[go: up one dir, main page]

MXPA03008946A - Metodos para sintetizar compuestos que contienen fenol. - Google Patents

Metodos para sintetizar compuestos que contienen fenol.

Info

Publication number
MXPA03008946A
MXPA03008946A MXPA03008946A MXPA03008946A MXPA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A MX PA03008946 A MXPA03008946 A MX PA03008946A
Authority
MX
Mexico
Prior art keywords
methods
containing compounds
synthesizing phenol
synthesizing
phenol
Prior art date
Application number
MXPA03008946A
Other languages
English (en)
Inventor
L Widdowson Katherine
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MXPA03008946A publication Critical patent/MXPA03008946A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/37—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/43—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Esta invencion describe un metodo para colocar un grupo sulfona o sulfonamida que es orto con respecto a un fenol en una sustancia de farmaco a fin de incrementar la estabilidad metabolica y la vida media del compuesto, mientras se mantiene la acidez del fenol; tambien se describen metodos para sintetizar compuestos que contienen fenol.
MXPA03008946A 2001-03-30 2002-03-27 Metodos para sintetizar compuestos que contienen fenol. MXPA03008946A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US28041101P 2001-03-30 2001-03-30
PCT/US2002/010038 WO2002079122A2 (en) 2001-03-30 2002-03-27 Methods of synthesizing phenol-containing compounds

Publications (1)

Publication Number Publication Date
MXPA03008946A true MXPA03008946A (es) 2004-05-21

Family

ID=23072962

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA03008946A MXPA03008946A (es) 2001-03-30 2002-03-27 Metodos para sintetizar compuestos que contienen fenol.

Country Status (16)

Country Link
US (1) US20040110954A1 (es)
EP (1) EP1383488A2 (es)
JP (1) JP2005507366A (es)
KR (1) KR20030088044A (es)
CN (1) CN1529591A (es)
AR (1) AR034299A1 (es)
BR (1) BR0208510A (es)
CA (1) CA2442480A1 (es)
CZ (1) CZ20032639A3 (es)
HU (1) HUP0500644A3 (es)
IL (1) IL158014A0 (es)
MX (1) MXPA03008946A (es)
NO (1) NO20034288L (es)
PL (1) PL373510A1 (es)
WO (1) WO2002079122A2 (es)
ZA (1) ZA200307443B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2344123C9 (ru) * 2001-04-16 2009-05-20 Шеринг Корпорейшн 3,4-дизамещенные циклобутен-1,2-дионы как лиганды схс-хемокинового рецептора
TW200418812A (en) * 2002-10-29 2004-10-01 Smithkline Beecham Corp IL-8 receptor antagonists
EP1812008A4 (en) * 2004-10-20 2008-10-29 Smithkline Beecham Corp ANTAGONISTS OF THE IL-8 RECEPTOR
WO2007124424A2 (en) * 2006-04-21 2007-11-01 Smithkline Beecham Corporation Il-8 receptor antagonists
JP2009534420A (ja) * 2006-04-21 2009-09-24 スミスクライン・ビーチャム・コーポレイション Ｉｌ−８受容体アンタゴニスト
PE20080943A1 (es) * 2006-06-23 2008-09-27 Smithkline Beecham Corp Sal toluenosulfonato de 4-{[6-cloro-3-({[(2-cloro-3-fluorofenil)amino]carbonil}amino)-2-hidroxifenil]sulfonil}-1-piperazinacarboxilato de 1,1-dimetiletilo como antagonista del receptor de il-8
UA103198C2 (en) 2008-08-04 2013-09-25 Новартис Аг Squaramide derivatives as cxcr2 antagonists
CA2783696A1 (en) 2009-12-17 2011-06-23 Galderma Research & Development Use of compounds in the treatment or prevention of skin disorders
CN103842330B (zh) 2011-09-02 2016-10-19 诺华股份有限公司 抗炎的取代的环丁烯二酮化合物的胆碱盐
EP3668832A1 (en) 2017-08-14 2020-06-24 Allergan, Inc. 3,4-disubstituted 3-cyclobutene-1,2-diones and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714232A (en) * 1969-06-25 1973-01-30 Merck & Co Inc 5-arylphenyl sulfonic acids
US3691185A (en) * 1970-04-20 1972-09-12 Lewis H Sarett 5-aryl and arylphenyl sulfonic acids in treating inflammation
DE3208189A1 (de) * 1982-03-06 1983-09-08 Hoechst Ag, 6230 Frankfurt 2-aminomethyl-6-sulfamoylphenolderivate, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
UY25842A1 (es) * 1998-12-16 2001-04-30 Smithkline Beecham Corp Antagonistas de receptores de il-8

Also Published As

Publication number Publication date
HUP0500644A2 (hu) 2005-09-28
US20040110954A1 (en) 2004-06-10
HUP0500644A3 (en) 2005-11-28
NO20034288L (no) 2003-12-01
NO20034288D0 (no) 2003-09-25
CA2442480A1 (en) 2002-10-10
WO2002079122A3 (en) 2002-11-28
CN1529591A (zh) 2004-09-15
BR0208510A (pt) 2005-04-19
WO2002079122A2 (en) 2002-10-10
ZA200307443B (en) 2004-10-29
JP2005507366A (ja) 2005-03-17
AR034299A1 (es) 2004-02-18
KR20030088044A (ko) 2003-11-15
CZ20032639A3 (cs) 2004-04-14
IL158014A0 (en) 2004-03-28
PL373510A1 (en) 2005-09-05
EP1383488A2 (en) 2004-01-28

Similar Documents

Publication Publication Date Title
PL369530A1 (en) Chemical compounds
SG145694A1 (en) Novel compounds
GB0124627D0 (en) Novel compounds
JO2410B1 (en) 6. Replaced pyrido-pyrimidines
AU2002237527A1 (en) Method of synthesizing camptothecin-relating compounds
CA97230S (en) Escutcheon
SI1485360T1 (sl) Blokatorji natrijevih kanalov
MXPA04003886A (es) Tiofen- y tiazolsulfonamidas como agentes antineoplasticos.
CA97229S (en) Escutcheon
ZA200404752B (en) 6-aminomorphinane derivatives method for the production and use thereof
AU2003290592A1 (en) Antitumor benzoylsulfonamides
YU61103A (sh) Postupci za produkciju supstituisanih 2-(2-piridilmetil) sulfinil-1h-benzimidazola
MXPA04003755A (es) Endoprotesis vasculares.
MXPA03008946A (es) Metodos para sintetizar compuestos que contienen fenol.
AU2001282147A1 (en) Enzymatic synthesis of antioxidant hydroxytyrosol
DE602004012146D1 (en) Pyrazolopyrimidine
AP2002002547A0 (en) Calcilytic compounds.
TW200510276A (en) Calcilytic compounds
SG146645A1 (en) Process for the synthesis of 6-amino-4-(3-chloro-4fluoro-phenylamino)-7- ethoxy-quinoline-3-carbonitrile
EP1383511A4 (en) CALCILYTIC COMPOUNDS
EP1436279B8 (en) Chemical compounds
MXPA02003042A (es) Proceso para prevenir formacion de incrustaciones.
MXPA04004526A (es) N-metil-homocisteinas, su uso y metodo para su produccion.
MXPA03005400A (es) Metodo para preparacion de 11 (12)-pentadecen-15-olidos.
MXPA04004757A (es) Uso de una ascomicina para el tratamiento de blefaritis.