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BRPI0808888B8 - composto de fenil amino pirimidina para uso no tratamento de uma doença associada à quinase, processo para a preparação do composto, composição farmacêutica, e, implante - Google Patents

composto de fenil amino pirimidina para uso no tratamento de uma doença associada à quinase, processo para a preparação do composto, composição farmacêutica, e, implante

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Publication number
BRPI0808888B8
BRPI0808888B8 BRPI0808888A BRPI0808888A BRPI0808888B8 BR PI0808888 B8 BRPI0808888 B8 BR PI0808888B8 BR PI0808888 A BRPI0808888 A BR PI0808888A BR PI0808888 A BRPI0808888 A BR PI0808888A BR PI0808888 B8 BRPI0808888 B8 BR PI0808888B8
Authority
BR
Brazil
Prior art keywords
compound
diseases
phenyl amino
kinase
treatment
Prior art date
Application number
BRPI0808888A
Other languages
English (en)
Inventor
Craig Donohue Andrew
Frederick Wilks Andrew
John Burns Christopher
Thomas Feutrill John
Zeng Jun
Lien Thi Nguyen Thao
Original Assignee
Cytopia Res Pty Ltd
Ym Biosciences Australia Pty
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cytopia Res Pty Ltd, Ym Biosciences Australia Pty filed Critical Cytopia Res Pty Ltd
Priority to BR122020010759-6A priority Critical patent/BR122020010759B1/pt
Publication of BRPI0808888A2 publication Critical patent/BRPI0808888A2/pt
Publication of BRPI0808888B1 publication Critical patent/BRPI0808888B1/pt
Publication of BRPI0808888B8 publication Critical patent/BRPI0808888B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract

composto de fenil amino pirimidina e seus usos a presente invenção está relacionada aos compostos de fenil amino pirimidina que são inibidores de proteína quinases, incluindo quinases jak. em particular, os compostos são seletivos para quinases jak2. os inibidores de quinase podem ser usados no tratamento de doenças associadas à quinase como, por exemplo, doenças imunológicas e inflamatórias que incluem transplantes de órgãos; doenças hiperproliferativas, incluindo câncer, e doenças mieloproliferativas; doenças virais; doenças metabólicas; e doenças vasculares.
BRPI0808888A 2007-03-12 2008-03-12 composto de fenil amino pirimidina para uso no tratamento de uma doença associada à quinase, processo para a preparação do composto, composição farmacêutica, e, implante BRPI0808888B8 (pt)

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