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BRPI0412903A - derivados de nicotinamida úteis como inibidores de pde4 - Google Patents

derivados de nicotinamida úteis como inibidores de pde4

Info

Publication number
BRPI0412903A
BRPI0412903A BRPI0412903-2A BRPI0412903A BRPI0412903A BR PI0412903 A BRPI0412903 A BR PI0412903A BR PI0412903 A BRPI0412903 A BR PI0412903A BR PI0412903 A BRPI0412903 A BR PI0412903A
Authority
BR
Brazil
Prior art keywords
pde4 inhibitors
nicotinamide derivatives
derivatives useful
derivatives
nicotinamide
Prior art date
Application number
BRPI0412903-2A
Other languages
English (en)
Inventor
Simon Bailey
Christopher Gordon Barber
Paul Alan Glossop
Donald Stuart Middleton
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of BRPI0412903A publication Critical patent/BRPI0412903A/pt

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    • C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
    • C04B35/632—Organic additives
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Abstract

"DERIVADOS DE NICOTINAMIDA úTEIS COMO INIBIDORES DE PDE4". Esta invenção está relacionada a derivados de nicotinamida de fórmula (I) e a composições farmacêuticas que os contêm, e os usos de tais derivados como inibidores de PDE4 onde R~ 7~ está anexado à posição 3- ou 4- do anel fenila e é S(O)~ p~R~ 8~, R~ 8~ é alquila (C~ 1~-C~ 4~) opcionalmente substituída por cicloalquila (C~ 3~-C~ 6~) ; m é O ou 1; L é um anel não aromático carbocíclico (C~ 3~-C~ 8~); e as variáveis restantes são como definido nas reivindicações.
BRPI0412903-2A 2003-07-25 2004-07-13 derivados de nicotinamida úteis como inibidores de pde4 BRPI0412903A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317516.3A GB0317516D0 (en) 2003-07-25 2003-07-25 Nicotinamide derivatives useful as PDE4 inhibitors
PCT/IB2004/002379 WO2005009966A1 (en) 2003-07-25 2004-07-13 Nicotinamide derivatives useful as pde4 inhibitors

Publications (1)

Publication Number Publication Date
BRPI0412903A true BRPI0412903A (pt) 2006-09-26

Family

ID=27772741

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0412903-2A BRPI0412903A (pt) 2003-07-25 2004-07-13 derivados de nicotinamida úteis como inibidores de pde4

Country Status (8)

Country Link
US (1) US7141586B2 (pt)
EP (1) EP1651609A1 (pt)
JP (1) JP2006528660A (pt)
BR (1) BRPI0412903A (pt)
CA (1) CA2534262A1 (pt)
GB (1) GB0317516D0 (pt)
MX (1) MXPA06001039A (pt)
WO (1) WO2005009966A1 (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20074055B (en) * 2002-02-11 2007-03-12 Pfizer Nicotinamide derivatives useful as pde4 inhibitors
PE20060272A1 (es) 2004-05-24 2006-05-22 Glaxo Group Ltd (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a
GB0514809D0 (en) 2005-07-19 2005-08-24 Glaxo Group Ltd Compounds
BRPI0617673C1 (pt) * 2005-10-19 2012-05-22 Ranbaxy Lab Ltd composições de inibidores de fosfodiesterase do tipo iv
TWI498115B (zh) * 2007-12-27 2015-09-01 Daiichi Sankyo Co Ltd 咪唑羰基化合物
AU2009252938B2 (en) 2008-05-27 2012-04-26 Astrazeneca Ab Phenoxypyridinylamide derivatives and their use in the treatment of PDE4 mediated disease states
EP2397482A1 (en) 2010-06-15 2011-12-21 Almirall, S.A. Heteroaryl imidazolone derivatives as jak inhibitors
JP2014001199A (ja) * 2012-01-25 2014-01-09 Ishihara Sangyo Kaisha Ltd 有害生物防除剤
JPWO2013161980A1 (ja) * 2012-04-27 2015-12-24 東レ株式会社 シクロヘキサンジアミド誘導体及びその医薬用途
KR20230026515A (ko) * 2014-09-10 2023-02-24 에피자임, 인코포레이티드 Ｓｍｙｄ 억제제
KR20200067170A (ko) 2017-10-05 2020-06-11 풀크럼 쎄러퓨틱스, 인코포레이티드 FSHD의 치료를 위하여 DUX4 및 하류 유전자 발현을 저감시키는 p38 키나제 저해제
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
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WO2023119230A1 (en) 2021-12-22 2023-06-29 L'oreal Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use
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