BRPI0817482B8 - uso de um anticorpo do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd) - Google Patents
uso de um anticorpo do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd)Info
- Publication number
- BRPI0817482B8 BRPI0817482B8 BRPI0817482A BRPI0817482A BRPI0817482B8 BR PI0817482 B8 BRPI0817482 B8 BR PI0817482B8 BR PI0817482 A BRPI0817482 A BR PI0817482A BR PI0817482 A BRPI0817482 A BR PI0817482A BR PI0817482 B8 BRPI0817482 B8 BR PI0817482B8
- Authority
- BR
- Brazil
- Prior art keywords
- host disease
- versus host
- graft versus
- gvhd
- interleukin
- Prior art date
Links
- 208000009329 Graft vs Host Disease Diseases 0.000 title abstract 4
- 208000024908 graft versus host disease Diseases 0.000 title abstract 4
- 102000004889 Interleukin-6 Human genes 0.000 title abstract 2
- 108090001005 Interleukin-6 Proteins 0.000 title abstract 2
- 229940100601 interleukin-6 Drugs 0.000 title abstract 2
- 102000005962 receptors Human genes 0.000 title abstract 2
- 108020003175 receptors Proteins 0.000 title abstract 2
- 239000003814 drug Substances 0.000 abstract 3
- 229940124597 therapeutic agent Drugs 0.000 abstract 3
- 239000013543 active substance Substances 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102000010781 Interleukin-6 Receptors Human genes 0.000 abstract 1
- 108010038501 Interleukin-6 Receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
agentes terapêuticos para a doença do enxerto versus hospedeiro compreendendo um inibidor do receptor da interleucina 6 como substância ativa. a presente invenção fornece um novo agente terapêutico para a doença do enxerto versus hospedeiro (gvhd). um agente terapêutico para a doença do enxerto versus hospedeiro (gvhd), que compreende um inibidor do receptor da interleucina-6 (il-6) como substância ativa.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122019021238A BR122019021238B8 (pt) | 2007-10-02 | 2008-10-01 | uso de um inibidor do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd) |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007258810 | 2007-10-02 | ||
| PCT/JP2008/067835 WO2009044774A1 (ja) | 2007-10-02 | 2008-10-01 | インターロイキン6受容体阻害剤を有効成分とする移植片対宿主病治療剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0817482A2 BRPI0817482A2 (pt) | 2015-09-29 |
| BRPI0817482B1 BRPI0817482B1 (pt) | 2020-01-14 |
| BRPI0817482B8 true BRPI0817482B8 (pt) | 2021-05-25 |
Family
ID=40526199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122019021238A BR122019021238B8 (pt) | 2007-10-02 | 2008-10-01 | uso de um inibidor do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd) |
| BRPI0817482A BRPI0817482B8 (pt) | 2007-10-02 | 2008-10-01 | uso de um anticorpo do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122019021238A BR122019021238B8 (pt) | 2007-10-02 | 2008-10-01 | uso de um inibidor do receptor da interleucina-6 (il-6) no tratamento da doença do enxerto versus hospedeiro (gvhd) |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8529895B2 (pt) |
| EP (1) | EP2196220B1 (pt) |
| JP (1) | JP5264752B2 (pt) |
| KR (1) | KR101601986B1 (pt) |
| CN (1) | CN101815532B (pt) |
| AU (1) | AU2008308163B2 (pt) |
| BR (2) | BR122019021238B8 (pt) |
| CA (1) | CA2701155C (pt) |
| MX (1) | MX2010003139A (pt) |
| RU (1) | RU2490025C2 (pt) |
| TW (1) | TWI468173B (pt) |
| WO (1) | WO2009044774A1 (pt) |
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| WO1998042377A1 (fr) | 1997-03-21 | 1998-10-01 | Chugai Seiyaku Kabushiki Kaisha | Substances servant a la prevention ou au traitement de maladies liees a la cellule-t sensibilisee contenant comme principe actif des antagonistes de l'il-6 |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| PL213311B1 (pl) | 2002-02-14 | 2013-02-28 | Chugai Pharmaceutical Co Ltd | Preparat roztworu zawierajacego przeciwcialo |
| GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| EP3269738A1 (en) | 2004-03-24 | 2018-01-17 | Chugai Seiyaku Kabushiki Kaisha | Subtypes of humanized antibody against interleukin-6 receptor |
| DK2006381T3 (en) | 2006-03-31 | 2016-02-22 | Chugai Pharmaceutical Co Ltd | PROCEDURE FOR REGULATING ANTIBODIES BLOOD PHARMACOKINETICS |
| ES2566957T3 (es) | 2007-09-26 | 2016-04-18 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| DK2202245T3 (en) | 2007-09-26 | 2016-11-21 | Chugai Pharmaceutical Co Ltd | A method of modifying an antibody isoelectric point VIA amino acid substitution in CDR |
| PE20091174A1 (es) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| UA121453C2 (uk) | 2008-04-11 | 2020-06-10 | Чугей Сейяку Кабусікі Кайся | Спосіб одержання фармацевтичної композиції, яка містить антитіло |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| MX2012004682A (es) | 2009-10-26 | 2012-09-07 | Hoffmann La Roche | Metodo para la produccion de una inmunoglobulina glicosilada. |
| EP4029881A1 (en) | 2010-11-08 | 2022-07-20 | F. Hoffmann-La Roche AG | Subcutaneously administered anti-il-6 receptor antibody |
| KR102385507B1 (ko) | 2010-11-30 | 2022-04-12 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| JP6442404B2 (ja) | 2013-06-11 | 2018-12-19 | 国立研究開発法人国立精神・神経医療研究センター | 再発寛解型多発性硬化症(rrms)患者の治療予後予測方法、及び新規治療適応判断方法 |
| EP3017303B1 (en) | 2013-07-04 | 2018-01-03 | F.Hoffmann-La Roche Ag | Interference-suppressed immunoassay to detect anti-drug antibodies in serum samples |
| US10617670B2 (en) | 2014-10-10 | 2020-04-14 | Pfizer Inc. | Synergistic auristatin combinations |
| WO2016136933A1 (ja) | 2015-02-27 | 2016-09-01 | 中外製薬株式会社 | Il-6関連疾患治療用組成物 |
| WO2016186154A1 (ja) | 2015-05-19 | 2016-11-24 | 国立研究開発法人国立精神・神経医療研究センター | 多発性硬化症(ms)患者の新規治療適用判断方法 |
| WO2017147169A1 (en) | 2016-02-22 | 2017-08-31 | Ohio State Innovation Foundation | Chemoprevention using controlled-release formulations of anti-interleukin 6 agents, synthetic vitamin a analogues or metabolites, and estradiol metabolites |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| EP3554541B1 (en) | 2016-12-14 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| EP3554540B1 (en) | 2016-12-14 | 2023-08-02 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device |
| WO2018170405A1 (en) | 2017-03-17 | 2018-09-20 | Ohio State Innovation Foundation | Nanoparticles for delivery of chemopreventive agents |
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| US11851486B2 (en) | 2017-05-02 | 2023-12-26 | National Center Of Neurology And Psychiatry | Method for predicting and evaluating therapeutic effect in diseases related to IL-6 and neutrophils |
| EP3698808B1 (en) | 2017-10-20 | 2025-01-01 | Hyogo College Of Medicine | Anti-il-6 receptor antibody-containing medicinal composition for preventing post-surgical adhesion |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
| EP4634214A1 (en) | 2022-12-15 | 2025-10-22 | Aarhus Universitet | Synthetic activation of multimeric transmembrane receptors |
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| US20040071666A1 (en) * | 2002-05-24 | 2004-04-15 | The Regents Of The University Of Michigan | Compositions and methods related to graft-versus-host disease |
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| WO2008090901A1 (ja) | 2007-01-23 | 2008-07-31 | Shinshu University | 慢性拒絶反応抑制剤 |
-
2008
- 2008-10-01 AU AU2008308163A patent/AU2008308163B2/en active Active
- 2008-10-01 JP JP2009536069A patent/JP5264752B2/ja active Active
- 2008-10-01 EP EP08836642.2A patent/EP2196220B1/en active Active
- 2008-10-01 CA CA2701155A patent/CA2701155C/en active Active
- 2008-10-01 BR BR122019021238A patent/BR122019021238B8/pt active IP Right Grant
- 2008-10-01 MX MX2010003139A patent/MX2010003139A/es active IP Right Grant
- 2008-10-01 WO PCT/JP2008/067835 patent/WO2009044774A1/ja not_active Ceased
- 2008-10-01 CN CN2008801100103A patent/CN101815532B/zh active Active
- 2008-10-01 US US12/733,951 patent/US8529895B2/en active Active
- 2008-10-01 KR KR1020107009597A patent/KR101601986B1/ko active Active
- 2008-10-01 RU RU2010117171/15A patent/RU2490025C2/ru active
- 2008-10-01 BR BRPI0817482A patent/BRPI0817482B8/pt active IP Right Grant
- 2008-10-02 TW TW97137932A patent/TWI468173B/zh active
Also Published As
| Publication number | Publication date |
|---|---|
| JP5264752B2 (ja) | 2013-08-14 |
| HK1145288A1 (en) | 2011-04-15 |
| RU2010117171A (ru) | 2011-11-10 |
| RU2490025C2 (ru) | 2013-08-20 |
| CN101815532B (zh) | 2012-08-15 |
| TWI468173B (zh) | 2015-01-11 |
| BR122019021238B8 (pt) | 2021-07-27 |
| US8529895B2 (en) | 2013-09-10 |
| AU2008308163B2 (en) | 2013-03-21 |
| EP2196220A1 (en) | 2010-06-16 |
| TW200932262A (en) | 2009-08-01 |
| BRPI0817482B1 (pt) | 2020-01-14 |
| BR122019021238B1 (pt) | 2021-02-23 |
| US20100255007A1 (en) | 2010-10-07 |
| KR20100075591A (ko) | 2010-07-02 |
| AU2008308163A1 (en) | 2009-04-09 |
| KR101601986B1 (ko) | 2016-03-17 |
| BRPI0817482A2 (pt) | 2015-09-29 |
| CA2701155A1 (en) | 2009-04-09 |
| JPWO2009044774A1 (ja) | 2011-02-10 |
| CN101815532A (zh) | 2010-08-25 |
| EP2196220A4 (en) | 2011-12-21 |
| MX2010003139A (es) | 2010-04-07 |
| CA2701155C (en) | 2016-11-22 |
| WO2009044774A1 (ja) | 2009-04-09 |
| EP2196220B1 (en) | 2014-12-03 |
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