BRPI0816785A2 - bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas - Google Patents
bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmasInfo
- Publication number
- BRPI0816785A2 BRPI0816785A2 BRPI0816785A BRPI0816785A BRPI0816785A2 BR PI0816785 A2 BRPI0816785 A2 BR PI0816785A2 BR PI0816785 A BRPI0816785 A BR PI0816785A BR PI0816785 A BRPI0816785 A BR PI0816785A BR PI0816785 A2 BRPI0816785 A2 BR PI0816785A2
- Authority
- BR
- Brazil
- Prior art keywords
- antibody libraries
- synthetic antibody
- rationally designed
- designed synthetic
- rationally
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/06—Biochemical methods, e.g. using enzymes or whole viable microorganisms
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99378507P | 2007-09-14 | 2007-09-14 | |
| PCT/US2008/076300 WO2009036379A2 (en) | 2007-09-14 | 2008-09-12 | Rationally designed, synthetic antibody libraries and uses therefor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0816785A2 true BRPI0816785A2 (pt) | 2017-05-02 |
Family
ID=40350153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0816785A BRPI0816785A2 (pt) | 2007-09-14 | 2008-09-12 | bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8691730B2 (pt) |
| EP (3) | EP2193146B1 (pt) |
| JP (6) | JP5933894B2 (pt) |
| CN (1) | CN101855242B (pt) |
| AU (1) | AU2008298603B2 (pt) |
| BR (1) | BRPI0816785A2 (pt) |
| CA (3) | CA2697193C (pt) |
| DK (1) | DK3124497T3 (pt) |
| MX (4) | MX2010002661A (pt) |
| WO (1) | WO2009036379A2 (pt) |
Families Citing this family (252)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
| US20030119056A1 (en) | 2000-12-18 | 2003-06-26 | Ladner Robert Charles | Focused libraries of genetic packages |
| CN100480260C (zh) | 2002-07-18 | 2009-04-22 | 克鲁塞尔荷兰公司 | 抗体混合物的重组生产 |
| USRE47770E1 (en) | 2002-07-18 | 2019-12-17 | Merus N.V. | Recombinant production of mixtures of antibodies |
| US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
| CA2527694C (en) | 2003-05-30 | 2015-07-14 | Hendricus Renerus Jacobus Mattheus Hoogenboom | Fab library for the preparation of anti vegf and anti rabies virus fabs |
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| WO2009036379A2 (en) | 2007-09-14 | 2009-03-19 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| US12529164B2 (en) | 2007-09-14 | 2026-01-20 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
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| PL2501817T5 (pl) | 2010-02-08 | 2021-08-16 | Regeneron Pharmaceuticals, Inc. | Mysz o wspólnym łańcuchu lekkim |
| WO2011100369A2 (en) * | 2010-02-09 | 2011-08-18 | The Trustees Of Columbia University In The City Of New York | Methods for altering polypeptide expression and solubility |
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