BRPI0810067A2 - Processo para a preparação de capecitabina - Google Patents
Processo para a preparação de capecitabinaInfo
- Publication number
- BRPI0810067A2 BRPI0810067A2 BRPI0810067-5A2A BRPI0810067A BRPI0810067A2 BR PI0810067 A2 BRPI0810067 A2 BR PI0810067A2 BR PI0810067 A BRPI0810067 A BR PI0810067A BR PI0810067 A2 BRPI0810067 A2 BR PI0810067A2
- Authority
- BR
- Brazil
- Prior art keywords
- capecitabin
- preparing
- preparing capecitabin
- Prior art date
Links
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/067—Pyrimidine radicals with ribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN850CH2007 | 2007-04-20 | ||
| US3082708P | 2008-02-22 | 2008-02-22 | |
| PCT/US2008/060573 WO2008131062A2 (en) | 2007-04-20 | 2008-04-17 | Process for preparing capecitabine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0810067A2 true BRPI0810067A2 (pt) | 2014-10-21 |
Family
ID=39645378
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0810067-5A2A BRPI0810067A2 (pt) | 2007-04-20 | 2008-04-17 | Processo para a preparação de capecitabina |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100130734A1 (pt) |
| EP (1) | EP2137201A2 (pt) |
| JP (1) | JP2010524960A (pt) |
| KR (1) | KR20100015568A (pt) |
| BR (1) | BRPI0810067A2 (pt) |
| MX (1) | MX2009011255A (pt) |
| WO (1) | WO2008131062A2 (pt) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR064165A1 (es) * | 2007-12-06 | 2009-03-18 | Richmond Sa Com Ind Y Financie | Un procedimiento para la preparacion de capecitabina e intermediarios utilizables en dicho procedimiento |
| JP5749017B2 (ja) | 2008-01-22 | 2015-07-15 | ダウ アグロサイエンシィズ エルエルシー | ５−フルオロピリミジン誘導体 |
| WO2010061402A2 (en) * | 2008-11-25 | 2010-06-03 | Vishwanath Kannan | An improved process for the preparation of capecitabine |
| EP2370414A4 (en) * | 2008-12-02 | 2012-11-14 | Reddys Lab Ltd Dr | PREPARATION OF CAPECITABINE |
| JP2012533618A (ja) * | 2009-07-23 | 2012-12-27 | サイノファーム タイワン リミテッド | フルオロシチジン誘導体の製造プロセス |
| WO2011067588A1 (en) | 2009-12-04 | 2011-06-09 | Generics [Uk] Limited | Cyclic sulphinyl esters of cytidine |
| WO2011104540A1 (en) | 2010-02-24 | 2011-09-01 | Generics [Uk] Limited | One step process for the preparation of capecitabine |
| CN101830953A (zh) * | 2010-05-26 | 2010-09-15 | 南京亚东启天药业有限公司 | 一种卡培他滨及其中间体的制备方法 |
| CN101928314A (zh) * | 2010-08-27 | 2010-12-29 | 广东肇庆星湖生物科技股份有限公司 | 一种卡培他滨的制备方法 |
| CN102140124B (zh) * | 2011-02-26 | 2013-05-15 | 湖南欧亚生物有限公司 | 一种新型的卡培他滨的合成工艺 |
| CN103509072B (zh) * | 2012-06-19 | 2016-01-13 | 齐鲁制药有限公司 | 一种微粉型卡培他滨的制备方法 |
| CN102977169A (zh) * | 2012-12-20 | 2013-03-20 | 齐鲁天和惠世制药有限公司 | 一种2＇3＇-二-o-乙酰基-5＇-脱氧-5-氟-n4-(戊氧羰基)胞苷制备方法 |
| CN103897005B (zh) * | 2012-12-27 | 2017-07-28 | 鲁南制药集团股份有限公司 | 一种连续操作合成卡培他滨的方法 |
| ES2885451T3 (es) | 2014-04-30 | 2021-12-13 | Inspirna Inc | Inhibidores del transporte de creatina y usos de los mismos |
| CN104650160A (zh) * | 2015-01-13 | 2015-05-27 | 济南大学 | 卡培他滨关键中间体1,2,3-o-三乙酰基-5-脱氧-d-核糖的合成新方法 |
| CN105566419A (zh) * | 2015-12-28 | 2016-05-11 | 上海金和生物技术有限公司 | 卡培他滨的制备方法 |
| CN106496294B (zh) * | 2016-09-21 | 2018-10-30 | 齐鲁天和惠世制药有限公司 | 一种制备微粉型卡培他滨的方法 |
| CN106699825A (zh) * | 2016-12-01 | 2017-05-24 | 齐鲁天和惠世制药有限公司 | 一种以卡培他滨废水提取物制备卡培他滨的方法 |
| CN107805274B (zh) * | 2017-11-08 | 2021-02-09 | 上海皓元生物医药科技有限公司 | 一种抗体偶联药物连接子中间体的工业化生产方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1327358C (en) * | 1987-11-17 | 1994-03-01 | Morio Fujiu | Fluoro cytidine derivatives |
| TW254946B (pt) * | 1992-12-18 | 1995-08-21 | Hoffmann La Roche | |
| AU671491B2 (en) * | 1992-12-18 | 1996-08-29 | F. Hoffmann-La Roche Ag | N-oxycarbonyl substituted 5'-deoxy-5-fluorcytidines |
| DE602004015331D1 (de) * | 2003-12-22 | 2008-09-04 | Hoffmann La Roche | Verfahren für fluorcytidinderivate |
| CN100383128C (zh) | 2004-02-23 | 2008-04-23 | 上海迪赛诺医药发展有限公司 | N4－氧羰基胞嘧啶衍生物及制备方法与应用 |
| CN100425617C (zh) * | 2006-10-31 | 2008-10-15 | 浙江海正药业股份有限公司 | 一种含氟嘧啶类化合物烷氧羰酰化的方法 |
-
2008
- 2008-04-17 KR KR1020097021442A patent/KR20100015568A/ko not_active Withdrawn
- 2008-04-17 MX MX2009011255A patent/MX2009011255A/es not_active Application Discontinuation
- 2008-04-17 JP JP2010504240A patent/JP2010524960A/ja not_active Withdrawn
- 2008-04-17 US US12/596,544 patent/US20100130734A1/en not_active Abandoned
- 2008-04-17 EP EP08746057A patent/EP2137201A2/en not_active Withdrawn
- 2008-04-17 BR BRPI0810067-5A2A patent/BRPI0810067A2/pt not_active Application Discontinuation
- 2008-04-17 WO PCT/US2008/060573 patent/WO2008131062A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2009011255A (es) | 2009-11-23 |
| JP2010524960A (ja) | 2010-07-22 |
| KR20100015568A (ko) | 2010-02-12 |
| EP2137201A2 (en) | 2009-12-30 |
| WO2008131062A3 (en) | 2008-12-18 |
| WO2008131062A2 (en) | 2008-10-30 |
| US20100130734A1 (en) | 2010-05-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
| B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] | ||
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |