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BRPI0916735B8 - compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos - Google Patents

compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos

Info

Publication number
BRPI0916735B8
BRPI0916735B8 BRPI0916735A BRPI0916735A BRPI0916735B8 BR PI0916735 B8 BRPI0916735 B8 BR PI0916735B8 BR PI0916735 A BRPI0916735 A BR PI0916735A BR PI0916735 A BRPI0916735 A BR PI0916735A BR PI0916735 B8 BRPI0916735 B8 BR PI0916735B8
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
modulating compounds
tgr5 modulating
tgr5
compounds
Prior art date
Application number
BRPI0916735A
Other languages
English (en)
Inventor
Pellicciari Roberto
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40433897&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0916735(B8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of BRPI0916735A2 publication Critical patent/BRPI0916735A2/pt
Publication of BRPI0916735B1 publication Critical patent/BRPI0916735B1/pt
Publication of BRPI0916735B8 publication Critical patent/BRPI0916735B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

moduladores de tgrs e métodos de uso do mesmo. a invenção refere-se a compostos de fórmula a: (a) ou um sal, solvato ou hidrato do mesmo. os compostos de fórmula a são de tgrs úteis para o tratamento de doenças.
BRPI0916735A 2008-07-30 2009-07-30 compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos BRPI0916735B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08013676.5 2008-07-30
EP08013676 2008-07-30
PCT/US2009/052290 WO2010014836A2 (en) 2008-07-30 2009-07-30 Tgr5 modulators and methods of use thereof

Publications (3)

Publication Number Publication Date
BRPI0916735A2 BRPI0916735A2 (pt) 2015-11-03
BRPI0916735B1 BRPI0916735B1 (pt) 2020-07-28
BRPI0916735B8 true BRPI0916735B8 (pt) 2021-05-25

Family

ID=40433897

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0916735A BRPI0916735B8 (pt) 2008-07-30 2009-07-30 compostos moduladores de tgr5, composições farmacêuticas compreendendo os mesmos e seus usos

Country Status (8)

Country Link
US (2) US8796249B2 (pt)
EP (1) EP2324046B1 (pt)
CN (2) CN102164940B (pt)
AU (1) AU2009276507B2 (pt)
BR (1) BRPI0916735B8 (pt)
CA (1) CA2732323C (pt)
EA (1) EA020310B1 (pt)
WO (1) WO2010014836A2 (pt)

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Also Published As

Publication number Publication date
US9540414B2 (en) 2017-01-10
CA2732323C (en) 2017-06-27
WO2010014836A2 (en) 2010-02-04
CN105037476A (zh) 2015-11-11
EP2324046A2 (en) 2011-05-25
HK1217335A1 (zh) 2017-01-06
CN105037476B (zh) 2018-06-12
CN102164940A (zh) 2011-08-24
EP2324046B1 (en) 2014-09-03
US8796249B2 (en) 2014-08-05
AU2009276507A1 (en) 2010-02-04
US20160052956A1 (en) 2016-02-25
WO2010014836A3 (en) 2010-04-01
AU2009276507B2 (en) 2015-11-19
BRPI0916735B1 (pt) 2020-07-28
BRPI0916735A2 (pt) 2015-11-03
HK1158212A1 (en) 2012-07-13
EA201170276A1 (ru) 2011-10-31
EA020310B1 (ru) 2014-10-30
US20110172198A1 (en) 2011-07-14
CA2732323A1 (en) 2010-02-04
CN102164940B (zh) 2015-08-19

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B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2733 DE 23-05-2023 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.