not_active Expired - Fee Related
- 2008-10-31 US US12/734,416 patent/US9249408B2/en active Active
- 2008-10-31 MX MX2010004807A patent/MX2010004807A/es not_active Application Discontinuation
- 2008-10-31 BR BRPI0819092 patent/BRPI0819092A2/pt not_active IP Right Cessation
- 2008-10-31 CA CA 2704494 patent/CA2704494A1/en not_active Abandoned
- 2008-10-31 WO PCT/US2008/012363 patent/WO2009061369A2/en not_active Ceased
-
2010
- 2010-04-22 IL IL205238A patent/IL205238A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101878303B (zh) | 2014-04-30 |
| EP2217702A4 (en) | 2012-05-16 |
| CA2704494A1 (en) | 2009-05-14 |
| JP5513398B2 (ja) | 2014-06-04 |
| WO2009061369A2 (en) | 2009-05-14 |
| US9249408B2 (en) | 2016-02-02 |
| WO2009061369A3 (en) | 2009-09-03 |
| US20110065596A1 (en) | 2011-03-17 |
| MX2010004807A (es) | 2010-08-02 |
| JP2011502507A (ja) | 2011-01-27 |
| US9150849B2 (en) | 2015-10-06 |
| CN101878303A (zh) | 2010-11-03 |
| US20090163368A1 (en) | 2009-06-25 |
| AU2008325239A1 (en) | 2009-05-14 |
| IL205238A0 (en) | 2010-11-30 |
| KR20100091997A (ko) | 2010-08-19 |
| EP2217702A2 (en) | 2010-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 5A E 6A ANUIDADES. |
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| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2329 DE 25-08-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] |