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AR065004A1 - Anticuerpos anti-receptor de il-6 - Google Patents

Anticuerpos anti-receptor de il-6

Info

Publication number
AR065004A1
AR065004A1 ARP080100282A ARP080100282A AR065004A1 AR 065004 A1 AR065004 A1 AR 065004A1 AR P080100282 A ARP080100282 A AR P080100282A AR P080100282 A ARP080100282 A AR P080100282A AR 065004 A1 AR065004 A1 AR 065004A1
Authority
AR
Argentina
Prior art keywords
rejection reaction
chronic
suppressing
administration
effect
Prior art date
Application number
ARP080100282A
Other languages
English (en)
Inventor
Masafumi Takahashi
Atsushi Izawa
Original Assignee
Univ Shinshu
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Shinshu, Chugai Pharmaceutical Co Ltd filed Critical Univ Shinshu
Publication of AR065004A1 publication Critical patent/AR065004A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Se evaluo el efecto de anticuerpos anti-receptor del IL-6 en la supresion de la reaccion de rechazo cronica. Se evaluo el efecto de la administracion de un anticuerpo anti-receptor de IL-6 de raton (MR 16-1) en la supresion de la reaccion de rechazo cronica usando un modelo de raton de rechazo cronico post-transplante de corazon. El resultado del análisis histopatologico de los corazones transplantados extirpados 60 días después del transplante revelo que la fibrosis de miocardio y las lesiones vasculares estenoticas, que son afecciones patologicas características de la reaccion de rechazo cronica, eran suprimidas significativamente en el grupo tratado con MR16-1 en comparacion con el grupo control. Por consiguiente, se demostro que la administracion de MR16-1 tenía efecto de suprimir la reaccion de rechazo cronica. Específicamente, los inventores de la presente descubrieron por primera vez que la reaccion de rechazo den la fase cronica después del transplante de organos era suprimida mediante la administracion de un anticuerpo anti-receptor de IL-6. Reivindicacion 1: Un agente para suprimir la reaccion de rechazo cronica, caracterizado porque comprende como ingrediente activo un inhibidor de la IL-6.
ARP080100282A 2007-01-23 2008-01-24 Anticuerpos anti-receptor de il-6 AR065004A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007012572 2007-01-23

Publications (1)

Publication Number Publication Date
AR065004A1 true AR065004A1 (es) 2009-05-06

Family

ID=39644475

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100282A AR065004A1 (es) 2007-01-23 2008-01-24 Anticuerpos anti-receptor de il-6

Country Status (16)

Country Link
US (1) US9725514B2 (es)
EP (1) EP2123302B1 (es)
JP (1) JP5254807B2 (es)
KR (1) KR101508019B1 (es)
CN (1) CN101646459B (es)
AR (1) AR065004A1 (es)
AU (1) AU2008208321B2 (es)
BR (1) BRPI0806812B8 (es)
CA (1) CA2675625C (es)
CL (1) CL2008000188A1 (es)
ES (1) ES2564392T3 (es)
MX (1) MX2009007830A (es)
PE (1) PE20081635A1 (es)
RU (1) RU2450829C2 (es)
TW (1) TWI438208B (es)
WO (1) WO2008090901A1 (es)

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