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BRPI0417830A - métodos para a sìntese de bibliotecas codificadas - Google Patents

métodos para a sìntese de bibliotecas codificadas

Info

Publication number
BRPI0417830A
BRPI0417830A BRPI0417830-0A BRPI0417830A BRPI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A BR PI0417830 A BRPI0417830 A BR PI0417830A
Authority
BR
Brazil
Prior art keywords
methods
encoded libraries
synthesizing
libraries
synthesizing encoded
Prior art date
Application number
BRPI0417830-0A
Other languages
English (en)
Inventor
Barry Morgan
Stephen Hale
Christopher C Arico-Muendel
Mathew Clark
Richard Wagner
Davide I Israel
Malcolm L Gefter
Dennis Benjamin
Nils Jacob Vest Hansen
Malcolm J Kavarna
Steffan Phillip Creaser
George J Franklin
Paolo A Centrella
Raksha A Achrya
Original Assignee
Praecis Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc
Publication of BRPI0417830A publication Critical patent/BRPI0417830A/pt
Publication of BRPI0417830B1 publication Critical patent/BRPI0417830B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B20/00—Methods specially adapted for identifying library members
    • C40B20/04—Identifying library members by means of a tag, label, or other readable or detectable entity associated with the library members, e.g. decoding processes
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C40B50/10—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support involving encoding steps

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Structural Engineering (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Analytical Chemistry (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

"MéTODOS PARA A SINTESE DE BIBLIOTECAS CODIFICADAS". A presente invenção proporciona um método de síntese de bibliotecas de moléculas as quais incluem um rótulo de oligonucleotídeo de codificação.
BRPI0417830-0A 2003-12-17 2004-12-17 métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação BRPI0417830B1 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US53085403P 2003-12-17 2003-12-17
US60/530,854 2003-12-17
US54068104P 2004-01-30 2004-01-30
US60/540,681 2004-01-30
US55371504P 2004-03-15 2004-03-15
US60/553,715 2004-03-15
US58867204P 2004-07-16 2004-07-16
US60/588,672 2004-07-16
PCT/US2004/042964 WO2005058479A2 (en) 2003-12-17 2004-12-17 Methods for synthesis of encoded libraries

Publications (2)

Publication Number Publication Date
BRPI0417830A true BRPI0417830A (pt) 2007-04-17
BRPI0417830B1 BRPI0417830B1 (pt) 2021-02-17

Family

ID=34705305

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0417830-0A BRPI0417830B1 (pt) 2003-12-17 2004-12-17 métodos para síntese de uma molécula compreendendo uma porção funcional operativamente ligada a um oligonucleotídeo de codificação

Country Status (16)

Country Link
US (4) US7972992B2 (pt)
EP (2) EP2366705A1 (pt)
JP (2) JP5646127B2 (pt)
KR (1) KR101300315B1 (pt)
CN (2) CN1898257B (pt)
AU (2) AU2004299145B2 (pt)
BR (1) BRPI0417830B1 (pt)
CA (1) CA2549386C (pt)
DK (1) DK180167B1 (pt)
IL (1) IL176008A (pt)
MX (1) MXPA06006863A (pt)
NO (1) NO20062702L (pt)
NZ (1) NZ547723A (pt)
RU (2) RU2470077C2 (pt)
WO (1) WO2005058479A2 (pt)
ZA (1) ZA200807366B (pt)

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