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BRPI0806812B8 - Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6 - Google Patents

Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6

Info

Publication number
BRPI0806812B8
BRPI0806812B8 BRPI0806812A BRPI0806812A BRPI0806812B8 BR PI0806812 B8 BRPI0806812 B8 BR PI0806812B8 BR PI0806812 A BRPI0806812 A BR PI0806812A BR PI0806812 A BRPI0806812 A BR PI0806812A BR PI0806812 B8 BRPI0806812 B8 BR PI0806812B8
Authority
BR
Brazil
Prior art keywords
rejection reaction
chronic rejection
suppressing
effect
inhibitor
Prior art date
Application number
BRPI0806812A
Other languages
English (en)
Inventor
Atsushi Izawa
Masafumi Takahashi
Original Assignee
Chugai Pharmaceutical Co Ltd
Univ Shinshu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd, Univ Shinshu filed Critical Chugai Pharmaceutical Co Ltd
Publication of BRPI0806812A2 publication Critical patent/BRPI0806812A2/pt
Publication of BRPI0806812B1 publication Critical patent/BRPI0806812B1/pt
Publication of BRPI0806812B8 publication Critical patent/BRPI0806812B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6. a presente invenção refere-se ao efeito de anticorpos de receptor anti-il-6 suprimindo reação de rejeição crônica. foi avaliado o efeito da administração de anticorpo de receptor de il-6 anticamundongo (mr16-1) na supressão da reação de rejeição crônica usando um modelo de camundongo para rejeição crônica pós- transplante de coração. o resultado de análise histopatológica de corações transplantados extirpados 60 dias após o transplante revelou que a fibroses de lesões estenóticas vasculares e do miocárdio, que são condições patológicas características da reação de rejeição crônica, foram significantemente suprimidos no grupo tratado com mr16-1 quando comparado ao grupo de controle. desse modo, a administração de mr16-1 foi demonstrada ter o efeito de suprimir reação de rejeição crônica. especificamente, a presente invenção descobriu pela primeira vez que a reação de rejeição na fase crônica após transplante de órgão foi suprimida administrando-se um anticorpo de receptor anti-il-6.
BRPI0806812A 2007-01-23 2008-01-23 Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6 BRPI0806812B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2007012572 2007-01-23
JP2007-012572 2007-01-23
PCT/JP2008/050842 WO2008090901A1 (ja) 2007-01-23 2008-01-23 慢性拒絶反応抑制剤

Publications (3)

Publication Number Publication Date
BRPI0806812A2 BRPI0806812A2 (pt) 2011-09-13
BRPI0806812B1 BRPI0806812B1 (pt) 2021-08-03
BRPI0806812B8 true BRPI0806812B8 (pt) 2021-09-14

Family

ID=39644475

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0806812A BRPI0806812B8 (pt) 2007-01-23 2008-01-23 Agente para suprimir reação de rejeição crônica e uso de um inibidor de il-6

Country Status (16)

Country Link
US (1) US9725514B2 (pt)
EP (1) EP2123302B1 (pt)
JP (1) JP5254807B2 (pt)
KR (1) KR101508019B1 (pt)
CN (1) CN101646459B (pt)
AR (1) AR065004A1 (pt)
AU (1) AU2008208321B2 (pt)
BR (1) BRPI0806812B8 (pt)
CA (1) CA2675625C (pt)
CL (1) CL2008000188A1 (pt)
ES (1) ES2564392T3 (pt)
MX (1) MX2009007830A (pt)
PE (1) PE20081635A1 (pt)
RU (1) RU2450829C2 (pt)
TW (1) TWI438208B (pt)
WO (1) WO2008090901A1 (pt)

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KR101508019B1 (ko) 2015-04-06
RU2450829C2 (ru) 2012-05-20
CN101646459B (zh) 2014-02-12
HK1140134A1 (en) 2010-10-08
CA2675625C (en) 2016-09-13
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CN101646459A (zh) 2010-02-10
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JPWO2008090901A1 (ja) 2010-05-20
AU2008208321B2 (en) 2013-03-21
CA2675625A1 (en) 2008-07-31
CL2008000188A1 (es) 2008-07-18
BRPI0806812A2 (pt) 2011-09-13
US20100061986A1 (en) 2010-03-11
KR20090109563A (ko) 2009-10-20
US9725514B2 (en) 2017-08-08
RU2009131747A (ru) 2011-02-27
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MX2009007830A (es) 2009-10-07
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