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UA94749C2 - Benzimidazole modulators of vr1 - Google Patents

Benzimidazole modulators of vr1

Info

Publication number
UA94749C2
UA94749C2 UAA200813889A UAA200813889A UA94749C2 UA 94749 C2 UA94749 C2 UA 94749C2 UA A200813889 A UAA200813889 A UA A200813889A UA A200813889 A UAA200813889 A UA A200813889A UA 94749 C2 UA94749 C2 UA 94749C2
Authority
UA
Ukraine
Prior art keywords
benzimidazole
modulators
benzimidazole modulators
compounds
directed
Prior art date
Application number
UAA200813889A
Other languages
English (en)
Inventor
Рауль Р. Кальво
Марк Р. Плейер
Скотт Л. Дакс
Уилльям Х. Парсонс
Майкл Брандт
Шармила Пател
Цзянь Лю
Винг С. Чеунг
Мишэль С. Джеттер
Юй-Кай Ли
Марк А. Янгман
Веньси Пан
Кеннет М. Уэллс
Дерек А. Бошам
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of UA94749C2 publication Critical patent/UA94749C2/ru

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/10Drugs for disorders of the urinary system of the bladder
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08Radicals containing only hydrogen and carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
UAA200813889A 2006-05-03 2007-04-17 Benzimidazole modulators of vr1 UA94749C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79750406P 2006-05-03 2006-05-03

Publications (1)

Publication Number Publication Date
UA94749C2 true UA94749C2 (en) 2011-06-10

Family

ID=38566108

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200813889A UA94749C2 (en) 2006-05-03 2007-04-17 Benzimidazole modulators of vr1

Country Status (36)

Country Link
US (3) US7951829B2 (ru)
EP (1) EP2021330B1 (ru)
JP (1) JP5302884B2 (ru)
KR (1) KR101434883B1 (ru)
CN (1) CN101511797B (ru)
AR (1) AR060840A1 (ru)
AT (1) ATE482201T1 (ru)
AU (1) AU2007248341C1 (ru)
BR (1) BRPI0709803B8 (ru)
CA (1) CA2651128C (ru)
CO (1) CO6160329A2 (ru)
CR (1) CR10479A (ru)
CY (1) CY1111269T1 (ru)
DE (1) DE602007009378D1 (ru)
DK (1) DK2021330T3 (ru)
EA (1) EA019386B1 (ru)
EC (1) ECSP088854A (ru)
ES (1) ES2350959T3 (ru)
HR (1) HRP20100700T1 (ru)
IL (1) IL194916A (ru)
JO (1) JO3602B1 (ru)
MX (1) MX2008014108A (ru)
MY (1) MY154595A (ru)
NI (1) NI200800290A (ru)
NO (1) NO341965B1 (ru)
NZ (1) NZ572251A (ru)
PE (1) PE20080065A1 (ru)
PL (1) PL2021330T3 (ru)
PT (1) PT2021330E (ru)
RS (1) RS51473B (ru)
SI (1) SI2021330T1 (ru)
TW (1) TWI419882B (ru)
UA (1) UA94749C2 (ru)
UY (1) UY30322A1 (ru)
WO (1) WO2007130780A2 (ru)
ZA (1) ZA200810234B (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009006473A (es) 2006-12-15 2009-08-25 Janssen Pharmaceutica Nv Inhibidores de receptor vainilloide de bencimidazol.
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
US20090156598A1 (en) * 2007-12-17 2009-06-18 Lebsack Alec D Imidazolopyrimidine modulators of TRPV1
CL2008003749A1 (es) * 2007-12-17 2010-01-15 Janssen Pharmaceutica Nv Compuestos derivados de imidazol, oxazol, y tiazol pirimidina, moduladores de trpv1, proceso de preparacion, composicion farmaceutica y su uso en el tratamiento de enfermedades, trastornos o condicion de dolor, prurito, artritis, tos, asma, trastorno del oido interno y enfermedad inflamatoria intestinal, entre otras.
CA2719515C (en) * 2008-04-18 2013-11-05 Daewoong Pharmaceutical Co., Ltd. A novel benzoxazine benzimidazole derivative, a pharmaceutical composition comprising the same, and a use thereof
US8232409B2 (en) 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
US8217060B2 (en) 2009-05-15 2012-07-10 Janssen Pharmaceutica, Nv Benzimidazole derivatives useful as TRP M8 receptor modulators
US8323805B2 (en) * 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
CN102002010A (zh) * 2009-08-31 2011-04-06 住友化学株式会社 双噁唑啉基烷烃化合物的精制方法
RU2606128C2 (ru) * 2011-05-16 2017-01-10 Селлсьютикс Корпорейшн Соединения для применения в лечении мукозита
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
JP6387391B2 (ja) 2013-03-14 2018-09-05 ノバルティス アーゲー 眼科疾患の処置に有用な補体因子B阻害剤としての2−(1H−インドール−4−イルメチル)−3H−イミダゾ[4,5−b]ピリジン−6−カルボニトリル誘導体
CN105517999B (zh) * 2013-07-11 2019-06-28 百时美施贵宝公司 Ido抑制剂
JP2016535042A (ja) 2013-10-30 2016-11-10 ノバルティス アーゲー 2−ベンジル−ベンゾイミダゾール補体因子b阻害剤およびその使用
JP6705458B2 (ja) * 2015-09-08 2020-06-03 住友化学株式会社 トリアゾール化合物の製造方法
JP7041141B2 (ja) * 2016-11-01 2022-03-23 メルク・シャープ・アンド・ドーム・コーポレーション 置換された二環式ヘテロアリール系ニコチン性アセチルコリン受容体アロステリック調節剤
RS64348B1 (sr) * 2018-05-03 2023-08-31 Jiangsu Hengrui Pharmaceuticals Co Ltd Derivati benzimidazola kao modulatori orfan gama receptora (rorγ) srodnih retinoida i njihova farmaceutska upotreba
CN108997398B (zh) * 2018-07-23 2020-12-15 被忽略疾病药物研发组织 一种3,3-二甲基苯并[c][1,2]氧杂戊硼烷-1(3h)-醇的制备方法
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
US20220411380A1 (en) * 2019-10-31 2022-12-29 Jiangsu Hengrui Medicine Co., Ltd. ACID ADDITION SALT OF RORy REGULATOR
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6299796B1 (en) 1997-12-18 2001-10-09 Fuji Photo Film Co., Ltd. Styryl compound, method for the preparation thereof and electroluminescent element employing the same
US6748803B1 (en) * 2000-02-22 2004-06-15 Simmonds Precison Products, Inc. Liquid measurement system and shared interface apparatus for use therein
MXPA05003948A (es) * 2002-10-17 2005-06-17 Amgen Inc Derivados de bencimidazol y su uso como ligandos de receptor vaniloide.
TW200418806A (en) * 2003-01-13 2004-10-01 Fujisawa Pharmaceutical Co HDAC inhibitor
DE602004016002D1 (de) * 2003-07-28 2008-10-02 Janssen Pharmaceutica Nv Benzimidazol-, benzothiazol- und benzoxazolderivate und deren verwendung als lta4h-modulatoren
NZ547109A (en) * 2003-10-28 2010-03-26 Vertex Pharma Benzimidazoles useful as modulators of ion channels
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
AU2007271241A1 (en) * 2006-07-04 2008-01-10 Janssen Pharmaceutica Nv Benzimidazole cannabinoid agonists bearing a substituted heterocyclic group
MX2009006473A (es) * 2006-12-15 2009-08-25 Janssen Pharmaceutica Nv Inhibidores de receptor vainilloide de bencimidazol.

Also Published As

Publication number Publication date
MY154595A (en) 2015-06-30
BRPI0709803B1 (pt) 2019-12-10
CN101511797A (zh) 2009-08-19
ECSP088854A (es) 2008-11-27
US7951829B2 (en) 2011-05-31
ES2350959T3 (es) 2011-01-28
TW200808738A (en) 2008-02-16
RS51473B (sr) 2011-04-30
WO2007130780A3 (en) 2008-02-14
PE20080065A1 (es) 2008-02-25
CR10479A (es) 2009-03-31
US20110190364A1 (en) 2011-08-04
NI200800290A (es) 2012-01-30
TWI419882B (zh) 2013-12-21
BRPI0709803A2 (pt) 2011-07-26
AR060840A1 (es) 2008-07-16
NO20085031L (no) 2009-01-06
PL2021330T3 (pl) 2011-03-31
CY1111269T1 (el) 2015-08-05
DK2021330T3 (da) 2010-12-06
WO2007130780A2 (en) 2007-11-15
NO341965B1 (no) 2018-03-05
CA2651128A1 (en) 2007-11-15
US20070259936A1 (en) 2007-11-08
IL194916A (en) 2013-01-31
ATE482201T1 (de) 2010-10-15
AU2007248341B2 (en) 2011-12-08
IL194916A0 (en) 2009-08-03
HRP20100700T1 (hr) 2011-02-28
KR101434883B1 (ko) 2014-08-27
BRPI0709803B8 (pt) 2021-05-25
US20110190344A1 (en) 2011-08-04
HK1131971A1 (en) 2010-02-12
EA200870497A1 (ru) 2009-06-30
EP2021330B1 (en) 2010-09-22
CO6160329A2 (es) 2010-05-20
DE602007009378D1 (de) 2010-11-04
SI2021330T1 (sl) 2011-01-31
JP2009535414A (ja) 2009-10-01
PT2021330E (pt) 2010-12-03
UY30322A1 (es) 2007-08-31
AU2007248341C1 (en) 2013-01-17
MX2008014108A (es) 2008-11-14
JP5302884B2 (ja) 2013-10-02
NZ572251A (en) 2010-08-27
AU2007248341A1 (en) 2007-11-15
KR20090008428A (ko) 2009-01-21
CN101511797B (zh) 2013-01-02
EP2021330A2 (en) 2009-02-11
ZA200810234B (en) 2010-02-24
EA019386B1 (ru) 2014-03-31
CA2651128C (en) 2014-09-02
JO3602B1 (ar) 2020-07-05

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