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MXPA06001039A - Derivados de nicotinamida utiles como inhibidores de pde4. - Google Patents

Derivados de nicotinamida utiles como inhibidores de pde4.

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Publication number
MXPA06001039A
MXPA06001039A MXPA06001039A MXPA06001039A MXPA06001039A MX PA06001039 A MXPA06001039 A MX PA06001039A MX PA06001039 A MXPA06001039 A MX PA06001039A MX PA06001039 A MXPA06001039 A MX PA06001039A MX PA06001039 A MXPA06001039 A MX PA06001039A
Authority
MX
Mexico
Prior art keywords
pde4 inhibitors
nicotinamide derivatives
derivatives useful
derivatives
nicotinamide
Prior art date
Application number
MXPA06001039A
Other languages
English (en)
Inventor
Simon Bailey
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MXPA06001039A publication Critical patent/MXPA06001039A/es

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    • C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
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    • C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
    • C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
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Abstract

Esta invencion se refiere a derivados de nicotinamida de formula (I) y a procedimientos para la preparacion de, a intermedios usados en la preparacion de, a composiciones farmaceuticas que contienen, y a los usos de tales derivados: (ver Formula (I)) en la que R1 se selecciona entre el grupo compuesto por hidrogeno, metilo o halo; R7 se une a la posicion 3 o 4 del anillo fenilo y es S(O)pR8, R8 es alquilo (C1-C4) opcionalmente sustituido con cicloalquilo (C3-C6); p es 0, 1 o 2; R6 se selecciona entre el grupo compuesto por hidrogeno, halo, alquilo (C1-C3) y alcoxi (C1-C3); m es 0 o 1; L es un anillo carbociclico (C3-C8) no aromatico; R2 es hidrogeno, hidroxi, alcoxi (C1-C3), alquilo (C1-C3) (opcionalmente sustituido con hidroxi o con alcoxi (C1-C3)), CO2R9, NR10R11 o CONR10R11; R3 es hidrogeno o alquilo (C1-C3); R9 es hidrogeno o alquilo (C1-C3), cada uno de R10 y R11 es independiente hidrogeno, o se selecciona entre el grupo compuesto por: alquilo (C1-C6) opcionalmente sustituido con fenilo o un anillo heterociclico de 5 o 6 miembros que tiene de 1 a 3 heteroatomo(s) seleccionados independientemente entre N, O y S, donde el fenilo esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre hidroxi, halo, alquilo (C1-C3) o alcoxi (C1-C3) y donde el anillo heterociclico esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre hidroxi, halo, alquilo (C1-C3), alcoxi (C1-C3) u oxo; cicloalquilo (C3-C8); CO(alquilo (C1-C6)) opcionalmente sustituido con hidroxi, halo, cicloalquilo (C3-C8), alcoxi (C1-C3), fenilo o un anillo heterociclico que tiene 5 o 6 miembros que incluye de 1 a 3 heteroatomo(s) seleccionados independientemente entre N, O y S, donde el fenilo esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre hidroxi, halo, alquilo (C1-C3) o alcoxi (C1-C3) y donde el anillo heterociclico esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre hidroxi, halo, alquilo (C1-C3), alcoxi (C1-C3) u oxo; CO(R12), donde R12 es cicloalquilo (C3-C8) opcionalmente sustituido con alquilo (C1-C3) o R12 es fenilo o un anillo heterociclico de 5 o 6 miembros que tiene de 1 a 3 heteroatomo(s) seleccionados independientemente entre N, O y S, donde el fenilo esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre hidroxi, halo, alquilo (C1-C3) o alcoxi (C1-C3) y donde el anillo heterociclico esta opcionalmente sustituido con uno o mas sustituyentes seleccionados entre hidroxi, halo, alquilo (C1-C3), alcoxi (C1-C3) u oxo; y CO2-(alquilo (C1-C3)); o R10 y R11 se toman junto con el atomo de N al que estan unidos para formar una lactama de 5 o 6 miembros.
MXPA06001039A 2003-07-25 2004-07-13 Derivados de nicotinamida utiles como inhibidores de pde4. MXPA06001039A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0317516.3A GB0317516D0 (en) 2003-07-25 2003-07-25 Nicotinamide derivatives useful as PDE4 inhibitors
PCT/IB2004/002379 WO2005009966A1 (en) 2003-07-25 2004-07-13 Nicotinamide derivatives useful as pde4 inhibitors

Publications (1)

Publication Number Publication Date
MXPA06001039A true MXPA06001039A (es) 2006-04-11

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MXPA06001039A MXPA06001039A (es) 2003-07-25 2004-07-13 Derivados de nicotinamida utiles como inhibidores de pde4.

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Country Link
US (1) US7141586B2 (es)
EP (1) EP1651609A1 (es)
JP (1) JP2006528660A (es)
BR (1) BRPI0412903A (es)
CA (1) CA2534262A1 (es)
GB (1) GB0317516D0 (es)
MX (1) MXPA06001039A (es)
WO (1) WO2005009966A1 (es)

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