BRPI0507104A - n-ciclohexilimidazolinonas substituìdas com efeito modulador de mch - Google Patents
n-ciclohexilimidazolinonas substituìdas com efeito modulador de mchInfo
- Publication number
- BRPI0507104A BRPI0507104A BRPI0507104-6A BRPI0507104A BRPI0507104A BR PI0507104 A BRPI0507104 A BR PI0507104A BR PI0507104 A BRPI0507104 A BR PI0507104A BR PI0507104 A BRPI0507104 A BR PI0507104A
- Authority
- BR
- Brazil
- Prior art keywords
- mch
- substituted
- modulating effect
- cyclohexylimidazolinones
- production
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 239000013585 weight reducing agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/70—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
N-CICLOHEXILIMIDAZOLINONAS SUBSTITUìDAS COM EFEITO MODULADOR DE MCH. A invenção refere-se a heterocilos de N-cicloexila substituídos, bem como os sais fisiologicamente compatíveis e derivados fisiologicamente funcionais dos mesmos, a processos para produção dos mesmos, e ao uso dos mesmos como medicamento. São descritos compostos da fórmula I, Q(R2)~ n~, na qual os radicais têm os significados indicados, em como os sais fisiologicamente compatíveis dos mesmos para sua produção. Os compostos provocam, por exemplo, uma redução de peso em mamíferos e são apropriados, por exemplo, para prevenção e tratamento de obesidade e diabetes.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004003811A DE102004003811A1 (de) | 2004-01-25 | 2004-01-25 | Substituierte N-Cyclohexylimidazolinone, Verfahren ihrer Herstellung und ihre Verwendung als Arzneimittel |
| PCT/EP2005/000700 WO2005070898A1 (de) | 2004-01-25 | 2005-01-25 | Substituierte n-cyclohexylimidazolinone mit mch-modulatorischer wirkung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0507104A true BRPI0507104A (pt) | 2007-06-19 |
Family
ID=34745115
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0507104-6A BRPI0507104A (pt) | 2004-01-25 | 2005-01-25 | n-ciclohexilimidazolinonas substituìdas com efeito modulador de mch |
Country Status (26)
| Country | Link |
|---|---|
| EP (1) | EP1711473B1 (pt) |
| JP (1) | JP2007518771A (pt) |
| KR (1) | KR20060128955A (pt) |
| CN (1) | CN1934090B (pt) |
| AR (1) | AR047453A1 (pt) |
| AT (1) | ATE383342T1 (pt) |
| AU (1) | AU2005206308A1 (pt) |
| BR (1) | BRPI0507104A (pt) |
| CA (1) | CA2554233A1 (pt) |
| CY (1) | CY1107429T1 (pt) |
| DE (2) | DE102004003811A1 (pt) |
| DK (1) | DK1711473T3 (pt) |
| ES (1) | ES2297667T3 (pt) |
| HR (1) | HRP20080077T3 (pt) |
| IL (1) | IL176917A0 (pt) |
| MA (1) | MA28345A1 (pt) |
| MY (1) | MY139107A (pt) |
| NO (1) | NO20063757L (pt) |
| PE (1) | PE20051091A1 (pt) |
| PL (1) | PL1711473T3 (pt) |
| PT (1) | PT1711473E (pt) |
| RS (1) | RS50543B (pt) |
| RU (1) | RU2006130626A (pt) |
| TW (1) | TW200604182A (pt) |
| UY (1) | UY28726A1 (pt) |
| WO (1) | WO2005070898A1 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1966164B1 (en) | 2005-12-21 | 2013-03-06 | Janssen Pharmaceutica N.V. | Novel substituted pyrazinone derivatives for use in mch-1 mediated diseases |
| JP2010500300A (ja) | 2006-08-08 | 2010-01-07 | サノフィ−アベンティス | アリールアミノアリール−アルキル−置換イミダゾリジン−２，４−ジオン、それらの製造法、それらの化合物を含有する薬剤、およびそれらの使用 |
| CA2664112C (en) | 2006-12-05 | 2015-02-17 | Janssen Pharmaceutica N.V. | Novel substituted diaza-spiro-pyridinone derivatives for use in mch-1 mediated diseases |
| KR100893394B1 (ko) * | 2007-05-11 | 2009-04-17 | 한국화학연구원 | 아릴 피페리딘기-함유 이미다졸 유도체, 이의 제조방법 및이를 유효성분으로 포함하는 약학적 조성물 |
| WO2010003624A2 (en) | 2008-07-09 | 2010-01-14 | Sanofi-Aventis | Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof |
| DE102008060967A1 (de) * | 2008-12-06 | 2010-06-10 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Phenylsulfonyltriazolone und ihre Verwendung |
| WO2010068601A1 (en) | 2008-12-08 | 2010-06-17 | Sanofi-Aventis | A crystalline heteroaromatic fluoroglycoside hydrate, processes for making, methods of use and pharmaceutical compositions thereof |
| KR20120060207A (ko) | 2009-08-26 | 2012-06-11 | 사노피 | 신규한 결정성 헤테로방향족 플루오로글리코시드 수화물, 이들 화합물을 포함하는 약제 및 이들의 용도 |
| WO2012120057A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120055A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120051A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Mit adamantan- oder noradamantan substituierte benzyl-oxathiazinderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2683701B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Mit benzyl- oder heteromethylengruppen substituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683702B1 (de) | 2011-03-08 | 2014-12-24 | Sanofi | Neue substituierte phenyl-oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| PL223830B1 (pl) | 2012-04-03 | 2016-11-30 | Univ Jagiellonski | Pochodne aromatycznych imidazolidynonów i ich zastosowanie |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2002348269A1 (en) * | 2001-12-04 | 2003-06-17 | Schering Corporation | N-aryl-n'-arylcycloalkyl-urea derivatives as mch antagonists for the treatment of obesity |
| DE10233817A1 (de) * | 2002-07-25 | 2004-02-12 | Aventis Pharma Deutschland Gmbh | Substituierte Diarylheterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
-
2004
- 2004-01-25 DE DE102004003811A patent/DE102004003811A1/de not_active Withdrawn
-
2005
- 2005-01-24 AR ARP050100240A patent/AR047453A1/es not_active Application Discontinuation
- 2005-01-25 UY UY28726A patent/UY28726A1/es unknown
- 2005-01-25 TW TW094102156A patent/TW200604182A/zh unknown
- 2005-01-25 MY MYPI20050274A patent/MY139107A/en unknown
- 2005-01-25 DE DE502005002497T patent/DE502005002497D1/de not_active Expired - Lifetime
- 2005-01-25 CN CN2005800091349A patent/CN1934090B/zh not_active Expired - Fee Related
- 2005-01-25 KR KR1020067015035A patent/KR20060128955A/ko not_active Ceased
- 2005-01-25 RS RSP-2008/0082A patent/RS50543B/sr unknown
- 2005-01-25 AU AU2005206308A patent/AU2005206308A1/en not_active Abandoned
- 2005-01-25 JP JP2006550073A patent/JP2007518771A/ja not_active Abandoned
- 2005-01-25 WO PCT/EP2005/000700 patent/WO2005070898A1/de not_active Ceased
- 2005-01-25 BR BRPI0507104-6A patent/BRPI0507104A/pt not_active IP Right Cessation
- 2005-01-25 PT PT05707002T patent/PT1711473E/pt unknown
- 2005-01-25 EP EP05707002A patent/EP1711473B1/de not_active Expired - Lifetime
- 2005-01-25 HR HR20080077T patent/HRP20080077T3/xx unknown
- 2005-01-25 AT AT05707002T patent/ATE383342T1/de not_active IP Right Cessation
- 2005-01-25 CA CA002554233A patent/CA2554233A1/en not_active Abandoned
- 2005-01-25 PE PE2005000095A patent/PE20051091A1/es not_active Application Discontinuation
- 2005-01-25 PL PL05707002T patent/PL1711473T3/pl unknown
- 2005-01-25 DK DK05707002T patent/DK1711473T3/da active
- 2005-01-25 ES ES05707002T patent/ES2297667T3/es not_active Expired - Lifetime
- 2005-01-25 RU RU2006130626/04A patent/RU2006130626A/ru not_active Application Discontinuation
-
2006
- 2006-07-17 IL IL176917A patent/IL176917A0/en not_active IP Right Cessation
- 2006-08-03 MA MA29233A patent/MA28345A1/fr unknown
- 2006-08-22 NO NO20063757A patent/NO20063757L/no not_active Application Discontinuation
-
2008
- 2008-03-21 CY CY20081100322T patent/CY1107429T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE102004003811A1 (de) | 2005-08-11 |
| AR047453A1 (es) | 2006-01-18 |
| AU2005206308A1 (en) | 2005-08-04 |
| CY1107429T1 (el) | 2012-12-19 |
| CN1934090A (zh) | 2007-03-21 |
| EP1711473B1 (de) | 2008-01-09 |
| MA28345A1 (fr) | 2006-12-01 |
| PL1711473T3 (pl) | 2008-05-30 |
| ES2297667T3 (es) | 2008-05-01 |
| EP1711473A1 (de) | 2006-10-18 |
| MY139107A (en) | 2009-08-28 |
| CN1934090B (zh) | 2010-04-07 |
| DK1711473T3 (da) | 2008-05-26 |
| DE502005002497D1 (de) | 2008-02-21 |
| IL176917A0 (en) | 2006-12-10 |
| TW200604182A (en) | 2006-02-01 |
| CA2554233A1 (en) | 2005-08-04 |
| WO2005070898A1 (de) | 2005-08-04 |
| HRP20080077T3 (en) | 2008-03-31 |
| KR20060128955A (ko) | 2006-12-14 |
| NO20063757L (no) | 2006-10-11 |
| ATE383342T1 (de) | 2008-01-15 |
| UY28726A1 (es) | 2005-08-31 |
| RU2006130626A (ru) | 2008-02-27 |
| PE20051091A1 (es) | 2006-01-23 |
| RS50543B (sr) | 2010-05-07 |
| PT1711473E (pt) | 2008-03-07 |
| JP2007518771A (ja) | 2007-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |