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MX2010003612A - Derivados de oxadiazol. - Google Patents

Derivados de oxadiazol.

Info

Publication number
MX2010003612A
MX2010003612A MX2010003612A MX2010003612A MX2010003612A MX 2010003612 A MX2010003612 A MX 2010003612A MX 2010003612 A MX2010003612 A MX 2010003612A MX 2010003612 A MX2010003612 A MX 2010003612A MX 2010003612 A MX2010003612 A MX 2010003612A
Authority
MX
Mexico
Prior art keywords
sup
oxadiazole derivatives
compounds
useful
formula
Prior art date
Application number
MX2010003612A
Other languages
English (en)
Inventor
Wolfgang Sauer
Anna Quattropani
Agnes Bombrun
Patrick Gerber
J R Me Gonzalez
Stefano Crosignani
Jerome Dorbais
Cyril Montagne
Delphine Marin
Mathilde Muzerelle
Original Assignee
Merck Serono Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Serono Sa filed Critical Merck Serono Sa
Publication of MX2010003612A publication Critical patent/MX2010003612A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • AIDS & HIV (AREA)

Abstract

La invenci?n se refiere a compuestos de la f?rmula I: (ver f?rmula I) los compuestos son ?tiles, v.gr., en el tratamiento de trastornos autoinmunes, tales como esclerosis m?ltiple.
MX2010003612A 2007-10-04 2008-10-01 Derivados de oxadiazol. MX2010003612A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07117921 2007-10-04
US99825407P 2007-10-09 2007-10-09
PCT/EP2008/063180 WO2009043889A2 (en) 2007-10-04 2008-10-01 Oxadiazole derivatives

Publications (1)

Publication Number Publication Date
MX2010003612A true MX2010003612A (es) 2010-04-30

Family

ID=38984441

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003612A MX2010003612A (es) 2007-10-04 2008-10-01 Derivados de oxadiazol.

Country Status (15)

Country Link
US (1) US8202865B2 (es)
EP (1) EP2193125B1 (es)
JP (2) JP6144450B2 (es)
KR (1) KR20100075608A (es)
CN (1) CN101970420B (es)
AR (1) AR068731A1 (es)
AU (1) AU2008306885B2 (es)
BR (1) BRPI0818457A2 (es)
CA (1) CA2696863C (es)
EA (1) EA201070422A1 (es)
ES (1) ES2622423T3 (es)
IL (1) IL204521A0 (es)
MX (1) MX2010003612A (es)
WO (1) WO2009043889A2 (es)
ZA (2) ZA201001121B (es)

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SI2125797T1 (sl) 2007-03-16 2014-03-31 Actelion Pharmaceuticals Ltd. Derivati amino-piridina kot agonisti receptorja s1p1/edg1
ES2547877T3 (es) 2007-10-04 2015-10-09 Merck Serono S.A. Compuestos diaril-oxadiazol
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WO2010085581A1 (en) 2009-01-23 2010-07-29 Bristol-Myers Squibb Company Substituted oxadiazole derivatives as s1p agonists in the treatment of autoimmune and inflammatory diseases
EP2241558A1 (en) * 2009-04-03 2010-10-20 Merck Serono SA Oxadiazole derivatives
GB0911130D0 (en) * 2009-06-26 2009-08-12 Glaxo Group Ltd Novel compounds
WO2010148649A1 (en) * 2009-06-26 2010-12-29 Glaxo Group Limited 5-membered heteroaryl derivatives used as sphingosine 1-phosphate receptor agonists
EP2454255B1 (en) 2009-07-16 2013-11-06 Actelion Pharmaceuticals Ltd. Pyridin-4-yl derivatives as s1p1/edg1 agonists
US8399451B2 (en) 2009-08-07 2013-03-19 Bristol-Myers Squibb Company Heterocyclic compounds
KR20130036171A (ko) 2009-10-29 2013-04-11 브리스톨-마이어스 스큅 컴퍼니 트리시클릭 헤테로시클릭 화합물
CN102781898B (zh) * 2009-11-05 2014-12-24 菲布他丁有限合伙公司 使用q2拟肽的gpbp抑制
EP2547662A4 (en) * 2010-03-17 2013-10-02 Glaxo Group Ltd PYRIMIDINE DERIVATIVES FOR USE AS AGONISTS OF SPHINGOSIN 1-PHOSPHATE 1 (S1P1) RECEPTORS
EP2560969B1 (en) 2010-04-23 2015-08-12 Bristol-Myers Squibb Company 4-(5-isoxazolyl or 5-pyrrazolyl-1,2,4-oxadiazol-3-yl)-mandelic acid amides as sphingosin-1-phosphate 1 receptor agonists
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JP5869579B2 (ja) 2010-09-24 2016-02-24 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 置換オキサジアゾール化合物およびそれらのｓ１ｐ１アゴニストとしての使用
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