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CY2017016I2 - Αναστολεις πρωτεασωματος - Google Patents

Αναστολεις πρωτεασωματος

Info

Publication number
CY2017016I2
CY2017016I2 CY2017016C CY2017016C CY2017016I2 CY 2017016 I2 CY2017016 I2 CY 2017016I2 CY 2017016 C CY2017016 C CY 2017016C CY 2017016 C CY2017016 C CY 2017016C CY 2017016 I2 CY2017016 I2 CY 2017016I2
Authority
CY
Cyprus
Prior art keywords
proteasomy
inhibitors
proteasomy inhibitors
Prior art date
Application number
CY2017016C
Other languages
English (en)
Other versions
CY2017016I1 (el
Original Assignee
Millennium Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38691782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2017016(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Millennium Pharmaceuticals, Inc. filed Critical Millennium Pharmaceuticals, Inc.
Publication of CY2017016I1 publication Critical patent/CY2017016I1/el
Publication of CY2017016I2 publication Critical patent/CY2017016I2/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/69—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Toxicology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CY2017016C 2007-08-06 2017-04-26 Αναστολεις πρωτεασωματος CY2017016I2 (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2007/017440 WO2009020448A1 (en) 2007-08-06 2007-08-06 Proteasome inhibitors

Publications (2)

Publication Number Publication Date
CY2017016I1 CY2017016I1 (el) 2017-07-12
CY2017016I2 true CY2017016I2 (el) 2017-07-12

Family

ID=38691782

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20121100845T CY1113386T1 (el) 2007-08-06 2012-09-17 Αναστολεις πρωτεασωματος
CY2017016C CY2017016I2 (el) 2007-08-06 2017-04-26 Αναστολεις πρωτεασωματος

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20121100845T CY1113386T1 (el) 2007-08-06 2012-09-17 Αναστολεις πρωτεασωματος

Country Status (32)

Country Link
EP (3) EP2178888B1 (el)
JP (1) JP5261488B2 (el)
KR (6) KR20160040735A (el)
CN (1) CN101772507B (el)
AU (1) AU2007357338B2 (el)
BR (1) BRPI0721905B8 (el)
CA (1) CA2695082C (el)
CY (2) CY1113386T1 (el)
DK (1) DK2178888T3 (el)
EA (1) EA028622B1 (el)
EC (1) ECSP10010015A (el)
ES (1) ES2390606T3 (el)
FR (1) FR17C1011I2 (el)
GE (1) GEP20125599B (el)
HR (1) HRP20120745T1 (el)
HU (1) HUS1700018I1 (el)
IL (4) IL203641A (el)
LT (1) LTC2178888I2 (el)
LU (1) LUC00013I2 (el)
MY (1) MY161991A (el)
NL (1) NL300871I2 (el)
NZ (1) NZ582693A (el)
PH (1) PH12014500053B1 (el)
PL (1) PL2178888T3 (el)
PT (1) PT2178888E (el)
RS (1) RS52435B (el)
SG (1) SG10201508712QA (el)
SI (1) SI2178888T1 (el)
TN (1) TN2010000060A1 (el)
UA (1) UA97536C2 (el)
WO (1) WO2009020448A1 (el)
ZA (1) ZA201000348B (el)

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* Cited by examiner, † Cited by third party
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US7576206B2 (en) 2003-08-14 2009-08-18 Cephalon, Inc. Proteasome inhibitors and methods of using the same
US7468383B2 (en) 2005-02-11 2008-12-23 Cephalon, Inc. Proteasome inhibitors and methods of using the same
JP5436860B2 (ja) 2005-11-09 2014-03-05 オニキス セラピューティクス， インク． 酵素阻害のための化合物
WO2007149512A2 (en) 2006-06-19 2007-12-27 Proteolix, Inc. Peptide epoxyketones for pr0teas0me inhibition
US7442830B1 (en) 2007-08-06 2008-10-28 Millenium Pharmaceuticals, Inc. Proteasome inhibitors
MY173938A (en) 2007-10-04 2020-02-27 Onyx Therapeutics Inc Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
PT2730581T (pt) 2008-06-17 2016-08-17 Millennium Pharm Inc Compostos de ésteres de boronato e suas composições farmacêuticas
AR075090A1 (es) 2008-09-29 2011-03-09 Millennium Pharm Inc Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden.
AU2009308516B2 (en) 2008-10-21 2016-08-25 Onyx Therapeutics, Inc. Combination therapy with peptide epoxyketones
AR075899A1 (es) 2009-03-20 2011-05-04 Onyx Therapeutics Inc Tripeptidos epoxicetonas cristalinos inhibidores de proteasa
US8853147B2 (en) 2009-11-13 2014-10-07 Onyx Therapeutics, Inc. Use of peptide epoxyketones for metastasis suppression
CA2785300A1 (en) 2009-12-22 2011-07-21 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
BR112012022060A2 (pt) 2010-03-01 2018-05-08 Onyx Therapeutics Inc composto para a inibição de imunoproteassoma
MX2012011298A (es) 2010-03-31 2012-11-06 Millennium Pharm Inc Derivados del acido 1-amino-2-ciclopropiletilboronico.
CA2833775A1 (en) * 2011-06-22 2012-12-27 Cephalon, Inc. Proteasome inhibitors and processes for their preparation, purification and use
CN108383893A (zh) * 2011-08-30 2018-08-10 塔夫茨大学信托人 用于治疗实体瘤的fap-活化的蛋白酶体抑制剂
EA201400735A1 (ru) * 2011-12-22 2015-04-30 Арес Трейдинг С.А. Производные альфа-амино бороновой кислоты, селективные ингибиторы иммунопротеасомы
EP2812338A4 (en) * 2012-01-24 2015-09-23 Millennium Pharm Inc METHOD FOR THE TREATMENT OF NASOPHARYNGEAL CANCER
EP2810066B1 (en) * 2012-01-24 2019-07-31 Millennium Pharmaceuticals, Inc. Methods of treatment of cancer
US20140105921A1 (en) 2012-07-09 2014-04-17 Onyx Therapeutics, Inc. Prodrugs of Peptide Epoxy Ketone Protease Inhibitors
CN103570806B (zh) * 2012-07-26 2020-04-07 圣特莱国际公司 多肽环氧酮化合物
JP2013006855A (ja) * 2012-09-03 2013-01-10 Millennium Pharmaceuticals Inc プロテアソーム阻害剤
JP6018319B2 (ja) * 2012-12-03 2016-11-02 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 置換トリアゾールボロン酸化合物
US20160250238A1 (en) * 2013-10-03 2016-09-01 Millennium Pharmaceuticals, Inc. Method for the Prophylaxis or Treatment of Systemic Lupus Erythematosus and/or Lupus Nephritis
US20150335668A1 (en) 2014-05-20 2015-11-26 Millennium Pharmaceuticals, Inc. Method for cancer therapy
EP3177292B1 (en) 2014-08-07 2020-11-25 Mayo Foundation for Medical Education and Research Compounds and methods for treating cancer
MA41555A (fr) * 2015-02-17 2017-12-26 Millennium Pharm Inc Polythérapie pour le traitement du cancer
WO2016205790A2 (en) 2015-06-19 2016-12-22 Hanlin Scientific, Inc. Chiral specific boron-containing compounds and their use in treating cancer or amyloidosis
CN106608883A (zh) * 2015-10-21 2017-05-03 北京大学 蛋白酶体抑制剂mln9708的合成方法
WO2017198194A1 (zh) * 2016-05-19 2017-11-23 成都奥璟生物科技有限公司 一种硼酸和硼酸酯类化合物及其应用
CN106008572B (zh) * 2016-05-23 2018-08-17 成都千禧莱医药科技有限公司 一类二肽硼酸化合物及制备方法和用途
EP3472151A4 (en) 2016-06-21 2020-03-04 Orion Ophthalmology LLC CARBOCYCLIC PROLINAMIDE DERIVATIVES
JP7179721B2 (ja) 2016-06-21 2022-11-29 オリオン・オフサルモロジー・エルエルシー 複素環式プロリンアミド誘導体
WO2018019196A1 (zh) * 2016-07-25 2018-02-01 深圳市塔吉瑞生物医药有限公司 一种取代的硼酸化合物及包含该化合物的药物组合物及其用途
CN108440583B (zh) * 2017-01-23 2020-12-04 成都奥璟生物科技有限公司 一种新的硼酸衍生物及其药物组合物
US11596629B2 (en) 2017-02-28 2023-03-07 Mayo Foundation For Medical Education And Research Compounds and methods for treating cancer
CN108794516A (zh) * 2017-04-26 2018-11-13 上海时莱生物技术有限公司 硼酸和硼酸酯类化合物及其制备方法和用途
CN109305980B (zh) * 2017-07-28 2022-10-11 成都奥璟生物科技有限公司 一种硼酸酯化合物、其合成方法及其用途
ES2901022T3 (es) 2017-08-25 2022-03-21 Synthon Bv Procedimiento para la preparación de ixazomib y sus intermedios
JP2018024694A (ja) * 2017-10-03 2018-02-15 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． プロテアソーム阻害剤
US11243207B2 (en) 2018-03-29 2022-02-08 Mayo Foundation For Medical Education And Research Assessing and treating cancer
CN115403603A (zh) * 2018-09-14 2022-11-29 成都奥璟生物科技有限公司 一种硼酸酯类药物及其用途
CN110357787A (zh) * 2019-08-02 2019-10-22 苏州艾和医药科技有限公司 依沙佐米合成工艺研究
US20220362268A1 (en) * 2019-10-07 2022-11-17 Cornell University Antimicrobial and antiviral effects of c2-c7 alkyl boronic acids
CN110950897B (zh) * 2019-12-12 2021-05-28 山东大学 一种组蛋白去乙酰化酶、蛋白酶体双靶点抑制剂及其制备方法和应用

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US5250720A (en) 1987-06-05 1993-10-05 The Dupont Merck Pharmaceutical Company Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases
US5242904A (en) 1987-06-05 1993-09-07 The Dupont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0315574A3 (de) 1987-11-05 1990-08-22 Hoechst Aktiengesellschaft Renin-Inhibitoren
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Also Published As

Publication number Publication date
CY1113386T1 (el) 2016-06-22
EA201070247A1 (ru) 2010-06-30
CA2695082A1 (en) 2009-02-12
CY2017016I1 (el) 2017-07-12
LUC00013I2 (el) 2017-06-19
SG10201508712QA (en) 2015-11-27
KR20150010802A (ko) 2015-01-28
EP2527347A1 (en) 2012-11-28
IL242290A0 (en) 2015-11-30
SI2178888T1 (sl) 2012-11-30
KR20160040735A (ko) 2016-04-14
KR20140042932A (ko) 2014-04-07
LUC00013I1 (el) 2017-04-06
BRPI0721905A2 (pt) 2014-02-25
FR17C1011I1 (el) 2017-05-26
ES2390606T3 (es) 2012-11-14
BRPI0721905B8 (pt) 2021-05-25
IL242292A0 (en) 2015-11-30
IL242291A0 (en) 2015-11-30
HUS1700018I1 (hu) 2017-05-29
KR101831674B1 (ko) 2018-02-23
EP3210987A1 (en) 2017-08-30
LTC2178888I2 (lt) 2018-03-12
ECSP10010015A (es) 2010-04-30
KR101474831B1 (ko) 2014-12-19
CA2695082C (en) 2015-07-28
LTPA2017010I1 (lt) 2017-05-10
HK1182924A1 (zh) 2013-12-13
EP2178888B1 (en) 2012-07-04
NZ582693A (en) 2012-01-12
IL242290A (en) 2017-12-31
PH12014500053A1 (en) 2015-03-30
HRP20120745T1 (hr) 2012-10-31
IL242292A (en) 2017-12-31
RS52435B (sr) 2013-02-28
JP2010535759A (ja) 2010-11-25
WO2009020448A1 (en) 2009-02-12
PT2178888E (pt) 2012-10-04
BRPI0721905B1 (pt) 2020-11-17
IL203641A (en) 2015-11-30
KR20170004031A (ko) 2017-01-10
ZA201000348B (en) 2011-03-30
CN101772507B (zh) 2012-12-12
PH12014500053B1 (en) 2015-03-30
IL242291A (en) 2017-12-31
CN101772507A (zh) 2010-07-07
KR20100059811A (ko) 2010-06-04
AU2007357338B2 (en) 2014-03-20
TN2010000060A1 (en) 2011-09-26
EP2178888A1 (en) 2010-04-28
DK2178888T3 (da) 2012-10-01
JP5261488B2 (ja) 2013-08-14
NL300871I2 (nl) 2017-12-07
HK1143595A1 (en) 2011-01-07
EA028622B1 (ru) 2017-12-29
KR20140042933A (ko) 2014-04-07
GEP20125599B (en) 2012-08-10
PL2178888T3 (pl) 2012-11-30
UA97536C2 (en) 2012-02-27
FR17C1011I2 (fr) 2018-04-27
MY161991A (en) 2017-05-31
AU2007357338A1 (en) 2009-02-12

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