[go: up one dir, main page]

BRPI0814288A2 - Processo para a preparação de um intermediário para antagonistas de receptor de opióide mu - Google Patents

Processo para a preparação de um intermediário para antagonistas de receptor de opióide mu

Info

Publication number
BRPI0814288A2
BRPI0814288A2 BRPI0814288-2A2A BRPI0814288A BRPI0814288A2 BR PI0814288 A2 BRPI0814288 A2 BR PI0814288A2 BR PI0814288 A BRPI0814288 A BR PI0814288A BR PI0814288 A2 BRPI0814288 A2 BR PI0814288A2
Authority
BR
Brazil
Prior art keywords
preparing
receptor antagonists
opioid receptor
opioid
antagonists
Prior art date
Application number
BRPI0814288-2A2A
Other languages
English (en)
Inventor
Pierre-Jean Colson
Ying Yu
Daniel D Long
Ioanna Stergiades
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of BRPI0814288A2 publication Critical patent/BRPI0814288A2/pt
Publication of BRPI0814288B1 publication Critical patent/BRPI0814288B1/pt
Publication of BRPI0814288B8 publication Critical patent/BRPI0814288B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BRPI0814288A 2007-07-20 2008-07-15 processo para a preparação de um composto que tem o nome químico 3-endo-(8-azabiciclo[3.2.l]oct-3-il)benzamida, processo para preparação de um composto que tem um grupo de proteção de amino e composto BRPI0814288B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US96135307P 2007-07-20 2007-07-20
US60/961,353 2007-07-20
PCT/US2008/008607 WO2009014610A2 (en) 2007-07-20 2008-07-15 Process for preparing an intermediate to mu opioid receptor antagonists

Publications (3)

Publication Number Publication Date
BRPI0814288A2 true BRPI0814288A2 (pt) 2015-02-03
BRPI0814288B1 BRPI0814288B1 (pt) 2021-04-20
BRPI0814288B8 BRPI0814288B8 (pt) 2021-05-25

Family

ID=40265383

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0814288A BRPI0814288B8 (pt) 2007-07-20 2008-07-15 processo para a preparação de um composto que tem o nome químico 3-endo-(8-azabiciclo[3.2.l]oct-3-il)benzamida, processo para preparação de um composto que tem um grupo de proteção de amino e composto

Country Status (13)

Country Link
US (3) US7932402B2 (pt)
EP (2) EP3037420B1 (pt)
JP (1) JP5351157B2 (pt)
KR (1) KR101531617B1 (pt)
CN (1) CN101743245B (pt)
AU (1) AU2008279749B2 (pt)
BR (1) BRPI0814288B8 (pt)
CA (1) CA2690606C (pt)
ES (2) ES2701251T3 (pt)
MX (1) MX2010000813A (pt)
RU (1) RU2469035C2 (pt)
TW (1) TWI415850B (pt)
WO (1) WO2009014610A2 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY145633A (en) 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物
ES2390195T3 (es) * 2007-08-27 2012-11-07 Theravance, Inc. Compuestos de amidoalquil-8-azabiciclo(3,2,1)octano, como antagonistas del receptor opioide mu
ES2364686T3 (es) * 2007-08-27 2011-09-12 Theravance, Inc. Compuestos de alquil-8-azabiciclo[3.2.1]octano disustituidos como antagonistas del receptor opioide mu.
US7691878B2 (en) * 2007-08-27 2010-04-06 Theravance, Inc. Heteroarylalkyl-8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
LT3277278T (lt) 2015-04-02 2020-03-25 Theravance Biopharma R&D Ip, Llc Kombinuota vaisto forma mu opioidinio receptoriaus antagonisto ir opioidinio agento

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3829879B2 (ja) 1994-05-18 2006-10-04 大正製薬株式会社 キノリンカルボン酸誘導体
US5731317A (en) * 1995-03-10 1998-03-24 Merck & Co., Inc. Bridged piperidines promote release of growth hormone
RU2157372C2 (ru) * 1995-10-13 2000-10-10 Нюросерч А/С Производные 8-азабицикло[3.2.1.]-окт-2-ена, способ их получения, фармацевтическая композиция, способ изготовления лекарственного средства, способы ингибирования обратного захвата моноаминного нейромедиатора, в особенности серотонина
ATE267199T1 (de) * 1997-05-30 2004-06-15 Neurosearch As 8-azabicyclo(3,2,1)oct-2-en- und octanderivate als liganden der nicotinergen ach rezeptoren
JP2002518331A (ja) * 1998-06-19 2002-06-25 イーライ・リリー・アンド・カンパニー セロトニン再取り込みの阻害
DE69914935T2 (de) * 1998-11-27 2009-10-01 Neurosearch A/S 8-azabicyclo[3.2.1]okt-2-en- und -oktanderivate
CA2522323C (en) * 2003-04-14 2009-09-15 Pfizer Products Inc. 3-azabicyclo[3.2.1]octane derivatives as opioid receptor ligands
TWI351282B (en) 2004-04-07 2011-11-01 Theravance Inc Quinolinone-carboxamide compounds as 5-ht4 recepto
JP2008534653A (ja) * 2005-04-08 2008-08-28 ノイロサーチ アクティーゼルスカブ 新規エナンチオマー及びモノアミン神経伝達物質再取り込み阻害剤としてのそれらの使用
AU2006233884A1 (en) * 2005-04-08 2006-10-19 Neurosearch A/S (+) - and (-) -8-alkyl-3-(trifluoralkylsulfonyloxy)-8-azabicycl (3.2.1.)oct-2-ene
MY145633A (en) * 2006-03-01 2012-03-15 Theravance Inc 8-azabicyclo[3.2.1]octane compounds as mu opioid receptor antagonists
TWI409067B (zh) * 2007-02-28 2013-09-21 Theravance Inc ８-氮雜雙環〔３．２．１〕辛烷化合物之結晶型
TWI423801B (zh) * 2007-08-27 2014-01-21 Theravance Inc 作為μ類鴉片受體拮抗劑之８－氮雜雙環〔３．２．１〕辛基－２－羥基苯甲醯胺化合物

Also Published As

Publication number Publication date
ES2701251T3 (es) 2019-02-21
WO2009014610A3 (en) 2009-06-04
EP2173746B1 (en) 2016-09-28
RU2469035C2 (ru) 2012-12-10
RU2010106082A (ru) 2011-08-27
BRPI0814288B8 (pt) 2021-05-25
EP3037420A1 (en) 2016-06-29
AU2008279749B2 (en) 2013-05-23
US7932402B2 (en) 2011-04-26
EP2173746A2 (en) 2010-04-14
AU2008279749A1 (en) 2009-01-29
JP2010534205A (ja) 2010-11-04
WO2009014610A2 (en) 2009-01-29
BRPI0814288B1 (pt) 2021-04-20
CA2690606C (en) 2015-05-26
EP3037420B1 (en) 2018-09-12
MX2010000813A (es) 2010-03-01
US20090023934A1 (en) 2009-01-22
ES2608412T3 (es) 2017-04-10
US8476440B2 (en) 2013-07-02
CA2690606A1 (en) 2009-01-29
KR20100034748A (ko) 2010-04-01
US20110166355A1 (en) 2011-07-07
TW200911801A (en) 2009-03-16
US8247559B2 (en) 2012-08-21
CN101743245A (zh) 2010-06-16
US20130079523A1 (en) 2013-03-28
TWI415850B (zh) 2013-11-21
JP5351157B2 (ja) 2013-11-27
KR101531617B1 (ko) 2015-06-25
CN101743245B (zh) 2015-06-10

Similar Documents

Publication Publication Date Title
IL193153A (en) Process for making adenosine receptor a2a agonist
BRPI0820733A2 (pt) Processo para a preparação de macrociclo
DK2252581T3 (da) Kappa-selektiv opioidreceptorantagonist
BRPI0910910A2 (pt) processo para preparar um composto
BRPI0910911A2 (pt) processo para preparar um composto
DK3409274T3 (da) Doseringsskema for en s1p-receptoragonist
BRPI0813903A2 (pt) Processos para a prepração de pirazóis
BRPI0812422A2 (pt) Processo de preparação de um aldeído hidroxiaromático
GB0720390D0 (en) G-Protein coupled receptor agonists
BRPI0819568A2 (pt) métodos para a preparação de um composto
GB0720389D0 (en) G-Protein Coupled Receptor Agonists
BRPI0810067A2 (pt) Processo para a preparação de capecitabina
BRPI0816911A2 (pt) Processo para preparação de 4-aminobut-2-enolidas
BRPI0910118A2 (pt) antagonistas de receptores do glucagon
BRPI0914674A2 (pt) processo para preparação de um pó
BRPI0812999A2 (pt) Método para preparar um composto
BRPI0809652A2 (pt) Processo melhorado para a síntese de solifenacina
BRPI1012018A2 (pt) processo para preparar um composto
BRPI0815797A2 (pt) Compostos 8-azabiciclo[3.2.1]octil-2-hidroxibanzamida como antagonistas de receptor opióide mu
BRPI0807870A2 (pt) Método para a produção de um revestimento
IL199922A0 (en) Quaternary ammonium diphenylamethyl compounds useful as muscarinic receptor antagonists
BRPI0918906A2 (pt) método para a produção de comprimidos de cetirizina
BRPI0912558A2 (pt) Processo para a preparação de amidas
BRPI0814288A2 (pt) Processo para a preparação de um intermediário para antagonistas de receptor de opióide mu
BRPI0912202A2 (pt) processo para a preparação de um painel

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25A Requested transfer of rights approved

Owner name: THERAVANCE BIOPHARMA RANDD IP, LLC (US)

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B11N Dismissal: publication cancelled [chapter 11.14 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 11.5 NA RPI NO 2502 DE 18/12/2018 POR TER SIDO INDEVIDA.

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/07/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME MEDIDA CAUTELAR DE 07/04/2021 - ADI 5.529/DF

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/07/2008 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 16A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2783 DE 07-05-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.