BRPI0817315A2 - Inibidores de quinase do tipo polo - Google Patents

Inibidores de quinase do tipo polo

Info

Publication number: BRPI0817315A2
Authority: BR; Brazil
Prior art keywords: kinase inhibitors; type kinase; polo type; polo; inhibitors
Prior art date: 2007-09-25

Application number

Other languages

English (en)

Inventor

Sheldon X Cao

Victoria Feher

Takashi Ichikawa

Benjamin Jones

Stephen W Kaldor

Andre A Kiryanov

Yan Liu

Christopher Mcbride

Srinivasa Reddy Natala

Jeffrey A Stafford

Zhe Nie

Betty Lam

Original Assignee

Takeda Pharmaceutical

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-09-25

Filing date

2008-09-24

Publication date

2015-03-17

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40219644&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0817315(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2008-09-24 Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical

2015-03-17 Publication of BRPI0817315A2 publication Critical patent/BRPI0817315A2/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Dermatology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Physical Education & Sports Medicine (AREA)
Neurology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Orthopedic Medicine & Surgery (AREA)
Heart & Thoracic Surgery (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Psychology (AREA)
Toxicology (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Psychiatry (AREA)
Vascular Medicine (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

BRPI0817315 2007-09-25 2008-09-24 Inibidores de quinase do tipo polo BRPI0817315A2 (pt)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US97512707P	2007-09-25	2007-09-25
US3730308P	2008-03-17	2008-03-17
PCT/US2008/077558 WO2009042711A1 (en)	2007-09-25	2008-09-24	Polo-like kinase inhibitors

Publications (1)

Publication Number	Publication Date
BRPI0817315A2 true BRPI0817315A2 (pt)	2015-03-17

Family

ID=40219644

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0817315 BRPI0817315A2 (pt)	2007-09-25	2008-09-24	Inibidores de quinase do tipo polo

Country Status (26)

Country	Link
US (4)	US20110201818A1 (pt)
EP (3)	EP2564850B1 (pt)
JP (2)	JP5372939B2 (pt)
KR (2)	KR101444924B1 (pt)
CN (2)	CN103122001A (pt)
AR (1)	AR071729A1 (pt)
AU (1)	AU2008304417B2 (pt)
BR (1)	BRPI0817315A2 (pt)
CA (2)	CA2699607A1 (pt)
CL (1)	CL2008002852A1 (pt)
CO (1)	CO6270231A2 (pt)
CR (1)	CR11370A (pt)
DO (1)	DOP2010000091A (pt)
EA (1)	EA019487B1 (pt)
EC (1)	ECSP10010129A (pt)
ES (1)	ES2488966T3 (pt)
GE (1)	GEP20125704B (pt)
MA (1)	MA31763B1 (pt)
MX (2)	MX2010003249A (pt)
MY (1)	MY152283A (pt)
NZ (1)	NZ584760A (pt)
PE (1)	PE20090710A1 (pt)
TN (1)	TN2010000131A1 (pt)
TW (1)	TWI436769B (pt)
WO (2)	WO2009042711A1 (pt)
ZA (1)	ZA201002543B (pt)

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EP2564850B1 (en) *	2007-09-25	2014-08-13	Takeda Pharmaceutical Company Limited	Polo-like kinase inhibitors
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CA2756568C (en)	2009-04-06	2018-02-13	University Health Network	Kinase inhibitors and method of treating cancer with same
ES2567280T3 (es)	2009-09-25	2016-04-21	Vertex Pharmaceuticals Incorporated	Métodos para preparar derivados de pirimidina útiles como inhibidores de proteína quinasa
EP2480553A2 (en) *	2009-09-25	2012-08-01	Vertex Pharmaceuticals Incorporated	Methods for preparing pyrimidine derivatives useful as protein kinase inhibitors
EP2516441B1 (en)	2009-12-23	2015-01-21	Elan Pharmaceuticals Inc.	Pteridinones as inhibitors of polo-like kinase
ES2639757T3 (es)	2010-04-06	2017-10-30	University Health Network	Síntesis de 2-(1H-indazol-6-il)espiro[ciclopropan-1,3'-indolin]-2'-onas quirales
TW201307347A (zh)	2010-11-01	2013-02-16	Arqule Inc	經取代苯並－咪唑並－吡啶並－二氮呯化合物
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EA031569B1 (ru)	2013-10-18	2019-01-31	Юниверсити Хелс Нетуорк	Солевые и кристаллические формы ингибитора plk-4
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PE20181086A1 (es)	2015-09-11	2018-07-05	Dana Farber Cancer Inst Inc	Acetamida tienotrizolodiazepinas y usos de las mismas
MX2018006499A (es)	2015-11-25	2018-08-01	Dana Farber Cancer Inst Inc	Inhibidores de bromodominio bivalentes y usos de los mismos.
TW202506629A (zh) *	2016-05-05	2025-02-16	美商嘉來克生命科學有限責任公司	整合應激途徑之調節劑
AU2020264143A1 (en)	2019-04-24	2021-10-28	University Health Network	Crystal form S4 of the PLK4 inhibitor (1R,2S)-(E)-2-(3-(4-((cis-2,6-dimethylmorpholino)methyl)styryl)- 1 H-imidazol-6- yl)-5'-methoxyspiro(cyclopropane-1,3'-indolin)-2'-one fumarate
WO2021194319A1 (en)	2020-03-27	2021-09-30	Uppthera	Vanillin derivative compounds inducing selective degradation of plk1
WO2022145989A1 (ko) *	2020-12-31	2022-07-07	(주) 업테라	선택적 plk1 억제제로서의 피리미도디아제핀 유도체
CN116761806B (zh) *	2021-02-08	2025-10-10	上海复星医药产业发展有限公司	5，6-二氢噻吩并[3，4-h]喹唑啉类化合物
WO2024229406A1 (en)	2023-05-04	2024-11-07	Revolution Medicines, Inc.	Combination therapy for a ras related disease or disorder
WO2025034702A1 (en)	2023-08-07	2025-02-13	Revolution Medicines, Inc.	Rmc-6291 for use in the treatment of ras protein-related disease or disorder
TW202530228A (zh)	2023-10-12	2025-08-01	美商銳新醫藥公司	Ｒａｓ抑制劑
WO2025171296A1 (en)	2024-02-09	2025-08-14	Revolution Medicines, Inc.	Ras inhibitors
WO2025240847A1 (en)	2024-05-17	2025-11-20	Revolution Medicines, Inc.	Ras inhibitors
US20250375445A1 (en)	2024-06-07	2025-12-11	Revolution Medicines, Inc.	Methods of treating a ras protein-related disease or disorder
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EP2139892B1 (en) *	2007-03-22	2011-09-14	Takeda Pharmaceutical Company Limited	Substituted pyrimidodiazepines useful as plk1 inhibitors
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EP2564850B1 (en) *	2007-09-25	2014-08-13	Takeda Pharmaceutical Company Limited	Polo-like kinase inhibitors
EP2610256B1 (en)	2007-09-28	2016-04-27	Cyclacel Limited	Pyrimidine derivatives as protein kinase inhibitors
WO2009153197A1 (en)	2008-06-18	2009-12-23	F. Hoffmann-La Roche Ag	Halo-substituted pyrimidodiazepines as plkl inhibitors

2008
- 2008-09-24 EP EP12189293.9A patent/EP2564850B1/en active Active
- 2008-09-24 ES ES08834219.1T patent/ES2488966T3/es active Active
- 2008-09-24 CA CA2699607A patent/CA2699607A1/en not_active Abandoned
- 2008-09-24 MX MX2010003249A patent/MX2010003249A/es active IP Right Grant
- 2008-09-24 WO PCT/US2008/077558 patent/WO2009042711A1/en not_active Ceased
- 2008-09-24 CN CN2012105686507A patent/CN103122001A/zh active Pending
- 2008-09-24 CN CN2008801169537A patent/CN101917995A/zh active Pending
- 2008-09-24 EA EA201070395A patent/EA019487B1/ru not_active IP Right Cessation
- 2008-09-24 AU AU2008304417A patent/AU2008304417B2/en not_active Ceased
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- 2008-09-24 KR KR1020147017278A patent/KR20140097440A/ko not_active Ceased
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- 2008-09-25 PE PE2008001672A patent/PE20090710A1/es not_active Application Discontinuation
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- 2008-09-25 EP EP08833760A patent/EP2197442B1/en not_active Not-in-force
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- 2008-09-25 JP JP2010526073A patent/JP2010540464A/ja active Pending
2010
- 2010-03-22 TN TNP2010000131A patent/TN2010000131A1/fr unknown
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Also Published As

Publication number	Publication date
TW200927135A (en)	2009-07-01
JP2010540463A (ja)	2010-12-24
HK1145144A1 (en)	2011-04-08
US20110082111A1 (en)	2011-04-07
AU2008304417B2 (en)	2013-07-18
CN103122001A (zh)	2013-05-29
TN2010000131A1 (en)	2011-09-26
WO2009042711A4 (en)	2009-06-04
ECSP10010129A (es)	2010-06-29
US8318727B2 (en)	2012-11-27
JP5372939B2 (ja)	2013-12-18
NZ584760A (en)	2012-03-30
EP2197442B1 (en)	2012-09-12
US20090281092A1 (en)	2009-11-12
KR20140097440A (ko)	2014-08-06
CO6270231A2 (es)	2011-04-20
MX2010003244A (es)	2010-04-21
EA201070395A1 (ru)	2010-10-29
EA019487B1 (ru)	2014-04-30
US8026234B2 (en)	2011-09-27
KR101444924B1 (ko)	2014-10-07
EP2564850B1 (en)	2014-08-13
EP2564850A1 (en)	2013-03-06
PE20090710A1 (es)	2009-07-15
AU2008304417A1 (en)	2009-04-02
EP2205241B1 (en)	2014-05-21
EP2197442A1 (en)	2010-06-23
CA2700295A1 (en)	2009-04-02
KR20100087292A (ko)	2010-08-04
GEP20125704B (en)	2012-12-10
ZA201002543B (en)	2011-11-30
AR071729A1 (es)	2010-07-14
DOP2010000091A (es)	2010-07-31
MA31763B1 (fr)	2010-10-01
US8202990B2 (en)	2012-06-19
WO2009042711A1 (en)	2009-04-02
TWI436769B (zh)	2014-05-11
MY152283A (en)	2014-09-15
WO2009042806A1 (en)	2009-04-02
CN101917995A (zh)	2010-12-15
MX2010003249A (es)	2010-11-09
CR11370A (es)	2010-07-16
US20100222575A1 (en)	2010-09-02
EP2205241A1 (en)	2010-07-14
US20110201818A1 (en)	2011-08-18
CL2008002852A1 (es)	2009-03-27
CA2699607A1 (en)	2009-04-02
JP2010540464A (ja)	2010-12-24
ES2488966T3 (es)	2014-09-01

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