BRPI0818457A2 - Derivados de oxadiazol - Google Patents

Derivados de oxadiazol

Info

Publication number: BRPI0818457A2
Authority: BR; Brazil
Prior art keywords: oxadiazol derivatives; oxadiazol; derivatives
Prior art date: 2007-10-04

Application number

Other languages

English (en)

Inventor

Anna Quattropani

Wolfgang Sauer

Mathilde Muzerelle

Delphine Marin

Cyril Montagne

Stefano Crosignani

Agnes Bombrun

Jérôme Dorbais

Jérôme Gonzalez

Patrick Gerber

Original Assignee

Merck Serono Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-10-04

Filing date

2008-10-01

Publication date

2015-04-14

2008-10-01 Application filed by Merck Serono Sa filed Critical Merck Serono Sa

2015-04-14 Publication of BRPI0818457A2 publication Critical patent/BRPI0818457A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Oncology (AREA)
Virology (AREA)
Physical Education & Sports Medicine (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Biomedical Technology (AREA)
Rheumatology (AREA)
Neurosurgery (AREA)
Molecular Biology (AREA)
Hematology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychiatry (AREA)

BRPI0818457 2007-10-04 2008-10-01 Derivados de oxadiazol BRPI0818457A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP07117921		2007-10-04
US99825407P	2007-10-09	2007-10-09
PCT/EP2008/063180 WO2009043889A2 (en)	2007-10-04	2008-10-01	Oxadiazole derivatives

Publications (1)

Publication Number	Publication Date
BRPI0818457A2 true BRPI0818457A2 (pt)	2015-04-14

Family

ID=38984441

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0818457 BRPI0818457A2 (pt)	2007-10-04	2008-10-01	Derivados de oxadiazol

Country Status (15)

Country	Link
US (1)	US8202865B2 (pt)
EP (1)	EP2193125B1 (pt)
JP (2)	JP6144450B2 (pt)
KR (1)	KR20100075608A (pt)
CN (1)	CN101970420B (pt)
AR (1)	AR068731A1 (pt)
AU (1)	AU2008306885B2 (pt)
BR (1)	BRPI0818457A2 (pt)
CA (1)	CA2696863C (pt)
EA (1)	EA201070422A1 (pt)
ES (1)	ES2622423T3 (pt)
IL (1)	IL204521A0 (pt)
MX (1)	MX2010003612A (pt)
WO (1)	WO2009043889A2 (pt)
ZA (2)	ZA201001121B (pt)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUE047569T2 (hu)	2003-04-11	2020-04-28	Ptc Therapeutics Inc	1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
CN101627034B (zh)	2007-03-16	2013-05-15	埃科特莱茵药品有限公司	氨基-吡啶衍生物作为s1p1/edg1受体激动剂
WO2009043890A1 (en)	2007-10-04	2009-04-09	Merck Serono S.A.	Oxadiazole diaryl compounds
EA020887B1 (ru) *	2007-12-21	2015-02-27	Мерк Сероно С.А.	Триазолсодержащие производные оксадиазола
CA2715317A1 (en)	2008-03-07	2009-09-11	Actelion Pharmaceuticals Ltd	Novel aminomethyl benzene derivatives
US8389509B2 (en)	2009-01-23	2013-03-05	Bristol-Myers Squibb Company	Substituted pyrazole compounds
US8354398B2 (en)	2009-01-23	2013-01-15	Bristol-Myers Squibb Company	Substituted isoxazole compounds
EP2389377B1 (en)	2009-01-23	2014-07-16	Bristol-Myers Squibb Company	Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
EP2241558A1 (en) *	2009-04-03	2010-10-20	Merck Serono SA	Oxadiazole derivatives
WO2010148649A1 (en) *	2009-06-26	2010-12-29	Glaxo Group Limited	5-membered heteroaryl derivatives used as sphingosine 1-phosphate receptor agonists
GB0911130D0 (en) *	2009-06-26	2009-08-12	Glaxo Group Ltd	Novel compounds
ES2441845T3 (es)	2009-07-16	2014-02-06	Actelion Pharmaceuticals Ltd.	Derivados de piridin-4-ilo como agonistas de S1P1/EDG1
US8399451B2 (en)	2009-08-07	2013-03-19	Bristol-Myers Squibb Company	Heterocyclic compounds
EP2597089A1 (en)	2009-10-29	2013-05-29	Bristol-Myers Squibb Company	Tricyclic heterocyclic compounds
JP5883794B2 (ja) *	2009-11-05	2016-03-15	フィブロスタチンソシエダリミターダＦｉｂｒｏｓｔａｔｉｎ，ＳｏｃｉｅｄａｄＬｉｍｉｔａｄａ	擬似ｑ２ペプチドを用いるｇｐｂｐ抑制
WO2011113309A1 (en) *	2010-03-17	2011-09-22	Glaxo Group Limited	Pyrimidine derivatives for use as sphingosine 1-phosphate 1 (s1p1) receptor agonists
ES2548683T3 (es)	2010-04-23	2015-10-20	Bristol-Myers Squibb Company	Amidas del ácido 4-(5-isoxazolil o 5-pirrazolil-1,2,4-oxadiazol-3-il)-mandélico como agonistas de receptor de esfingosina-1-fosfato 1
TW201206429A (en) *	2010-07-08	2012-02-16	Merck Serono Sa	Substituted oxadiazole derivatives
EP2595969B1 (en)	2010-07-20	2015-04-22	Bristol-Myers Squibb Company	Substituted 3-phenyl-1,2,4-oxadiazole compounds
ES2548258T3 (es)	2010-09-24	2015-10-15	Bristol-Myers Squibb Company	Compuestos de oxadiazol sustituidos y su uso como agonistas de S1P1
WO2012061459A1 (en)	2010-11-03	2012-05-10	Bristol-Myers Squibb Company	Heterocyclic compounds as s1p1 agonists for the treatment of autoimmune and vascular diseases
WO2012071278A1 (en)	2010-11-22	2012-05-31	Allergan, Inc.	Novel compounds as receptor modulators with therapeutic utility
TWI546300B (zh)	2011-01-19	2016-08-21	艾克泰聯製藥有限公司	２－甲氧基－吡啶－４－基衍生物
EP2511275A1 (en) *	2011-04-12	2012-10-17	Bioprojet	Novel piperidinyl monocarboxylic acids as S1P1 receptor agonists
CN102250035A (zh) *	2011-06-10	2011-11-23	北京富卡生物技术有限公司	二芳基取代-1，3，4-噁二唑化合物的合成方法和其药物用途
UY35338A (es)	2013-02-21	2014-08-29	Bristol Myers Squibb Company Una Corporación Del Estado De Delaware	Compuestos bicíclicos moduladores de la actividad de s1p1 y composiciones farmacéuticas que los contienen
CN105189487B (zh)	2013-03-15	2017-12-26	爱杜西亚药品有限公司	吡啶‑4‑基衍生物
EP2853532B1 (en) *	2013-09-28	2020-12-09	Instytut Farmakologii Polskiej Akademii Nauk	1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III
CN106455571A (zh)	2014-03-06	2017-02-22	Ptc医疗公司	1,2,4‑噁二唑苯甲酸的药物组合物和盐
AU2015281799B2 (en) *	2014-06-26	2019-11-28	Central Adelaide Local Health Network Incorporated	Enzyme interacting agents
AR101591A1 (es)	2014-08-20	2016-12-28	Bristol Myers Squibb Co	Compuestos bicíclicos sustituidos
WO2016065583A1 (en) *	2014-10-30	2016-05-06	Merck Sharp & Dohme Corp.	Oxazole orexin receptor antagonists
BR112017024785B1 (pt)	2015-05-20	2022-05-17	Idorsia Pharmaceuticals Ltd	Forma cristalina do composto (s)-3-{4-[5-(2-ciclopentil-6-metoxi-piridin-4-il)-[1,2,4] oxadiazol-3- il]-2-etil-6-metilfenoxi}-propano-1,2-diol, composição farmacêutica, e, uso
WO2017075312A1 (en)	2015-10-30	2017-05-04	Ptc Therapeutics, Inc.	Methods for treating epilepsy
JP6192130B2 (ja) *	2015-12-09	2017-09-06	株式会社大一商会	遊技機
JP2019516670A (ja) *	2016-04-12	2019-06-20	シンジェンタパーティシペーションズアーゲー	殺微生物性オキサジアゾール誘導体
TW201808922A (zh)	2016-06-20	2018-03-16	台灣神隆股份有限公司	製備阿塔魯仁及其中間體的方法
CN106279057B (zh) *	2016-08-15	2022-04-15	广州明药科技有限公司	Ataluren的合成方法
WO2018045149A1 (en)	2016-09-02	2018-03-08	Bristol-Myers Squibb Company	Substituted tricyclic heterocyclic compounds
US11046646B2 (en)	2017-08-09	2021-06-29	Bristol-Myers Squibb Company	Alkylphenyl compounds
WO2019032631A1 (en)	2017-08-09	2019-02-14	Bristol-Myers Squibb Company	Oxime ether compounds
CN109180439A (zh) *	2018-10-22	2019-01-11	江苏长青农化股份有限公司	一种麦草畏的合成方法
CN113563166B (zh) *	2019-04-24	2023-08-01	珠海市柏瑞医药科技有限公司	一种香兰醇醚的合成方法
KR20230038457A (ko)	2020-06-10	2023-03-20	알리고스 테라퓨틱스 인코포레이티드	코로나바이러스, 피코르나바이러스 및 노로바이러스 감염을 치료하기 위한 항바이러스 화합물
KR20220055802A (ko) *	2020-10-27	2022-05-04	서울대학교산학협력단	단백질 발현 억제제를 포함하는 항산화, 항염 및 치매 예방 또는 개선용 조성물 및 이의 용도
JP2024525589A (ja)	2021-07-09	2024-07-12	アリゴスセラピューティクスインコーポレイテッド	抗ウイルス化合物
CN113754646B (zh) *	2021-07-19	2023-07-25	安徽医科大学	(4-(1,2,4-恶二唑-5-基)苯基)甲酰胺衍生物及其在抗关节炎药物中的应用
CN113651805B (zh) *	2021-07-19	2023-07-25	安徽医科大学	一种1,2,4-噁二唑-吡啶类化合物及其在治疗阿尔茨海默症中的应用
WO2023043816A1 (en)	2021-09-17	2023-03-23	Aligos Therapeutics, Inc.	Anti-viral compounds for treating coronavirus, picornavirus, and norovirus infections
CN115141120B (zh) *	2022-06-30	2025-03-21	湖南大学	一种阿塔鲁伦的电氧化制备方法
CN116041277B (zh) *	2023-01-18	2024-11-01	中国药科大学	苯基和联苯基取代的五元杂环类化合物及其制备方法、药物组合物和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH623971B5 (de)	1976-06-04	1982-01-15	Hoechst Ag	Verfahren zur herstellung neuer benzofuranderivate und deren verwendung als optische aufheller.
US4135910A (en) *	1977-05-12	1979-01-23	Monsanto Company	Oxadiazol-3-yl-benzoates as plant growth regulants
DE4320801A1 (de)	1993-06-23	1995-01-05	Fahlberg List Pharma Gmbh	2-Hydroxyphenylsubstituierte 1,2,4-Triazole und 1,2,4-Oxadiazole, ihre Verwendung als pharmazeutische Wirkstoffe und sie enthaltende Arzneimittel
AUPP999799A0 (en)	1999-04-27	1999-05-20	Fujisawa Pharmaceutical Co., Ltd.	New compound
HUE047569T2 (hu)	2003-04-11	2020-04-28	Ptc Therapeutics Inc	1,2,4-oxadiazol-benzoesav vegyület és nonszensz szupresszióra történõ alkalmazása
AU2004240586A1 (en) *	2003-05-15	2004-12-02	Merck & Co., Inc.	3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as S1P receptor agonists
EP1670463A2 (en)	2003-10-01	2006-06-21	Merck & Co., Inc.	3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists
CA2547198A1 (en) *	2003-12-17	2005-06-30	Merck & Co., Inc.	(3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists
JP2008500991A (ja)	2004-05-29	2008-01-17	７ティーエムファーマエイ／エス	医学的使用のためのｃｒｔｈ２レセプターリガンド
AU2006256968A1 (en) *	2005-06-08	2006-12-14	Novartis Ag	Polycyclic oxadiazoles or I soxazoles and their use as SIP receptor ligands
CA2623327A1 (en)	2005-10-07	2007-04-19	Kissei Pharmaceutical Co., Ltd.	Nitrogenated heterocyclic compound and pharmaceutical composition comprising the same
JP2009269819A (ja) *	2006-08-25	2009-11-19	Asahi Kasei Pharma Kk	アミン化合物
KR20090057070A (ko)	2006-09-29	2009-06-03	노파르티스 아게	소염성 및 면역억제성을 갖는 옥사디아졸 유도체
BRPI0720043A2 (pt)	2006-12-15	2014-01-07	Abbott Lab	Composto oxadiazol
EP2014653A1 (en) *	2007-06-15	2009-01-14	Bioprojet	Novel dicarboxylic acid derivatives as S1P1 receptor agonists
WO2009043890A1 (en)	2007-10-04	2009-04-09	Merck Serono S.A.	Oxadiazole diaryl compounds

2008
- 2008-10-01 EP EP08804970.5A patent/EP2193125B1/en active Active
- 2008-10-01 WO PCT/EP2008/063180 patent/WO2009043889A2/en not_active Ceased
- 2008-10-01 ES ES08804970.5T patent/ES2622423T3/es active Active
- 2008-10-01 US US12/675,235 patent/US8202865B2/en not_active Expired - Fee Related
- 2008-10-01 CA CA2696863A patent/CA2696863C/en not_active Expired - Fee Related
- 2008-10-01 JP JP2010527449A patent/JP6144450B2/ja not_active Expired - Fee Related
- 2008-10-01 KR KR1020107009976A patent/KR20100075608A/ko not_active Withdrawn
- 2008-10-01 EA EA201070422A patent/EA201070422A1/ru unknown
- 2008-10-01 MX MX2010003612A patent/MX2010003612A/es not_active Application Discontinuation
- 2008-10-01 AU AU2008306885A patent/AU2008306885B2/en not_active Ceased
- 2008-10-01 CN CN200880110421.2A patent/CN101970420B/zh not_active Expired - Fee Related
- 2008-10-01 BR BRPI0818457 patent/BRPI0818457A2/pt not_active IP Right Cessation
- 2008-10-03 AR ARP080104333A patent/AR068731A1/es not_active Application Discontinuation
2010
- 2010-02-16 ZA ZA2010/01121A patent/ZA201001121B/en unknown
- 2010-03-16 IL IL204521A patent/IL204521A0/en unknown
2011
- 2011-06-14 ZA ZA2011/04423A patent/ZA201104423B/en unknown
2015
- 2015-01-15 JP JP2015006185A patent/JP6148263B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US8202865B2 (en)	2012-06-19
AU2008306885A1 (en)	2009-04-09
EA201070422A1 (ru)	2010-12-30
AU2008306885B2 (en)	2013-12-05
ZA201104423B (en)	2012-03-28
WO2009043889A3 (en)	2009-08-20
JP6148263B2 (ja)	2017-06-14
KR20100075608A (ko)	2010-07-02
IL204521A0 (en)	2010-11-30
AR068731A1 (es)	2009-12-02
ES2622423T3 (es)	2017-07-06
CA2696863C (en)	2016-10-18
JP6144450B2 (ja)	2017-06-07
CA2696863A1 (en)	2009-04-09
CN101970420A (zh)	2011-02-09
CN101970420B (zh)	2014-09-24
JP2010540592A (ja)	2010-12-24
EP2193125A2 (en)	2010-06-09
JP2015063571A (ja)	2015-04-09
ZA201001121B (en)	2011-10-26
US20100240658A1 (en)	2010-09-23
MX2010003612A (es)	2010-04-30
EP2193125B1 (en)	2017-01-11
WO2009043889A2 (en)	2009-04-09

Publication	Publication Date	Title
BRPI0818457A2 (pt)	2015-04-14	Derivados de oxadiazol
DK2164844T3 (da)	2012-08-20	Pyrimidinyl-pyridazinonderivater
DK2209786T3 (da)	2013-06-03	Pyrimidinsubstituerede purinderivater
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
BRPI0812155A2 (pt)	2019-09-24	derivados de espiroindolinona
BRPI0813836A2 (pt)	2015-01-06	Derivados pirazólicos
BRPI0817935A2 (pt)	2015-04-07	Derivados de biarila
DK2016080T3 (da)	2010-11-22	Dihydropyrazolopyrimidinon-derivater
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
ATE483711T1 (de)	2010-10-15	Spiroindolinonderivate
ATE518837T1 (de)	2011-08-15	Indazolamidderivate
ATE469905T1 (de)	2010-06-15	Pyridopyrimidinonderivate
EP2226315A4 (en)	2012-01-25	2-aminoquinazoline DERIVATIVE
DK2308877T3 (da)	2014-04-22	Imidazopyridin-2-on-derivater
ATE512135T1 (de)	2011-06-15	Spiroindolinonderivate
BRPI0820649A2 (pt)	2015-06-16	Derivados de isoxazalo-pirazina
DK2035394T3 (da)	2009-10-05	2-pyrazincarboxamidderivater
DK2152370T3 (da)	2011-08-15	Aryletherpyridazinonderivater
BRPI0915064A2 (pt)	2015-10-27	derivados de qunoxalinadiona
BRPI0913832A2 (pt)	2015-10-20	derivados de pirrolopiridinilpirimidin-2-ilamina
BRPI0817579A2 (pt)	2015-04-07	Derivados de tiazol
DK2275414T3 (da)	2015-06-22	Cyclopentylacrylamidderivat
ATE544764T1 (de)	2012-02-15	5-hydroxymethyloxazolidin-2-onderivate

Legal Events

Date	Code	Title	Description
2015-12-01	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 7A ANUIDADE.
2016-04-05	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.