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BRPI0709803B8 - compostos moduladores de benzimidazol de vr1, sais, processo de preparação do mesmo, seu uso e composição farmacêutica que os compreende - Google Patents

compostos moduladores de benzimidazol de vr1, sais, processo de preparação do mesmo, seu uso e composição farmacêutica que os compreende

Info

Publication number
BRPI0709803B8
BRPI0709803B8 BRPI0709803A BRPI0709803A BRPI0709803B8 BR PI0709803 B8 BRPI0709803 B8 BR PI0709803B8 BR PI0709803 A BRPI0709803 A BR PI0709803A BR PI0709803 A BRPI0709803 A BR PI0709803A BR PI0709803 B8 BRPI0709803 B8 BR PI0709803B8
Authority
BR
Brazil
Prior art keywords
benzimidazole
salts
preparation
pharmaceutical composition
modulating compounds
Prior art date
Application number
BRPI0709803A
Other languages
English (en)
Inventor
A Beauchamp Derek
Liu Jian
M Wells Kenneth
A Youngman Mark
R Player Mark
Brandt Michael
C Jetter Michele
L Calvo Raul
L Dax Scott
Patel Sharmila
H Parsons William
Pan Wenxi
S Cheung Wing
Lee Yu-Kai
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BRPI0709803A2 publication Critical patent/BRPI0709803A2/pt
Publication of BRPI0709803B1 publication Critical patent/BRPI0709803B1/pt
Publication of BRPI0709803B8 publication Critical patent/BRPI0709803B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

moduladores de benzimidazol de vr1. a invenção é direcionada a compostos de fórmula (i): (i) às composições farmacêuticas contendo tais compostos e a métodos de tratamento utilizando-os.
BRPI0709803A 2006-05-03 2007-04-17 compostos moduladores de benzimidazol de vr1, sais, processo de preparação do mesmo, seu uso e composição farmacêutica que os compreende BRPI0709803B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79750406P 2006-05-03 2006-05-03
US60/797,504 2006-05-03
PCT/US2007/066748 WO2007130780A2 (en) 2006-05-03 2007-04-17 Benzimidazole modulators of vr1

Publications (3)

Publication Number Publication Date
BRPI0709803A2 BRPI0709803A2 (pt) 2011-07-26
BRPI0709803B1 BRPI0709803B1 (pt) 2019-12-10
BRPI0709803B8 true BRPI0709803B8 (pt) 2021-05-25

Family

ID=38566108

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0709803A BRPI0709803B8 (pt) 2006-05-03 2007-04-17 compostos moduladores de benzimidazol de vr1, sais, processo de preparação do mesmo, seu uso e composição farmacêutica que os compreende

Country Status (36)

Country Link
US (3) US7951829B2 (pt)
EP (1) EP2021330B1 (pt)
JP (1) JP5302884B2 (pt)
KR (1) KR101434883B1 (pt)
CN (1) CN101511797B (pt)
AR (1) AR060840A1 (pt)
AT (1) ATE482201T1 (pt)
AU (1) AU2007248341C1 (pt)
BR (1) BRPI0709803B8 (pt)
CA (1) CA2651128C (pt)
CO (1) CO6160329A2 (pt)
CR (1) CR10479A (pt)
CY (1) CY1111269T1 (pt)
DE (1) DE602007009378D1 (pt)
DK (1) DK2021330T3 (pt)
EA (1) EA019386B1 (pt)
EC (1) ECSP088854A (pt)
ES (1) ES2350959T3 (pt)
HR (1) HRP20100700T1 (pt)
IL (1) IL194916A (pt)
JO (1) JO3602B1 (pt)
MX (1) MX2008014108A (pt)
MY (1) MY154595A (pt)
NI (1) NI200800290A (pt)
NO (1) NO341965B1 (pt)
NZ (1) NZ572251A (pt)
PE (1) PE20080065A1 (pt)
PL (1) PL2021330T3 (pt)
PT (1) PT2021330E (pt)
RS (1) RS51473B (pt)
SI (1) SI2021330T1 (pt)
TW (1) TWI419882B (pt)
UA (1) UA94749C2 (pt)
UY (1) UY30322A1 (pt)
WO (1) WO2007130780A2 (pt)
ZA (1) ZA200810234B (pt)

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* Cited by examiner, † Cited by third party
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MX2009006473A (es) 2006-12-15 2009-08-25 Janssen Pharmaceutica Nv Inhibidores de receptor vainilloide de bencimidazol.
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
US20090156598A1 (en) * 2007-12-17 2009-06-18 Lebsack Alec D Imidazolopyrimidine modulators of TRPV1
CL2008003749A1 (es) * 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
CA2719515C (en) * 2008-04-18 2013-11-05 Daewoong Pharmaceutical Co., Ltd. A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof
US8232409B2 (en) 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
US8217060B2 (en) 2009-05-15 2012-07-10 Janssen Pharmaceutica, Nv Benzimidazole derivatives useful as TRP M8 receptor modulators
US8323805B2 (en) * 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
CN102002010A (zh) * 2009-08-31 2011-04-06 住友化学株式会社 双噁唑啉基烷烃化合物的精制方法
RU2606128C2 (ru) * 2011-05-16 2017-01-10 Селлсьютикс Корпорейшн Соединения для применения в лечении мукозита
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
JP6387391B2 (ja) 2013-03-14 2018-09-05 ノバルティス アーゲー 眼科疾患の処置に有用な補体因子Ｂ阻害剤としての２−（１Ｈ−インドール−４−イルメチル）−３Ｈ−イミダゾ［４，５−ｂ］ピリジン−６−カルボニトリル誘導体
CN105517999B (zh) * 2013-07-11 2019-06-28 百时美施贵宝公司 Ido抑制剂
JP2016535042A (ja) 2013-10-30 2016-11-10 ノバルティス アーゲー ２−ベンジル−ベンゾイミダゾール補体因子ｂ阻害剤およびその使用
JP6705458B2 (ja) * 2015-09-08 2020-06-03 住友化学株式会社 トリアゾール化合物の製造方法
JP7041141B2 (ja) * 2016-11-01 2022-03-23 メルク・シャープ・アンド・ドーム・コーポレーション 置換された二環式ヘテロアリール系ニコチン性アセチルコリン受容体アロステリック調節剤
RS64348B1 (sr) * 2018-05-03 2023-08-31 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivati benzimidazola kao modulatori orfan gama receptora (rorγ) srodnih retinoida i njihova farmaceutska upotreba
CN108997398B (zh) * 2018-07-23 2020-12-15 被忽略疾病药物研发组织 一种3,3-二甲基苯并[c][1,2]氧杂戊硼烷-1(3h)-醇的制备方法
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
US20220411380A1 (en) * 2019-10-31 2022-12-29 Jiangsu Hengrui Medicine Co., Ltd. ACID ADDITION SALT OF RORy REGULATOR
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

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US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6299796B1 (en) 1997-12-18 2001-10-09 Fuji Photo Film Co., Ltd. Styryl compound, method for the preparation thereof and electroluminescent element employing the same
US6748803B1 (en) * 2000-02-22 2004-06-15 Simmonds Precison Products, Inc. Liquid measurement system and shared interface apparatus for use therein
MXPA05003948A (es) * 2002-10-17 2005-06-17 Amgen Inc Derivados de bencimidazol y su uso como ligandos de receptor vaniloide.
TW200418806A (en) * 2003-01-13 2004-10-01 Fujisawa Pharmaceutical Co HDAC inhibitor
DE602004016002D1 (de) * 2003-07-28 2008-10-02 Janssen Pharmaceutica Nv Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren
NZ547109A (en) * 2003-10-28 2010-03-26 Vertex Pharma Benzimidazoles useful as modulators of ion channels
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
AU2007271241A1 (en) * 2006-07-04 2008-01-10 Janssen Pharmaceutica Nv Benzimidazole cannabinoid agonists bearing a substituted heterocyclic group
MX2009006473A (es) * 2006-12-15 2009-08-25 Janssen Pharmaceutica Nv Inhibidores de receptor vainilloide de bencimidazol.

Also Published As

Publication number Publication date
MY154595A (en) 2015-06-30
BRPI0709803B1 (pt) 2019-12-10
CN101511797A (zh) 2009-08-19
ECSP088854A (es) 2008-11-27
US7951829B2 (en) 2011-05-31
ES2350959T3 (es) 2011-01-28
TW200808738A (en) 2008-02-16
RS51473B (sr) 2011-04-30
WO2007130780A3 (en) 2008-02-14
PE20080065A1 (es) 2008-02-25
CR10479A (es) 2009-03-31
US20110190364A1 (en) 2011-08-04
NI200800290A (es) 2012-01-30
TWI419882B (zh) 2013-12-21
BRPI0709803A2 (pt) 2011-07-26
AR060840A1 (es) 2008-07-16
NO20085031L (no) 2009-01-06
PL2021330T3 (pl) 2011-03-31
CY1111269T1 (el) 2015-08-05
DK2021330T3 (da) 2010-12-06
WO2007130780A2 (en) 2007-11-15
NO341965B1 (no) 2018-03-05
CA2651128A1 (en) 2007-11-15
US20070259936A1 (en) 2007-11-08
IL194916A (en) 2013-01-31
ATE482201T1 (de) 2010-10-15
AU2007248341B2 (en) 2011-12-08
IL194916A0 (en) 2009-08-03
HRP20100700T1 (hr) 2011-02-28
KR101434883B1 (ko) 2014-08-27
US20110190344A1 (en) 2011-08-04
HK1131971A1 (en) 2010-02-12
EA200870497A1 (ru) 2009-06-30
EP2021330B1 (en) 2010-09-22
CO6160329A2 (es) 2010-05-20
DE602007009378D1 (de) 2010-11-04
SI2021330T1 (sl) 2011-01-31
JP2009535414A (ja) 2009-10-01
PT2021330E (pt) 2010-12-03
UA94749C2 (en) 2011-06-10
UY30322A1 (es) 2007-08-31
AU2007248341C1 (en) 2013-01-17
MX2008014108A (es) 2008-11-14
JP5302884B2 (ja) 2013-10-02
NZ572251A (en) 2010-08-27
AU2007248341A1 (en) 2007-11-15
KR20090008428A (ko) 2009-01-21
CN101511797B (zh) 2013-01-02
EP2021330A2 (en) 2009-02-11
ZA200810234B (en) 2010-02-24
EA019386B1 (ru) 2014-03-31
CA2651128C (en) 2014-09-02
JO3602B1 (ar) 2020-07-05

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